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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | REE composition in scheelite and scheelite Sm-Nd dating for the Xuebaoding W-Sn-Be deposit in Sichuan显示文摘The scheelite with large size and euhedral shape from Xuebaoding, Sichuan Province is an ideal min- eral to study REE patterns and Sm-Nd dating of non-gold deposits. The scheelite has diameters of 1― 10 cm and colors of pale beige to deep orange. Most of these scheelites occur in association with beryl, cassiterite and muscovite. The rare earth elements indicate that scheelite samples from Xuebaoding W-Sn-Be deposits contain high concentrations of rare earth elements with total ΣREE+Y contents in the range of 369―1725 μg·g?1 and nearly all of these scheelite samples are enriched in LREE and depleted in HREE and have negative Eu anomalies. The REE patterns of the scheelites are similar to those of A-type granite with obvious tetrad effect, similar to that of type II scheelites. Based on reported fluid inclusion studies, the mineralizing-fluid of the Xuebaoding W-Sn-Be deposit indicates low Na activity. The REE patterns of the scheelite are probably controlled by partition coefficient in hydrothermal fluid. In the 147Sm/144Nd-143Nd/144Nd diagram, the scheelites show a linear array corresponding to an isochron age of 182.0±9.2 Ma (MSWD = 0.52). The Sm-Nd age represents the formation age of the scheelite and can indicate that the W, Sn and Be mineralization at Xuebaoding took place in the Early Yanshanian. The Sm-Nd dating result is important for the study of the multi-metal resources in western Sichuan Province. | LIU Yan DENG Jun LI ChaoFeng SHI GuangHai ZHENG AiLi | 2007 | Chinese Science Bulletin2007，52，18： | 25 |
| 3 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 4 | Structure Refinement of Cs-rich Na-Li Beryl and Analysis of Its Typomorphic Characteristics of Configurations显示文摘The tabular beryl found in Huya Country, Sichuan Province is a rare and special member among beryls. Chemical analysis reveals that the beryl is a new type of Cs-rich Na-Li beryl, and the content of alkalis (Li2O, Na2O, K2O, Rb2O, Cs2O) is up to 2.41%. The CCD system on the SMART APEX four circle single crystal diffractometer was used in this experiment to determine the structure of the sample accurately. The beryl belongs to the hexagonal system; its space group is P6/mcc. The dimensions of the unit cell are as follows: a = 0.91961(3) nm, c = 0.91969(7) nm, c/a = 1.0000, V = 0.67357 nm3, γ = 120°, α = 90°, β = 90°. The accurate atomic coordinates of alkali metal ions and other crystallographic parameters are also obtained: Z = 2, the calculated density D = 2.754 g/cm3 and final R ( I > 2 σ (I) )= 0.046 for 5597 reflections. The crystal structure was described by coordination polyhedron. Based on the data gained, a three-dimensional graph of the crystal structure of tabular beryl was made with the ATOMS 6.0 software. The refinement of crystal structure indicates that there are two main reasons for the cause of the tabular configuration: (1) The substitution of Be by Li into the tetrahedral framework weakened the stacked six-sided rings [Si6O18]12- of the tetrahedral Si; (2) Alkalis (mainly Na and Cs) are too large to substitute in four-fold or six-fold coordination within the structure and are accommodated in the vacant channel. The accommodation of these alkalis strengthened the structure of six-sided rings of the tetrahedral Si. And other alkali metal ions and free volatile molecules such as H2O and CO2 occupy variable positions in the channel. The equation of the electrovalence is Li++Na+→Be2+. According to structural and compositional differences, the monoclinic crystal of tabular beryl is considered to be a new member of the beryl group. Chemical constraints of the environment, namely, the bulk-rock chemistry and the fluid-phase composition and physical-chemical conditions during the growth of the mineral may account for these occurrences of rare elements. In addition, that Li and Be have approximate physical parameters is also the key factor for the substitution. The direction of the mineralized hydrothermal liquid and the special occurrence conditions of the beryl such as the pH, temperature and pressure are also considered to be the main causes of the configuration of the tabular beryl. | LIU Yan DENG Jun LI Guowu SHI Guanghai | 2007 | Acta Geologica Sinica(English Edition)2007，81，1： | 7 |
| 5 | New index of ferromanganese crusts reflecting oceanic environmental oxidation显示文摘Ferromanganese crusts (hereinafter crusts) form in aerobic environment and the environmental oxida-tion degree is recorded by the redox sensitive element Co in the crusts. The ages of the layers from the surface to bottom of the crusts are determined, and main element contents at high resolution along the depth sections of three crusts from the Pacific Ocean are analyzed by an electron microprobe. Thus the variations of Co/(Fe+Mn) and Co/(Ni+Cu) with age/depth of the crust layers are obtained. By comparing the ratios of Co/(Fe+Mn) and Co/(Ni+Cu) with the δ 18O curves of the Pacific benthic foraminifera, we find that these two ratios can reflect the variation of the environmental oxidation state under which the crust layers deposit. The evolution of the oxidation degree reflected by the two indexes resembles the evo-lution of temperature since the Oligocene reflected by the δ 18O curves of the Pacific benthic foraminif-era. This suggests that the crust-forming environment after the Oligocene is controlled mainly by the oxygen-rich bottom water originated from the Antarctic bottom water (AABW). However it is not the case prior to the Oligocene. Furthermore it suggests that the environmental oxidation degree controls the formation of the crusts and the Co contents in the crusts. This explains why the Co contents in the crusts increase with time up to now. | WU GuangHai ZHOU HuaiYang ZHANG HaiSheng LING HongFei MA WeiLin ZHAO HongQiao CHEN JianLin LIU JieHong | 2007 | Science China Earth Sciences2007，50，3： | 7 |
| 6 | Origin and Geological Significance of TTG Gneisses from the Maevatanana Greenstone Belt in North-Central Madagascar,and A Comparison with India显示文摘The Maevatanana greenstone belt in north-central Madagascar contains widespread exposures of tonalite-trondhjemite-granodiorite(TTG) gneisses,and is important for its concentrations of various metal deposits(e.g.,chromium,nickle,iron,gold).In this paper we report on the petrography,and major and trace element compositions of the TTG gneisses within the Berere Complex of the Maevatanana area,as well as LA-ICP-MS U-Pb ages and Lu-Hf isotopic compositions of zircons from the gneisses.The gneisses consist mainly of granitoid gneiss and biotite(±hornblende) plagiogneiss,and analysis of thin sections provides evidence of crushing,recrystallization,and metasomatism related to dynamic metamorphism.Samples have large variations in their major and trace element contents,with SiO_2 = 55.87-68.06 wt%,Al_2O_3 = 13.9-17.8 wt%,and Na_2O/K_2O =0.97-2.13.Geochemically,the granitoid gneisses and biotite plagiogneisses fall on a low-Al trondhjemite to granodiorite trend,while the biotite-hornblende plagiogneisses represent a high-Al tonalite TTG assemblage.Zircon U-Pb dating shows that the Berere Complex TTG gneisses formed at2.5-2.4 Ga.Most ε_(Hf(t)) values of zircons from the biotite(± hornblende) plagiogneisses are positive,while most ε_(Hf(t)) values from the granitoid gneisses are negative,suggesting a degree of crustal contamination.Two-stage Hf model ages suggest that the age of the protolith of the TTG gneisses was ca.3.4-2.6 Ga,representing a period of paleocontinent formation in the Mesoarchean.Geothermometries indicate the temperature of metamorphism of the TTG gneisses was 522-612℃.Based on these data,the protolith of the TTG gneisses is inferred to have formed during the development of a Mesoarchean paleocontinent that is now widely exposed as a TTG gneiss belt(mostly lower amphibolite facies) in the Maevatanana area,and which records a geological evolution related to the subduction of an ancient oceanic crust and the collision of microcontinents during the formation of the Rodinia supercontinent.The lithological similarity of Precambrian basement,the close ages of metamorphism within greenstone belts and the comparable distribution of metamorphic grade all show a pronounced Precambrian geology similarity between Madagascar and India,which can provide significative clues in understanding the possible Precambrian Supercontinent tectonics,and also important constraints on the correlation of the two continental fragments. | LI Peng LI Jiankang LIU Shanbao PEI Rongfu SHI Guanghai | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 7 |
| 7 | The Tashisayi nephrite deposit from South Altyn Tagh, Xinjiang,northwest China显示文摘The Tashisayi nephrite deposit is located in South Altyn Tagh.in Qiemo County,Xinjiang Province,northwest China.It is a recent discovery in the vast,well-known Kunlun-Altyn nephrite belt distributed along the south of the Tarim Basin,producing more than half of the nephrite from the whole belt in 2017.Field investigations revealed that it is a dolomitic marble-related(D-type)nephrite deposit,but little is known about its age of formation and relationships between the granites and marble.Here we report field investigations,petrography of the neph rite,as well as petrography,geochemistry,geochronology of the zoisite-quartz altered intrusive rock and adjacent granites.An A-type granite is identified with a SHRIMP U-Pb zircon age of 926±7 Ma,suggesting it was emplaced in an extensional tectonic environment at that time.The altered intrusive rock has a cluster of U-Pb zircon age of 433±10 Ma.with similar trace element features to the A-type granite,suggesting it was formed in an extensional regime at this later time.Nephrite formed because of the metasomatism of dolomite marble by hydrothermal fluids.It is inferred that Ca^2+was released from the dolomitic marble by metasomatism forming Ca-rich fluids,which caused alteration of both the intrusive rocks(6.00-8.22 wt.%CaO)and granite(1.76-3.68 wt.%CaO)near the nephrite ore bodies.It is also inferred that Fe^2+from the granite migrated towards the dolomite marble.The fluids gave rise to the formation of Ca-minerals.such as zoisite,in the nephrite and altered intrusive rock,and epidote in the granite.Based on the contact relationships.similarity in hydrothermal processes,and consumption of Ca^2+,the Tashisayi nephrite is considered to have formed at the same time as the alteration of the intrusive rocks,i.e.~433 Ma.The geochronological similarity(~926 Ma.433 Ma)of South Altyn and North Qaidam may suggest that tectonically they belong to one single complex in the past,which was offset by the Altyn Tagh fault(ATF).The similar formation ages of the nephrites from Altyn Tagh(433 Ma)and the previously studied areas of West Kunlun(378-441 Ma)and East Kunlun(416 Ma)indicate that these nephrites formed during the closure of Proto-Tethys and in the accompanving post-collisional.extensional environment. | Kong Gao Guanghai Shi Meili Wang Gen Xie Jian Wang Xiaochong Zhang Ting Fang Weiyan Lei Yan Liu | 2019 | Geoscience Frontiers2019，10，4： | 6 |
| 8 | Runout prediction and dynamic characteristic analysis of a potential submarine landslide in Liwan 3-1 gas field显示文摘A large number of submarine landslides with different scales have been identified in the canyon area of the submarine pipeline route of Liwan 3-1 gas field. There is still much chance that submarine slope failures would happen, and the following mass movement would present great risk to the submarine pipeline. In view of this, a numerical prediction method based on Eulerian-Eulerian two-phase flow model is introduced to simulate the mass movement of potential submarine landslides. The sliding soil and ambient water are respectively simulated by Herschel-Bulkley rheology model and Newtonian fluid model. The turbulence is simulated using the k-e model. Compared with both the experiment data and Bing result, the two-phase flow model shows a good accuracy, and its result is more close to the actual situation; the dynamic coupling between soil and ambient water can be effectively simulated and the phenomena of hydroplaning and head detachment can be obtained.Finally, the soil movement of a potential submarine landslide is simulated as an example, according to the seismic profile in the canyon area. The result shows that the hydroplaning occurs during the movement process. The runout distance calculated by the two-phase flow model is 877 m, which is 27.1% larger than the Bing result.However, the peak front velocity of soil is relative small, with a maximum value of 8.32 m/s. The Bing program with a simple and rapid process can be used for a preliminary evaluation, while the two-phase flow model is more appropriate for an accurate assessment. | XIU Zongxiang LIU Lejun XIE Qiuhong LI Jiagang HU Guanghai YANG Jianghui | 2015 | Acta Oceanologica Sinica2015，34，7： | 6 |
| 9 | ^(40)Ar/^(39)Ar Dating of Xuebaoding Granite in the Songpan-Garze Orogenic Belt,Southwest China,and its Geological Significance显示文摘Thus far,our understanding of the emplacement of Xuebaoding granite and the occurrence and evolution of the Songpan-Garze Orogenic Belt has been complicated by differing age spectra results.Therefore,in this study,the ^(40)Ar/^(39)Ar and sensitive high resolution ion micro-probe(SHRIMP) U-Pb dating methods were both used and the results compared,particularly with respect to dating data for Pankou and Pukouling granites from Xuebaoding,to establish ages that are close to the real emplacements.The results of SHRIMP U-Pb dating for zircon showed a high amount of U,but a very low value for Th/U.The high U amount,coupled with characteristics of inclusions in zircons,indicates that Xuebaoding granites are not suitable for U-Pb dating.Therefore,muscovite in the same granite samples was selected for ^(40)Ar/^(39)Ar dating.The ^(40)Ar/^(39)Ar age spectrum obtained on bulk muscovite from Pukouling granite in the Xuebaoding,gave a plateau age of 200.1±1.2 Ma and an inverse isochron age of 200.6±1.2 Ma.The ^(40)Ar/^(39)Ar age spectrum obtained on bulk muscovite from Pankou granite in the Xuebaoding gave another plateau age of 193.4±1.1 Ma and an inverse isochron age of 193.7±1.1 Ma. The ^(40)Ar/^(36)Ar intercept of 277.0±23.4(2σ) was very close to the air ratio,indicating that no apparent excess argon contamination was present.These age dating spectra indicate that both granites were emplaced at 200.6±1.3 Ma and 193.7±1.1 Ma,respectively.Through comparison of both dating methods and their results,we can conclude that it is feasible that the muscovite in the granite bearing high U could be used for ^(40)Ar/^(39)Ar dating without extra Ar.Based on this evidence,as well as the geological characteristics of the Xuebaoding W-Sn-Be deposit and petrology of granites,it can be concluded that the material origin of the Xuebaoding W-Sn-Be deposit might partially originate from the Xuebaoding granite group emplacement at about 200 Ma.Moreover,compared with other granites and deposits distributed in various positions in the Songpan-Garze Orogenic Belt,the Xuebaoding emplacement ages further show that the main rare metal deposits and granites in peripheral regions occurred earlier than those in the inner Songpan-Garze.Therefore,^(40)Ar/^(39)Ar dating of Xuebaoding granite will lay a solid foundation for studying the occurrence and evolution of granite and rare earth element deposits in the Songpan-Garze Orogenic Belt. | LIU Yan DENG Jun ZHANG Guibin SHI Guanghai YANG Liqiang WANG Qingfei | 2010 | Acta Geologica Sinica(English Edition)2010，84，2： | 5 |
| 10 | Geochemistry and petrology of nephrite from Alamas, Xinjiang, NW China显示文摘 | Yan Liu Jun Deng Guanghai Shi Tzen-Fu Yui Guibin Zhang Maituohuti Abuduwayiti Liqiang Yang Xiang Sun | 2011 | Journal of Asian Earth Sciences2011，，3： | 3 |
| 11 | Numerical research on evolvement of submarine sand waves in the Northern South China Sea显示文摘 | Qikun ZHOU Guanghai HU Yongfu SUN Xiaohui LIU Yupeng SONG Lifeng DONG Changming DONG | 2017 | Frontiers of Earth Science2017，11，1： | 3 |
| 12 | Feasibility study using simulation mode for offshore field SZ36-1显示文摘绥中36—1作为中海油主力注水生产、疏松砂岩稠油油田,提高采收率成为当前的主要技术方向。时移地震作为提高采收率的主要地球物理手段,使之成为主要的研究方向。本文阐述了我们利用已有的生产数据、油藏认识的可行研究,即利用动态及历史拟合的油藏模型,分析油藏可能时移地震响应,寻找时移地震响应在时空的分布特征。一方面可以分析在本地区应用时移地震技术的可行性;另一方面对第二次甚至第三次采集时移地震数据的时机进行分析。经过分析认为绥中36—1的时移地震响应除受到疏松储层的影响外,将受油藏脱气的影响。并认为生产10年后采集时移地震数据有相当的可行性。 | Zhang Jinmiao Zhao Wei Huang Xuri Wang Guanghai Liu Li | 2006 | Applied Geophysics2006，3，2： | 3 |
| 13 | The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma显示文摘Chimeric antigen receptor T(CAR T)cell therapy has demonstrated efficacy in the treatment of haematologic malignancies.However,the accompanying adverse events,the most common of which is cytokine release syndrome(CRS),substantially limit its wide application.Due to its unique physiological characteristics,CRS in CAR T-cell treatment for B-cell non-Hodgkin lymphoma(BNHL)may exhibit some special features.Although existing guidelines had greatly promoted the recognition and management of CRS,many recommendations are not fully applicable to B-NHL.Therefore,it is imperative to identify responses that are specific to CRS observed following CAR T treatment for B-NHL.Based on underlying biological processes and known pathophysiological mechanisms,we tentatively propose a new model to illustrate the occurrence and evolution of CAR T-cell-therapy-related CRS in BNHL.In this model,tumour burden and bone marrow suppression are considered determinants of CRS.Novel phenomena after CAR T-cell infusion(such as local inflammatory response)are further identified.The proposed model will help us better understand the basic biology of CRS and recognize and manage it more rationally. | Jianshu Wei Yang Liu Chunmeng Wang Yajing Zhang Chuan Tong Guanghai Dai Wei Wang John E.J.Rasko J.Joseph Melenhorst Wenbin Qian Aibin Liang Weidong Han | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 14 | Image retrieval based on micro-structure descriptor 显示文摘 | GUANGHAI LIU ZUOYONG LI LEI ZHANG | 2011 | Pattern Recognition2011，44，9： | 1 |
| 15 | Statistical thresholding method for infrared images显示文摘 | Li Zuoyong Liu Chuancai Liu Guanghai | 2011 | Pattern Analysis and Applications2011，14，： | 1 |
| 16 | Ion microprobe zircon U-Pb age and geochemistry of the Myanmar jadeitite 显示文摘 | Shi Guanghai Cui Wenyuan Cao Shumin Jiang Neng Jian Ping Liu Dunyi Miao Laicheng Chu Bingbing | 2008 | Journal of the Geological Society2008，165，1： | 1 |
| 17 | Image retrieval based on the texton co-occurrence matrix显示文摘 | Liu Guanghai Yang Jingyu | 2008 | Pattern Recognition2008，41，12： | 1 |
| 18 | Image retrieval based on multi-texton histogram显示文摘 | Liu Guanghai Zhang Lei Hou Yingkun | 2010 | Pattern Recognition2010，43，7： | 1 |
| 19 | Image retrieval based on multi-structure descriptor显示文摘 | Liu Guanghai Li Zuoyong Zhang Lei | 2011 | Pattern Reeognition2011，44，9： | 1 |
| 20 | Content-based image retrieval using color difference bistogram显示文摘 | Liu Guanghai Yang Jingyu | 2013 | Pattern Recognition2013，46，1： | 1 |
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