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| 1 | Monitoring, Warning, and Control of Rockburst in Deep Metal Mines显示文摘 | Xia-Ting Feng Jianpo Liu Bingrui Chen Yaxun Xiao Guangliang Feng Fengpeng Zhang | 2017 | Engineering2017，3，4： | 29 |
| 2 | The impacts of climate change on the Neolithic cultures of Gansu-Qinghai region during the late Holocene Megathermal显示文摘Holocene Megathermal 被划分成早、中间、迟了的时期,各由于他们改变趋势的不同气候在过时的文化上有不同影响。这研究基于在金海·莱克,记录的环境进化信息的比较分析黄土高原和 Zoige 和 Gansu-Qinghai 区域的过时的地点的空间分发的西方的边。结果证明早、中间的时期向温暖、潮湿在 Gansu-Qinghai 区域作为主要扇区与农业支持了过时的文化的开发,而且, Yangshao 文化繁荣的一个全盛时期出现了。Holocene 在 Gansu-Qinghai 区域在 5.9 ka BP 在冷气候事件以后进入了迟了的时期。后来,气候开始变得冷。然而,在 5.84.2 ka BP,相对稳定的温暖、潮湿的气候在这个区域为过时的年龄的 Majiayao 文化的发展创造了条件,因此,它的文化遗产地点的分发向高高度和高纬度膨胀了。从 4.2 ka BP 向前,气候变得冷、干燥,它在 Gansu-Qinghai 区域的过时的文化上有重要影响,在 4.2 ka BP 附近在文化人物和 Qijia 文化的空间分发导致一个戏剧的变化。在以后一将近 300 年冷、干燥的时期,统一过时的耕作文化完全崩溃了。以后,畜牧和耕作和地区性的多重文化的一个工业部门形成了,并且最终导致了原始社会并且开始一个使文明的社会的结束。 | LIU Fenggui ZHANG Yili FENG Zhaodong HOU Guangliang ZHOU Qiang ZHANG Haifeng | 2010 | Journal of Geographical Sciences2010，20，3： | 18 |
| 3 | Characteristics of the lunar samples returned by the Chang'E-5 mission显示文摘Forty-five years after the Apollo and Luna missions returned lunar samples,China's Chang’E-5(CE-5)mission collected new samples from the mid-latitude region in the northeastern Oceanus Procellarum of the Moon.Our study shows that 95%of CE-5 lunar soil sizes are found to be within the range of 1.40-9.35μm,while 95%of the soils by mass are within the size range of 4.84-432.27μm.The bulk density,true density and specific surface area of CE-5 soils are 1.2387 g/cm^(3),3.1952 g/cm^(3) and 0.56 m^(2)/g,respectively.Fragments from the CE-5 regolith are classified into igneous clasts(mostly basalt),agglutinate and glass.A few breccias were also found.The minerals and compositions of CE-5 soils are consistent with mare basalts and can be classified as low-Ti/low-Al/low-K type with lower rare-earth-element contents than materials rich in potassium,rare earth element and phosphorus.CE-5 soils have high FeO and low Mg index,which could represent a new class of basalt. | Chunlai Li Hao Hu Meng-Fei Yang Zhao-Yu Pei Qin Zhou Xin Ren Bin Liu Dawei Liu Xingguo Zeng Guangliang Zhang Hongbo Zhang Jianjun Liu Qiong Wang Xiangjin Deng Caijin Xiao Yonggang Yao Dingshuai Xue Wei Zuo Yan Su Weibin Wen Ziyuan Ouyang | 2022 | National Science Review2022，9，2： | 12 |
| 4 | Preliminary results of TiO_2 mapping using Imaging Interferometer data from Chang'E-1显示文摘The distribution of titanium abundance on the lunar surface is important knowledge for lunar geologic studies and future resource utilization.In this paper,we develop a preliminary model based on'ground truths'from Apollo and Luna sample-return sites to produce a titanium abundance map from Chang’E-1 Imaging Interferometer(IIM) images.The derived TiO2 abundances are validated with Clementine UVVIS results in several regions,including lunar highlands neighboring the Apollo 16 landing site,and high-Ti and low-Ti maria near the standard site of Mare Serenitatis(MS2) .The validation results show that TiO2 abundances modeled with Chang’E-1 IIM data are overestimated for highlands(~0.7 wt.%) and low-Ti maria(~1.5 wt.%) and underestimated for high-Ti maria(~0.8 wt.%). | LING ZongCheng ZHANG Jiang LIU JianZhong ZHANG WenXi ZHANG GuangLiang LIU Bin REN Xin MU LingLi LIU JianJun LI ChunLai | 2011 | Chinese Science Bulletin2011，56，20： | 10 |
| 5 | Data Analysis of Chang'E-1 Gamma-Ray Spectrometer and Global Distribution of U,K,and Th Elemental Abundances显示文摘Gamma 光线分光计(GRS ) 是 Chang'E-1 (CE-1 ) 上的主要收费载重之一月亮的探查,主要试图在月亮的表面上检测元素的丰富和分布。在 03:58 在 2007 年 11 月 28 日,它执行了月亮的 gamma 光线的第一观察。2008 年 10 月 24 日,有效 gamma 光线系列的 2105 h 被 CE-1 GRS 获得了,它盖住月亮的整个表面。这份报纸主要描述处理由使用导出元素的丰富的过程和 CE-1 GRS 时间系列改正了系列的方法的数据:首先,到进为印射的象素的箱数据;然后,执行累积系列的背景扣除并且获得元素的一个山峰区域;并且最后,当模特儿使用元素的丰富倒置生产元素的丰富。在这些上基于比 EPR 在 5s 处理方法, U 的全球丰富地图, K,和 Th。在在 near-EPR 海底山下面的岩浆结晶化压力和融化的条件之间的关联暗示来源吗? | ZOU Yongliao ZHANG Liyan LIU Jianzhong MU Lingli REN Xin ZHANG Guangliang CHANG Jin YAN Jun ZHANG Nan ZHANG Hongbo LU Chang LIU Jianjun ZUO Wei SU Yan WEN Weibin BIAN Wei WANG Min XU Chun LI Chunlai OUYANG Ziyuan | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 6 |
| 6 | Thiolated arsenicals in arsenic metabolism: Occurrence,formation, and biological implications显示文摘Arsenic(As) is a notoriously toxic pollutant of health concern worldwide with potential risk of cancer induction, but meanwhile it is used as medicines for the treatment of different conditions including hematological cancers. Arsenic can undergo extensive metabolism in biological systems, and both toxicological and therapeutic effects of arsenic compounds are closely related to their metabolism. Recent studies have identified methylated thioarsenicals as a new class of arsenic metabolites in biological systems after exposure of inorganic and organic arsenicals, including arsenite, dimethylarsinic acid(DMAV), dimethylarsinous glutathione(DMAIIIGS), and arsenosugars. The increasing detection of thiolated arsenicals,including monomethylmonothioarsonic acid(MMMTAV), dimethylmonothioarsinic acid(DMMTAV) and its glutathione conjugate(DMMTAVGS), and dimethyldithioarsinic acid(DMDTAV) suggests that thioarsenicals may be important metabolites and play important roles in arsenic toxicity and therapeutic effects. Here we summarized the reported occurrence of thioarsenicals in biological systems, the possible formation pathways of thioarsenicals, and their toxicity, and discussed the biological implications of thioarsenicals on arsenic metabolism, toxicity, and therapeutic effects. | Yuzhen Sun Guangliang Liu Yong Cai | 2016 | Journal of Environmental Sciences2016，28，11： | 6 |
| 7 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 8 | Quality metrics and outcomes among critically ill patients in China:results of the national clinical quality control indicators for critical care medicine survey 2015-2019显示文摘Background:It is crucial to improve the quality of care provided to ICU patient,therefore a national survey of the medical quality of intensive care units(ICUs)was conducted to analyze adherence to quality metrics and outcomes among critically ill patients in China from 2015 to 2019.Methods:This was an ICU-level study based on a 15-indicator online survey conducted in China.Considering that ICU care quality may vary between secondary and tertiary hospitals,direct standardization was adopted to compare the rates of ICU quality indicators among provinces/regions.Multivariate analysis was performed to identify potential factors for in-hospital mortality and factors related to ventilator-associated pneumonia(VAP),catheter-related bloodstream infections(CRBSIs),and catheter-associated urinary tract infections(CAUTIs).Results:From the survey,the proportions of structural indicators were 1.83%for the number of ICU inpatients relative to the total number of inpatients,1.44%for ICU bed occupancy relative to the total inpatient bed occupancy,and 51.08%for inpatients with Acute Physiology and Chronic Health Evaluation II scores≥15.The proportions of procedural indicators were 74.37%and 76.60%for 3-hour and 6-hour surviving sepsis campaign bundle compliance,respectively,62.93%for microbiology detection,58.24%for deep vein thrombosis prophylaxis,1.49%for unplanned endotracheal extubations,1.99%for extubated inpatients reintubated within 48 hours,6.38%for unplanned transfer to the ICU,and 1.20%for 48-hour ICU readmission.The proportions of outcome indicators were 1.28‰for VAP,3.06‰for CRBSI,3.65‰for CAUTI,and 10.19%for in-hospital mortality.Although the indicators varied greatly across provinces and regions,the treatment level of ICUs in China has been stable and improved based on various quality control indicators in the past 5 years.The overall mortality rate has dropped from 10.19%to approximately 8%.Conclusions:The quality indicators of medical care in China’s ICUs are heterogeneous,which is reflected in geographic disparities and grades of hospitals.This study is of great significance for improving the homogeneity of ICUs in China. | Xi Rui Fen Dong Xudong Ma Longxiang Su Guangliang Shan Yanhong Guo Yun Long Dawei Liu Xiang Zhou | 2022 | Chinese Medical Journal2022，，9： | 4 |
| 9 | An Examination of the Predictability of Tropical Cyclone Genesis in High-Resolution Coupled Models with Dynamically Downscaled Coupled Data Assimilation Initialization显示文摘Predicting tropical cyclone(TC)genesis is of great societal importance but scientifically challenging.It requires fineresolution coupled models that properly represent air−sea interactions in the atmospheric responses to local warm sea surface temperatures and feedbacks,with aid from coherent coupled initialization.This study uses three sets of highresolution regional coupled models(RCMs)covering the Asia−Pacific(AP)region initialized with local observations and dynamically downscaled coupled data assimilation to evaluate the predictability of TC genesis in the West Pacific.The APRCMs consist of three sets of high-resolution configurations of the Weather Research and Forecasting−Regional Ocean Model System(WRF-ROMS):27-km WRF with 9-km ROMS,and 9-km WRF with 3-km ROMS.In this study,a 9-km WRF with 9-km ROMS coupled model system is also used in a case test for the predictability of TC genesis.Since the local sea surface temperatures and wind shear conditions that favor TC formation are better resolved,the enhanced-resolution coupled model tends to improve the predictability of TC genesis,which could be further improved by improving planetary boundary layer physics,thus resolving better air−sea and air−land interactions. | Mingkui LI Shaoqing ZHANG Lixin WU Xiaopei LIN Ping CHANG Gohkan DANABASOGLU Zhiqiang WEI Xiaolin YU Huiqin HU Xiaohui MA Weiwei MA Haoran ZHAO Dongning JIA Xin LIU Kai MAO Youwei MA Yingjing JIANG Xue WANG Guangliang LIU Yuhu CHEN | 2020 | Advances in Atmospheric Sciences2020，37，9： | 4 |
| 10 | Hd1,Ghd7,and DTH8 synergistically determine the rice heading date and yield-related agronomic traits显示文摘Heading date determines the seasonal and regional adaptation of rice(Oryza sativa L.)varieties and is mainly controlled by photoperiod sensitivity(PS).The core heading date genes Hd1,Ghd7,DTH8,and PRR37 act synergistically in regulating the PS.In this study,we systematically analyze the heading date,PS,and agronomic traits of eight homozygous lines with various combinations of Hd1,Ghd7,and DTH8 alleles in the prr37 background under long-day(LD)and short-day(SD)conditions,respectively.We find that Hd1 alone promotes heading,regardless of the day length.However,under LDs,Hd1 suppresses flowering,in coordination with functional Ghd7 or with Ghd7 and DTH8.These loci cooperate to negatively regulate the Ehd1-Hd3 a/RFT1 pathway and delay heading.Under SDs,Hd1 competes with various heading suppressors to promote heading.Therefore,the dual function of Hd1 is vital for PS.The lines carrying Hd1 alone show reduced plant height with fewer primary and secondary branches in panicles.Lines carrying Ghd7 and DTH8(with hd1)show delayed heading and improve agronomic traits.Overall,our results reveal the regulation of rice PS flowering by the core heading date genes and their effects on agronomic traits,providing valuable information for the selection of rice varieties for adaptation to different light and temperature conditions. | Kangli Sun Minghui Huang Wubei Zong Dongdong Xiao Chen Lei Yanqiu Luo Yingang Song Shengting Li Yu Hao Wanni Luo Bingqun Xu Xiaotong Guo Guangliang Wei Letian Chen Yao-Guang Liu Jingxin Guo | 2022 | Journal of Genetics and Genomics2022，49，5： | 4 |
| 11 | Fangjihuangqi Tang improved lower urinary tract dysfunction in benign prostatic hyperplasia rats model显示文摘OBJECTIVE: To investigated the effect and mechanism of Fangjihuangqi Tang (FHT) on lower urinary tract dysfunction induced by benign prostatic hyperplasia (BPH) in rats. METHODS: Male rats were randomly divided into seven groups: normal, model, finasteride (0.5 mg/ kg), terazosin (0.5 mg/kg), and FHT (10, 5, 2.5 g/kg). Rats were administered testosterone (0.5 mg sc) for 6 weeks after orchiectomy, excluding the normal group. All rats were intragastrically administered assigned drugs for 4 weeks from the third week. Urodynamics were assessed in rats under anesthesia. Serum dihydrotestosterone (DHT) and prostatic acid phosphatase (PAP) were measured. The prostate index (PI), bladder index (BI), and pathological detection were evaluated. RESULTS: In the model group, the PI, BI, serum DHT, serum PAP, threshold pressure (TP), micturition pressure (MP), and residual urine volume (RV)were significantly higher. Moreover, inter-micturition duration (IMD) was significantly lower and the prostatic and bladder showed obvious pathological changes. The IMD was significantly higher, while BI, TP, MP, and RV were significantly lower and bladder pathological changes were alleviated in the FHT (10, 5 g/kg), finasteride, and terazosin groups. The PI, DHT, and PAP were significantly lower in the finasteride group, but they did not change significantly in the FHT (10, 5, 2.5 g/kg) and terazosin groups. CONCLUSION: FHT could relieve symptoms of lower urinary tract dysfunction in BPH rats but with no apparent effect on reducing the volume of the enlarged prostate itself. | Guangliang Chen Haipeng Liu Fang Cheng | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 3 |
| 12 | Color image detail enhancement based on quaternion guided filter显示文摘Color image enhancement is an active research field in image processing. Currently, many image enhancement methods are capable of enhancing the details of the color image. However, these methods only process the red, green and blue(RGB) color channels separately, which leads to color distortion easily. In order to overcome this problem, the paper presents an approach to integrate the quaternion theory into the traditional guided filter to obtain a quaternion guided filter(QGF). This method makes full use of the color information of an image to realize the holistic processing of RGB color channels. So as to preserve color information while enhancing details, this paper proposes a color image detail enhancement algorithm based on the QGF. Experimental results show that the proposed algorithm is effective in the applications of the color image detail enhancement, and enables image's edges to be more prominent and texture clearer while avoiding color distortion. Compared with the existing image enhancement methods, the proposed method achieves better enhancement performance in terms of the visual quality and the objective evaluating indicators. | Wu Kun Li Guiju Han Guangliang Yang Hang Liu Peixun | 2017 | The Journal of China Universities of Posts and Telecommunications2017，24，4： | 3 |
| 13 | Temporal gravity changes before the 2008 Yutian Ms7.3 earthquake显示文摘Based on the data of the repeated gravity observation network in Chinese mainland since 1998,we analyzed the temporal changes of regional gravity field before the 2008 Yutian Ms7.3 earthquake.The result shows some mid-to-long term(two to ten years)changes during the earthquake's preparation.Notable features are a gravity increase lasting several years and a relatively large-scaled gradient zone of gravity change,the former indicating a continuous energy accumulation and the latter a possible location of seismic rupture.These gravity changes showed a trend of increase-accelerated increase-decelerated increase,similar to that of the Tangshan Ms7.8 earthquake in 1976.The maximum accumulated gravity change related to the earthquake reached 200×10-8 ms-2. | Shen Chongyang Li Hui Sun Shaoan Yang Guangliang Xuan Songbai Tan Hongbo Liu Shaoming | 2012 | Geodesy and Geodynamics2012，3，1： | 3 |
| 14 | Simulation of urban expansion based on cellular automata and maximum entropy model显示文摘Urban expansion is a hot topic in land use/land cover change(LUCC)researches.In this paper,maximum entropy model and cellular automata(CA)model are coupled into a new CA model(Maxent-CA)for urban expansion.This model can help to obtain transition rules from single-period dataset.Moreover,it can be constructed and calibrated easily with several steps.Firstly,Maxent-CA model was built by using remote sensing data of China in 2000(basic data)and spatial variables(such as population density and Euclidean distance to cities).Secondly,the proposed model was calibrated by analyzing training samples,neighborhood structure and spatial scale.Finally,this model was verified by comparing logistic regression CA model and their simulation results.Experiments showed that suitable sampling ratio(sampling ratio equals the proportion of urban land in the whole region)and von Neumann neighborhood structure will help to yield better results.Spatial structure of simulation results becomes simple as spatial resolution decreases.Besides,simulation accuracy is significantly affected by spatial resolution.Compared to simulation results of logistic regression CA model,Maxent-CA model can avoid clusters phenomenon and obtain better results matching actual situation.It is found that the proposed model performs well in simulating urban expansion of China.It will be helpful for simulating even larger study area in the background of global environment changes. | Yihan ZHANG Xiaoping LIU Guangliang CHEN Guohua HU | 2020 | Science China Earth Sciences2020，63，5： | 3 |
| 15 | Correlation analysis and partial least square modeling to quantify typical minerals with Chang'E-3 visible and near-infrared imaging spectrometer's ground validation data显示文摘In 2013, Chang'E-3 program will develop lunar mineral resources in-situ detection. A Visible and Near-infrared Imaging Spectrometer(VNIS) has been selected as one payload of CE-3 lunar rover to achieve this goal. It is critical and urgent to evaluate VNIS' spectrum data quality and validate quantification methods for mineral composition before its launch. Ground validation experiment of VNIS was carried out to complete the two goals, by simulating CE-3 lunar rover's detection environment on lunar surface in the laboratory. Based on the hyperspectral reflectance data derived, Correlation Analysis and Partial Least Square(CA-PLS) algorithm is applied to predict abundance of four lunar typical minerals(pyroxene, plagioclase, ilmenite and olivine) in their mixture. We firstly selected a set of VNIS' spectral parameters which highly correlated with minerals' abundance by correlation analysis(CA), and then stepwise regression method was used to find out spectral parameters which make the largest contributions to the mineral contents. At last, functions were derived to link minerals' abundance and spectral parameters by partial least square(PLS) algorithm. Not considering the effect of maturity, agglutinate and Fe0, we found that there are wonderful correlations between these four minerals and VNIS' spectral parameters, e.g. the abundance of pyroxene correlates positively with the mixture's absorption depth, the value of absorption depth added as the increasing of pyroxene's abundance. But the abundance of plagioclase correlates negatively with the spectral parameters of band ratio, the value of band ratio would decrease when the abundance of plagioclase increased. Similar to plagioclase, the abundance of ilmenite and olivine has a negative correlation with the mixture's reflectance data, if the abundance of ilmenite or olivine increase, the reflectance values of the mixture will decrease. Through model validation, better estimates of pyroxene, plagioclase and ilmenite's abundances are given. It is concluded that VNIS has the capability to be applied on lunar minerals' identification, and CA-PLS algorithm has the potential to be used on lunar surface's in-situ detection for minerals' abundance prediction. | LIU Bin LIU Jianzhong ZHANG Guangliang LING Zongcheng ZHANG Jiang HE Zhiping YANG Benyong ZOU Yongliao | 2014 | Chinese Journal Of Geochemistry2014，33，1： | 3 |
| 16 | Porcine Bocavirus: A 10-Year History since Its Discovery显示文摘Porcine bocavirus(PBoV)is a single-stranded DNA virus,belongs to the genus Bocaparvovirus of family Parvoviridae.It was discovered along with porcine circovirus 2(PCV 2)and torque tenovirus(TTV)in the lymph nodes of pigs suffering from postweaning multisystemic wasting syndrome(PMWS)in Sweden in 2009.PBoV has been reported throughout the world,mostly in weaning piglets,and has a broad range of tissue tropism.Since PBoV is prevalent in healthy as well as clinically infected pigs and is mostly associated with coinfection with other viruses,the pathogenic nature of PBoV is still unclear.Currently,there are no cell lines available for the study of PBoV,and animal model experiments have not been described.This review summarizes the current state of knowledge about PBoV,including the epidemiology,evolution analysis,detection methods,pathogenesis and public health concerns. | Manita Aryal Guangliang Liu | 2021 | Virologica Sinica2021，36，6： | 3 |
| 17 | Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/β-catenin/c-Myc/cyclin A2 signaling pathway显示文摘Skin epidermal stem cells(EpSCs)play an important role in wound healing.Quercetin is a phytoestrogen reported to accelerate skin wound healing,but its effect on EpSCs is unknown.In this study,we investigated the effect of quercetin on human EpSC proliferation and explored the underlying mechanisms.We found that quercetin at 0.1~1μM significantly promoted EpSC proliferation and increased the number of cells in S phase.The pro-proliferative effect of quercetin on EpSCs was confirmed in cultured human skin tissue.Mechanistic studies showed that quercetin significantly upregulated the expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.Inhibitor forβ-catenin or c-Myc significantly inhibited quercetin-induced EpSC proliferation.Theβ-catenin inhibitor XAV-939 suppressed quercetin-induced expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.The c-Myc inhibitor 10058-F4 inhibited the upregulation of c-Myc and cyclin A2 by quercetin.Pretreatment of EpSCs with estrogen receptor(ER)antagonist ICI182780,but not the G protein-coupled ER1 antagonist G15,reversed quercetin-induced cell proliferation and upregulation ofβ-catenin,c-Myc,and cyclin A2.Collectively,these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation ofβ-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation.As EpSCs are used not only in clinic to treat skin wounds but also as seed cells in skin tissue engineering,quercetin is a useful reagent to expand EpSCs for basic research,skin wound treatment,and skin tissue engineering. | Zhaodong Wang Guangliang Zhang Yingying Le Jihui Ju Ping Zhang Dapeng Wan Qiang Zhao Guangzhe Jin Hao Su Jinwei Liu Jiaxuan Feng Yi Fu Ruixing Hou | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 3 |
| 18 | Engineering of tungsten carbide nanoparticles for imaging-guided single 1,064 nm laser-activated dual-type photodynamic and photothermal therapy of cancer显示文摘光力学的治疗(太平洋夏季时间) 的有希望的潜力为癌症治疗造成了最低限度地侵略的治疗学的途径的发展。然而,在 hypoxic 肿瘤环境和轻穿入深度在太平洋夏季时间功效克服限制仍然是挑战。我们报导钨碳化物 nanoparticles 的工程(W 2 C NP ) 为 1,064 nm 激活激光的双类型的太平洋夏季时间和联合 theranostics。综合 W 2 C NP 允许双类型的反应的氧种类的柔韧的产生,包括氢氧根激进分子(类型我) 并且汗衫氧(类型 II ) ,用仅仅挑选 1,064 nm 激光激活,甚至在 hypoxic 肿瘤的创新有效太平洋夏季时间环境。W 2 C NP 也在 1,064 nm 激光照耀下面拥有高 photothermal 性能,这样创新的 synergistically 提高的癌症太平洋夏季时间和 photothermal 治疗的治疗学的功效。另外, photoacoustic 和 X 光检查计算了 W 2 C NP 便于肿瘤诊断和治疗的集成。发达 W 2 C 基于 theranostic nanoagents 在 hypoxic 肿瘤增加反应的氧种类的产生,改进轻穿入深度,并且便于联合 photothermal 治疗和 photoacoustic/computed 断层摄影术双模式的 bioimaging。这些属性能为先进生物医学的应用程序刺激转变金属碳化物的探索。 | Shi-Hua Li Wen Yang Yang Liu Xiao-Rong Song Rui Liu Guangliang Chen Chun-Hua Lu Huang-Hao Yang | 2018 | Nano Research2018，11，9： | 2 |
| 19 | A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis显示文摘Cell source is the key to decellularized matrix(DM)strategy.This study compared 3 cell types,osteocytes with/without dominant active Wnt/β-catenin signaling(daCO and WTO)and bone marrow stromal cells(BMSCs)for their DMs in bone repair.Decellularization removes all organelles and>95%DNA,and retained>74%collagen and>71%GAG,maintains the integrity of cell basement membrane with dense boundaries showing oval and honeycomb structure in osteocytic DM and smooth but irregular shape in the BMSC-DM.DM produced higher cell survival rate(90%)and higher proliferative activity.In vitro,daCO-DM induces more and longer stress fibers in BMSCs,conducive to cell adhesion,spreading,and osteogenic differentiation.8-wk after implantation of the critical-sized parietal bone defect model,daCO-DM formed tight structures,composed of a large number of densely-arranged type-I collagen under polarized light microscope,which is similar to and integrated with host bone.BV/TV(>54%)was 1.5,2.9,and 3.5 times of WTO-DM,BMSC-DM,and none-DM groups,and N.Ob/T.Ar(3.2×10^(2)/mm^(2))was 1.7,2.9,and 3.3 times.At 4-wk,daCO-DM induced osteoclastogenesis,2.3 times higher than WTO-DM;but BMSC-DM or none-DM didn't.daCO-DM increased the expression of RANKL and MCSF,Vegfa and Angpt1,and Ngf in BMSCs,which contributes to osteoclastogenesis,angiogenesis,and neurogenesis,respectively.daCO-DM promoted H-type vessel formation and nerve markersβ3-tubulin and NeuN expression.Conclusion:daCO-DM produces metabolic and neurovascularized organoid bone to accelerate the repair of bone defects.These features are expected to achieve the effect of autologous bone transplantation,suitable for transformation application. | Xiaofang Wang Yufei Ma Jie Chen Yujiao Liu Guangliang Liu Pengtao Wang Bo Wang Makoto M.Taketo Teresita Bellido Xiaolin Tu | 2023 | Bioactive Materials2023，，3： | 2 |
| 20 | Refining mercury emission estimations to the atmosphere from iron and steel production显示文摘Due to its long-range transport in the atmosphere,mercury is a pollutant of global concern with health risks to humans and ecosystems worldwide(Li et al.,2012;Lindqvist et al.,1991;Liu et al.,2012a;Tang et al.,2016;Wang et al.,2015;Shao et al.,2016).Atmospheric mercury,mainly from emission from various natural and anthropogenic sources | Yongmin Wang Guangliang Liu Dingyong Wang Yong Cai | 2016 | Journal of Environmental Sciences2016，28，5： | 2 |
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