|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 2 | Middle–Upper Ordovician(Darriwilian–Early Katian) Positive Carbon Isotope Excursions in the Northern Tarim Basin, Northwest China: Implications for Stratigraphic Correlation and Paleoclimate显示文摘Three positive carbon isotope excursions are reported from Middle–Upper Ordovician in Tahe oil-gas field, northern Tarim Basin. Based on conodont biostratigraphy, the Middle Darriwilian Isotope Carbon Excursion(MDICE) and the Guttenberg Carbon Isotope Excursion(GICE) are identified from Darriwilian to Early Katian by the aid of whole-rock carbon isotope data from two well cores. Positive excursion within conodont Pygodus anserinus zone is developed in Early Sandbian, and the fluctuation range is no less than MDICE. Because the range of this excursion in the generalized global carbon isotope curve is short, previous studies paid little attention to it, and named Early Sandbian Isotope Carbon Excursion(ESICE) in this paper. Furthermore, these positive excursions are not directly related to sea level fluctuations and the MDICE and GICE identified in northern Tarim can be globally correlated to that in southern China, North America, South America, and Europe. The Saergan Fm. source rocks of Middle-Upper Ordovician in Kalpin Dawangou outcrop are in accord with the geologic time of MDICE and ESICE, and GICE have strong ties to the source rock of Lianglitag Fm. in basin. Abundant organic carbon burial is an important factor in genesis of positive isotope carbon excursions. Positive oxygen isotope excursion, conodont fauna turnover, decreased conodont total diversity, and the change of sedimentary facies indicated that dramatic changes of paleoceanographic environment of Early-Middle Ordovician in Tarim Basin started from the end of Darriwillian, and an obvious icehouse climate of Late Ordovician occurred in ESICE. | Cunge Liu Guorong Li Dawei Wang Yongli Liu Mingxia Luo Xiaoming Shao | 2016 | Journal of Earth Science2016，27，2： | 9 |
| 3 | Primarily screening and analyzing ESTs differentially expressed in rats' primary liver cancer显示文摘Objective: To screen and analyze key express sequence tags (ESTs) which were differentially displayed in every period of SD rats' primary hepatic carcinoma and reveal the molecular mechanism of carcinogenesis. Methods: Using diethylnitrosamine (DENA) as a cancerigenic agent, animal models with different phases of primary hepatic cancer were constructed in SD rats. Rats were respectively sacrificed at d 14, d 28, d 56, d 77, d 105 and d 112 after the rats received DENA by gavage, then the livers were harvested. One part of the livers was classified according to their pathological changes, while the other was reserved for molecular mechanism studies on hepatocarcinogenesis. The differentially expressed genes were isolated from both normal and morbid tissues by mRNA differential display technique (DDRT-PCR). After the fragments were sequenced, bioinformatics were used to analyze the results. Results: Twelve differentially expressed cDNA fragments were obtained. Nine fragments had the homology with known cDNA clones, especially EST-7 was similar to BN/SsNHsdMCW mitochondrion gene and the identity was 100% which suggested EST-7 may be the part of BN/SsNHsdMCW mitochondrion gene. In contrast, other three fragments (EST-1, EST-3 and EST-5) had extremely low identity to any genes registered in GENBANK databases. Conclusions: BN/SsNHsdMCW mitochondrion gene was expressed in different periods of hepatocarcinogenesis. Moreover, EST-1, EST-3 and EST-5 were suggested to contribute to the development of rat hepatocarcinogenesis, and thus may be candidates of new targets of oncogenes or cancer suppressor genes. | Dandan Liu Lijuan Zhi Mingxia Ma Dan Qiao Meijuan Wang Yawei Wang Baijie Jin Anqi Li Guting Liu Yiqing Zhang Yanyan Song Hongxu Zhang | 2013 | Chinese Journal of Cancer Research2013，25，1： | 9 |
| 4 | Remarkably improved hydrogen storage properties of nanocrystalline TiO2-modified NaAlH4 and evolution of Ti- containing species during dehydrogenation/hydrogenation显示文摘增加 nanocrystalline TiO 的小数量<潜水艇class=“ a-plus-plus ”> 2 @C ( TiO <潜水艇class=“ a-plus-plus ”>在 nanoporous 碳上支持的 2 )合成戏剧性地减少操作温度并且在 NaAlH 为氢存储改进反应动力学<潜水艇class=“ a-plus-plus ”> 4 。nanocrystalline TiO < 潜水艇 class= “ a-plus-plus ” > 2 @C 合成在 900 AVO 八面体综合了是盖住试剂和生长的赞成过度饱和的选择吸附的结果种。随后, 3D 多孔的 V < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 5 八面体被 AVO 八面体的简单 thermolysis 经由一个锻烧处理获得。作为为锂电池的阴极材料,多孔的 V < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 5 八面体阴极在西班牙的北方展出 96 mAsga 盆的一个能力;并且(3 ) Zpy (n ?=? 17 ) , LV 质量从 226 被减少[178;306 ] g 到 220 [169;254 ] g (p ?=? 0.007 ) 在 13 点 ? 桴 ? 畦摮浡湥慴? 牦煥敵据敩 ? 景琠敨猠摥浩湥獴? 敢楳敤琠敨氠湯楧畴楤慮? 湡 ? 牴湡癳牥敳映湵慤敭瑮污映敲畱湥楣獥漠 ? 慥档戠極摬湩 ? 慢敳 ? 湯琠敨愠灭楬畴敤猠数瑣慲愠摮琠敨映潬牯猠数瑣慲? 慲楴?? 剓? 敭桴摯? | Xin Zhang Yongfeng Liu Ke Wang Mingxia Gao Hongge Pan | 2015 | Nano Research2015，8，2： | 8 |
| 5 | Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected patients显示文摘Dear Editor,In late December 2019,an outbreak of severe pneumonia caused by an unknown etiological agent was initially reported in Wuhan,China,and then quickly spread throughout China and even abroad(Zhu et al.,2020).Swift control measures and etiological investigations were conducted by the Chinese government,physicians and researchers,and by using high throughput sequencing and virological testing,the mysterious pneumonia pathogen was shown to be a novel coronavirus(SARS-CoV-2)capable of person-to-person transmission(Zhu et al.,2020).Coronaviruses are a group of non-segmented,enveloped and positive-sense RNA viruses that belong to the subfamily of Coronavirinae in the family of Coronavirdiae and order of Nidovirales. | Dachuan Lin Lei Liu Mingxia Zhang Yunlong Hu Qianting Yang Jiubiao Guo Yongchao Guo Youchao Dai Yuzhong Xu Yi Cai Xinchun Chen Zheng Zhang Kaisong Huang | 2020 | Science China(Life Sciences)2020，63，4： | 6 |
| 6 | Glucose-regulated protein 75 suppresses apoptosis induced by glucose deprivation in PC12 cells through inhibition of Bax conformational change显示文摘调整葡萄糖的蛋白质(Grp75 ) 75 是属于热吃惊蛋白质的重要分子的女伴 70 家庭并且在线粒体主要住。Grp75 能保护房间免受葡萄糖剥夺(GD ) 的伤害损害。然而,它由执行这功能的分子的机制是未知的。这里,我们报导 Grp75 能推迟细胞色素 c 的版本,还原剂 apoptosis 由 GD 导致,并且我们也发现 Grp75 能减少 Bax/Bcl-2 基因表示比率并且在这个过程期间禁止 Bax 的 conformational 变化。在结论,这些调查结果建议 Grp75 overexpression 能禁止 GD 导致的 apoptosis。Grp75 禁止了 Bax conformational 变化推迟细胞色素 c 的版本,因此提供保护给对 GD 毒性首先被用作一个神经原模型的 PC12 房间。 | Ling Yang Xiaoyu Liu Jinyu Hao Yunlong Yang Mingxia Zhao Ji Zuo Wen Liu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，4： | 6 |
| 7 | Brief Introduction to a Unique Edible Bolete---Phlebopus portentosus in Southern China显示文摘 | Chunxia Zhang Mingxia He Jing Liu Xinjing Xu Yang Cao Feng Gao Yiwei Fang Wenbing Wang Yun Wang | 2017 | Journal of Agricultural Science and Technology(B)2017，7，6： | 6 |
| 8 | Characterization and performance of Pt/SBA-15 for low-temperature SCR of NO by C_3H_6显示文摘Pt supported on mesoporous silica SBA-15 was investigated as a catalyst for low temperature selective catalytic reduction(SCR) of NO by C 3 H 6 in the presence of excess oxygen.The prepared catalysts were characterized by means of XRD,BET surface area,TEM,NO-TPD,NO/C 3 H 6-TPO,NH 3-TPD,XPS and 27 Al MAS NMR.The effects of Pt loading amount,O 2 /C 3 H 6 concentration,and incorporation of Al into SBA-15 have been studied.It was found that the removal efficiency increased significantly after Pt loading,but an optimal loading amount was observed.In particular,under an atmosphere of 150 ppm NO,150 ppm C 3 H 6,and 18 vol.% O 2,0.5% Pt/SBA-15 showed remarkably high catalytic performance giving 80.1% NOx reduction and 87.04% C 3 H 6 conversion simultaneously at 140°C.The enhanced SCR activity of Pt/SBA-15 is associated with its outstanding oxidation activities of NO to NO 2 and C 3 H 6 to CO 2 in low temperature range.The research results also suggested that higher concentration of O 2 and higher concentration of C 3 H 6 favored NO removal.The incorporation of Al into SBA-15 improved catalytic performance,which could be ascribed to the enhancement of catalyst surface acidity caused by tetrahedrally coordinated AlO 4.Moreover,the catalysts could be easily reused and possessed good stability. | Xinyong Liu Zhi Jiang Mingxia Chen Jianwei Shi Wenfeng Shangguan Yasutake Teraoka | 2013 | Journal of Environmental Sciences2013，25，5： | 5 |
| 9 | Comparison of Dryland Climate Change in Observations and CMIP5 Simulations显示文摘A comparison of observations with 20 climate model simulations from the Coupled Model Intercomparison Project, Phase5(CMIP5) revealed that observed dryland expansion amounted to 2.61 × 106km2 during the 58 years from 1948 to 2005,which was four times higher than that in the simulations(0.55 × 106km2). Dryland expansion was accompanied by a decline in aridity index(AI)(drying trend) as a result of decreased precipitation and increased potential evapotranspiration across all dryland subtype areas in the observations, especially in the semi-arid and dry subhumid regions. However, the CMIP5multi-model ensemble(MME) average performed poorly with regard to the decreasing trends of AI and precipitation. By analyzing the factors controlling AI, we found that the overall bias of AI in the simulations, compared with observations, was largely due to limitations in the simulation of precipitation. The simulated precipitation over global drylands was substantially overestimated compared with observations across all subtype areas, and the spatial distribution of precipitation in the MME was largely inconsistent in the African Sahel, East Asia, and eastern Australia, where the semi-arid and dry subhumid regions were mainly located. | JI Mingxia HUANG Jianping XIE Yongkun LIU Jun | 2015 | Advances in Atmospheric Sciences2015，32，11： | 5 |
| 10 | Effect of Shot Peening and Plasma Electrolytic Oxidation on the Intergranular Corrosion Behavior of 7A85 Aluminum Alloy显示文摘The effects of shot peening(SP) and plasma electrolytic oxidation(PEO) on the intergranular corrosion behavior of the novel high strength aluminum alloy 7A85(AA 7A85) were investigated by electrochemical polarization and electrochemical impedance tests.The intergranular corrosion mechanism of SP,PEO and PEO combined with sealingtreated AA 7A85 was studied by the metallographic analysis,residual stress testing,X-ray diffractometer analysis and scanning electron microscopy.The results show that AA 7A85-T7452 is very sensitive to intergranular corrosion.SP would significantly improve its intergranular corrosion resistance.This is attributed to the combination action of residual compressive stress and grain refinement.PEO would reduce the largest corrosion depth by 41.6%.Moreover,PEO without sealing did not eliminate the intergranular corrosion due to the existence of the micropores and microcracks in the oxide coating.However,PEO combined with the SiO2sol–gel sealing treatment could effectively protect the AA 7A85-T7452 from intergranular corrosion because of the good corrosion resistance and barrier function of the sealed coating. | Zuoyan Ye Daoxin Liu Chongyang Li Xiaoming Zhang Zhi Yang Mingxia Lei | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，4： | 4 |
| 11 | The template preparation and characterization of three new shapes of titania nanometer-array systems显示文摘A two-step anodization process was used to prepare highly ordered porous anodic alu- mina template (PAA). The template method was combined with the sol-electrophoresis deposition and sol-gel method to synthesize three types of nano- meter-array systems. The titania nano-arrays have a high specific surface area. The sol-gel template method was also applied to prepare the rod-shaped titania nanowire-arrays. The diameter of titania nanometer-array is about 50 nm; the length is about 20 μm; and the distance of neighboring two nanowires is about 100 nm. Through controlling the pore depth of the template, the membrane with peri- odical modulating titania nanodots was prepared. The diameter of the nanodots on the membrane surface was about 75 nm and the dot distance was about 100 nm. Also a compact structure has been found on the back face of the membrane. The sol-electrophoresis template method was used to prepare the nanowire-array system with the shape of string of candied haws. The diameter of nanowires was about 75 nm and the length was about 20 μm. The periodic concave-convex structures were found in each nanowire and the shape looked like string of candied haws. The three types of nano-array systems have a high specific surface area. It can be predicted that this type of surface modulating array system will have new properties and effects that are different from those of common membranes, nanodots and nanowires. | TIAN Yuming XU Mingxia LIU Xiangzhi GE Lei | 2006 | Chinese Science Bulletin2006，51，12： | 4 |
| 12 | Packet Cache-Forward Method Based on Improved Bayesian Outlier Detection for Mobile Handover in Satellite Networks显示文摘In this paper, we propose a Packet Cache-Forward(PCF) method based on improved Bayesian outlier detection to eliminate out-of-order packets caused by transmission path drastically degradation during handover events in the moving satellite networks, for improving the performance of TCP. The proposed method uses an access node satellite to cache all received packets in a short time when handover occurs and forward them out in order. To calculate the cache time accurately, this paper establishes the Bayesian based mixture model for detecting delay outliers of the entire handover scheme. In view of the outliers' misjudgment, an updated classification threshold and the sliding window has been suggested to correct category collections and model parameters for the purpose of quickly identifying exact compensation delay in the varied network load statuses. Simulation shows that, comparing to average processing delay detection method, the average accuracy rate was scaled up by about 4.0%, and there is about 5.5% cut in error rate in the meantime. It also behaves well even though testing with big dataset. Benefiting from the advantage of the proposed scheme in terms of performance, comparing to conventional independent handover and network controlled synchronizedhandover in simulated LEO satellite networks, the proposed independent handover with PCF eliminates packet out-of-order issue to get better improvement on congestion window. Eventually the average delay decreases more than 70% and TCP performance has improved more than 300%. | Hefei Hu Dongming Yuan Mingxia Liao Yuan'an Liu | 2016 | China Communications2016，13，6： | 4 |
| 13 | Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition显示文摘细胞的 deoxyribonucleotide triphosphates (dNTP ) 由把 ribonucleotides 变换成相应 deoxy 形式分享使用基于激进分子的化学的 Ribonucleotide reductase (RNR ) 供应。真核细胞的 RNR 包括并且子单元:包含催化并且 allosteric 地点;房子一个 diferric-tyrosyl 激进分子余因子(FeIII 2-Y?? | Caiguo ZHANG Guoqi LIU Mingxia HUANG | 2014 | Frontiers in Biology2014，9，2： | 3 |
| 14 | Highly active multivalent multielement catalysts derived from hierarchical porous TiNb_(2)O_(7) nanospheres for the reversible hydrogen storage of MgH_(2)显示文摘Critical limitations in applying MgH_(2) as a hydrogen-storage medium include the high H_(2) desorption temperature and slow reaction kinetics.In this study,we synthesized hierarchical porous TiNb_(2)O_(7) spheres in micrometer scale built with 20-50 nm nanospheres,which showed stable activity to catalyze hydrogen storage in MgH_(2) as precursors.The addition of 7 wt.%TiNb_(2)O_(7) in MgH_(2) reduced the dehydrogenation onset temperature from 300 to 177℃.At 250℃,approximately 5.5 wt.%H_(2) was rapidly released in 10 min.Hydrogen uptake was detected even at room temperature under 50 bar hydrogen;4.5 wt.%H_(2) was absorbed in 3 min at 150℃,exhibiting a superior low-temperature hydrogenation performance.Moreover,nearly constant capacity was observed from the second cycle onward,demonstrating stable cyclability.During the ball milling and initial de/hydrogenation process,the high-valent Ti and Nb of TiNb_(2)O_(7) were reduced to the lower-valent species or even zero-valent metal,which in situ created multivalent multielement catalytic surroundings.A strong synergistic effect was obtained for hybrid oxides of Nb and Ti by density functional theory(DFT)calculations,which largely weakens the Mg-H bonding and results in a large reduction in kinetic barriers for hydrogen storage reactions of MgH_(2).Our findings may guide the further design and development of high-performance complex catalysts for the reversible hydrogen storage of hydrides. | Lingchao Zhang Ke Wang Yongfeng Liu Xin Zhang Jianjiang Hu Mingxia Gao Hongge Pan | 2021 | Nano Research2021，14，1： | 2 |
| 15 | Influence of Shot Peening Treatment on the Fatigue and Corrosion Resisting Properties of 2Cr13 Stainless Steel显示文摘In the present paper,shot peening treatments were used to strengthen the steel surface,and the influence on the fatigue and corrosion resisting properties of 2Cr13 stainless steel was examined.The residual stress and the surface roughness were investigated by XRD and AFM.The characteristics of fatigue and corrosion resistance have also been analyzed by bending fatigue and salt spray tests.The result reveals that the fatigue limit of the samples is improved dramatically with the increasing of the peening strength by 7.5%.Meanwhile,the peenging angle has no evident influence on the fatigue properties.Compared with the untreated samples,the acid corrosion weight loss of the samples after the shot peening treatment is decreased almost by 90%.From the above experimental results proper shot peening would improve not only the fatigue property but also the corrosion resistance of 2Cr13-typed stainless steel. | Liu Mingxia Zhang Haicun Liu Daoxin Han Zengfu Zhi Jinhua Guo Wenyong Zhou Yafeng | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 16 | miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn’s disease显示文摘 | Yu Chen Xiaochun Meng Chengxiao Wang Ying Liu Liwei Tang Mingxia Zheng Chundi Xu Jian Song | 2013 | Biochemical and Biophysical Research Communications2013，，： | 2 |
| 17 | miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn’s disease显示文摘 | Yu Chen Chengxiao Wang Ying Liu Liwei Tang Mingxia Zheng Chundi Xu Jian Song Xiaochun Meng | 2013 | Biochemical and Biophysical Research Communicatio2013，，1： | 2 |
| 18 | Heterologous expression of Hp BHY and Cr BKT increases heat tolerance in Physcomitrella patens显示文摘Heat stress can restrict plant growth,development,and crop yield.As essential plant antioxidants,carotenoids play significant roles in plant stress resistance.b-carotene hydroxylase(BHY)and b-carotene ketolase(BKT),which catalyze the conversions of b-carotene to zeaxanthin and b-carotene to canthaxanthin,respectively,are key enzymes in the carotenoid biosynthetic pathway,but little is known about their potential functions in stress resistance.Here,we investigated the roles of b-carotene hydroxylase and b-carotene ketolase during heat stress in Physcomitrella patens through expressing a b-carotene ketolase gene from Chlamydomonas reinhardtii(Cr BKT)and a b-carotene hydroxylase gene from Haematococcus pluvialis(Hp BHY)in the moss P.patens.In transgenic moss expressing these genes,carotenoids content increased(especially lutein content),and heat stress tolerance increased,with reduced leafy tissue necrosis.To investigate the mechanism of this heat stress resistance,we measured various physiological indicators and found a lower malondialdehyde level,higher peroxidase and superoxide dismutase activities,and higher endogenous abscisic acid and salicylate content in the transgenic plants in response to high-temperature stress.These results demonstrate that Cr BKT and Hp BHY increase plant heat stress resistance through the antioxidant and damage repair metabolism,which is related to abscisic acid and salicylate signaling. | Jianfang He Ping Li Heqiang Huo Lina Liu Ting Tang Mingxia He Junchao Huang Li Liu | 2019 | Plant Diversity2019，41，4： | 2 |
| 19 | Systemic Infusion of FLK1+ Mesenchymal Stem Cells Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis in Mice显示文摘 | Baijun Fang Mingxia Shi Lianming Liao Shaoguang Yang Yuhao Liu Robert Chunhua Zhao | 2004 | Transplantation2004，，1： | 2 |
| 20 | A facile synthesis of Fe 3 O 4 /C composite with high cycle stability as anode material for lithium-ion batteries显示文摘 | Peng Wang Mingxia Gao Hongge Pan Jialei Zhang Chu Liang Junhua Wang Pei Zhou Yongfeng Liu | 2013 | Journal of Power Sources2013，，： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员