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| 1 | Eutrophication and algal blooms in channel type reservoirs:A novel enclosure experiment by changing light intensity显示文摘To explore eutrophication and algal bloom mechanisms in channel type reservoirs,a novel enclosure experiment was conducted by changing light intensity (LI) in the Daning River of the Three Gorges Reservoir (TGR).Square enclosures (side 5.0 m) were covered on the surface with shading materials of different thickness,and with their bases open to the river.Changes and characteristics of the main eutrophication factors under the same water quality and hydrodynamic conditions but different LI were evaluated.All experimental water samples were neutral and alkalescent,with high nitrogen and phosphate concentrations,low potassium permanganate index,stable water quality,and different LI.At the same water depth,LI decreased with increasing shade material,while dissolved oxygen and water temperature were both stable.The growth peak of phytoplankton was with light of 345-4390 lux underwater or 558-7450 lux above the water surface,and water temperature of 25.6-26.5 C.Algae were observed in all water samples,accounting for 6 phylum and 57 species,with algal density changing frequently.The results showed that significantly strong or weak light was unfavorable for phytoplankton growth and the function together with suitable temperature and LI and ample sunshine encouraged algal blooms under the same water quality and hydrodynamic conditions.Correlation analysis indicated that algae reduced gradually lengthwise along water depth in the same enclosure while pH became high.The power exponent relationship between chlorophyll a (Chl-a) and LI was found by curve fitting,that is Chl-a=K(LI) n. | Chengjin Cao Binghui Zheng Zhenlou Chen Minsheng Huang Jialei Zhang | 2011 | Journal of Environmental Sciences2011，23，10： | 13 |
| 2 | Weekly albumin-bound paclitaxel/cisplatin versus gemcitabine/cisplatin as first-line therapy for patients with advanced non-small-cell lung cancer:A phase II open-label clinical study显示文摘Objective: The aim of this trial was to compare both the efficacy and the safety of a weekly nanoparticle albumin-bound paclitaxel(nab-paclitaxel) plus cisplatin vs. gemcitabine plus cisplatin in patients with advanced non-small-cell lung cancer(NSCLC).Methods: A total of 84 participants received either 100 mg/m^2 nab-paclitaxel each week on d 1, 8 and 15 of a 28 day cycle, as well as cisplatin 75 mg/m^2 on d 1 every three weeks(nab-TP arm); or gemcitabine 1,000 mg/m^2 on d 1 and 8, plus cisplatin 75 mg/m^2 on d 1 every three weeks(GP arm). The primary end point was progression-free survival(PFS). The secondary end points were overall response rate(ORR) and overall survival(OS).Results: According to our analysis, the median PFS was 4.8 months for the nab-TP arm vs. 5.2 months for the GP arm(P=0.55). Analysis showed the median OS was 14.6 months for participants who were in the nab-TP arm vs. 15.1 months for those in the GP arm(P=0.94). Besides, nab-TP showed OS advantages over GP in patients harboring epidermal growth factor receptor(EGFR) mutation(26.7 vs. 15.3 months, P=0.046) and patients with a performance status of 0(23.5 vs. 14.7 months, P=0.020). It was found that incidences of drug-related grade 3 or 4 toxicities were comparable between the two treatment arms.Conclusions: Therefore, it can be seen that weekly nab-TP treatment has a similar efficacy and tolerability to GP treatment for patients who are undergoing their first-line treatment for NSCLC. It could be that survival differences among platinum doublets in the context of both EGFR mutation and performance status have the potential to be the basis for our further clinical trials. | Shanshan Qin Hui Yu Xianghua Wu Zhiguo Luo Huijie Wang Si Sun Mingzhu Huang Jia Jin Zhonghua Tao Jie Qiao Yu Feng Jialei Wang Jianhua Chang | 2019 | Chinese Journal of Cancer Research2019，31，2： | 9 |
| 3 | Preparation and Performance of Salt Tolerance and Thermal Stability Cellulose Nanofibril Hydrogels and Their Application in Drilling Engineering显示文摘The poor salt tolerance,thermal stability,and environmental performance of petrochemicals can severely limit their applications in drilling engineering.In this study,cellulose nanofibril(CNF)hydrogels with improved salt tolerance and thermal stability were prepared,and their filtration performance was evaluated.The hydrogels were prepared through the simultaneous grafting of 2-acrylamido-2-methylpropane sulfonic acid(AMPS)and butyl acrylate(BA)onto the CNF surface through ceric ammoniumnitrate-induced radical polymerization.The modified and original CNF samples were characterized using Fourier Transform infrared spectroscopy(FT-IR)and rheological measurements.The FT-IR analysis results showed that both AMPS and BA were grafted onto the CNF backbone,affirming the successful preparation of the grafted CNFs.The rheological analysis results showed that the modified CNF hydrogels exhibited significantly improved salt tolerance,thermal stability,and“salt-thickening”effect.Moreover,the results of the fluid loss test showed that the modified CNF hydrogels exhibited a much better fluid loss control than the original CNF hydrogels.In addition,after adding 2%modified CNF hydrogels as a filtrate reducer in the drilling fluids prepared with a 6%combined salt solution,the filtrate loss was significantly reduced even after aging for 72 h at 160℃. | XiongLi Liu An Wang ChunPing Wang JiaLei Qu YangBing Wen Bin Chen ZhongGuang Wang BinBin Wu ZhaoYang Yuan Bing Wei | 2019 | Paper And Biomaterials2019，4，2： | 7 |
| 4 | Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology显示文摘Proper reprogramming of parental DNA methylomes is essential for mammalian embryonic development.However,it is unknown whether abnormal methylome reprogramming occurs and is associated with the failure of embryonic development.Here we analyzed the DNA methylomes of 57 blastocysts and 29 trophectoderm samples with different morphological grades during assisted reproductive technology(ART) practices.Our data reveal that the global methylation levels of high-quality blastocysts are similar(0.30 ± 0.02,mean ± SD).while the methylation levels of low-quality blastocysts are divergent and away from those of high-quality blastocysts.The proportion of blastocysts with a methylation level falling within the range of 0.30 ± 0.02 in different grades correlates with the live birth rate for that grade.Moreover,abnormal methylated regions are associated with the failure of embryonic development.Furthermore,we can use the methylation data of cells biopsied from trophectoderm to predict the blastocyst methylation level as well as to detect the aneuploidy of the blastocysts.Our data indicate that global abnormal methylome reprogramming often occurs in human embryos,and suggest that DNA methylome is a potential biomarker in blastocyst selection in ART. | Guoqiang Li Yang Yu Yong Fan Congru Li Xiaocui Xu Jialei Duan Rong Li Xiangjin Kang Xin Ma Xuepeng Chen Yuwen Ke Jie Yan Ying Lian Ping Liu Yue Zhao Hongcui Zhao Yaoyong Chen Xiaofang Sun Jianqiao Liu Jie Qiao Jiang Liu | 2017 | Journal of Genetics and Genomics2017，44，10： | 5 |
| 5 | Full-duplex light communication with a monolithic multicomponent system显示文摘A monolithic multicomponent system is proposed and implemented on a III-nitride-on-silicon platform,whereby two multiple-quantum-well diodes(MQW-diodes)are interconnected by a suspended waveguide.Both MQW-diodes have an identical low-In-content InGaN/Al0.10Ga0.90N MQW structure and are produced by the same fabrication process flow.When appropriately biased,both MQW-diodes operate under a simultaneous emission-detection mode and function as a transmitter and a receiver at the same time,forming an in-plane full-duplex light communication system.Real-time full-duplex audio communication is experimentally demonstrated using the monolithic multicomponent system in combination with an external circuit. | Yongjin Wang Xin Wang Bingcheng Zhu Zheng Shi Jialei Yuan Xumin Gao Yuhuai Liu Xiaojuan Sun Dabing Li Hiroshi Amano | 2018 | Light(Science & Applications)2018，7，1： | 5 |
| 6 | An all-round AI-Chemist with a scientific mind显示文摘The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI)laboratory.Several AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains challenging.Here,we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research.Based on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly.It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations,including synthesis,characterization and performance tests.The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be proposed.The competence of the AI-Chemist has been scrutinized by three different chemical tasks.In the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory. | Qing Zhu Fei Zhang Yan Huang Hengyu Xiao LuYuan Zhao XuChun Zhang Tao Song XinSheng Tang Xiang Li Guo He BaoChen Chong JunYi Zhou YiHan Zhang Baicheng Zhang JiaQi Cao Man Luo Song Wang GuiLin Ye WanJun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou WeiWei Shang Jun Jiang Yi Luo | 2022 | National Science Review2022，9，10： | 5 |
| 7 | Radiator Optimization of LED Street Lamp Based on Parameterized Language APDL of ANSYS显示文摘Heat management is one of the burning questions for the spreading of LED lighting,one solution for which is to design radiators reasonably.In this article,a radiator sold on the market was modeled on ANSYS using APDL and an optimum radiator structure was achieved by making use of the optimization function of ANSYS.The radiator efficiency was increased by optimizing several parameters simultaneously.Experimental results indicate that the volume of the optimum radiator is decreased to 75.79% of that of the initial model with the junction temperature remaining at the primary level,which saves a considerable amount of material with higher radiant efficiency. | FENG Jinyuan DING Jialei | 2010 | Semiconductor Photonics and Technology2010，16，2： | 3 |
| 8 | C/EBPαp30 plays transcriptional regulatory roles distinct from C/EBPαp42显示文摘CCAAT/enhancer 有约束力的蛋白质α(C/EBP α) 是 transcriptional 禁止细胞增殖的规章的因素,和其他的翻译开始生产二多肽, C/EBP α p 30 并且 C/EBP α p 42。由表示介绍, C/EBP α p 30specifically 禁止了基因的一个唯一的集合,这被揭示,包括 MPP11, p84N5 和 SMYD2,它没被 C/EBP α p 影响 42 在两根 QSG-7701 hepatocyte 房间线和 QGY-7703 hepatoma, cells.Semi 量的 RT-PCR 分析独立地证实了这些结果。Chromatinimmunoprecipitation 试金显示出 30 比 C/EBP α p 更强烈绑了在这些基因的倡导者的那 C/EBP α p 42。在 C/EBP α是调整的 down 的临床的 hepatoma 在样品,所有三基因明确地由 30 在上面的 C/EBP α p 禁止了调整。然而, MPP11, p84N5 和 SMYD2genes 的压抑可能直接不涉及 C/EBP α p 30-mediated 生长抑制。我们的数据建议 30 调整的那 C/EBP α p 目标基因的一个唯一的集合并且多于 C/EBP α p 的 dominant-negativeregulator 42。 | Chunxi Wang~1 Xiaotao Chen~1 Yanping Wang~1 Jialei Gong~1 Gengxi Hu ~1State Key Laboratory of Molecular Biology institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,Shanghai 200031,China | 2007 | Cell Research2007，17，4： | 2 |
| 9 | Green Design Studio: A modular-based approach for high-performance building design显示文摘A modular-based Green Design Studio(GDS)platform has been developed in this study for fast and accurate performance analysis for early stage green building design.The GDS platform aims to simplify the design and analysis process by embedding performance parameters into design elements in modules and employing near-real-time model for whole building performance simulation as well as by providing an easy-to-use and intuitive user interface to assist users without extensive knowledge on building physics.The platform consists of building modules as fundamental building blocks,performance predicting models,and a user interface for visualization and interactive design.In the platform,a whole building is composed of modules organized in a hierarchical structure,including spaces,enclosures,service systems,sustainable resource systems and sites.Both physics-based and data-driven models can be used to simulate the building performance and optimize building systems.A simplified physics-based model,the Resistance–Capacitance(RC)model,has been proposed as a generic simulation model for the flows of heat,air,moisture and pollutants,which is significantly faster than conventional simulation tools such as EnergyPlus,and hence more practical for use in real-time design interaction and optimization.A pilot case study is conducted to illustrate the modular-based design approach using a section of an office building.Compared to conventional building performance analysis tools,the GDS platform can provide fast and reliable feedback on performance prediction for early design.The modular approach makes it easier to modify the building design and evaluate the potentials and contributions of various green design features and technologies. | Jialei Shen Bess Krietemeyer Amber Bartosh Zhi Gao Jianshun Zhang | 2021 | Building Simulation2021，14，2： | 2 |
| 10 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 11 | Application of Cellulose and Cellulose Nanofibers in Oil Exploration显示文摘In this article, the application of cellulose and cellulose nanofibers in oil exploration was discussed, and the research status of using cellulose and cellulose nanofibers as oil displacement agents, oil-well cementing additives, and foam stabilizers were summarized. | Xiongli Liu Chunping Wang An Wang Jialei Qu Yangbing Wen Bing Wei | 2019 | Paper And Biomaterials2019，4，3： | 2 |
| 12 | A facile synthesis of Fe 3 O 4 /C composite with high cycle stability as anode material for lithium-ion batteries显示文摘 | Peng Wang Mingxia Gao Hongge Pan Jialei Zhang Chu Liang Junhua Wang Pei Zhou Yongfeng Liu | 2013 | Journal of Power Sources2013，，： | 2 |
| 13 | Correlation analysis on central lymph node metastasis in 276 patients with c N0 papillary thyroid carcinoma显示文摘 | Wendong W Jialei G Jinbiao S et a1 | 2013 | Int J Clin Exp Pathol2013，6，3： | 1 |
| 14 | Characterization of visibility and its affecting factors over Nanjing, China显示文摘 | Junjun Deng Tijian Wang Ziqiang Jiang Min Xie Renjian Zhang Xiaoxian Huang Jialei Zhu | 2011 | Atmospheric Research2011，，3： | 1 |
| 15 | A novel electrochemical sensor based on electropolymerized molecularly imprinted polymer and gold nanomaterials amplification for estradiol detection显示文摘 | ZHANG Xiaoyan PENG Yuan BAI Jialei | 2014 | Sens Actuators B2014，200，： | 1 |
| 16 | Rapid and sensitive determination of vinorelbine in human plasma by liquid chromatography–tandem mass spectrometry and its pharmacokinetic application显示文摘 | Jun Qian Yixuan Wang Jianhua Chang Jian Zhang Jialei Wang Xichun Hu | 2011 | Journal of Chromatography B2011，，9： | 1 |
| 17 | Endocrine pheromones couple fat rationing to dauer diapause through HNF4αnuclear receptors显示文摘Developmental diapause is a widespread strategy for animals to survive seasonal starvation and environmental harshness.Diapaused animals often ration body fat to generate a basal level of energy for enduring survival.How diapause and fat rationing are coupled,however,is poorly understood.The nematode Caenorhabditis elegans excretes pheromones to the environment to induce a diapause form called dauer larva.Through saturated forward genetic screens and CRISPR knockout,we found that dauer pheromones feed back to repress the transcription of ACOX-3,MAOC-1,DHS-28,DAF-22(peroxisomalβ-oxidation enzymes dually involved in pheromone synthesis and fat burning),ALH-4(aldehyde dehydrogenase for pheromone synthesis),PRX-10 and PRX-11(peroxisome assembly and proliferation factors).Dysfunction of these pheromone enzymes and factors relieves the repression.Surprisingly,transcription is repressed not by pheromones excreted but by pheromones endogenous to each animal.The endogenous pheromones regulate the nuclear translocation of HNF4αfamily nuclear receptor NHR-79 and its co-receptor NHR-49,and,repress transcription through the two receptors.The feedback repression maintains pheromone homeostasis,increases fat storage,decreases fat burning,and prolongs dauer lifespan.Thus,the exocrine dauer pheromones possess an unexpected endocrine function to mediate a peroxisome-nucleus crosstalk,coupling dauer diapause to fat rationing. | Cheng Gao Qi Li Jialei Yu Shiwei Li Qingpo Cui Xiao Hu Lifeng Chen Shaobing O.Zhang | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
| 18 | Quantum superalgebras uq(sl(m│n)) at roots of unity显示文摘有限维的 Hopf superalgebras u q (sl (m|n )) 相应于谎言 superalgebras sl (m|n ) 被构造。PBW 类型基础和 u q (sl (m|n )) 的左、正确的积分被获得。而且, Hopf superalgebra 自守的组被描述。 | Jialei CHEN Shilin YANG | 2012 | Frontiers of Mathematics in China2012，7，4： | 1 |
| 19 | Hydrogen-bonded network: An effective approach to improve the thermal stability of organic/polymer electro-optic materials显示文摘Preparation of PMMA-co-PHPMN-(4-hydroxyphenyl)maleimide was prepared according tothe literature [1]. The monomer mixtures, comprising of 0.6g N-(4-hydroxyphenyl)maleimide, 0.4 g MMA and 0.004 g , ′-azobisisobutyronitrile (AIBN) were dissolved in 2 mLDMF. Air above the monomers was swept out using thefreeze-pump-thaw procedure three times and filled | DENG GuoWei BO ShuHui ZHOU TingTing ZHANG Rong LIU JiaLei LIU XinHou ZHEN Zhen QIU Ling | 2013 | Science China Chemistry2013，56，2： | 1 |
| 20 | X16老年人平衡能力测试量表的信度和效度评估(摘译)显示文摘近几十年来,老龄化已成为当今社会的重要公共卫生问题之一。全世界几乎所有国家中60岁及以上的人口数都在逐步、迅速地增长。2012年,全球老年人口占总人口的11%以上。据联合国人口基金会估计,到2050年这一比例将达到约22%。2012年,我国有1.8亿老年人,截至2015年,65岁及以上老人占全国总人口的10.5%,预计到2050年该比例还会增长近三分之一。上海是我国人口最多也是平均期望寿命最高的城市,2014年老年人口比例达到28.8%。随着年龄的增长,老年人的生理、认知和行动能力均有不同程度下降,因此,有必要对老龄化进程中的特点进行研究。 | 姜玉(摘译) 夏庆华(审校) Jingjuan Ju Peng Zhou Lin Li Xiaolei Ye Hongmei Wu Bin Shen Jialei Zhang Xiaoding He Chunjin Niu | 2021 | 伤害医学(电子版)2021，10，1： | 1 |
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