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| 1 | A novel peptide, selected from phage display library of random peptides, can efficiently target into human breast cancer cell显示文摘To develop a targeting vector for breast cancer biotherapy, MDA-MB-231 cell, a human breast cancer cell line, was co-cultured with pC89 (9 aa) phage display library of random peptides. In multiple inde- pendent peptide-presenting phage screening trials, subtilisin was used as a protease to inactivate ex- tra-cellular phages. The internalized phages were collected by cell lysising and amplified in E. coli XLI-Blue. Through five rounds of selection, the peptide-presenting phages which could be internalized in MDA-MB-231 cells were isolated. A comparison was made between internalization capacities of pep- tide-presenting phages isolated from MDA-MB-231 cells and RGD-integrin binding phage by cocultur- ing them with other human tumor cell lines and normal cells. The nucleotide sequences of isolated peptide-presenting phages were then determined by DNA sequencing. To uncover whether phage coat protein or amino acid order was required for the character of the peptide to MDA-MB-231 cells, three peptides were synthesized. They are CASPSGALRSC, ASPSGALRS and CGVIFDHSVPC (the shifted sequence of CASPSGALRSC), and after coculturing them with different cell lines, their targeting ca- pacities to MDA-MB-231 cells were detected. These data suggested that the internalization process was highly selective, and capable of capturing a specific peptide from parent peptide variants. Moreover, the targeting internalization event of peptides was an amino acid sequence dependent manner. The results demonstrated the feasibility of using phage display library of random peptides to develop new targeting system for intracellular delivery of macromolecules, and the peptide we obtained might be modified as a targeting vector for breast cancer gene therapy. | DONG Jian LIU WeiQing ZHANG KeJian JIANG AiMei CHEN MingQing | 2008 | Chinese Science Bulletin2008，53，6： | 12 |
| 2 | A review on application of composite truss bridges composed of hollow structural section members显示文摘Composite truss with hollow structural section(HSS) members is deemed as the structure applicable to large-span and heavily-loaded bridges. To promote the application of composite truss bridge with HSS members in China, this paper described its structural characteristics and technology in details. Besides, not only were 32 typical design cases of composite truss bridges with HSS members collected, but also the corresponding historical development was summed up. Comparisons on structural components, characteristics and engineering applications were made among composite truss bridges with HSS members in different structural forms. Then, the analysis on the characteristics of composite truss bridges with concrete-filled steel tubular(CFST) chords was conducted, and the challenges on the aspects of complicated joints and interfacial debonding were pointed out. To address these problems, the concrete-filled rectangular hollow section(CFRHS)stiffened with PBLs(Perfobond Ribs) was proposed to improve the reliability of confinement effect in CFST member and force transfer in joints. The advantages on the mechanical properties of CFRHS structure stiffened using PBLs were systematically expounded with respect to the behaviors of steel plate, interface, member and joint. Moreover, the structure design, construction technology, structural calculation and economic efficiency of the practical bridge with CFRHS chords stiffened using PBLs were comprehensively analyzed.The results demonstrated that composite truss bridge with PBL-stiffened CFRHS members was competitive in mechanical performance and construction. | Zhijuan Tian Yongjian Liu Lei Jiang Weiqing Zhu Yinping Ma | 2019 | Journal of Traffic and Transportation Engineering(English Edition)2019，6，1： | 11 |
| 3 | Reuse of Fenton sludge as an iron source for NiFe_2O_4 synthesis and its application in the Fenton-based process显示文摘The potentially hazardous iron-containing sludge from the Fenton process requires proper treatment and disposal, which often results in high treatment cost. In this study, a novel method for the reuse of Fenton sludge as an iron source for the synthesis of nickel ferrite particles(NiFe_2O_4) is proposed. Through a co-precipitation method followed by sintering at 800°C, magnetic NiFe_2O_4 particles were successfully synthesized, which was confirmed by powder X-ray diffraction(XRD), scanning electronic microscopy(SEM), energy dispersive spectroscopy(EDS), Fourier transform infrared spectroscopy(FT-IR) and Raman spectroscopy. The synthesized NiFe_2O_4 could be used as an efficient catalyst in the heterogeneous Fenton process. In phenol degradation with H_2O_2 or NiFe_2O_4 alone, the phenol removal efficiencies within the reaction time of 330 min were as low as 5.9% ± 0.1% and 13.5% ±0.4%, respectively. However, in the presence of both NiFe_2O_4 and H_2O_2, phenol removal efficiency as high as 95% ± 3.4% could be achieved, indicating the excellent catalytic performance of NiFe_2O_4 in the heterogeneous Fenton process. Notably, a rapid electron exchange between_Ni II and_Fe III ions in the NiFe_2O_4 structure could be beneficial for the Fenton reaction. In addition, the magnetic catalyst was relatively stable, highly active and recoverable, and has potential applications in the Fenton process for organic pollutant removal. | Hui Zhang Jianguo Liu Changjin Ou Faheem Jinyou Shen Hongxia Yu Zhenhuan Jiao Weiqing Han Xiuyun Sun Jiansheng Li Lianjun Wang | 2017 | Journal of Environmental Sciences2017，29，3： | 10 |
| 4 | Removal of phosphate from wastewater using alkaline residue显示文摘Alkaline residue(AR) was found to be an efficient adsorbent for phosphate removal from wastewater. The kinetic and equilibrium of phosphate removal were investigated to evaluate the performance of modified alkaline residue. After treatment by NaOH(AR-NaOH), removal performance was significantly improved, while removal performance was almost completely lost after treatment by HCl(AR-HCl). The kinetics of the removal process by all adsorbents was well characterized by the pseudo second-order model. The Langmuir model exhibited the best correlation for AR-HCl, while AR was effectively described by Freundlich model. Both models were well fitted to AR-NaOH. The maximum adsorption capacities calculated from Langmuir equation were in following manner: AR-NaOH > AR > AR-HCl. Phosphate removal by alkaline residue was pH dependent process. Mechanisms for phosphate removal mainly involved adsorption and precipitation, varied with equilibrium pH of solution. For AR-HCl, the acid equilibrium pH(< 6.0) was unfavorable for the formation of Ca-P precipitate, with adsorption as the key mechanism for phosphate removal. In contrast, for AR and ARNaOH, precipitation was the dominant mechanism for phosphate removal, due to the incrase on pH(> 8.0) after phosphate removal. The results of both XRD and SEM analysis confirmed CaHPO4·2H2O formation after phosphate removal by AR and AR-NaOH. | Yubo Yan Xiuyun Sun Fangbian Ma Jiansheng Li Jinyou Shen Weiqing Han Xiaodong Liu Lianjun Wang | 2014 | Journal of Environmental Sciences2014，26，5： | 8 |
| 5 | Estimating the directions of arrival based on multi-subarray subspace fitting显示文摘拿估计到达的方向被介绍的进报道的在数组元素之中的相互的联合的一个 multi-subarray subspace 试穿方法。一致线性数组的相互的联合矩阵与 banded 被建模对称的 Toeplitz 矩阵。根据相互的联合矩阵的 DOF (自由的度) ,在二个方面的数组元素的部分被忽视。精神算法的理论特征,适合算法的 subspace 之一,被学习。为大 N 和一致线性数组, MCLS 精神评价错误是 asymptotically,联合,与零个工具散布的 Gaussian,和它的协变性表达式被获得。它从模拟被知道在那里存在当当它的变化有一些增加时,相互的联合不存在时,有为数组元素和信号来源的某些数字的最低评价错误的 subarray,和它估计到达的方向的性能接近理想的状况。方法与高分辨率被用于深测术的 sidescan 声纳,并且好结果被获得了。以增加数组元素的数字的成本,方法能减少在数组元素之中的相互的联合的爱。 | ZHU Weiqing LIU Xiaodong ZHANG Dongsheng LIAO Zheng ZHANG Fangsheng | 2006 | Chinese Journal of Acoustics2006，25，1： | 7 |
| 6 | Simultaneous pyridine biodegradation and nitrogen removal in an aerobic granular system显示文摘Simultaneous pyridine biodegradation and nitrogen removal were successfully achieved in a sequencing batch reactor(SBR) based on aerobic granules. In a typical SBR cycle, nitritation occurred obviously after the majority of pyridine was removed, while denitrification occurred at early stage of the cycle when oxygen consumption was aggravated. The effect of several key operation parameters, i.e., air flow rate, influent NH_4^+-N concentration,influent p H and pyridine concentration, on nitritation, pyridine degradation and total nitrogen(TN) removal, was systematically investigated. The results indicated that high air flow rate had a positive effect on both pyridine degradation and nitritation but a negative impact of overhigh air flow rate. With the increase of NH_4^+ dosage, both nitritation and TN removal could be severely inhibited. Slightly alkaline condition, i.e., pH 7.0–8.0, was beneficial for both pyridine degradation and nitritation. High pyridine dosage often resulted in the delay of both pyridine degradation and nitritation. Besides, extracellular polymeric substances production was affected by air flow rate, NH_4^+ dosage, pyridine dosage and p H.In addition, high-throughput sequencing analysis demonstrated that Bdellovibrio and Paracoccus were the dominant species in the aerobic granulation system. Coexistence of pyridine degrader, nitrification related species, denitrification related species, polymeric substances producer and self-aggregation related species was also confirmed by highthroughput sequencing. | Xiaodong Liu Shijing Wu Dejin Zhang Jinyou Shen Weiqing Han Xiuyun Sun Jiansheng Li Lianjun Wang | 2018 | Journal of Environmental Sciences2018，30，5： | 7 |
| 7 | GOVERNANCE OF GLOBAL SUPPLY CHAINS VULNERABILITY BY BUSINESS-BASED INTERORGANIZATIONAL INFORMATION PLATFORM显示文摘The paper introduces the business-based interorganizational information platform(IOP) and analyzes the feasibility and mechanism of business-based IOP governing global supply chains vulnerability,and then aims to develop a risk evaluation software under reliable algorithm to appraise the capability of an interorganizational information platform resisting to global supply chains risks that supports platform users and providers to make decisions.The paper respectively starts with a basic conceptual model of global supply chains vulnerability and a conceptual model of global supply chains vulnerability in business-based IOP,and then gives the simulation model of governance of global supply chain vulnerability in business-based IOP;then has a discussion with the beneficial model of governing global supply chains vulnerability by using business-based IOP or not.The results of research:(1) If given the ratio of expense per income on global supply chains using business-based IOP, we can estimate the costs to take precautions against risks that decides to the maximum value of the average income of per transaction on global supply chains using business-based IOP.(2) If given total income of transaction on global supply chains using business-based IOP,we can estimate the maximum value of the ratio of expense per income on global supply chains using business-based IOP, which would help to make pricing policy for IOP service provider. | Zhenyu LIU Weiqing ZHUANG | 2013 | Journal of Systems Science and Systems Engineering2013，22，1： | 7 |
| 8 | Triglycerides and ratio of triglycerides to high-density lipoprotein cholesterol are better than liver enzymes to identify insulin resistance in urban middle-aged and older non-obese Chinese without diabetes显示文摘 | Sun Yu Li Wenjuan Hou Xinguo Wang Chuan Li Chengqiao Zhang Xiuping Yang Weifang Ma Zeqiang Wang Weiqing Ning Guang Zheng Huizhen Ma Aixia Song Jun Lin Peng Liang Kai Liu Fuqiang Gong Lei Wang Meijian Xiao Juan Yan Fei Yang Junpeng Wang Lingshu Tian Meng Liu Jidong Zhao Ruxing Zhu Ping Chen Li | 2014 | Chinese Medical Journal2014，，10： | 7 |
| 9 | Highly effective and reproducible surface-enhanced Raman scattering substrates based on Ag pyramidal arrays显示文摘 | Yandong Wang Nan Lu Wentao Wang Lingxiao Liu Lei Feng Zhoufang Zeng Haibo Li Weiqing Xu Zijian Wu Wei Hu Yanqing Lu Lifeng Chi | 2013 | Nano Research2013，6，3： | 6 |
| 10 | Simplified analysis of frame structures with viscoelastic dampers considering the effect of soil-structure interaction显示文摘In this study, simplified numerical models are developed to analyze the soil-structure interaction(SSI) effect on frame structures equipped with viscoelastic dampers(VEDs) based on pile group foundation.First, a single degree-offreedom(SDOF) oscillator is successfully utilized to replace the SDOF energy dissipated structure considering the SSI effect.The equivalent period and damping ratio of the system are obtained through analogical analysis using the frequency transfer function with adoption of the modal strain energy(MSE) technique.A parametric analysis is carried out to study the SSI effect on the performance of VEDs.Then the equilibrium equations of the multi degree-of-freedom(MDOF) structure with VEDs considering SSI effect are established in the frequency domain.Based on the assumption that the superstructure of the coupled system possesses the classical normal mode, the MDOF superstructure is decoupled to a set of individual SDOF systems resting on a rigid foundation with adoption of the MSE technique through formula derivation.Numerical results demonstrate that the proposed methods have the advantage of reducing computational cost, however, retaining the satisfactory accuracy.The numerical method proposed herein can provide a fast evaluation of the efficiency of VEDs considering the SSI effect. | Zhao Xuefei Wang Shuguang Du Dongsheng Liu Weiqing | 2017 | Earthquake Engineering and Engineering Vibration2017，16，1： | 6 |
| 11 | Microstructure and texture evolution of fine-grained Mg-Zn-Y-Nd alloy micro-tubes for biodegradable vascular stents processed by hot extrusion and rapid cooling显示文摘Magnesium alloys have narrow available slip result from close-packed hexagonal structure that limit their processing properties.In the recent work,the Mg-2Zn-0.46Y-0.5Nd,as materials for degradable stents,was applied to produce as-extruded micro-tube with an outer diameter of 3.0mm and a wall thickness of 0.35mm by hot extrusion with an extrusion ratio of 105:1 at 653K and rapid cooling.The fine microstructure of the dynamic recrystallization of as-extruded micro-tube could be preserved by rapid cooling such as water-cooled,resulting in more excellent mechanical properties relative to air-cooled micro-tube.The addition of rare earth elements Y and Nd results in continuous dynamic recrystallization dominated the dynamic recrystallization mechanism.During the hot extrusion process,the activation of the non-basal slip system,especially the pyramidal(c+a)slip,could significantly weaken the texture strength,and the as-extruded micro-tube exhibits weak'RE'texture components(011^(-)1)||ED and(1^(-)21^(-)1)||ED.Hence,the magnesium alloy micro-tube prepared by the rapid cooling has fine microstructure and weak texture,which is favorable for further process and governance. | Kaikai Guo Mengyao Liu Jianfeng Wang Yufeng Sun Weiqing Li Shijie Zhu Liguo Wang Shaokang Guan | 2020 | Journal of Magnesium and Alloys2020，8，3： | 3 |
| 12 | Holey graphene hydrogel with in-plane pores for high- performance capacitive desalination显示文摘电容的 deionization 是一条吸引人的途径浇脱盐和治疗。完成有效 capacitative 脱盐,有高特定的电容的讲道理地设计的电极,传导性,和稳定性是必要的。这里,我们报导构造一三维(3D ) 有穴的 graphene hydrogel (HGH ) 。这材料包含丰富的在里面飞机毛孔,提供有效离子运输小径。而且,它形成 graphene 表的一个高度互连的网络,提供层次多孔的结构能提供的有效电子运输小径,和它的 3D 为离子的吸附和存储的一个大特定的表面区域。因而, HGH 与优秀电的电导率用作没有文件夹的电极材料。周期的 voltammetry (CV ) 大小显示优化 HGH 能由于他们的分解完成 358.4 Femovable | Weiqing Kong Xidong Duan Yongjie Ge Hongtao Liu Jiawen Hu Xiangfeng Duan | 2016 | Nano Research2016，9，8： | 3 |
| 13 | Shale pore characteristics of Shahejie Formation: Implication for pore evolution of shale oil reservoirs in Dongying sag, north China显示文摘The pore characteristics of shale reservoirs in the lower submember of Member 3 to upper submember of Member 4 of Shahejie Formation in Dongying sag are analyzed,influences of mineral content and organic matter content on porosity and pore size are also investigated,and through the diagenetic thermal simulation experiment,the main pore evolution is further discussed.The results show that the pore structure of shale reservoirs is complex,the micron-nanometer pores can storage liquid hydrocarbons,and the free-phase crude oil is mainly distributed in intergranular dissolution pores of calcite,recrystallized intergranular pores,intergranular shrinkage fractures of clay mineral which have large pore size.Framework minerals and organic matter content directly influence porosity and pore size of shale reservoirs,relationship between porosity and content of felsic mineral as well as content of organic matter content is linear and positive,while relationship between content of carbonated mineral is negative.At the buried depth from 2500 to 3500 m,concentration of organic acid from hydrocarbon generation and expulsion of organic matter,increasing range of pressure coefficient,are well corresponding to highporosity intervals;pore formation in shale oil reservoirs are almost controlled by diagenetic evolution of clay minerals;framework storage spaces formed by carbonate grain crystals as well as intergranular and intergranular dissolution pores of carbonate increases porosity of shale oil reservoirs;local increase of porosity at the depth of 3500e3800 m is mainly caused by coupling of hydrocarbon-generating overpressure and dissolution,and size,distribution and connectivity of pores are enhanced obviously. | Shun Zhang Huimin Liu Min Wang Xinjin Liu Huilai Liu Youshu Bao Weiqing Wang Runze Li Xin Luo Zhengwei Fang | 2019 | Petroleum Research2019，4，2： | 2 |
| 14 | Transcriptome analysis of purple pigment formation in Colocasia esculenta显示文摘Taro(Colocasia esculenta(L.)Schott)is an important crop in Africa,Southeast Asia,and subtropics and is used as a food and medicine.The purple color pigmentation is an appealing character in taro.We sampled taro corms of the cultivar‘Lipu Taro’at four developmental stages,including LPYS1(without purple pigment,50 days of development(DOD)),LPYS2(very few purple pigments,75 DOD),LPYS3(moderate purple pigments,115 DOD)and LPYS4(high purple pigments,205 DOD).The purpose of our study was to identify the key genes underpinning the purple pigmentation in taro based on RNA-sequencing.Through RNA-Seq,6453 differentially expressed transcripts(DETs)were identified between purple and non-purple pigmented samples.We identified 41 and 12 flavonoid and anthocyanin related DETs transcripts,respectively.These DETs were upregulated at LPYS2,LPYS3,and LPYS4 as compared to LPYS1,indicating their positive contribution to the color formation in taro.Moreover,we identified several DETs encoding for transcription factors,including MYB and bHLH,known to be major regulators of structural genes involved in the flavonoid-anthocyanin pathway.Finally,we reported several plant hormones(ethylene,auxin,gibberellin,jasmonic acid,and cytokinin)related DETs,which are predicted to play important roles in the corm coloration.Different regulation of transcripts representing the flavonoid-anthocyanin biosynthesis pathway,plant hormone transduction pathway,and transcription factors may have key roles in purple pigmentation in taro.Our findings will facilitate future research on improving the quality and appeal of taro. | FANGLIAN HE WEIQING DONG SHAOLONG WEI ZUYANG QIU JINGLI HUANG HUIPING JIANG SHIYU HUANG LILI LIU | 2021 | BIOCELL2021，45，3： | 2 |
| 15 | Protective effects and potential underlying mechanisms of sodium copper chlorophyllin against ethanol-induced gastric ulcer in mice显示文摘In study,we aimed to determine the mechanisms underlying the gastroprotective effects of sodium copper chlorophyllin(SCC)against ethanol-induced gastric ulcer injury in mice.First,the gastroprotective effects of SCC against gastric ulcer induced by ethanol were assessed.Then,biochemical,histopathological,immunohistochemistry assays,and western blot analysis were conducted to determine the possible mechanisms of action underlying the effects of SCC.Compared to the effects of omeprazole(OME)in a confirmed mouse model of ethanol-induced gastric ulcer injury,treatment with various doses of SCC resulted in up-regulation of Bcl-2 and down-regulation of the pro-apoptotic protein Bax.Significant decreases in the levels of the malondialdehyde(MDA),myeloperoxidase(MPO),and NO in the gastric tissues were observed.Furthermore,inflammatory cytokine analysis revealed that SCC treatment inhibited the expressions of TNF-αand IL-6,greatly reduced the phosphorylation level of IκB,and repressed the nuclear translocation of NF-κB p65,which demonstrated that SCC inhibited the activation of the NF-κB pathway.The present findings suggest that the protective effects of SCC may be beneficial as a potential preventive and therapeutic agent for gastric ulcer through the NF-κB pathway.Taken together,SCC administration significantly decreased the levels of MPO,NO,and MDA in gastric tissue and exerted a powerful anti-inflammatory activity as demonstrated by reduction in the secretions of proinflammatory mediators such as IL-6 and TNF-α in the serum of mice exposed to ethanol. | Huawei Lv Yan Lin Peigang Liu Weiqing Liang Kemin Wei Jinbao Pu Hongjian Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 2 |
| 16 | Properties and Acceleration Mechanism of Cement Mortar Added with Low Alkaline Liquid State Setting Accelerator显示文摘Low alkaline liquid state setting accelerator(LSA) for Portland cement was prepared in laboratory from aqueous solution of several inorganic sulfate salts and some organic chemical substances. Properties of cement with addition of LSA relating to its setting time and strength development as well as its resistance to sulfate attack for short and long term exposure were experimentally examined. The experimental results showed that 5%-7% addition of LSA significantly accelerated the initial and final setting of Portland cement in the presence or absence of the blending of mineral admixtures, the initial and final setting time being less than 3 min and 6 min respectively. Meanwhile, the early 1 day curing age compressive strength increased remarkably by 20%, while the late 28 th day curing age compressive strength remained almost unchanged as compared with that of the reference accelerator free cement mortar specimen. Furthermore, mortar specimens of cement added with LSA and exposed to 5% Na2SO4 solution showed their excellent resistance to sulfate attack, with their short and long term curing age resistance coefficient to sulfate attack being around 1.04 to 1.17, all larger than 1.0. XRD analysis on hardened cement paste specimens at very early curing ages of several minutes disclosed the existence of more ettringite in specimens added with LSA than that of the reference specimens, meanwhile SEM observation also revealed the existence of well crystallized ettringite at very early hydration stage, suggesting that the accelerated setting of Portland cement can be attributed to the early and rapid formation of ettringite over the whole cement paste matrix due to the introduction of LSA. MIP measurement revealed that hardened cement paste specimens with the addition of LSA presented less medium diameter pores, more proportion of small pores and less proportion of large capillary pores, which is in a very good coincidence with the improvement of strength development of cement mortars added with LSA. | 潘志华 WANG Xuebing LIU Weiqing | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，6： | 2 |
| 17 | Study on coupled vibration characteristics of a cylindrical container with multiple elastic annular baffles显示文摘The coupled vibration characteristics of multiple elastic annular baffles of the same inner radius in a partially liquid-filled rigid cylindrical container were studied. The liquid domain was divided into several simple sub-domains so that the liquid velocity potential in each liquid sub-domain was of class C1 with continuous boundary conditions. Based on the superposition principle, the general solution of the liquid velocity potential corresponding to each liquid sub-domain was obtained by means of the method of separation of variables. The coupled modes of the multiple elastic annular baffles were expressed in terms of dry-modal functions. The free surface condition, the interface conditions and coupled vibration conditions were expressed in terms of Fourier series along the liquid height and Bessel series in the radial direction, respectively. Stable and fast numerical computations were investigated by the convergence study. Excellent agreements have been achieved in the comparison of results obtained by the proposed approach with those given by the finite element software ADINA. The natural frequencies and mode shapes versus the position, the inner radius and the number of the annular baffles were thoroughly discussed. | WANG JiaDong ZHOU Ding LIU WeiQing | 2012 | Science China(Technological Sciences)2012，55，12： | 2 |
| 18 | H_(2)S promotes developmental brain angiogenesis via the NOS/NO pathway in zebrafish显示文摘Background Hydrogen sulphide(H_(2)S)is considered as the third member of the gasotransmitter family,along with nitric oxide(NO)and carbon monoxide.H_(2)S has been reported to induce angiogenesis by promoting the growth,migration and tube-like structure formation of endothelial cells.Those studies were conducted in conditions of cell culture,mouse Matrigel plug assay model,rat wound healing model or rat hindlimb ischaemia model.Recent in vivo studies showed the physiological importance of H_(2)S in muscle angiogenesis.However,the importance of endogenous H_(2)S for brain angiogenesis during development remains unknown.We therefore aimed at determining the role of H_(2)S in brain vascular development.Methods and results Both knockdown and knockout of H2S-producing enzymes,cystathionineβ-synthase(cbs)and cystathionineγ-lyase(cth),using morpholino oligonucleotides and clustered regularly interspaced short palindromic repeats/Cas9-mediated mutation,impaired brain vascular development of larval zebrafish.Incubation with the slow-releasing H_(2)S donor GYY4137 alleviated the defects of brain vascular development in cbs and cth morphants.Quantitative analysis of the midbrain vascular network showed that H_(2)S enhances angiogenesis without affecting the topological structure of the brain vasculature.Mechanically,nitric oxide synthase 2a(nos2a)expression and NO production were decreased in both cbs and cth morphants.Overexpression of nos2a by coinjection of cbs or cth MO with full-length zebrafish nos2a mRNA alleviated the brain vascular developmental defects in cbs and cth morphants.Conclusion We conclude that H_(2)S promotes brain developmental angiogenesis via the NOS/NO pathway in zebrafish. | Weiqing Jiang Chen Liu Mingzhu Deng Fei Wang Xiao Ren Yilin Fan Jiulin Du Yonggang Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 2 |
| 19 | MXene based mechanically and electrically enhanced film for triboelectric nanogenerator显示文摘The development of triboelectric nanogenerator(TENG)technology which can directly convert ambient mechanical energy into electric energy may affect areas from green energy harvesting to emerging wearing electronics.And,the material of triboelectric layer is critical to the mechanical robustness and electrical output characteristics of the TENGs.Herein,a MXene enhanced electret polytetrafluoroethylene(PTFE)film with a high mechanical property and surface charge density is developed.The MXene/PTFE composite film was synthesized by spraying and annealing treatment.With the doping of MXene,the crystallinity of composite film could be tuned,leading to an enhancement in the tensile property of 450%and reducing the wear volume about 80%in the friction test.Furthermore,the as-fabricated TENG with this composite film outputs 397 V of open-circuit voltage,21µA of short-circuit current,and 232 nC of transfer charge quantity,which are 4,6,and 6 times higher than that of the TENG made by pure PTFE film,respectively.Therefore,this work provides a creative strategy to simultaneously improve the mechanical property and electrical performance of the TENGs,which have great potential in improving device stability under a complex mechanical environment. | Yuyu Gao Guoxu Liu Tianzhao Bu Yaoyao Liu Youchao Qi Yanting Xie Shaohang Xu Weili Deng Weiqing Yang Chi Zhang | 2021 | Nano Research2021，14，12： | 2 |
| 20 | Quantitative Determination of Urine Glucose: Combination of Laminar Flow in Microfluidic Chip with SERS Probe Technique显示文摘 | SUN Dan LIU Xiangyuan XU Shuping TIAN Yu XU Weiqing TAO Yanchun | 2018 | Chemical Research in Chinese Universities2018，34，6： | 2 |
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