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| 1 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 2 | Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration显示文摘Due to the sophisticated hierarchical structure and limited reparability of articular cartilage(AC),the ideal regeneration of AC defects has been a major challenge in the field of regenerative medicine.As defects progress,they often extend from the cartilage layer to the subchondral bone and ultimately lead to osteoarthritis.Tissue engineering techniques bring new hope for AC regeneration.To meet the regenerative requirements of the heterogeneous and layered structure of native AC tissue,a substantial number of multilayered biomimetic scaffolds have been studied.Ideal multilayered scaffolds should generate zone-specific functional tissue similar to native AC tissue.This review focuses on the current status of multilayered scaffolds developed for AC defect repair,including design strategies based on the degree of defect severity and the zone-specific characteristics of AC tissue,the selection and composition of biomaterials,and techniques for design and manufacturing.The challenges and future perspectives of biomimetic multilayered scaffold strategies for AC regeneration are also discussed. | Liwei Fu Zhen Yang Cangjian Gao Hao Li Zhiguo Yuan Fuxin Wang Xiang Sui Shuyun Liu Quanyi Guo | 2020 | Regenerative Biomaterials2020，7，6： | 7 |
| 3 | Spatial expansion effects on urban ecosystem services supply-demand mismatching in Guanzhong Plain Urban Agglomeration of China显示文摘Global urbanization has led to drastic land use change,interfering the ecosystem services(ES)supply-demand balance,in turn threatening the well-being of humans.However,existing studies mainly stranded at the historical and current analysis,and the effects of urban spatial expansion on the relationship between ES supply and demand in the future are less clear,in particular at an urban agglomeration scale.This study was constructed with a framework of assessing the effects of urban spatial expansion on ES supply-demand mismatching under different future scenarios in the Guanzhong Plain Urban Agglomeration(GPUA)by using the Future Land Use Simulation(FLUS)model and expert-based Land-Use and Land-Cover Change(LUCC)matrix.The results showed that:(1)Urban expansion is significant in the natural development(ND)scenario,mainly manifesting the great transfer of dry land to construction land.(2)The gap between total ES supply and demand is narrowed from 2000 to 2030 and the mismatch between ES supply and demand is mainly reflected in the spatial distribution pattern in the GPUA.The ES budgets were in high surplus in Northern Qinling Mountains and northeast mountain areas,while they were in severe deficit in urban center areas.The budgets deficit under the ND scenario in 2030 is the most severe.(3)The gradient differences of ES budgets of the GPUA between urban centers and suburbs increase from 2000 to 2030 under two scenarios.The deficit region expands largest under ND scenario.The findings revealed that ES declining and supply-demand mismatching were triggered by the drastic land-use change driven by rapid urban expansion.The expansion has brought about an increasing material demand and growing industries,threatening the sustainability of ecosystems.Scenarios setting could contribute to coordinating the relationship between future urban development and ecological protection,and the policy strategies proposed in the study could inform ecological management and urban planning in the regions facing the similar urbanization situation. | PENG Lixian ZHANG Liwei LI Xupu WANG Zhuangzhuang WANG Hao JIAO Lei | 2022 | Journal of Geographical Sciences2022，32，5： | 2 |
| 4 | Anisotropy study of the microstructure and properties of AlCoCrFeNi2.1 eutectic high entropy alloy additively manufactured by selective laser melting显示文摘The AlCoCrFeNi2.1 eutectic high-entropy alloy(EHEA) was prepared by selective laser melting(SLM), focusing on the anisotropy of microstructure and mechanical performance. The AlCoCrFeNi2.1 EHEA printed by SLM has face-centered cubic(FCC) and body-centered cubic(BCC)/B2 phases, and the FCC phase accumulates at the boundary of the molten pool. With the increase in volumetric energy density(VED), the content of the FCC phase parallel to the surface in the direction of the building increases from 30.9% to 41%. The X–Z plane mainly produces columnar crystals along the temperature gradient, while a large number of equiaxed crystals are produced in the X–Y direction. When the volume energy density is 157 k J/mol(VED 157), the average grain size is 1.33 μm for BCC and 1.14 μm for FCC, which is significantly smaller than other preparation methods. Due to defect distribution and size, the microhardness of the X–Y plane is generally higher than that of the X–Z plane, with maximum hardnesses of 660 HV and 655 HV, respectively, which is much higher than those of traditionally manufactured counterparts.The compression performance of SLM process AlCoCrFeNi2.1 EHEAs shows maximum yield strength of 1567 MPa, and the ultimate compressive strength can reach 3276 MPa. | Liwei Lan Wenxian Wang Zeqin Cui Xiaohu Hao Dong Qiu | 2022 | Journal of Materials Science & Technology2022，，34： | 2 |
| 5 | Field study on occupants’ thermal comfort and residential thermal environment in a hot-humid climate of China显示文摘 | Jie Han Guoqiang Zhang Quan Zhang Jinwen Zhang Jianlong Liu Liwei Tian Cong Zheng Junhong Hao Jianping Lin Yanhui Liu Demetrios. J. Moschandreas | 2006 | Building and Environment2006，，12： | 1 |
| 6 | High-Performance Low-Temperature Transparent Conducting Aluminum- Doped ZnO 1lain Films and Apphcations 显示文摘 | Hao Xiaotao Tan Liwei Ong Kiansoo | 2006 | Journal of Crystal Growth2006，287，： | 1 |
| 7 | Dynamic oxygen storage and release over Mn 0.1 Ce 0.9 O x and Mn 0.1 Ce 0.6 Zr 0.3 O x complex compounds and structural characterization显示文摘 | Liwei Jia Meiqing Shen Jingjing Hao Ting Rao Jun Wang | 2006 | Journal of Alloys and Compounds2006，，： | 1 |
| 8 | Synthesis and optical properties of Mg-doped ZnO nanofibers prepared by electrospinning显示文摘 | Minggang Zhao Xinchang Wang Lingling Ning Hao He Jianfeng Jia Liwei Zhang Xinjian Li | 2010 | Journal of Alloys and Compounds2010，，1： | 1 |
| 9 | Tetrahedral framework nucleic acids promote the biological functions and related mechanism of synovium-derived mesenchymal stem cells and show improved articular cartilage regeneration activity in situ显示文摘Many recent studies have shown that joint-resident mesenchymal stem cells(MSCs)play a vital role in articular cartilage(AC)in situ regeneration.Specifically,synovium-derived MSCs(SMSCs),which have strong chondrogenic differentiation potential,may be the main driver of cartilage repair.However,both the insufficient number of MSCs and the lack of an ideal regenerative microenvironment in the defect area will seriously affect the regeneration of AC.Tetrahedral framework nucleic acids(tFNAs),notable novel nanomaterials,are considered prospective biological regulators in biomedical engineering.Here,we aimed to explore whether tFNAs have positive effects on AC in situ regeneration and to investigate the related mechanism.The results of in vitro experiments showed that the proliferation and migration of SMSCs were significantly enhanced by tFNAs.In addition,tFNAs,which were added to chondrogenic induction medium,were shown to promote the chondrogenic capacity of SMSCs by increasing the phosphorylation of Smad2/3.In animal models,the injection of tFNAs improved the therapeutic outcome of cartilage defects compared with that of the control treatments without tFNAs.In conclusion,this is the first report to demonstrate that tFNAs can promote the chondrogenic differentiation of SMSCs in vitro and enhance AC regeneration in vivo,indicating that tFNAs may become a promising therapeutic for AC regeneration. | Liwei Fu Pinxue Li Junyao Zhu Zhiyao Liao Cangjian Gao Hao Li Zhen Yang Tianyuan Zhao Wei Chen Yu Peng Fuyang Cao Chao Ning Xiang Sui Quanyi Guo Yunfeng Lin Shuyun Liu | 2022 | Bioactive Materials2022，7，3： | 1 |
| 10 | An ischemic area-targeting,peroxynitrite-responsive,biomimetic carbon monoxide nanogenerator for preventing myocardial ischemia-reperfusion injury显示文摘Myocardial ischemia-reperfusion (MI/R) injury is common in patients who undergo revascularization therapy for myocardial infarction, often leading to cardiac dysfunction. Carbon monoxide (CO) has emerged as a therapeutic molecule due to its beneficial properties such as anti-inflammatory, anti-apoptotic, and mitochondrial biogenesis-promoting properties. However, its clinical application is limited due to uncontrolled release, potential toxicity, and poor targeting efficiency. To address these limitations, a peroxynitrite (ONOO )-triggered CO donor (PCOD585) is utilized to generate a poly (lactic-co-glycolic acid) (PLGA)-based, biomimetic CO nanogenerator (M/PCOD@PLGA) that is coated with the macrophage membrane, which could target to the ischemic area and neutralize proinflammatory cytokines. In the ischemic area, local produced ONOO triggers the continuous release of CO from M/PCOD@PLGA, which efficiently ameliorates MI/R injury by clearing harmful ONOO , attenuating the inflammatory response, inhibiting cardiomyocyte apoptosis, and promoting mitochondrial biogenesis. This study provides a novel insight into the safe therapeutic use of CO for MI/R injury by utilizing a novel CO donor combined with biomimetic technology. The M/PCOD@PLGA nanogenerator offers targeted delivery of CO to the ischemic area, minimizing potential toxicity and enhancing therapeutic efficacy. | Jinyan Zhang Liwei Liu Zhen Dong Xicun Lu Wenxuan Hong Jin Liu Xiaoyi Zou Jinfeng Gao Hao Jiang Xiaolei Sun Kai Hu Youjun Yang Junbo Ge Xiao Luo Aijun Sun | 2023 | Bioactive Materials2023，，10： | 1 |
| 11 | Application to induction motor faults diagnosis of the amplitude recovery method combined with FFT显示文摘 | Yukun Liu Liwei Guo Qixiang Wang Guoqing An Ming Guo Hao Lian | 2010 | Mechanical Systems and Signal Processing2010，，8： | 1 |
| 12 | Identification and impact of hepatitis B virus DNA and antigens in pancreatic cancer tissues and adjacent non-cancerous tissues显示文摘 | Yan Jin Hengjun Gao Hao Chen Jian Wang Min Chen Guohua Li Liwei Wang Jianren Gu Hong Tu | 2013 | Cancer Letters2013，，2： | 1 |
| 13 | Interseismic and coseismic displacements of the Lushan Ms 7.0 earthquake inferred from leveling measurements显示文摘By using precise leveling data observed between 1985 and 2010 across the south section of the Longmenshan fault zone,and eliminating the coseismic displacements caused by the Wenchuan Ms 8.0 earthquake,the interseismic vertical deformation field was obtained.The result shows that the Lushan region,located between the Shuangshi–Dachuan fault(front range of the Longmenshan fault) and the Xinkaidian fault(south section of the Dayi fault),is situated in the intersection zone of positive and negative vertical deformation gradient zones,indicating that this zone was locked within 25 years before the Lushan earthquake.Based on leveling data across the rupture zone surveyed between 2010 and 2013,and by eliminating the vertical deformation within 3 years before the earthquake,the coseismic vertical displacement was derived.The coseismic vertical displacement for the benchmark DD35,which is closest to the epicenter,is up to198.4 mm(with respect to MY165A).The coseismic displacement field revealed that the northwest region(hanging wall) moved upwards in comparison with the southeastern region(foot wall),suggesting that the seismogenic fault mainly underwent thrust faulting.By comparing the coseismic and interseismic vertical deformation fields,it was found that the mechanisms of this earthquake are consistent with the elastic rebound theory; the elastic strain energy(displacement deficit) accumulated before the Lushan earthquake was released during this quake. | Ming Hao Qingliang Wang Liwei Liu Qi Shi | 2014 | Chinese Science Bulletin2014，59，35： | 1 |
| 14 | Synthesis and optical properties of Mg-doped ZnO nanofibers prepared by electrospinning显示文摘 | Minggang Zhao Xinchang Wang Lingling Ning Hao He Jianfeng Jia Liwei Zhang Xinjian Li | 2010 | Journal of Alloys and Compounds2010，，： | 1 |
| 15 | Metabolic profile of chiral cobalt oxide nanoparticles in vitro and in vivo显示文摘In this study,we investigated the in vivo behaviors of chiral cobalt oxide nanoparticles(Co_(3)O_(4) NPs)stabilized with D-or L-cysteine(denoted D-or L-NPs,respectively),as representative chiral metal oxide NPs.Chiral Co_(3)O_(4) NPs exerted no observable cytotoxicity within the tested dose range.Both D-NPs and L-NPs were internalized by dendritic cells through caveola-dependent endocytosis,and L-NPs entered the cells faster than D-NPs.Significantly,a metabolic analysis indicated that chiral L-NPs had the same effect on the level of bile acids in the liver as D-NPs,which is attributed to the almost equal amount of farnesoid X receptor(FXR)induced by the chiral NPs.This study suggests that low chiroptical activity nanomaterials would not affect the metabolism and kinetics under physiological conditions even if there is some difference in their transport. | Si Li Liwei Xu Meiru Lu Maozhong Sun Liguang Xu Changlong Hao Xiaoling Wu Chuanlai Xu Hua Kuang | 2021 | Nano Research2021，14，7： | 0 |
| 16 | A Study on the Characterization of Mechanical Properties of Grade X80 High Strain Line Pipe Steel显示文摘This paper introduces mechanical and metallurgical properties of 27mm thick Grade X80 high strain line pipe steel which aims at constructing long distance natural gas over permafrost and seismic areas.The steel is molybdenum and boron free.Dual phase of the X80 steel plates are regulated by thermal-mechanical controlled processing.The outer diameter of 1219mm pipes are manufactured by UOE process.DWTT toughness and longitudinal tensile properties including the Rt0.5/Rm,Rt1.5/Rt0.5 and Rt2.0/Rt1.0 are analyzed on both the plates and the pipes.Strain aging properties are also evaluated on the base material of the pipe,demonstrating that the pipe complies well with the pipeline construction requirements.Strengthening effects of precipitates are analyzed,revealing a 58.1MPa strengthening contribution by precipitates less than 20nm in size.Dislocation hardening is approximately 176MPa in the present studied steel. | Weihua Sun Shue Hu Guobao Li Hao Yu Lei Zhang Liwei Liu | 2015 | 材料科学研究(中英文版)2015，4，4： | 0 |
| 17 | Probability stopping criterion for analog decoding of LDPC codes显示文摘To detect uncorrectable frames and terminate the decoding procedure early, a probability stopping criterion for iterative analog decoding of low density parity check(LDPC) codes is proposed in this paper. By using probabilities of satisfied checks to detect uncorrectable frames and terminate decoding, the proposed criterion could be applied to analog decoders without much structure modifications. Simulation results show that the proposed criterion can reduce the average number of iterations and achieve a better balance in bit error ratio(BER) performance and decoding complexity than other stopping criteria using extrinsic information. | Zheng Hao Zhang Shuyi Li Lintao Gao Yuan Shao Liwei | 2017 | The Journal of China Universities of Posts and Telecommunications2017，24，1： | 0 |
| 18 | Hierarchical metal-peptide assemblies with chirality-encoded spiral architecture and catalytic activity显示文摘We report the coordination assembly of the ferrocene-diphenylalanine(Fc-FF)with divalent copper ions(Cu^(2+))into metalpeptide assemblies(MPAs)with hierarchical spiral architectures.The MPA particles are composed of helically organized nanofibers which can be correlated to the logarithmic spirals.The MPAs are hierarchically porous with abundant Fc and Cu2+active sites and show much higher catalytic activity than natural laccase toward the decolorization reaction.Moreover,a series of hierarchical structures of the MPAs can be synthesized by controlling the temperature and enantiomeric excess(ee).The peptide enantiomers with higher ee values will self-assemble into highly complex and ordered structures,which show higher surface area and porosity and thus enhanced catalytic activity compared with those assembled by peptides with lower ee values.The results provide new insights into the vital role of chirality in directing the self-assembly of biomolecules into highly ordered complex functional structures. | Jiayu Liu Jiaxing Zhang Liwei Zhang Yuefei Wang Hao Wei Yuhe Shen Jiwei Min Xi Rong Wei Qi Rongxin Su Zhimin He | 2023 | Science China Chemistry2023，66，1： | 0 |
| 19 | High frequency of alternative splicing variants of the oncogene Focal Adhesion Kinase in neuroendocrine tumors of the pancreas and breast显示文摘The characteristic genetic abnormality of neuroendocrine neoplasms(NENs),a heterogeneous group of tumors found in various organs,remains to be identified.Here,based on the analysis of the splicing variants of an oncogene Focal Adhesion Kinase(FAK)in The Cancer Genome Atlas datasets that contain 9193 patients of 33 cancer subtypes,we found that Box 6/Box 7-containing FAK variants(FAK^(6/7))were observed in 7(87.5%)of 8 pancreatic neuroendocrine carcinomas and 20(11.76%)of 170 pancreatic ductal adenocarcinomas(PDACs).We tested FAK variants in 157 tumor samples collected from Chinese patients with pancreatic tumors,and found that FAK^(6/7)was positive in 34(75.6%)of 45 pancreatic NENs,19(47.5%)of 40 pancreatic solid pseudopapillary neoplasms,and 2(2.9%)of 69 PDACs.We further tested FAK splicing variants in breast neuroendocrine carcinoma(BrNECs),and found that FAK^(6/7)was positive in 14(93.3%)of 15 BrNECs but 0 in 23 non-NEC breast cancers.We explored the underlying mechanisms and found that a splicing factor serine/arginine repetitive matrix protein 4(SRRM4)was overexpressed in FAK^(6/7)-positive pancreatic tumors and breast tumors,which promoted the formation of FAK^(6/7)in cells.These results suggested that FAK^(6/7)could be a biomarker of NENs and represent a potential therapeutic target for these orphan diseases. | Dawei Xie Zheng Wang Beibei Sun Liwei Qu Musheng Zeng Lin Feng Mingzhou Guo Guizhen Wang Jihui Hao Guangbiao Zhou | 2023 | Frontiers of Medicine2023，17，5： | 0 |
| 20 | 线粒体自噬决定肌肉与脂肪之间的对话来改善饮食导致的肥胖显示文摘文章简介线粒体质量控制是骨骼肌糖脂代谢功能及其应答生理或病理反应所必需的。然而,人们对于骨骼肌线粒体质量是如何控制的,以及这一控制机制的生理功能十分不清楚。本研究发现,线粒体外膜蛋白FUNDC1在调节骨骼肌线粒体质量以及机体代谢稳态维持中起着至关重要的作用。 | 付婷婷 徐志圣 Lin Liu Qiqi Guo Hao Wu Xijun Liang Danxia Zhou Liwei Xiao Lei Liu Yong Liu Min-Sheng Zhu 陈佺 甘振继 | 2019 | 科学新闻2019，0，2： | 0 |
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