|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevalence of transmitted drug resistance mutations among patients infected with human immunodeficiency virus type 1 (HIV-1) in Henan Province, China显示文摘To the Editor:Even with the emergence of highly active antiretroviral therapy,human immunodeficiency virus type 1(HIV-1)remains a serious public health problem worldwide.The widespread use of antiretroviral therapy(ART)has,on the one hand,significantly improved life expectancy in patients infected with HIV-1;on the other hand,it has inevitably brought along with it a difficult problem—viral resistance.Viral resistance is a common phenomenon evolutionarily,particularly in patients with poor adherence and suboptimal drug levels. | Jinjin Liu Xiaohua Zhang Mingjie Hou Shuguang Wei Jie Ma Lixia Xu Xuan Yang Yan Sun Chunli Liu Qingxia Zhao Yuqi Huo | 2022 | Chinese Medical Journal2022，135，22： | 2 |
| 2 | Ammonia-nitrogen and phosphates sorption from simulated reclaimed waters by modified clinoptilolite显示文摘 | Hanxin Huo Hai Lin Yingbo Dong Huang Cheng Han Wang Lixia Cao | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 3 | Synthesis of Hyperbranched Polymer for 3D Printing显示文摘3D printing has been developing rapidly in recent years owing to its application in academic and industry areas,but the poor mechanical property of printing materials limits its application.Herein,a photocurable resin with good mechanical property was obtained based on hyperbranched polymer synthesized through the reaction of carboxylic acids with isocyanates catalyzed by magnesium stearate.Three kinds of hyperbranched polymers with different molecular weight were fabricated by modulating the content of isocyanates.By mixing hyperbranched polymer with acryloylmorpholine,polyethylene glycol diacrylate 400 and photoinitiator of 819,the photocurable resin was obtained.The influence of various factors on mechanical properties of samples was investigated such as molecular weight of hyperbranched polymer and the light exposure time.Comparing with the commercial resin,the flexural strength(116.06 MPa)and impact strength(34.59 kJ/m^(2))of the resultant resin increased by 21.2%and 20.8%,respectively. | Yibo Song Fahu Yang Zhenwei Zheng Pingping Wu Lixia Huo Jinshan Guo Jingxia Wang | 2021 | Chinese Journal of Chemistry2021，39，11： | 1 |
| 4 | Design,synthesis,and evaluation of PD-L1 degraders to enhance T cell killing activity against melanoma显示文摘Inhibitor targeting immune checkpoint is a promising new anticancer therapy.Blocking the interaction between PD-1 and PD-L1 can reverse the immunosuppression state and improve the lethality of immune cells to tumor cells.Here,we report PROTAC-based PD-L1 degraders to enhance T cell killing activity against melanoma.Four series of PD-L1 degraders were designed and synthesized to VHL,CRBN,MDM2 or c IAP E3 ligase system,in which CRBN-ligand-based compound BMS-37-C3 was identified as the most active PROTAC molecule.BMS-37-C3 also significantly enhanced the killing ability of T cells in a co-culture model of A375 and T cells.Furthermore,western blot data and flow cytometry demonstrated that BMS-37-C3 could reduce the protein levels of PD-L1 in dose and time dependent manner,which may provide a new therapeutic method for tumor immunotherapy. | Yang Liu Mengzhu Zheng Zhilu Ma Yirong Zhou Junfeng Huo Wenbo Zhang Yu Liu Yuanyuan Guo Xuechen Zhou Hua Li Lixia Chen | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员