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| 1 | The impacts of conservation agriculture on crop yield in China depend on specific practices, crops and cropping regions显示文摘For smooth and wide application of conservation agriculture(CA), remaining uncertainties about its impacts on crop yield need to be reduced. Based on previous field experiments in China, a meta-analysis was performed to quantify the actual impacts of CA practices(NT: no/reduced-tillage only, CTSR: conventional tillage with straw retention, NTSR: NT with straw retention) on crop yields as compared to conventional tillage without straw retention(CT).Although CA practices increased crop yield by 4.6% on average, there were large variations in their impacts. For each CA practice, CTSR and NTSR significantly increased crop yield by 4.9%and 6.3%, respectively, compared to CT. However, no significant effect was found for NT. Among ecological areas, significant positive effects of CA practices were found in areas with an annual precipitation below 600 mm. Similar effects were found in areas with annual mean air temperature above 5 °C. For cropping regions, CA increased crop yield by 6.4% and 5.5%compared to CT in Northwest and South China, respectively, whereas no significant effects were found in the North China and Northeast China regions. Among crops, the positive effects of CA practices were significantly higher in maize(7.5%) and rice(4.1%) than in wheat(2.9%). NT likely decreased wheat yield. Our results indicate that there are great differences in the impacts of CA practices on crop yield, owing to regional variation in climate and crop types. CA will most likely increase maize yield but reduce wheat yield. It is strongly recommended to apply CA with crop straw retention in maize cropping areas and seasons with a warm and dry climate pattern. | Chengyan Zheng Yu Jiang Changqing Chen Yanni Sun Jinfei Feng Aixing Deng Zhenwei Song Weijian Zhang | 2014 | The Crop Journal2014，2，5： | 15 |
| 2 | Organic amendments increase corn yield by enhancing soil resilience to climate change显示文摘A 22-year field experiment was conducted in Gongzhuling, Jilin province, China to investigate corn yield response to fertilization practice. Compared to an unfertilized control(CK), all fertilization treatments, including inorganic nitrogen fertilizer only(N), balanced inorganic fertilizers(NPK), NPK plus corn straw(SNPK), and NPK plus farmyard manure(MNPK), resulted in significant increases in corn yield. However, only organic matter amendments sustained increasing yield trends, with annual rates of 0.137 and 0.194 t ha-1for the SPNK and MNPK treatments, respectively(P < 0.05). During the 22 years, the daily mean, maximum and minimum temperatures increased by 0.50, 0.53, and 0.46 °C per decade, whereas precipitation displayed no significant change but showed large seasonal variation. According to a regression analysis, increased air temperature exerted positive effects on corn yields under the SNPK and the MNPK treatments. Under both treatments,soil organic carbon contents and soil nutrient availabilities increased significantly compared to their initial levels in 1990, whereas soil bulk density and total porosity changed slightly under the two treatments, which showed higher soil water storage than other treatments. In contrast, significant increases in soil bulk density and decreases in soil total porosity and soil nutrient availability were observed under the CK, N and NPK treatments. The contributions of soil fertility to corn yield were 28.4%, 37.9%, 38.4%, 39.0%,and 42.9% under CK, N, NPK, SNPK, and MNPK treatments, respectively, whereas climate changes accounted for 27.0%, 14.6%, 12.4%, 11.8%, and 10.8%. These results indicate that, in Northeast China, organic matter amendments can mitigate negative and exploit positive effects of climate change on crop production by enhancing soil quality. | Zhenwei Song Hongjun Gao Ping Zhu Chang Peng Aixing Deng Chengyan Zheng Md Abdul Mannaf Md Nurul Islam Weijian Zhang | 2015 | The Crop Journal2015，3，2： | 8 |
| 3 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 4 | Intraoperative ultrasound assistance in resection of intracranial meningiomas显示文摘Objective: Intracranial meningiomas, especially those located at anterior and middle skull base, are difficult to be completely resected due to their complicated anatomy structures and adjacent vessels. It's essential to locate the tumor and its vessels precisely during operation to reduce the risk of neurological deficits. The purpose of this study was to evaluate intraoperative ultrasonography in displaying intracranial meningioma and its surrounding arteries, and evaluate its potential to improve surgical precision and minimize surgical trauma. Methods: Between December 2011 and January 2013, 20 patients with anterior and middle skull base meningioma underwent surgery with the assistance of intraoperative ultrasonography in the Neurosurgery Department of Shanghai Huashan Hospital. There were 7 male and 13 female patients, aged from 31 to 66 years old. Their sonographic features were analyzed and the advantages of intraoperative ultrasonography were discussed. Results: The border of the meningioma and its adjacent vessels could be exhibited on intraoperative ultrasonography. The sonographic visualization allowed the neurosurgeon to choose an appropriate approach before the operation. In addition, intraoperative ultrasonography could inform neurosurgeons about the location of the tumor, its relation to the surrounding arteries during the operation, thus these essential arteries could be protected carefully. Conclusions: Intraoperative ultrasonography is a useful intraoperative technique. When appropriately applied to assist surgical procedures for intracranial meningioma, it could offer very important intraoperative information (such as the tumor supplying vessels) that helps to improve surgical resection and therefore might reduce the postoperative morbidity. | Hailiang Tang Huaping Sun Liqian Xie Qisheng Tang Ye Gong Ying Mao Qing Xie Mingzhe Zheng Daijun Wang Hongda Zhu Jianhong Zhu Xiaoyuan Feng Zhenwei Yao Xiancheng Chen Liangfu Zhou | 2013 | Chinese Journal of Cancer Research2013，25，3： | 3 |
| 5 | Highly uniform ultrasound-sensitive nanospheres produced by a pH-induced micelle-to-vesicle transition for tumor-targeted drug delivery显示文摘尽管有高 echogenicity 的充满气体的 microbubbles 是广泛地应用的 inclinical ultrasonography,微米规模粒子尺寸在稳固的肿瘤的处理阻碍他们的使用,它对目标可存取不到几百纳米。我们此处建议包含导致 apH 的核心壳 micelle-to-vesicle 转变准备拥有多重特征的超声敏感的聚合 nanospheres (在结构的 polymersomes ) 的一条不平常的途径,包括进水的腔的一个阶段过渡的成像代理人的 nanosize, monodispersity,和加入。这些特征不经由为 polymersome 准备的常规双乳剂方法是可完成的。nanospheres 与双 pH 敏感基于新奇 triblock 共聚物被构造。外部低频率的超声导致的成像代理人的 liquid-to-gas 阶段转变可以为一个快速的药版本破坏 nanospheres,与在一个肿瘤内的同时的渗透织物的药交货。这些效果可以为有效癌症治疗的发展向新机会提供很少不利效果。 | Yiru Wang Tinghui Yin Zhenwei Su Chen Qiu Yong Wang Rongqin Zheng Meiwan Chen Xintao Shuai | 2018 | Nano Research2018，11，7： | 3 |
| 6 | Intelligent Polling Scheme of Fault Management in the MAN显示文摘 | Zheng Hongfang Yuan Zhenwei Wang Guangxing | 2005 | Journal of Northeastern University2005，26，4： | 1 |
| 7 | Impacts of planting systems on soil moisture, soil temperature and corn yield in rainfed area of Northeast China显示文摘 | Zhenwei Song Jinrui Guo Zhenping Zhang Taiji Kou Aixing Deng Chengyan Zheng Jun Ren Weijian Zhang | 2013 | European Journal of Agronomy2013，，： | 1 |
| 8 | A review of water flooding issues in the proton exchange membrane fuel cell显示文摘 | Hui Li Yanghua Tang Zhenwei Wang Zheng Shi Shaohong Wu Datong Song Jianlu Zhang Khalid Fatih Jiujun Zhang Haijiang Wang Zhongsheng Liu Rami Abouatallah Antonio Mazza | 2007 | Journal of Power Sources2007，，1： | 1 |
| 9 | SJES14110700524164显示文摘 | Chengyan Zheng Yu Jiang Changqing Chen Yanni Sun Jinfei Feng Aixing Deng Zhenwei Song Weijian Zhang | 2014 | The Crop Journal2014，，5： | 1 |
| 10 | Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice显示文摘Methyltransferase-like 3(Mettl3)is a component of methyltransferase complex that mediates m6A modification of RNAs,and participates in multiple biological processes.However,the role of Mettl3 in cardiac electrophysiology remains unknown.This study aims to explore the ventricular arrhythmia susceptibility of Mettl3+/–mice and the underlying mechanisms.Mice were anesthetized with 2%avertin(0.1 mL/10 g body weight)for echocardiography and programmed electrical pacing.Whole-cell patch clamp technique was used to examine the electrophysiological property of cardiomyocytes.The expression of Cav1.2 was determined by qRT-PCR and western blot analysis.The m6A medication of mRNA was examined by MeRIP-Seq and MeRIP-qPCR.No differences are found in the morphology and function of the hearts between Mettl3+/–mice and wild-type(WT)controls.The QT and QTc intervals of Mettl3+/–mice are significantly longer.High-frequency electrical stimulation showed that heterozygous knockout of Mettl3 increases ventricular arrhythmia susceptibility.The whole-cell patch-clamp recordings showed that the APD is prolonged in Mettl3+/–ventricular myocytes and more EADs were observed.The density of ICa-L is substantially increased in ventricular myocytes of Mettl3+/–mice.The pore-forming subunit of L-type calcium channel Cav1.2 is upregulated in Mettl3+/–mice,while the mRNA of its coding gene CACNA1C does not change.MeRIP-Seq and MeRIP-qPCR showed that the m6A methylation of CACNA1C mRNA is decreased in cultured Mettl3-knockdown cardiomyocytes and Mettl3+/–hearts.Collectively,deficiency of Mettl3 increases ventricular arrhythmia susceptibility due to the upregulation of Cav1.2 by reducing m6A modification on CACNA1C mRNA in mice.This study highlights the role of m6A modification in the regulation of cardiac electrophysiology. | Ling Shi Xuexin Jin Zheng Li Rui Gong Yang Guo Jiudong Ma Yang Zhang Benzhi Cai Baofeng Yang Dongmei Gong Zhenwei Pan | 2022 | Acta Biochimica et Biophysica Sinica2022，54，2： | 1 |
| 11 | Growth of rat dorsal root ganglion neurons on a novel self-assembling scaffold containing IKVAV sequence显示文摘 | Zou Zhenwei Zheng Qixin Wu Yongchao | 2009 | Mater Sci Eng C2009，29，： | 1 |
| 12 | Synthesis of Hyperbranched Polymer for 3D Printing显示文摘3D printing has been developing rapidly in recent years owing to its application in academic and industry areas,but the poor mechanical property of printing materials limits its application.Herein,a photocurable resin with good mechanical property was obtained based on hyperbranched polymer synthesized through the reaction of carboxylic acids with isocyanates catalyzed by magnesium stearate.Three kinds of hyperbranched polymers with different molecular weight were fabricated by modulating the content of isocyanates.By mixing hyperbranched polymer with acryloylmorpholine,polyethylene glycol diacrylate 400 and photoinitiator of 819,the photocurable resin was obtained.The influence of various factors on mechanical properties of samples was investigated such as molecular weight of hyperbranched polymer and the light exposure time.Comparing with the commercial resin,the flexural strength(116.06 MPa)and impact strength(34.59 kJ/m^(2))of the resultant resin increased by 21.2%and 20.8%,respectively. | Yibo Song Fahu Yang Zhenwei Zheng Pingping Wu Lixia Huo Jinshan Guo Jingxia Wang | 2021 | Chinese Journal of Chemistry2021，39，11： | 1 |
| 13 | Effects of cyclooxygenase 2 inhibitor on growth-associated protein 43 and nerve growth factor expression in dorsal root ganglion during neuropathic pain development显示文摘BACKGROUND:Inflammatory responses in injured nerves have been recognized as important factors for initially sensitizing nociceptive neurons.Cyclooxygenase(COX) is the rate-limiting enzyme in prostaglandin synthesis,and COX-2 inhibitor is involved in mechanisms of analgesia and anti-inflammation. OBJECTIVE:To investigate the effects of COX-2 inhibitor on thermal and mechanical hyperalgesia, as well as expression of growth associated protein 43(GAP-43) and nerve growth factor(NGF) in dorsal root ganglion,in a rat model of neuropathic pain due to chronic constriction injury. DESIGN,TIME AND SETTING:A randomized,controlled,comparison study that was performed at the Surgical Department and Pathological Laboratory,Second Affiliated Hospital of Shantou University Medical College from September 2006 to September 2007. MATERIALS:COX-2 inhibitor,lornoxicam,was purchased from Nycomed Pharmaceutical(Austria); rabbit anti-GAP-43,and rabbit anti-NGF polyclonal antibodies were purchased from Boster,Wuhan, China. METHODS:A total of 50 adult,Wistar rats were randomly assigned to four groups:normal control (n = 5),model(n = 15),normal saline control(n = 15),and lornoxicam treatment(n = 15).With exception of the control group,the sciatic nerve of all rats was loosely ligated to establish a model of chronic constriction injury.The model rats were divided into three subgroups according to varying post-operative survival periods:3,7 and 14 days(n = 5),respectively.Rats in the lornoxicam treatment group were intraperitoneally injected with 1.3 mg/kg lornoxicam every 12 hours throughout the entire experimental procedure.Rats in the normal saline control group were intraperitoneally injected with 1.3 mL/kg saline. MAIN OUTCOME MEASURES:Immunohistochemistry revealed expression of GAP-43 and NGF in the L5 dorsal root ganglions.Mechanical withdrawal threshold and thermal withdrawal latency were used to observe neurological behavioral changes in rats. RESULTS:The relative gray values of GAP-43- and NGF-positive neurons in the model group were remarkably increased compared with the normal control rats(P<0.01),while the relative gray values in the lornoxicam treatment group were significantly less than the model and normal saline control groups(P<0.01).Mechanical withdrawal threshold and thermal withdrawal latency gradually decreased with increasing injury time in the model,normal saline control,and lornoxicam treatment groups,and were significantly less than the normal control group(P<0.05).In addition,mechanical withdrawal threshold and thermal withdrawal latency were significantly greater in the lornoxicam treatment group compared with the model and normal saline control groups(P<0.05). CONCLUSION:Intraperitoneal injection of the COX-2 inhibitor lornoxicam attenuated mechanical and thermal hyperalgesia induced by sciatic nerve chronic constriction injury and inhibited the increased expression of GAP-43 and NGF. | Chen Wang Zhenwei Zheng | 2009 | Neural Regeneration Research2009，4，10： | 0 |
| 14 | tsrCert:Traceable Self-Randomization Certificate and Its Application to Blockchain Supervision显示文摘Traditional public key infrastructure(PKI)only provides authentication for network communication,and the standard X.509 certificate used in this architecture reveals the user’s identity.This lack of privacy protection no longer satisfies the increasing demands for personal privacy.Though an optimized anonymous PKI certificate realizes anonymity,it has the potential to be abused due to the lack of identity tracking.Therefore,maintaining a balance between user anonymity and traceability has become an increasing requirement for current PKI.This paper introduces a novel traceable self-randomization certificate authentication scheme based on PKI architecture that achieves both anonymity and traceability.We propose a traceable self-randomization certificate authentication scheme based on the short randomizable signature.Specifically,certificate users can randomize the initial certificate and public key into multiple anonymous certificates and public keys by themselves under the premise of traceability,which possesses lower computational complexity and fewer interactive operations.Users can exhibit different attributes of themselves in different scenarios,randomizing the attributes that do not necessarily need to be displayed.Through security and performance analysis,we demonstrate the suitability of the improved PKI architecture for practical applications.Additionally,we provide an application of the proposed scheme to the permissioned blockchain for supervision. | Yan Zhu Haibin Zheng Bo Qin Wanting Fu Zhenwei Guo Yujue Wang Qianhong Wu Bingyu Li Xuan Ding | 2023 | Tsinghua Science and Technology2023，28，6： | 0 |
| 15 | Key technological innovations in the construction of the main terminal of Beijing Daxing International Airport显示文摘Beijing Daxing International Airport,a major landmark project in China and a new driver for national development,will represent the direction for the development of civil aviation airports in China.The airport,situated in the junction of Nangezhuang,Daxing District,Beijing City and Gu’an County,Hebei Province,has seen its north terminal area and north terminal built in the first phase,covering a total construction area of about 1.4 million m2.The north terminal area is designed to have an annual throughput of 45 million passengers. | Jianhua LI Xianjun DUAN Hanchao LIU Susu LEI Zheng ZHANG Zhenwei LI | 2022 | Frontiers of Engineering Management2022，9，4： | 0 |
| 16 | Light-up lipid droplets for the visualization of lipophagy and atherosclerosis by coumarin-derived bioprobe显示文摘Lipid droplets(LDs) are intracellular lipid-metabolism organelles that involved in many physiological processes,metabolic disorders as well as diseases such as atherosclerosis.However,the specific probes that can visually locate abnormal LDs-rich tissues and track LDs-associated behavior to the naked eye with adequate biosafety still are rare.Herein,we develop a new design strategy of LDs-targeted probe based on the solvatochromism of coumarin derivatives.The results revealed that the emission wavelength of coumarin fluorophores gradually red shift in different solvents with increasing polarity,while absorption wavelength almost unchanged.As a result,the enlarged stokes shift of coumarin was emerged from oil to water.Furthermore,properly reducing water solubility and adding electronic donor at the structure of coumarins can enlarge this type of solvatochromism.This discovery was utilized to develop suitable probe for the image of LDs and LDs-rich tissues with high resolution and biosafety.Therefore,LDs-associated behavior was visible to the naked eye during the process of lipophagy and atherosclerosis.We deem that the developed probe here offers a new possibility to accurately diagnosis and analyse LDs-related diseases in clinic and preclinical study. | Jinrong Zheng Shuheng Qin Lijuan Gui Hua Li Lixue Fan Yifei Yang Haiyan Chen Hui Xu Zhenwei Yuan | 2021 | Chinese Chemical Letters2021，32，8： | 0 |
| 17 | Asponchimides A−E: new enantiomeric N-acetyldopamine trimers from Aspongopus chinensis显示文摘Five new racemic N-acetyldopamine (NADA) trimers, asponchimides A−E ( 1 − 5 ), were isolated from Aspongopus chinensis, a prominent traditional Chinese medicinal insect employed for alleviating pain, treating indigestion, and addressing kidney ailments. Compounds 1 − 5 were successfully resolved by chiral high-performance liquid chromatography (HPLC), yielding five pairs of enantiomers: (+)- and (−)-asponchimides A−E ( 1a / 1b − 5a / 5b ). Their structural identities were discerned by extensive spectroscopic analyses, including high-resolution mass spectrometry (HRMS), ultraviolet-visible (UV-Vis) spectroscopy, infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR), and their absolute configurations were determined by electronic circular dichroism (ECD) calculations. Compounds 1 − 5 are pioneering instances of NADA trimers featuring a Δ7 double bond. When subjected to a series of bioassays, a majority of the compounds exhibited weak inhibitory activity against nitric oxide (NO) production in LPS-induced RAW 264.7 cells. | NIE Jinchun MEI Fang ZHENG Yueyuan WEN Qiuyi LI Zhenwei ZHANG Daidi LI Wei GUO Dean | 2023 | Chinese Journal of Natural Medicines2023，21，11： | 0 |
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