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| 1 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 2 | Study on the antiulcer effects of Veronicastrum axillare on gastric ulcer in rats induced by ethanol based on tumor necrosis factor-α(TNF-α)and endothelin-1(ET-1)显示文摘Objective:To assess whether Veronicastrum axillare(V.axillare)can ameliorate ethanol-induced gastric mucosal lesions in rats,reduce the production of pro-inflammatory cytokines,suppress apoptosis and improve local microcirculation disturbances.Methods:Totally 48 male Sprague-Dawley rats were randomly divided into six groups,eight rats in each group.Rats in the normal group and the model group were administered with 0.9%normal saline respectively.Rats in the positive group and ranitidine group were administered with 0.18%ranitidine suspension by intragastric administration respectively.Those in the high dose V.axillare group,the medium dose V.axillare group and the low dose V.axillare group were administrated with V.axillare at the daily dose of 2.8 g/kg,1.4 g/kg and 0.7 g/kg by intragastric administration.Gastric mucosal lesions were produced by intragastric administration of absolute ethanol.Water extract of V.axillare was successively injected for 14 d and last day was injected 1 h before ethanol administration.Gastric mucosal ulcer index and ulcer inhibitory rate were counted by improved Guth methods.The tissue sections were made for pathological histology analysis.Also,we measured the concentrations of tumor necrosis factor-α(TNF-α)and endothelin-1(ET-1)in gastric mucosal,as an index of the pro-inflammatory cytokines,apoptosis and local microcirculation.Besides,the mRNA contents of TNF-αand ET-1 were measured to verify effects on gene expression by real-time fluorescent quantitative PCR.Results:Water extract of V.axillare significantly ameliorated the gastric mucosal lesions induced by ethanol administration(P<0.01).Pro-inflammatory cytokines,TNF-a and ET-1 were increased after ethanol administration and significantly reduced by water extract of V.axillare.The expressions of TNF-αand ET-1 mRNA were also be inhibited by water extract of V.axillare.Conclusion:Current evidences show water extract of V.axillare is effective for defending against ethanol-induced gastric mucosal lesions,significantly inhibiting the production of proinflammatory cytokines and the expressions of TNF-αand ET-1 mRNA,which may be useful for inhibiting apoptosis and improving local microcirculation. | Yong Du Weichun Zhao Leilei Lu Jiayan Zheng Xishi Hu Zhehan Yu Lixin Zhu | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，12： | 13 |
| 3 | Composition, origin and weathering process of surface sediment in Kumtagh Desert, Northwest China显示文摘Kumtagh 沙漠是在中国的八最大的沙漠之一,但是因为存取的困难,以前糟糕调查我们的学科交差的学习。在这份报纸, 33 件代表性的表面沉积样品从在实验室荒芜、分析的 Kumtagh 被收集获得重矿物质部件和 geochemical 元素内容。结果证明重矿物质的各种各样的类型在这些样品是在场的,与绿帘石和角闪石的高水平。Si 和艾尔收起化学作文的大部分。与上面的大陆人外壳(UCC ) 的 geochemical 元素的平均作文相比,除了 Si 和 Ca,所有元素被弄空到某个度;Fe, Mg, Ca, P, Ti 和 Mn 在他们的内容有高关联系数。矿物质和 Kumtagh 荒芜的沉积的 geochemical 作文在 Altyn Tagh 山脉和 Taklamakan 沙漠的附近与 Altyn Tagh 山脉,和冲积/洪水的扇子的表面沉积的岩石的有类似,显示 Kumtagh 荒芜的沉积的一主要来源位于 Altyn Tagh 山脉。在 Aqik 山谷和 Shule 河的更低的活动范围的冲积沉积物和湖沉积是容易的被侵蚀并且搬运由强壮在东北弯屈进 Kumtagh 沙漠,形成沙漠的另一来源扔。一张 A-CN-K 第三的图证明由 Na 和 K 的损失捱过的弱度化学药品发生在这些沉积,而 A-CNK-FM 第三的图建议 Fe 和 Mg 经历了重要化学区别。物理捱过过程为 mafic 矿物质在好粒子引起容易的侵蚀和丰富,这样粗糙的荒芜的沙粒子能相对在 Fe 和 Mg 被弄空。在经历不太化学的捱过的干旱区域的沉积的矿物质和 geochemical 作文被物理捱过主要影响。 | XU Zhiwei LU Huayu ZHAO Cunfa WANG Xianyan SU Zhizhu WANG Zhenting LIU Hongyi WANG Lixin LU Qi | 2011 | Journal of Geographical Sciences2011，21，6： | 13 |
| 4 | CloudRank-D: benchmarking and ranking cloud computing systems for data processing applications显示文摘与信息的爆炸生长,越来越多的组织正在部署私人云系统或租公共的云系统处理大数据。然而,为在整个系统水平上评估云性能没有存在基准套房。就我们的知识而言,这份报纸建议第一基准套房 CloudRank-D 到计算为运行大数据应用程序被分享的系统的基准和等级云。我们分析以前的度量标准的限制,例如,浮点操作为评估一个云计算系统,并且建议二个简单度量标准:每秒处理的数据和为评估作为二个互补度量标准每朱尔处理的数据遮蔽计算系统。我们详细说明那认为应用程序,数据特征的差异,和应用程序和系统软件平台的动态行为代表性的 CloudRank-D 的设计。通过实验,我们表明我们的建议度量标准的优点。在几案例研究,我们用 CloudRank-D 评估云计算系统的二小规模的推广。 | Chunjie LUO Jianfeng ZHAN Zhen JIA Lei WANG Gang LU Lixin ZHANG Cheng-Zhong XU Ninghui SUN | 2012 | Frontiers of Computer Science2012，6，4： | 5 |
| 5 | Recent Research Developments of Perovskite Solar Cells显示文摘For the first time in 2009,the inorganic-organic hybrid perovskite materials were applied in liquid dye-sensitized solar cells.In 2013,the power conversion efficiency successfully reached 15%,followed by great amount of research papers bursting out.Till August 2014,the highest efficiency is certified to 17.9%,and the reported efficiency is even up to 19.3%.They quickly go beyond dye-sensitized solar cells and organic solar cells.It is expected the perovskite has its efficiency same to the single-crystal silicon cells.The“game changer”of solar cells is coming.The perovskite solar cells are cheap and easily to be made,which will benefit both science and industry.This review summarized recent development of both perovskite materials and solar cell devices,not only including new material developments of perovskite compositions,structures,and fabrication methods,but also focusing on device structures,charge transfer mechanism and stability properties of perovskite solar cells.Their perspective is also estimated. | Yingzhuang Ma Shufeng Wang Lingling Zheng Zelin Lu Danfei Zhang Zuqiang Bian Chunhui Huang Lixin Xiao | 2014 | Chinese Journal of Chemistry2014，32，10： | 3 |
| 6 | Geochemical Features and Metallogenic Prediction of the Caixiashan-Weiquan Area in the East Tianshan Region显示文摘Caixiashan-Weiquan 区域是在东方 Tianshan metallogenic 带的一个重要矿石集中区域。第一,这份报纸学习 Matoutan mapsheet 的 1:200000 溪流沉积的 1564 件样品的 geochemical 特征,在 Caixiashan 和 Weiquan 存款被定位的地方。处理,探索 geochemical 数据的分析和解释在发现矿石的过程起一个重要作用,它与 geochemical 样品的测量元素内容是否能有效地指导矿物质探索的工作有关。作为一个高度非线性的动态系统,神经网络与常规 geochemical 途径相比以原则和特征更类似于人的大脑。它能使自己适应环境,总结法律,完全的模式识别。第二,作者使用了分类所有的神经网络基于溪流沉积样品的 10 个矿化作用元素取样以便决定可能的矿物质矿石,减少矿石目标的范围并且学习第九组样品的指示物元素的 Kohonen ,它是主要,最近到沉积物,结果证明神经网络能描出 metallogenic 未来的区域并且在深 geochemical 信息的发现是有效的。 | LU Lu ZHU Lixin XIAO Keyan MA Shengming YIN Jiangning XU Mingzuan | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 3 |
| 7 | Community phylogenetic structure of grasslands and its relationship with environmental factors on the Mongolian Plateau显示文摘The community assembly rules and species coexistence have always been interested by ecologists. The community phylogenetic structure is the consequence of the interaction process between the organisms and the abiotic environment and has been used to explain the relative impact of abiotic and biotic factors on species co-existence. In recent years, grassland degradation and biodiversity loss have become increasingly severe on the Mongolian Plateau, while the drivers for these changes are not clearly explored, especially whether climate change is a main factor is debated in academia. In this study, we examined the phylogenetic structure of grassland communities along five transects of climate aridity on the Mongolian Plateau, and analyzed their relations with environmental factors, with the aims to understand the formation mechanism of the grassland communities and the role of climatic factors. We surveyed grassland communities at 81 sites along the five transects, and calculated their net relatedness index(NRI) at two different quadrat scales(small scale of 1 m2 and large scale of 5 m2) to characterize the community phylogenetic structure and analyze its relationship with the key 11 environmental factors. We also calculated the generalized UniFrac distance(GUniFrac) among the grassland communities to quantify the influence of spatial distance and environmental distance on the phylogenetic β diversity. The results indicated that plant community survey using the large scale quadrat contained sufficient species to represent community compositions. The community phylogenetic structure of grasslands was significantly overdispersed at both the small and large scales, and the degree of overdispersion was greater at the large scale than at the small scale, suggesting that competitive exclusion instead of habitat filtering played a major role in determination of community composition. Altitude was the main factor affecting the community phylogenetic structure, whereas climatic factors, such as precipitation and temperature, had limited influence. The principal component analysis of the 11 environmental factors revealed that 94.04% of their variation was accounted by the first four principal components. Moreover only 14.29% and 23.26% of the variation in community phylogenetic structure were explained by the first four principal components at the small and large scales, respectively. Phylogenetic β diversity was slightly significantly correlated with both spatial distance and environmental distance, however, environmental distance had a less explanatory power than spatial distance, indicating a limited environmental effect on the community phylogenetic structure of grasslands on the Mongolian Plateau. In view of the limited effect of climatic factors on the community phylogenetic structure of grasslands, climate change may have a smaller impact on grassland degradation than previously thought. | DONG Lei LIANG Cunzhu LI Frank Yonghong ZHAO Liqing MA Wenhong WANG Lixin WEN Lu ZHENG Ying LI Zijing ZHAO Chenguang Indree TUVSHINTOGTOKH | 2019 | Journal of Arid Land2019，11，4： | 2 |
| 8 | Comparing the VGCG model as the unification of dark sectors with observations显示文摘Current observations indicate that 95% of the energy density in the universe is the unknown dark component.The dark component is considered composed of two fluids:dark matter and dark energy.Or it is a mixture of these two dark components,i.e.,one can consider it an exotic unknown dark fluid.With this consideration,the variable generalized Chaplygin gas(VGCG)model is studied with not dividing the unknown fluid into dark matter and dark energy parts in this paper.By using the Markov Chain Monte Carlo method,the VGCG model as the unification of dark sectors is constrained,and the constraint results on the VGCG model parameters are,n=0.00057+0.0001+0.0009-0.0006-0.0006,α=0.0015+0.0003+0.0017-0.0015-0.0015and B s=0.778+0.016+0.030-0.016-0.035,obtained by the cosmic microwave background data from the 7-year WMAP full data points,the baryon acoustic oscillation data from Sloan Digital Sky Survey(SDSS)and 2-degree Field Galaxy Redshift(2dFGRS)survey,and the Union2 type Ia supernova data with systematic errors.At last,according to the evolution of deceleration parameter it is shown that an expanded universe from deceleration to acceleration can be obtained in VGCG cosmology. | LU JianBo CHEN LiDong XU LiXin LI TianQiang | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 2 |
| 9 | Interleukin 1 beta-induced chloride currents are important in osteoarthritis onset:an in vitro study显示文摘Persistent hypotonic and inflammatory conditions in the joint cavity can lead to the loss of cartilage matrix and cell death,which are the important mechanisms of osteoarthritis(OA)onset.Previous studies have confirmed that the existence of a hypotonic environment is a red flag for inflammation,as hypotonic environment induces the opening of the chloride channel of the cell and promotes chloride ion efflux,which prompts the cell volume to increase.Chloride channels play an important role in the regulation of mineralization and chondrocyte death.Here,we reported that OA chondrocytes showed a significant increase of cell death rate and the imbalance of cartilage matrix catabolism.We found that the distribution of skeleton protein F-actin was disordered.In addition,the volume-sensitive chloride current of OA chondrocytes decreased significantly with the increase of the expression levels of inflammation-related proteins caspase-1,caspase-3,and NLRP3.Moreover,interleukin-1β(IL-1β)showed a potential to activate the chloride current of normal chondrocytes.These results indicate that IL-1β-induced chloride channel opening in chondrocytes may be closely related to the occurrence of OA.This chloride channel opening process may therefore be a potential target for the treatment of OA. | Zhiqin Deng Zicong Lin Qing Zhong Minqiang Lu Huankun Fang Jianquan Liu Li Duan Lixin Chen Liwei Wang Daping Wang Wencui Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 2 |
| 10 | Strain modulation on graphene/ZnO nanowire mixed- dimensional van der Waals heterostructure for high- performance photosensor显示文摘因为它在紧张下面避免契约破裂和原子重建,混合维的货车 der Waals (vdW ) heterostructure 是为拉紧的电子学和光电子的一块有希望的积木。我们为高效的 photosensing 建议在二维的 graphene 和一个维的 ZnO nanowire 之间的新奇混合维的 vdW heterostructure。由利用 ZnO 的压电的性质,紧张调整在混合维的 vdW heterostructure 被完成优化设备表演。由联合超离频在 graphene 的电子转移速度并且极其在 ZnO 的洞的长寿时间, 1.87 ? 的突出的 responsivity?? | Shuo Liu Qingliang Liao Zheng Zhang Xiankun Zhang Shengnan Lu Lixin Zhou Mengyu Hong Zhuo Kang Yue Zhang | 2017 | Nano Research2017，10，10： | 2 |
| 11 | Stability and demulsification of emulsions stabilized by asphaltenes or resins 显示文摘 | Xia Lixin Lu Shiwei Can Guoying | 2004 | Journal of Colloid and Interface Science2004，271，2： | 1 |
| 12 | Single-event burnout hardening of planar power MOSFET with partially widened trench source显示文摘We present a single-event burnout(SEB) hardened planar power MOSFET with partially widened trench sources by three-dimensional(3 D) numerical simulation. The advantage of the proposed structure is that the work of the parasitic bipolar transistor inherited in the power MOSFET is suppressed effectively due to the elimination of the most sensitive region(P-well region below the N+ source). The simulation result shows that the proposed structure can enhance the SEB survivability significantly. The critical value of linear energy transfer(LET),which indicates the maximum deposited energy on the device without SEB behavior, increases from 0.06 to0.7 p C/μm. The SEB threshold voltage increases to 120 V, which is 80% of the rated breakdown voltage. Meanwhile, the main parameter characteristics of the proposed structure remain similar with those of the conventional planar structure. Therefore, this structure offers a potential optimization path to planar power MOSFET with high SEB survivability for space and atmospheric applications. | Jiang Lu Hainan Liu Xiaowu Cai Jiajun Luo Bo Li Binhong Li Lixin Wang Zhengsheng Han | 2018 | Journal of Semiconductors2018，39，3： | 1 |
| 13 | Bullet-like vanadium-based MOFs as a highly active catalyst for promoting the hydrogen storage property in MgH_(2)显示文摘The practical application of magnesium hydride(MgH_(2))was seriously limited by its high desorption temperature and slow desorp-tion kinetics.In this study,a bullet-like catalyst based on vanadium related MOFs(MOFs-V)was successfully synthesized and doped with MgH_(2) by ball milling to improve its hydrogen storage performance.Microstructure analysis demonstrated that the as-synthesized MOFs was consisted of V_(2)O_(3) with a bullet-like structure.After adding 7wt%MOFs-V,the initial desorption temperature of MgH_(2) was reduced from 340.0 to 190.6℃.Besides,the MgH_(2)+7wt%MOFs-V composite released 6.4wt%H_(2) within 5 min at 300℃.Hydrogen uptake was started at 60℃under 3200 kPa hydrogen pressure for the 7wt%MOFs-V containing sample.The desorption and absorption apparent activity energies of the MgH_(2)+7wt%MOFs-V composite were calculated to be(98.4±2.9)and(30.3±2.1)kJ·mol^(-1),much lower than(157.5±3.3)and(78.2±3.4)kJ·mol^(−1) for the as-prepared MgH_(2).The MgH_(2)+7wt%MOFs-V composite exhibited superior cyclic property.During the 20 cycles isothermal dehydrogenation and hydrogenation experiments,the hydrogen storage capacity stayed almost unchanged.X-ray diffraction(XRD)and X-ray photoelectron spectrometer(XPS)measurements confirmed the presence of metallic vanadium in the MgH_(2)+7wt%MOFs-V composite,which served as catalytic unit to markedly improve the hydrogen storage properties of Mg/MgH_(2) system. | Zhiyu Lu Jiahuan He Mengchen Song Yan Zhang Fuying Wu Jiaguang Zheng Liuting Zhang Lixin Chen | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，1： | 1 |
| 14 | Enhanced sensitivity and characterization of photosystem II in transgenic tobacco plants with decreased chloroplast glutathione reductase under chilling stress显示文摘 | Shunhua Ding Ming Lei Qingtao Lu Aihong Zhang Yan Yin Xiaogang Wen Lixin Zhang Congming Lu | 2012 | BBA - Bioenergetics2012，，11： | 1 |
| 15 | In situ TEM revealing the effects of dislocations on lithium-ion migration in transition metal dichalcogenides显示文摘The two-dimensional (2D) structure of layered transition metal dichalcogenides (TMDs) provides unusual physical properties [1,2]and chemical reactivity [3,4], which can be influenced by defects such as dislocations [5,6]. For example, dislocations can act as nucleation sites for the onset of deformation when subjected to stress [7]. | Ruiwen Shao Chengkai Yang Chen Yang Shulin Chen Weikang Dong Bairong Li Xiumei Ma Jing Lu Lixin Dong Peng Gao Dapeng Yu | 2021 | Journal of Energy Chemistry2021，30，7： | 1 |
| 16 | Modeling the Complex Interaction between Packaged Product and Vehicle显示文摘 | Wang Jun Lu Lixin Wang Zhiwei | 2010 | Advanced Science Letters2010，，： | 1 |
| 17 | Policy study on development and utilization of clean coal technology in China显示文摘 | Lu Xin Yu Zhufeng Wu Lixin | 2008 | Fuel Processing Technology2008，89，： | 1 |
| 18 | Policy study on development and utilization of clean coal technology in China显示文摘 | Xin Lu Zhufeng Yu Lixin Wu Jie Yu Guifeng Chen Maohong Fan | 2007 | Fuel Processing Technology2007，，4： | 1 |
| 19 | Fine and coarse aerosol composition from a rural area in Northern China 显示文摘 | WINCHESTER J W LU Weixiu PEN Lixin | 1981 | Atmospheric Environment1981，15，： | 1 |
| 20 | Stability and demulsification of emulsions stabilized by asphaltenes or resins显示文摘 | Xia Lixin Lu Shiwei Cao Guoying | 2004 | Journal of Colloid and Interface Science2004，271，： | 1 |
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