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| 1 | The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital.based multi.center study显示文摘Background: Stage at diagnosis and molecular subtype are important clinical factors associated with breast cancer patient survival. However, subgroup survival data from a large study sample are limited in China.To estimate the survival differences among patients with different stages and various subtypes of breast cancer, we conducted a hospital-based multi-center study on breast cancer in Beijing, China.Methods: All resident patients diagnosed with primary, invasive breast cancer between January 1,2006 and December 31,2010 from four selected hospitals in Beijing were included and followed up until December 31,2015. Hospitalbased data of stage at diagnosis, hormone receptor status, and selected clinical characteristics, including body mass index(BMI), menopausal status, histological grade, and histological type, were collected from the medical records of the study subjects. Overall survival(OS) and cancer-specific survival(CSS) were estimated. Cox proportional hazards models were employed to evaluate the associations of stage at diagnosis and molecular subtype with patient survival.Results: The 5-year OS and CSS rates for all patients were 89.4% and 90.3%. Survival varied by stage and molecular subtype. The 5-year OS rates for patients with stage I, Ⅱ, Ⅲ, and IV diseases were 96.5%, 91.6%, 74.8%, and 40.7%,respectively, and the corresponding estimates of 5-year CSS rates were 97.1%, 92.6%, 75.6%, and 42.7%, respectively.The 5-year OS rates for patients with luminal A, luminal B, HER2, and triple-negative subtypes of breast cancer were92.6%, 88.4%, 83.6%, and 82.9%, respectively, and the corresponding estimates of 5-year CSS rates were 93.2%, 89.1 %,85.4%, and 83.5%, respectively. Multivariate analysis showed that stage at diagnosis and molecular subtype were important prognostic factors for breast cancer.Conclusions: Survival of breast cancer patients varied significantly by stage and molecular subtype. Cancer screening is encouraged for the early detection and early diagnosis of breast cancer. More advanced therapies and health care policies are needed on HER2 and triple-negative subtypes. | Tingting Zuo Hongmei Zeng Huichao Li Shuo Liu Lei Yang Changfa Xia Rongshou Zheng Fei Ma Lifang Liu Ning Wang Lixue Xuan Wanqing Chen | 2017 | Chinese Journal of Cancer2017，36，11： | 18 |
| 2 | Secure searchable public key encryption against insider keyword guessing attacks from indistinguishability obfuscation显示文摘Public key encryption with keyword search(PEKS)enables one to search encrypted data containing some keyword without decrypting the data in public key setting.Boneh et al.[1]introduced the notion of PEKS,but later Byun et al.[2]showed the scheme in[1]is vulnerable to the outsider/insider keyword guessing attacks(KGA).Many previous PEKS studies have tackled | Lixue SUN Chunxiang XU Mingwu ZHANG Kefei CHEN Hongwei LI | 2018 | Science China(Information Sciences)2018，61，3： | 4 |
| 3 | A radiomics prognostic scoring system for predicting progression-free survival in patients with stageⅣnon-small cell lung cancer treated with platinum-based chemotherapy显示文摘Objective:To develop and validate a radiomics prognostic scoring system(RPSS)for prediction of progressionfree survival(PFS)in patients with stageⅣnon-small cell lung cancer(NSCLC)treated with platinum-based chemotherapy.Methods:In this retrospective study,four independent cohorts of stageⅣNSCLC patients treated with platinum-based chemotherapy were included for model construction and validation(Discovery:n=159;Internal validation:n=156;External validation:n=81,Mutation validation:n=64).First,a total of 1,182 three-dimensional radiomics features were extracted from pre-treatment computed tomography(CT)images of each patient.Then,a radiomics signature was constructed using the least absolute shrinkage and selection operator method(LASSO)penalized Cox regression analysis.Finally,an individualized prognostic scoring system incorporating radiomics signature and clinicopathologic risk factors was proposed for PFS prediction.Results:The established radiomics signature consisting of 16 features showed good discrimination for classifying patients with high-risk and low-risk progression to chemotherapy in all cohorts(All P<0.05).On the multivariable analysis,independent factors for PFS were radiomics signature,performance status(PS),and N stage,which were all selected into construction of RPSS.The RPSS showed significant prognostic performance for predicting PFS in discovery[C-index:0.772,95%confidence interval(95%CI):0.765-0.779],internal validation(C-index:0.738,95%CI:0.730-0.746),external validation(C-index:0.750,95%CI:0.734-0.765),and mutation validation(Cindex:0.739,95%CI:0.720-0.758).Decision curve analysis revealed that RPSS significantly outperformed the clinicopathologic-based model in terms of clinical usefulness(All P<0.05).Conclusions:This study established a radiomics prognostic scoring system as RPSS that can be conveniently used to achieve individualized prediction of PFS probability for stageⅣNSCLC patients treated with platinumbased chemotherapy,which holds promise for guiding personalized pre-therapy of stageⅣNSCLC. | Lan He Zhenhui Li Xin Chen Yanqi Huang Lixu Yan Changhong Liang Zaiyi Liu | 2021 | Chinese Journal of Cancer Research2021，33，5： | 3 |
| 4 | Genome-wide identification and expression analysis of DNA demethylase family in cotton显示文摘Background:DNA methylation is an important epigenetic factor that maintains and regulates gene expression.The mode and level of DNA methylation depend on the roles of DNA methyltransferase and demethylase,while DNA demethylase plays a key role in the process of DNA demethylation.The results showed that the plant’s DNA demethylase all contained conserved DNA glycosidase domain.This study identified the cotton DNA demethylase gene family and analyzed it using bioinformatics methods to lay the foundation for further study of cotton demethylase gene function.Results:This study used genomic information from diploid Gossypium raimondii JGI(D),Gossypium arboreum L.CRI(A),Gossypium hirsutum L.JGI(AD1) and Gossypium barbadebse L NAU(AD2) to Arabidopsis thaliana.Using DNA demethylase genes sequence of Arabidopsis as reference,25 DNA demethylase genes were identified in cotton by BLAST analysis.There are 4 genes in the genome D,5 genes in the genome A,10 genes in the genome AD1,and 6 genes in the genome AD2.The gene structure and evolution were analyzed by bioinformatics,and the expression patterns of DNA demethylase gene family in Gossypium hirsutum L were analyzed.From the phylogenetic tree analysis,the DNA demethylase gene family of cotton can be divided into four subfamilies:REPRESSOR of SILENCING 1(ROS1),DEMETER(DME),DEMETER-LIKE 2(DML2),and DEMETER-LIKE3(DML3).The sequence similarity of DNA demethylase genes in the same species was higher,and the genetic relationship was also relatively close.Analysis of the gene structure revealed that the DNA demethylase gene family members of the four subfamilies varied greatly.Among them,the number of introns of ROS1 and DME subfamily was larger,and the gene structure was more complex.For the analysis of the conserved domain,it was known that the DNA demethylase family gene member has an endonuclease Ⅲ(END03 c) domain.Conclusion:The genes of the DNA demethylase family are distributed differently in different cotton species,and the gene structure is very different.High expression of ROS1 genes in cotton were under abiotic stress.The expression levels of ROS1 genes were higher during the formation of cotton ovule.The transcription levels of ROS1 family genes were higher during cotton fiber development. | YANG Xiaomin LU Xuke CHEN Xiugui WANG Delong WANG Junjuan WANG Shuai GUO Lixue CHEN Chao WANG Xiaoge WANG Xinlei YE Wuwei | 2019 | Journal of Cotton Research2019，2，3： | 3 |
| 5 | Coordination Method for DC Fault Current Suppression and Clearance in DC Grids显示文摘The modular multilevel converter(MMC)based DC grid is considered as a future solution for bulk renewable energy integration and transmission.However,the high probability of DC faults and their rapid propagation speed are the main challenges in the development of DC grids.Existing research primarily focuses on the DC fault clearance methods,while the fault current suppression methods are still barely researched.Additionally,the coordination method of fault current suppression and clearance needs to be optimized.In this paper,the technical characteristics of the current suppression methods are studied,and the coordinated methods of fault current suppression and clearance are proposed.At last,a cost comparison of these methods is presented.The research results show that the proposed strategies can reduce the cost of the protection equipment. | Xibei Zhao Lixu Chen Gen Li Jianzhong Xu Jinsha Yuan | 2022 | CSEE Journal of Power and Energy Systems2022，8，5： | 2 |
| 6 | Research on CMOS Mm-Wave Circuits and Systems for Wireless Communications显示文摘This paper discusses some challenges in the design of millimeter-wave(nunwave) circuits and systems for 5th generation(5G) wireless systems in CMOS process.The properties of some passive and active devices such as inductors,capacitors,transmission lines,transformers and transistors in mm-wave frequency band are discussed.Self-healing technique dealing with PVT variation,resonant mode switching technique to enhance frequency tuning range of voltage controlled oscillator(VCO) and dual mode technique for power amplifier(PA) efficiency enhancement are introduced.At last,A fully-integrated60 GHz 5 Gb/s QPSK transceiver with the transmit/receive(T/R) switch in 65 nm CMOS process is introduced.The measured error vector magnitude(EVM) of the TX is-21.9dB while the bit error rate(BER) of the RX with a-52 dBm sine-wave input is below 8e-7when transmitting/receiving 5 Gb/s data.The transceiver is powered by 1.0 V and 1.2 V supply(except the phase-frequency detector and charge-pump in the frequency synthesizer which are powered by 2.5 V supply) and consumes 135 mW in TX mode and 176 mW in RX mode. | JIA Haikun CHI Baoyong KUANG Lixue YU Xiaobao CHEN Lei ZHU Wei WEI Meng SONG Zheng WANG Zhihua | 2015 | China Communications2015，12，5： | 2 |
| 7 | Performance evaluation of deep learning-based post-processing and diagnostic reporting system for coronary CT angiography: a clinical comparative study显示文摘To the Editor:Coronary computed tomography angiography(CCTA)has been increasingly,widely performed for diagnosing coronary artery,disease,lAnatomical diagnosis,that is,stenosis grading,is stillthe main diagnostic index provided'by most CCTA tests.Post-processing and interpretation of stenosis are 2 essential'steps that need to be performed bycardiovascular imaging professionals from scan completion to diagnosis conclusion,which is repetitive and time-consuming,taking an average of 30 minutes each case in China and becoming the bottleneck and gradually creating an imbalance between supply and demand.In ine with the rapid development of artificial intelligence(Al)technology in recent years,it has been expected to solve these specific problems.We developed an AI system for automating post-processing and diagnostic reporting of CCTA data using deep learning algorithms to establishanew1-clickworkflowforeverydayuse,namely,CCTA-AI(Figure 1).To further assess its capabilities,this study intends to answer 2 following questions:To what extent can it improve the efficiency of post-processing?To what extent can CCTA-AI detect and calculate coronary artery stenosis due to each atherosclerotic plaque? | Nan Luo Yi He Jitao Fan Ning Guo Guang Yang Yuanyuan Kong Jianyong Wei Tao Bi Jie Zhou Jiaxin Cao Xianjun Han Fang Li Shiyu Zhang Rujing Sun Zhaozhao Wang Tian Ma Lixue Xu Hui Chen Hongwei Li Zhenchang Wang Zhenghan Yang | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 8 | Use of angiotensin-converting enzyme inhibitors and angiotensin Ⅱ receptor blockers in context of COVID-19 outbreak:a retrospective analysis显示文摘The possible effects of angiotensin-converting enzyme inhibitors(ACEIs)or angiotensin Ⅱ receptor blockers(ARBs)on COVID-19 disease severity have generated considerable debate.We performed a single-center,retrospective analysis of hospitalized adult COVID-19 patients in Wuhan,China,who had definite clinical outcome(dead or discharged)by February 15,2020.Patients on anti-hypertensive treatment with or without ACEI/ARB were compared on their clinical characteristics and outcomes.The medical records from 702 patients were screened.Among the 101 patients with a history of hypertension and taking at least one anti-hypertensive medication,40 patients were receiving ACEI/ARB as part of their regimen,and 61 patients were on antihypertensive medication other than ACEI/ARB.We observed no statistically significant differences in percentages of in-hospital mortality(28%vs.34%,P=0.46),ICU admission(20%vs.28%,P=0.37)or invasive mechanical ventilation(18%vs.26%,P=0.31)between patients with or without ACEI/ARB treatment.Further multivariable adjustment of age and gender did not provide evidence for a significant association between ACEI/ARB treatment and severe COVID-19 outcomes.Our findings confirm the lack of an association between chronic receipt of reninangiotensin system antagonists and severe outcomes of COVID-19.Patients should continue previous antihypertensive therapy until further evidence is available. | Jiuyang Xu Chaolin Huang Guohui Fan Zhibo Liu Lianhan Shang Fei Zhou Yeming Wang Jiapei Yu Luning Yang Ke Xie Zhisheng Huang Lixue Huang Xiaoying Gu Hui Li Yi Zhang Yimin Wang Frederick G.Hayden Peter W.Horby Bin Cao Chen Wang | 2020 | Frontiers of Medicine2020，14，5： | 2 |
| 9 | Cobalt-doped Mn3O4 nanocrystals embedded in graphene nanosheets as a high-performance bifunctional oxygen electrocatalyst for rechargeable Zn–Air batteries显示文摘A non-noble-metal bifunctional catalyst with efficient and durable activity towards both the oxygen reduction reaction(ORR)and the oxygen evolution reaction(OER)is crucial to the development of rechargeable Zn-air batteries.Herein,a facile one-step hydrothermal method is reported for the synthesis of a high-performance bifunctional oxygen electrocatalyst,cobalt-doped Mn_(3)O_(4) nanocrystals supported on graphene nanosheets(Co–Mn_(3)O_(4)/G).Compare to pristine Mn_(3)O_(4),this Co–Mn_(3)O_(4)/G exhibits greatly enhanced electrocatalytic activity,delivering a halfwave potential of 0.866 V for the ORR and a low overpotential of 275 mV at 10 mA cm^(-2) for the OER.The zinc-air battery built with Co–Mn_(3)O_(4)/G shows a reduced charge–discharge voltage of 0.91 V at 10 mA cm^(-2),an power density of 115.24 mW cm^(-2) and excellent stability without any degradation after 945 cycles(315 h),outperforming the state-of-the-art Pt/C–Ir/C catalyst-based device. | Mengyang Dong Xu Liu Lixue Jiang Zhengju Zhu Yajie Shu Shan Chen Yuhai Dou Porun Liu Huajie Yin Huijun Zhao | 2020 | Green Energy & Environment2020，5，4： | 2 |
| 10 | Analysis on Dynamic Characteristics in Time Domain of Slider with Ultra Thin Spacing显示文摘With increasing recording density in computer hard disks,the flying height of the magnetic head becomes 10 nm or less.The numerical method of the control equations needs to be optimized consistently with the decrease of the flying height.The iterative process is usually divergent with traditional methods which cannot ensure the accuracy of the analysis results and the stability of numerical calculations.Firstly,a new scheme is presented to solve the ultra-thin lubricating control equations in this paper.The equilibrium equation is obtained by taking the Couette flow terms and time term as dominating terms in iterative process.Moreover,the weighting flow factor is introduced for the abrupt change of film thickness in order to reduce calculated deviation.Secondly,the rules for variation of flying pose of the magnetic head with time are obtained by the time domain analysis.The results show that the magnetic head can recover to the equilibrium position after being slightly influenced by outside disturbance.And the dynamic lubrication properties of the head suffer heavily from the vibrations in the height direction and fluctuation in the pitch direction.Finally,the analysis of the sine roughness-passing capacity of the head indicates that the head can surpass small sine waves and the equilibrium position can be retrieved after a period of decaying oscillation.The proposed research ensures the accuracy and stability of the numerical calculation of the control equations,and the dynamic characteristics and flying stability of a magnetic head is studied systematically.It can also be the theoretical basis for the analysis of the flight characteristics of the slider. | YAO Huaping HUANG Ping CHEN Yangzhi ZHU Lixue | 2012 | Chinese Journal of Mechanical Engineering2012，25，3： | 2 |
| 11 | Promising flu- orescent probes from phycobiliproteins 显示文摘 | Sun Li Wang Shumei Chen Lixue | 2003 | Selected Topics in Quantum Electronics2003，9，2： | 1 |
| 12 | Epitaxial growth of ZnO nanorods on diamond and negative differential resistance of n-ZnO nanorod/p-diamond heterojunction显示文摘 | Hongdong Li Dandan Sang Shaoheng Cheng Jing Lu Xiuhua Zhai Lixue Chen Xiao-qiang Pei | 2013 | Applied Surface Science2013，，： | 1 |
| 13 | Engineered extracellular vesicles for concurrent Anti-PDL1 immunotherapy and chemotherapy显示文摘Immune checkpoint inhibitors(ICI)targeting PD-1/PD-L1 have been approved for the treatment of a variety of cancers.However,the efficacy of antibody-based ICIs could be further improved by mitigating anti-drug antibodies,proteolytic cleavage,and on-target off-tumor toxicity.One strategy for accomplishing this is through the use of extracellular vesicles(EVs),cell derived submicron vesicles with many unique properties.We constructed an engineered MDA-MB-231 cell line for harvesting EVs.This was accomplished by overexpressing a high-affinity variant human PD-1 protein(havPD-1),while simultaneously knocking out intrinsic PD-L1 and beta-2 microglobulin.The engineered havPD-1 EVs reduced PD-L1 overexpressing cancer cell proliferation and induced cellular apoptosis.Moreover,the EVs were shown to efficiently block PD-L1 mediated T cell suppression.Meanwhile antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity were not observed.The havPD-1 EVs treatment resulted in robust anti-tumor activity in both preventative co-implantation and therapeutic xenograft tumor models reconstituted with human T cells.The efficacy of the havPD-1 EVs was shown to be comparable to clinical anti-PD1 monoclonal antibodies.Additionally,loading the havPD-1 EVs with a potent PARP inhibitor was shown to further augment treatment efficacy.In brief,the engineered universal EVs harboring havPD-1 proteins can be used for cancer concurrent immunotherapy and chemotherapy. | Yundi Chen Lixue Wang Mingfeng Zheng Chuandong Zhu Guosheng Wang Yiqiu Xia Ethan J.Blumenthal Wenjun Mao Yuan Wan | 2022 | Bioactive Materials2022，7，3： | 1 |
| 14 | Augmentation of current ramp-down contact pressure in Cshaped armature railguns显示文摘 | CHEN Lixue HE Junjia XIAO Zheng | 2011 | IEEE Transactions on Plasma Science2011，39，1： | 1 |
| 15 | Simulations on arc surfaced C-shaped armatures for round-like bore railguns显示文摘 | Feng Deng He Junjia Chen Lixue | 2013 | IEEE Trans on Plas Sci2013，41，5： | 1 |
| 16 | Effects of a Wildfire on Selected Physical , hemical and Biochemical Soil Properties in a Pinus massoniana Forest in South hina 显示文摘 | LiXue Qiujing Li Hongyue chen | 2014 | Forest2014，5，： | 1 |
| 17 | An Improved Level Set for Liver Segmentation and Perfusion Analysis in MRIs显示文摘 | Chen Gang Gu Lixu | 2009 | IEEE Trans on Information Technology in Biomedicine2009，13，1： | 1 |
| 18 | Quinolone-Resistant Escherichia coli O127a:K63 Serotype with an Extended-Spectrum-Beta-Lactamase Phenotype from a Food Poisoning Outbreak in China显示文摘 | Rongzhang Hao Shaofu Qiu Yong Wang Guang Yang Wenli Su Lixue Song Jia Zhang Jiaxu Chen Leili Jia Ligui Wang Hongbin Song | 2012 | Journal of Clinical Microbiology2012，，7： | 1 |
| 19 | Simula- tion on arc surfaced C-shaped armatures for round-like bore railguns显示文摘 | FENG Deng HE Junjia CHEN Lixue | 2013 | IEEE Transactions of Magnetics2013，41，5： | 1 |
| 20 | Augmentation of current rampdown contact pressure in Cshaped armature railguns显示文摘 | Chen Lixue He Junjia Xiao Zheng | 2011 | IEEE Transactions on Plasma Science2011，39，1： | 1 |
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