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| 1 | Effectiveness of flesh-moistening paste in psoriasis vulgaris patients with symptom pattern of blood stasis:a randomized and parallel-controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of flesh-moistening paste for treating psoriasis vulgaris in patients with blood stasis pattern in terms of Traditional Chinese Medicine(TCM).METHODS:Eudipleural rashes on both the left and right side of the same patients with psoriasis vulgaris,diagnosed via TCM as blood stasis pattern,were selected as the targeted skin lesions.A randomized,double-blind,parallel-controlled,multicenter controlled trial was conducted.The targeted skin lesions were categorized into either the treatment or control group.The treatment group used the flesh-moistening paste;the control group used a placebo.Both the paste and the placebo were topically applied twice daily for eight weeks.The patients were examined biweekly to evaluate the effects.The two groups were compared in terms of the psoriasis area and severity index(PASI)of the targeted skin lesions,which is scored according to erythema,desquamation,infiltration,area,pruritus,and improvement of skin barrier function.Adverse events were recorded during the study period.SPSS 21.0 was used to analyze the data.RESULTS:Fifty-six patients were enrolled between February 2016 and October 2017.Two were complicated by cardio-cerebrovascular disease and were excluded;thus,54 outpatients were finally enrolled in the study.Four dropped out during the study period:three failed to complete their follow-up visits for unknown reasons,and one exited due to an adverse event.The final trial comprised 50 of the 56 originally selected patients,with a 92.6%completion rate.After 8 weeks of treatment,the targeted skin lesion scores differed significantly(P<0.05).The PASI scores of the targeted skin lesions differed significantly beginning at week 6(P<0.05).The treatment group presented better results than those of the control group.Only one patient had an adverse reaction associated with the treatment.Improvements in skin barrier function differed significantly(P<0.05).CONCLUSION:The flesh-moistening paste demonstrated a reliable curative effect and safety for treating psoriasis vulgaris in patients with blood stasis patterns.The topical paste improved the barrier function of the skin lesions. | Guo Xinwei Lang Na Li Guanru Li Ping Qu Jianhua Zhou Dongmei Wang Ping Cang Zhang Deng BingXu Lou Weihai Xu Jingna Lan Haibing Liu Yumin Zhang Weishu Sun Liyun | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 4 |
| 2 | Architecture of Co-layered double hydroxide nanocages/graphene composite electrode with high electrochemical performance for supercapacitor显示文摘A facile hydrolysis method was applied to fabricate high-performance Co-layered double hydroxide(LDH)nanocages/graphene composites for supercapacitors. The materials exhibit enhanced rate capability than the counterpart electrode free of graphene while maintaining a high specific capacitance. In addition,such Co-LDH nanocages/graphene composites display an excellent cycling stability; the capacitance retention of Co-LDH nanocages/graphene composite electrode remains 90.4% after 10000 cycles at a current density of 2 A g(-1). The integration of high capacity of double hydroxide and outstanding conductivity of graphene makes the delicately-designed composites promising candidates for electrode materials for supercapacitors. | Xianyu Chu Ting Deng Wei Zhang Dong Wang Xiaofei Liu Cai Zhang Tingting Qin Liyun Zhang Bingsen Zhang Chengmeng Chen Weitao Zheng | 2018 | Journal of Energy Chemistry2018，27，2： | 2 |
| 3 | Gynostemma pentaphyllum protects mouse male germ ceils against ap- optosis caused by zearalenone via Bax and Bel-2 regula- tion显示文摘 | Yuan Hui Deng Youtian Yuan Liyun | 2010 | Toxicol Mech Methods2010，20，3： | 1 |
| 4 | Optimized extraction protocol for extracellular polymeric substances from two activated sludges 显示文摘 | Ge Liyun Deng Huanhuan Gao Hongwei | 2010 | Research Journal of Chemistry and Environment2010，14，2： | 1 |
| 5 | Comparison of extraction methods for quantifying pextracellular olymers in activated sludge 显示文摘 | Liyun Ge Huanhuan Deng Hongwu Wang etc | | Fresenius Environmental Bulletin0，16，3： | 1 |
| 6 | Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice显示文摘Chronic pain is often associated with cognitive decline,which could influence the quality of the patient’s life.Recent studies have suggested that Toll-like receptor 3(TLR3)is crucial for memory and learning.Nonetheless,the contribution of TLR3 to the pathogenesis of cognitive decline after chronic pain remains unclear.The level of TLR3 in hippocampal neurons increased in the chronic constriction injury(CCI)group than in the sham group in this study.Importantly,compared to the wild-type(WT)mice,TLR3 knockout(KO)mice and TLR3-specific neuronal knockdown mice both displayed improved cognitive function,reduced levels of inflammatory cytokines and neuronal apoptosis and attenuated injury to hippocampal neuroplasticity.Notably,extracellular RNAs(exRNAs),specifically double-stranded RNAs(dsRNAs),were increased in the sciatic nerve,serum,and hippocampus after CCI.The co-localization of dsRNA with TLR3 was also increased in hippocampal neurons.And the administration of poly(I:C),a dsRNA analog,elevated the levels of dsRNAs and TLR3 in the hippocampus,exacerbating hippocampus-dependent memory.In additon,the dsRNA/TLR3 inhibitor improved cognitive function after CCI.Together,our findings suggested that exRNAs,particularly dsRNAs,that were present in the condition of chronic neuropathic pain,activated TLR3,initiated downstream inflammatory and apoptotic signaling,caused damage to synaptic plasticity,and contributed to the etiology of cognitive impairment after chronic neuropathic pain. | Xueying Zhang Rui Gao Changteng Zhang Yi Teng Hai Chen Qi Li Changliang Liu Jiahui Wu Liuxing Wei Liyun Deng Lining Wu Shixin Ye-Lehmann Xiaobo Mao Jin Liu Tao Zhu Chan Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 7 | Saturation Estimation with Complex Electrical Conductivity for Hydrate-Bearing Clayey Sediments:An Experimental Study显示文摘Clays have considerable influence on the electrical properties of hydrate-bearing sediments.It is desirable to understand the electrical properties of hydrate-bearing clayey sediments and to build hydrate saturation(S_(h))models for reservoir evaluation and monitoring.The electrical properties of tetrahydrofuran-hydrate-bearing sediments with montmorillonite are characterized by complex conductivity at frequencies from 0.01 Hz to 1 kHz.The effects of clay and Sh on the complex conductivity were analyzed.A decrease and increase in electrical conductance result from the clay-swelling-induced blockage and ion migration in the electrical double layer(EDL),respectively.The quadrature conductivity increases with the clay content up to 10%because of the increased surface site density of counterions in EDL.Both the in-phase conductivity and quadrature conductivity decrease consistently with increasing Sh from 0.50 to 0.90.Three sets of models for Sh evaluation were developed.The model based on the Simandoux equation outperforms Archie’s formula,with a root-mean-square error(E_(RMS))of 1.8%and 3.9%,respectively,highlighting the clay effects on the in-phase conductivity.The fre-quency effect correlations based on in-phase and quadrature conductivities exhibit inferior performance(E_(RMS)=11.6%and 13.2%,re-spectively)due to the challenge of choosing an appropriate pair of frequencies and intrinsic uncertainties from two measurements.The second-order Cole-Cole formula can be used to fit the complex-conductivity spectra.One pair of inverted Cole-Cole parameters,i.e.,characteristic time and chargeability,is employed to predict S_(h) with an E_(RMS) of 5.05%and 9.05%,respectively. | XING Lanchang ZHANG Shuli ZHANG Huanhuan WU Chenyutong WANG Bin LAO Liyun WEI Wei HAN Weifeng WEI Zhoutuo GE Xinmin DENG Shaogui | 2024 | Journal of Ocean University of China2024，23，1： | 0 |
| 8 | NiB_(2)O_(4)(B=Mn or Co)catalysts for NH_(3)-SCR of NO_(x) at low-temperature in microwave field显示文摘Microwave-assisted selective catalytic reduction of nitrogen oxides(NOx)was investigated over Nibased metal oxides.The NiMn2O4 and NiCo_(2)O_(4) catalysts were synthesized by the co-precipitation method and their activities were evaluated as potential candidate catalysts for low-temperature NH_(3)-SCR in a microwave field.The physicochemical properties and structures of the catalysts were characterized by X-ray diffraction(XRD),Scanning electron microscope(SEM),N_(2)-physisorption,NO adsorption-desorption in the microwave field,H2-temperature programmed reduction(H2-TPR)and NH3-temperature programmed desorption(NH_(3)-TPD).The results verified that microwave radiation reduced the reaction temperature required for NH_(3)-SCR compared to conventional heating,which needed less energy.For the NiMn_(2)O_(4) catalyst,the catalytic efficiency exceeded 90%at 70°C and reached 96.8%at 110°C in the microwave field.Meanwhile,the NiMn_(2)O_(4) also exhibited excellent low-temperature NH3-SCR reaction performance under conventional heating conditions,which is due to the high BET specific surface area,more suitable redox property,good NO adsorption-desorption in the microwave field and rich acidic sites. | Liyun Song Shilin Deng Chunyi Bian Cui Liu Zongcheng Zhan Shuangye Li Jian Li Xing Fan Hong He | 2023 | Frontiers of Environmental Science & Engineering2023，17，8： | 0 |
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