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| 1 | 冠状动脉内皮功能障碍患者循环MOTS-c水平下调显示文摘MOTS-c是一种新发现的线粒体衍生肽,其在调节代谢稳态中起作用。该研究旨在研究在没有显著冠状动脉结构性病变的患者中循环MOTS-c水平是否也与内皮功能障碍相关。方法:纳入无冠状动脉结构性病变的复发性心绞痛并接受冠状动脉造影和内皮功能检测的患者40例。 | Qin Q Delrio S Wan J Jay Widmer R Cohen P Lerman LO Lerman A 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 14 |
| 2 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 3 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 4 | SSJD15011600007878显示文摘 | María A. Mejía-Benítez Amélie Bonnefond Lo?c Yengo Marlène Huyvaert Aurélie Dechaume Jesús Peralta-Romero Miguel Klünder-Klünder Jaime García Mena Julia S. El-Sayed Moustafa Mario Falchi Miguel Cruz Philippe Froguel | 2015 | Diabetologia2015，，2： | 2 |
| 5 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 6 | Vanillin inhibits matrix metalloproteinase-9 expression through down-regulation of nuclear factor-kappaB signaling pathway in human hepatoeellular carcinoma cells显示文摘 | Liang J A Wu S L Lo H Y | 2009 | Mol Pharmacol2009，75，1： | 1 |
| 7 | Water storage in the wood and xylem cavitation in 1-year-old twigs of Populus deltoids 显示文摘 | Lo Gullo M A Salleo S | 1992 | Plant Cell and Environment1992，15，4： | 1 |
| 8 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 9 | Groundwater depletion in the Middle East from GRACE with implications for transhoundary water management in the Tigris-Euphrates-Western Iran region显示文摘 | Voss Katalyn A Famiglietti James S Lo Minhui | 2013 | Water resources research2013，49，2： | 1 |
| 10 | Treatment of acute respiratory failure secondaryto pulmonary edema with bilevel positive airway pressure by nasal mask 显示文摘 | Lo Coco A Vitale G Marchese S | 2001 | Monaldi Arch Chest Dia2001，63，： | 1 |
| 11 | Hypoxia-induced oxidative stress in ischemic retinopathy显示文摘 | Li S Y Fu Z J Lo A C | 2012 | Oxid Med Cell Longev2012，2012，42： | 1 |
| 12 | Compass-M1 broadcast codes in E2, E5b, and E6 frequency bands显示文摘 | Gao G X Chen A Lo S | 2009 | IEEE Journal of Selected Topics in Signal Processing2009，3，4： | 1 |
| 13 | Interventional treatment of sialoliths in main salivary glands 显示文摘 | Cannizzaro F Lo Casto A | 2002 | Radiol Med(Torino)2002，103，4： | 1 |
| 14 | Petrogenesis of post-orogenic syenites in the Sulu Orogenic Belt, East China: geochronological, geochemical and Nd-Sr isotopic evidence 显示文摘 | Yang Jin-hui Chung Sun-lin Wilde S A Wu Fu-yuan Chu Mei-fei Lo Ching-hua Fan Hong-rui | 2005 | Chemical Geology2005，214，12： | 1 |
| 15 | Physico-chemical treatment techniques for wastewater laden with heavy metals显示文摘 | KURNIAWAN T A CHAN C LO W H BABEL S | 2006 | Chemical Engineering Journal2006，118，1： | 1 |
| 16 | Third-order nonlinear optical properties of a soluble conjugated polythiophene derivative显示文摘 | JENEKHE S A LO S K FLOM S R | 1989 | Applied Physics Letters1989，54，25： | 1 |
| 17 | Diagnosis and conservative management of female stress urinary incontinence显示文摘 | Dass A K Lo T S Khanuengkitkong S | 2013 | Gynecol Minim Invasive Ther2013，2，2： | 1 |
| 18 | Degradation of recalcilrant compounds from stabilized landfill leachate using a combination of ozone-GAC adsorption treatment 显示文摘 | Kurniawan T A Lo W H Chan G Y S | 2006 | Journal of Hazardous Materials2006，137，1： | 1 |
| 19 | Physico-ehemieal treatment techniques for wastewater laden with heavy metals 显示文摘 | Kurniawan T A Chan G Y S Lo W H | 2006 | Chemical Engineering Journal2006，118，12： | 1 |
| 20 | HMGA molecular network: From transcriptional regulation to chromatin remodeling 显示文摘 | Sgarra R Zammitti S Lo Sardo A | 2010 | Biochim Biophys Ac ta2010，1799，12： | 1 |
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