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| 1 | The PI3K/AKT Pathway and Renal Cell Carcinoma显示文摘The phosphatidylinositol 3 kinase(PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway,and thus is frequently activated as a cancer driver.More importantly,the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades,providing many potential targets for cancer therapy.Renal cell carcinoma(RCC) is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies.The PI3K/AKT pathway is modestly mutated but highly activated in RCC,representing a promising drug target.Indeed,PI3 K pathway inhibitors of the rapalog family are approved for use in RCC.Recent large-scale integrated analyses of a large number of patients have provided a molecular basis for RCC,reiterating the critical role of the PI3K/AKT pathway in this cancer.In this review,we summarize the genetic alterations of the PI3K/AKT pathway in RCC as indicated in the latest large-scale genome sequencing data,as well as treatments for RCC that target the aberrant activated PI3K/AKT pathway. | Huifang Guo Peter German Shanshan Bai Sean Barnes Wei Guo Xiangjie Qi Hongxiang Lou Jiyong Liang Eric Jonasch Gordon B.Mills Zhiyong Ding | 2015 | Journal of Genetics and Genomics2015，42，7： | 39 |
| 2 | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China显示文摘Enterovirus 71(EV71),one of the major causative agents for hand-foot-and-mouth disease(HFMD),has caused more than 100 deaths among Chinese children since March 2008.The EV71 genome encodes an RNAdependent RNA polymerase(RdRp),denoted 3D^(pol),which is central for viral genome replication and is a key target for the discovery of specific antiviral therapeutics.Here we report the crystal structures of EV71 RdRp(3D^(pol))and in complex with substrate guanosine-5'-triphosphate and analog 5-bromouridine-5'-triphosphate best to 2.4Åresolution.The structure of EV71 RdRp(3D^(pol))has a wider open thumb domain compared with the most closely related crystal structure of poliovirus RdRp.And the EV71 RdRp(3D^(pol))complex with GTP or Br-UTP bounded shows two distinct movements of the polymerase by substrate or analogue binding.The model of the complex with the template:primer derived by superimposition with foot-and-mouth disease virus(FMDV)3D/RNA complex reveals the likely recognition and binding of template:primer RNA by the polymerase.These results together provide a molecular basis for EV71 RNA replication and reveal a potential target for anti-EV71 drug discovery. | Yang Wu Zhiyong Lou Yi Miao Yue Yu Hui Dong Wei Peng Mark Bartlam Xuemei Li Zihe Rao | 2010 | Protein & Cell2010，1，5： | 30 |
| 3 | Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species显示文摘 | Chen-chun ZHONG Feng CHEN Jun-ling YANG Wei-wei JIA Li LI Chen CHENG Fei-fei DU Su-ping ZHANG Chengying XIE Na-ting ZHANG Olajide E OLALEYE Feng-qing WANG Fang XU Li-guang LOU Dong-ying CHEN Wei NIU Chuan LI | 2018 | Acta Pharmacologica Sinica2018，39，6： | 24 |
| 4 | Bi-directional Selection in Upland Rice Leads to Its Adaptive Differentiation from Lowland Rice in Drought Resistance and Productivity显示文摘Drought resistance is required in rice breeding to address the challenge of frequent droughts . However, the evolutionary mechanism of rice drought resistance is not fully understood. We investigated the genetic differentiation between upland and lowland rice domesticated in agro-ecosystems with contrasting water-soil conditions using genome-wide SNPs. We estimated morphological differences among upland and lowland rice in drought resistance and productivity through common garden experiments. Upland rice had better drought resistance but poorer productivity. The negative correlations between traits of drought resistance and productivity are attributed to the underlying genetic trade-offs through tight linkages (e.g., DCA1 and OsCesA7) or pleiotropic effects (e.g., LAX1). The genetic trade-offs are comm on and greatly shape the evolutio n of drought resista nee in upland rice . In genomic regions associated with both productivity and drought resistance, signs of balancing selection were detected in upland rice, while signs of directional selection were detected in lowland rice, potentially contributing to their adaptive differentiation. Signs of balancing selection in upland rice resulted from bi-directional selection during its domestication in drought-prone upland agro-ecosystems.Using genome-wide association analysis, we ide ntified several valuable quantitative trait loci associated with drought resista nee, for which highly differentiated genes should be considered candidates. Bi-directional selection breaking tight linkages by accumulating recombination events would be applicable in breeding water-saving and droughtresistance rice. | Hui Xia Zhi Luo Jie Xiong Xiaosong Ma Qiaojun Lou Haibin Wei Jie Qiu Hua Yang Guolan Liu Longjiang Fan Liang Chen Lijun Luo | 2019 | Molecular Plant2019，12，2： | 16 |
| 5 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 6 | A conodont-based Middle Triassic age assignment for the Luoping Biota of Yunnan, China显示文摘The Luoping Biota consists of abundant and well-preserved marine fishes, reptiles, invertebrates, and plants. It occurs in the Middle Triassic Guanling Formation in Daaozi Village of Luoping County, Yun-nan Province, China. Based on conodonts, the Luoping Biota is determined to lie within the Nicoraella kockeli Zone, which is assigned to the Pelsonian substage of the Anisian. | ZHANG QiYue ZHOU ChangYong LU Tao XIE Tao LOU XiongYing LIU Wei SUN YuanYuan HUANG JinYuan ZHAO LaiShi | 2009 | Science China Earth Sciences2009，52，10： | 15 |
| 7 | Massive presacral bleeding during rectal surgery: From anatomy to clinical practice显示文摘AIM: To investigate control of two different types of massive presacral bleeding according to the anatomy of the presacral venous system. METHODS: A retrospective review was performed in 1628 patients with middle or low rectal carcinoma who were treated surgically in the Department of Colorectal Surgery, Changhai Hospital, Shanghai, China from January 2008 to December 2012. In four of these patients, the presacral venous plexus (n = 2) or basivertebral veins (n = 2) were injured with massive presacral bleeding during mobilization of the rectum. The first two patients with low rectal carcinoma were operated upon by a junior associate professor and the source of bleeding was the presacral venous plexus. The other two patients with recurrent rectal carcinoma were both women and the source of bleeding was the basivertebral veins.RESULTS: Two different techniques were used to con-trol the bleeding. In the first two patients with massive bleeding from the presacral venous plexus, we used suture ligation around the venous plexus in the area with intact presacral fascia that communicated with the site of bleeding (surrounding suture ligation). In the second two patients with massive bleeding from the basivertebral veins, the pelvis was packed with gauze, which resulted in recurrent bleeding as soon as it was removed. Following this, we used electrocautery applied through one epiploic appendix pressed with a long Kelly clamp over the bleeding sacral neural foramen where was felt like a pit Electrocautery adjusted to the highest setting was then applied to the clamp to 'weld' closed the bleeding point. Postoperatively, the blood loss was minimal and the drain tube was removed on days 4-7. CONCLUSION: Surrounding suture ligation and epiploic appendices welding are effective techniques for controlling massive presacral bleeding from presacral venous plexus and sacral neural foramen, respectively. | Zheng Lou Wei Zhang Rong-Gui Meng Chuan-Gang Fu | 2013 | World Journal of Gastroenterology2013，19，25： | 11 |
| 8 | Confirmation of pelitic granulite in the Altai orogen and its geological significance显示文摘The existence of pelitic granulite in the Altai orogen was confirmed for the first time by detailed petrographic research and P-T pseudosection modeling. The pelitic granulite has the assemblage of garnet + cordierite + K-feldspar + biotite + sillimanite + plagioclase + quartz with some samples containing the paragenesis of cordierite + spinel. Peak conditions of the pelitic granulite determined from the P-T pseudosection involved P = 0.5―0.6 GPa, T = 780―800℃, belonging to medium-to low-pressure type. SHRIMP U-Pb dating of zircon presented a metamorphic age of 292.8 ± 2.3 Ma. The discovery of pelitic granulite reflects an extensional environment with high heat flow in the southern margin of the Altai orogen during the Early Permian, which provides an important petrological constraint on the evolution of the Altai orogen. | WANG Wei WEI ChunJing WANG Tao LOU YuXing CHU Hang | 2009 | Chinese Science Bulletin2009，54，14： | 11 |
| 9 | Structural basis for the impact of phosphorylation on the activation of plant receptor-like kinase BAK1显示文摘 | Liming Yan Yuanyuan Ma Dan Liu Xiaochao Wei Yuna Sun Xiaoyue Chen Huadong Zhao Jingwen Zhou Zhiyong Wang Wenqing Shui Zhiyong Lou | 2012 | Cell Research2012，22，8： | 10 |
| 10 | Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer's disease显示文摘One of the early pathological hallmarks of Alzheimer's disease(AD) is the deposition of amyloid-β(Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes for early diagnosis of AD in the past decades. Optical imaging, particularly near-infrared fluorescence(NIRF) imaging, has emerged as a safe, low cost, real-time, and widely available technique, providing an attractive approach for in vivo detection of Aβ plaques among many different imaging techniques. In this review,we provide a brief overview of the state-of-the-art development of NIRF Aβ probes and their in vitro and in vivo applications with special focus on design strategies and optical, binding, and brain-kinetic properties. | Hongjuan Tong Kaiyan Lou Wei Wang | 2015 | Acta Pharmaceutica Sinica B2015，5，1： | 9 |
| 11 | Alleviation by abscisic acid of Al toxicity in rice bean is not associated with citrate efflux but depends on ABI5-mediated signal transduction pathways显示文摘Under conditions of aluminum(Al) toxicity,which severely inhibits root growth in acidic soils, plants rapidly alter their gene expression to optimize physiological fitness for survival. Abscisic acid(ABA) has been suggested as a mediator between Al stress and gene expression, but the underlying mechanisms remain largely unknown. Here,we investigated ABA-mediated Al-stress responses, using integrated physiological and molecular biology approaches.We demonstrate that Al stress caused ABA accumulation in the root apex of rice bean(Vigna umbellata [Thunb.] Ohwi &Ohashi), which positively regulated Al tolerance. However,this was not associated with known Al-tolerance mechanisms. Transcriptomic analysis revealed that nearly one-third of the responsive genes were shared between the Al-stress and ABA treatments. We further identified a transcription factor, ABI5, as being positively involved in Al tolerance. Arabidopsis abi5 mutants displayed increased sensitivity to Al, which was not related to the regulation of AtALMT1 and AtMATE expression. Functional categorization of ABI5-mediated genes revealed the importance of cell wall modification and osmoregulation in Al tolerance, a finding supported by osmotic stress treatment on Al tolerance. Our results suggest that ABA signal transduction pathways provide an additional layer of regulatory control over Al tolerance in plants. | Wei Fan Jia Meng Xu Pei Wu Zhi Xin Yang He Qiang Lou Wei Wei Chen Jian Fen Jin Shao Jian Zheng Jian Li Yang | 2019 | Journal of Integrative Plant Biology2019，61，2： | 9 |
| 12 | Ultrafine particle emission characteristics of diesel engine by on-board and test bench measurement显示文摘This study investigated the emission characteristics of ultrafine particles based on test bench and on-board measurements. The bench test results showed the ultrafine particle number concentration of the diesel engine to be in the range of (0.56-8.35)×10 8cm-3. The on-board measurement results illustrated that the ultrafine particles were strongly correlated with changes in real-world driving cycles. The particle number concentration was down to 2.0×106cm-3 and 2.7×107cm-3 under decelerating and idling operations and as high as 5.0×108cm-3 under accelerating operation. It was also indicated that the particle number measured by the two methods increased with the growth of engine load at each engine speed in both cases. The particle number presented a 'U' shaped distribution with changing speed at high engine load conditions, which implies that the particle number will reach its lowest level at medium engine speeds. The particle sizes of both measurements showed single mode distributions. The peak of particle size was located at about 50-80nm in the accumulation mode particle range. Nucleation mode particles will significantly increase at low engine load operations like idling and decelerating caused by the high concentration of unburned organic compounds. | Cheng Huang Diming Lou Zhiyuan Hu Piqiang Tai Di Yao Wei Hu Peng Li Jin Ren Changhong Chen | 2012 | Journal of Environmental Sciences2012，24，11： | 8 |
| 13 | New small-molecule drug design strategies for fighting resistant influenza A显示文摘In fluenza A virus is the major cause of seasonal or pandemic flu worldwide. Two main treatment strategies–vaccination and small molecule anti-in fluenza drugs are currently available. As an effective vaccine usually takes at least 6 months to develop, anti-in fluenza small molecule drugs are more effective for the fi rst line of protection against the virus during an epidemic outbreak, especially in the early stage. Two major classes of anti-in fluenza drugs currently available are admantane-based M2 protein blockers(amantadine and rimantadine) and neuraminidase(NA) inhibitors(oseltamivir, zanamivir, and peramivir). However, the continuous evolvement of in fluenza A virus and the rapid emergence of resistance to current drugs, particularly to amantadine, rimantadine, and oseltamivir, have raised an urgent need for developing new anti-in fluenza drugs against resistant forms of in fluenza A virus. In this review,we fi rst give a brief introduction of the molecular mechanisms behind resistance, and then discuss new strategies in small-molecule drug development to overcome in fluenza A virus resistance targeting mutant M2 proteins and neuraminidases, and other viral proteins not associated with current drugs. | Zuyuan Shen Kaiyan Lou Wei Wang | 2015 | Acta Pharmaceutica Sinica B2015，5，5： | 8 |
| 14 | MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells显示文摘MicroRNAs 玩在 carcinogenesis 和肿瘤的重要角色进行。肺癌症是世界范围的癌症死亡的领先的原因。在这研究, miR-181a-5p 的功能在 non-small-cell 肺癌症(NSCLC ) 被调查。结果证明 miR-181a-5p 显著地在 NSCLC 纸巾和房间线被减少。有 miR-181a-5p 的 A549 房间 transfected 的增长和迁居模仿显著地被禁止。酶活动试金结果证明 Kras 的二个有约束力的地点能被 miR-181a-5p 直接指向。而且, Kras 由在 transcriptional 和翻译层次的 miR-181a-5p 是下面调整的。调停 SiRNA 的 Kras 下面规定能模仿 miR-181a-5p 的效果在 A549 模仿房间。我们的调查结果建议 miR-181a-5p 由部分指向 Kras 在肿瘤抑制起一个潜在的作用并且在 NSCLC 病人有潜在的治疗学的申请。 | Zhongliang Ma Xiang Qiu Detao Wang Yanli Li Bingjie Zhang Tianwei Yuan Jiali Wei Botao Zhao Xintai Zhao Jiatao LOU Yan Jin Youxin Jin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 15 | Successful Production of an All-Female Common Carp (Cyprinus carpio L.) Population Using cyp17a1-Deficient Neomale Carp显示文摘Due to sexual dimorphism in the growth of certain cultured fish species,the production of monosex fishes is desirable for the aquaculture industry.Nowadays,the most widely practiced technique available for the mass production of monosex fish populations is sex steroid-induced sex reversal.Here,a novel strategy for the successful production of all-female(AF)common carp(Cyprinus carpio L.),to take advantage of the sexual dimorphism in growth documented in this species,has been developed using genetic engineering via single gene-targeting manipulation without any exogenous hormone treatments.Male and female heterozygous cyp17a1-deficient common carp were first obtained using the clustered regularly interspaced short palindromic repeats/CRISPR-associated endonuclease 9(CRISPR/Cas9)technique.An all-male phenotype for homozygous cyp17a1-deficient carp,regardless of the individuals’sexdetermination genotypes(XY or XX),has been observed.A male-specific DNA marker newly identified in our laboratory was used to screen the neomale carp population with the XX genotype from the cyp17a1-deficient carp.These neomale carp develop a normal testis structure with normal spermatogenesis and sperm capacity.The neomale common carp were then mated with wild-type(WT)females(cyp17a1^(+/+)XX genotype)using artificial fertilization.All the AF offspring sample fish from the neomale-WT female mating were confirmed as having the cyp17a^(1+/-)XX genotype,and normal development of gonads to ovaries was observed in 100.00%of this group at eight months post-fertilization(mpf).A total of 1000 carp fingerlings,500 from the WT male and female and 500 from the neomale and WT female mating,were mixed and reared in the same pond.The average body weight of cyp17a1^(+/-)XX females was higher by 6.60%(8 mpf)and 32.66%(12 mpf)than that of the control common carp.Our study demonstrates the first successful production of a monosex teleost population with the advantages of sexual dimorphism in growth using genetic manipulation targeting a single locus. | Gang Zhai Tingting Shu Kuangxin Chen Qiyong Lou Jingyi Jia Jianfei Huang Chuang Shi Xia Jin Jiangyan He Donghuo Jiang Xueqiao Qian Wei Hu Zhan Yin | 2022 | Engineering2022，8，1： | 7 |
| 16 | Exogenous Hematin Alleviates Mercury-induced Oxidative Damage in the Roots of Medicago sativa显示文摘在现在的学习,我们评估了保护的效果外长他我 oxygenase-1 (HO-1 EC 1.14.99.3 ) 对在苜蓿(Medicago sativa L.) 的根的导致水银的氧化损坏的 inducer 血色素。暴露于水银(HgCl ) 的植物每根延伸的氧化,以及抑制展出了类脂化合物的重要增加。然而,到对待的 HgCl (100 omol/L ) 的补充有效地种的血色素(50 oM ) 每氧化减少了类脂化合物并且部分增加了根延伸。这些回答被一氧化碳(公司) 的水溶液的申请与 50% 浸透模仿。另外,有血色素的处理能在根纸巾导致 HO-1 抄本的有势力正式就职,作为检测 12 h 列在后面处理。而且,抗氧化剂酶,包括的谷胱甘肽 reductase , monodehydroascorbate reductase 和超级氧化物 dismutase 活动的激活,和 lipoxygenase 活动的减少,被血色素在 12 h 或 24 h 导致,它被每膜正直的氧化和损失的为类脂化合物的察觉的组织化学的染色进一步证实。而, ascorbate 过氧化物酶和 guaiacol 过氧化物酶 isozyme 活动或他们的抄本被减少分别地,显示那过氧化氢可能充当一个信号调停在处理的开始的 Hg 忍耐。血色素的改善效果是特定的,自从 CO scavenger 血红素差别颠倒了上述行动。总起来说,我们的结果建议血色素在保护植物免于导致 Hg 的氧化损坏展出一个重要角色。 | Yi Han Wei Xuan Tian Yu Wen-Bing Fang Tian-Ling Lou Yin Gao Xiao-Yue Chen XiaoXiao Wen-Biao Shen | 2007 | Journal of Integrative Plant Biology2007，49，12： | 7 |
| 17 | Phase Equilibria of Hornblende-Bearing Eclogite in the Western Dabie Mountain,Central China显示文摘高压(HP ) 在西方的 Dabie 山的 eclogite 围住众多的角闪石,主要 barroisite。变形的磅状况,磅路径和它的矿物质同等发育不全仍然在争论的山峰上的意见。通常, HP eclogite 包含石榴石, omphacite,角闪石和石英,与或没有 glaucophane,黝帘石和 phengite。石榴石与 X Mg 增加, X Ca 和 X Mn 从核心减少到边界,它显示进步变态。最近开发的磅假节方法建模的 HP eclogite 的阶段 equilibria 显示出下列:(1 ) 石榴石的生长带状配列记录一条进步的变形的磅路径从预先达到顶点在到一座山峰的 508 ° C -514 ° C 的 1.9 2.1 GPa 的状况在为 HP eclogite 的 528 ° C -531 ° C 的 2.3 2.5 GPa 之一;(2 ) 山峰矿物质集合是 garnet+omphacite+glaucophane+quartz ± p hengite,与 lawsonite 基因的可能的帕拉;( 3 )广泛的角闪石由于解压缩主要源于 glaucophane ,部分 omphacite 甚至一点石榴石,一些在山峰以后的阶段期间加热,主要代表大约 1.4 1.6 GPa 和 580 °C -640°C,和他们的生长的条件被 lawsonite 的脱水赞成进黝帘石或绿帘石,但是大多数在 HP eclogite 的石榴石, omphacite 或 phengite 仍然以山峰状况保存他们的作文,并且他们不显然是有角闪石的 equilibrious 。 | ZHANG Jingsen WEI Chunjing LOU Yuxing SU Xiangli | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 7 |
| 18 | Recent advances in low-dimensional semiconductor nanomaterials and their applications in high-performance photodetectors显示文摘Low-dimensional(including two-dimensional[2D],one-dimensional[1D],and zero-dimensional[0D])semiconductor materials have great potential in electronic/optoelectronic applications due to their unique structure and characteristics.Many 2D(such as transition metal dichalcogenides and black phosphorus)and 1D(such as NWs)materials have demonstrated superior performance in field effect transistors,photodetectors(PDs),and some flexible devices.And in some hybrid structures of 0D materials and 1D or 2D materials,the modification of 1D and 2D devices by 0D materials is embodied.This type of hybrid heterostructure has a larger performance optimization compared with the original.In the application of PDs,the variety of lowdimensional materials and properties enable wide-spectrum detection from ultraviolet UV to infrared,which provide a potential option for PDs under various conditions.For flexible electronic devices,high performance and mechanical stability are two important features.Low-dimensional materials offer unparalleled advantages in flexible devices.In this review,we will focus on the various low-dimensional materials that have been extensively studied and their applications in the electronics/optoelectronic and flexible electronics.From the composition and lattice structure of materials(including alloys)to the construction of various devices and heterostructures,we will introduce their application and recent development under various conditions.These works can provide valuable guidance for the construction and application of more highperformance and multifunctional devices. | Jingzhi Fang Ziqi Zhou Mengqi Xiao Zheng Lou Zhongming Wei Guozhen Shen | 2020 | InfoMat2020，2，2： | 7 |
| 19 | Combination of olfactory test and substantia nigra transcranial sonopraphy in the differential diagnosis of Parkinson’s disease:a pilot study from China显示文摘Objectives:Both hyposmia and substania nigra(SN)hyperechogenicity on trascranial sonography(TCS)were risk markers for idiopathic Parkinson’s disease(PD),which was beneficial to the differential diagnosis of the disease.However,each of their single diagnostic value is often limited.The purpose of present study was to explore whether the combination of olfactory test and TCS of SN could enhance the differential diagnostic power in Chinese patients with PD.Methods:Thirty-seven patients with PD and twenty-six patients with essential tremor(ET)were evaluated on 16-item odor identification test from extended version of sniffin’sticks and TCS of SN.The frequency of hyposmia and SN hyperechogenicity in each group was compared.The sensitivity,specificity,positive predictive value(PPV)and negative predictive value(NPV)of the two clinical biomarkers were analyzed.Results:The frequency of hyposmia in patients with PD was significantly higher than in patients with ET(62.2%VS.3.8%,P=0.000).The frequency of SN hyperechogenicity in patients with PD was significantly higher than in ET subjects(48.6%VS.15.4%,P=0.006).The combination of hyposmia and SN hyperechogenicity(if either one or both present)discriminated patients with PD from ET with a sensitivity of 78.4%and 29.7%,specificity of 80.8%and 100%,PPV of 85.3%and 100%,and NPV of 72.4%and 50.0%,respectively.Conclusions:Our preliminary data suggested that the combination of hyposmia and SN hyperechogenicity could improve the diagnostic potential for discriminating Chinese patients with PD from ET. | Wei Chen Yu-Yan Tan Yun-Yun Hu Wei-Wei Zhan Li Wu Yue Lou Xi Wang Yi Zhou Pei Huang Yuan Gao Qin Xiao Sheng-Di Chen | 2012 | Translational Neurodegeneration2012，1，1： | 6 |
| 20 | Review on the recent progress of laser frontiers in China显示文摘The discussion on laser science and technology during the 'Laser Frontier' forum on 20 to 21 October 2012 in Beijing provided a global overview of laser development status and trends. Several frontiers in the application and industrial development of laser science and technology in China are reviewed. Suggestions on several aspects of China's laser technology and industry development, especially on a number of laser technology fields and their applications that are closely related to the national economy and industry, are proposed. | LIN ZunQi CHEN WeiBiao LOU QiHong FAN Wei XIANG ShiQing XUE HuiBin | 2013 | Science China(Technological Sciences)2013，56，7： | 6 |
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