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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | MicroRNA-185通过靶向调节DN-MT1/PTEN/Akt通路抑制肝细胞癌的生长显示文摘近来研究表明miRNAs与肝癌的发生密切相关,然而单个miRNAs的具体作用机制仍未完全阐明。作者对microR-NA-185(miR-185)在肝细胞癌生物学功能和分子机制方面做了一些研究。实验发现,与非肿瘤性的肝脏实质相比, miR-185在人肝细胞癌组织中的表达减少;qRT-PCR检测显示,与原代肝细胞相比, miR-185在人肝细胞癌细胞中的表达下降;在体外人肝细胞癌细胞中miR-185的过表达会抑制细胞的增殖和侵袭,并且阻止SCID小鼠体内肿瘤的生长。miR-185的过表达能够抑制肝细胞癌细胞中DNMT13′端非翻译区域荧光素酶的活性,当 miR-185结合位点发生突变时,就不存在该效应;miR-185的复制或过表达会减少肝细胞癌细胞中DNMT1蛋白的表达。这些结果表明DNMT1是miR-185在肝细胞癌细胞中的靶向作用蛋白。 DNMT1在miR-185诱导抑制肝细胞癌的增殖中所起的作用,可进一步通过DNMT1的过表达阻止miR-185诱导抑制肝细胞癌细胞的增殖和侵袭这一事实所证实。 miR-185的复制或过表达能够减少PTEN启动子DNA甲基化并且提高PTEN的表达,从而抑制Akt磷酸化;如果DNMT1过表达,这些效应刚好相反。以上结果表明:miR-185靶向作用于DNMT1,通过诱导PTEN和抑制Akt,从而抑制肝细胞癌细胞的增殖,活化或激活miR-185可能成为肝细胞癌新的治疗策略之一。 | Qadir X V Han C Lu D 魏建国 许春伟 | 2014 | 临床与实验病理学杂志2014，30，12： | 12 |
| 3 | Variations in Wool Growth with Nutrient Supply in Northern China显示文摘Field studies on essessment of nutritional status of the grazing sheep were carried out in each of the three major grassland regions, the eastern Inner Mongolia and beyond grassland, the Inner Mongolia - Ningxia - Gansu grassland and the Xinjiang grassland, in northern China. The results obtained showed that the wool production of fine wool sheep in these regions varied between regions and seasons, with similar seasonal patterns in all regions and that reducing the seasonal variations in nutrient supply would enhance wool production substantially. Nutritional limitations to wool growth of the grazing sheep in these regions were suggested, those were: the shortage of protein supply in winter and early spring; the poor quality of much of the pasture and the hay used as supplements, the low energy intake during winter which probably necessitated the use of body stores to maintain body temperature. | D X Lu,Iner(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)Z C Feng,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)H R Wang,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)R Z Yang,(Xinjiang Institute of Animal Science.Xinjiang Academy of Animal Science.Yiu Hou Road.Urumqi.Xinjiang Uygur Autonomous Region PRC)C T Ma,(Chinese Academy of Agricultural Sciences.Lanzhou.Gansu.PRC)D B Purser,(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)J R Lindsay(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)D W Peter(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014) | 1997 | 畜牧与饲料科学1997，22，S1： | 3 |
| 4 | In vivo chondrogenesis of adult bone-marrow-derived autologous mesenchymal stem cells显示文摘 | Chen J Wang C Lu S Wu J Guo X Duan C Dong L Song Y Zhang J Jing D Wu L Ding J Li D | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 5 | Synthesis of ultrafine zeolites by dry-gel conversion without any organic additive 显示文摘 | Hu D Xia Q H Lu X H | 2008 | Mater Res Bull2008，01，： | 1 |
| 6 | LDPC-based space-time coded OFDM systems over correlated fading channels: performance anatysis and receiver design显示文摘 | LU B WANG X D NARAYANAN K R | 2002 | IEEE Transactions on Communications2002，50，1： | 1 |
| 7 | Facile Synthesis of Straight Polyaniline Nanostick in Hydrogel 显示文摘 | Meng L H Lu Y Wang X D | 2007 | Macromolecules2007，40，9： | 1 |
| 8 | iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human显示文摘 | BERGAMASCHI D SAMUELS U LU X | 2003 | Nature Genetics2003，33，2： | 1 |
| 9 | Orientation analysis for rotated human face detection显示文摘 | Zhou J Lu X G Zhang D | 2002 | Image and Vision Compution2002，，20： | 1 |
| 10 | Behavior of Mg-6Al-xSi alloys during solution heat treatment at 420 ℃显示文摘 | LU Y Z WANG Q D ZENG X Q | 2001 | Materials Science and Engineering2001，301，： | 1 |
| 11 | Relation between the hypothalamic-pituitary-thyroid(HPT) axis and the hypothalamic-pituitary-adrenal(HPA)axis during repeated stress显示文摘 | HELMREICH D L PARFITT D B LU X Y | 2005 | Neuroendocrinology2005，81，3： | 1 |
| 12 | Studies on cutting propagation techniques of Spatholobus suberectus 显示文摘 | HUANG X Y LU H Z PENG Y D | 2010 | Medicinal Plant2010，1，3： | 1 |
| 13 | Anal Chim Acta显示文摘 | Cao D S Hu Q N Xu Q S Yang Y N Zhao J C Lu H M Zhang L X Liang Y Z | 2011 | 692(1-2):502011，692，12： | 1 |
| 14 | High-level expressionof bioactive recombinant human lysozyme in the milkof transgenic mice using a modified human lactoferrinBAC显示文摘 | LIU S LI X Q LU D | 2012 | Transgenic Res2012，21，2： | 1 |
| 15 | Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra 显示文摘 | Arimoto T Choi D Y Lu X | 2007 | Neurobiol Aging2007，28，6： | 1 |
| 16 | A new family of deploy- able mechanisms based on the Hoekens linkage显示文摘 | Lu S Zlatanov D Ding X | 2014 | Mech anismand Machine Theory2014，73，13： | 1 |
| 17 | Fano resonance and spectral compression i n a ring resonator drop filter with feedback显示文摘 | Lu Y Fu X Chu D | 2011 | Optics Communications2011，284，1： | 1 |
| 18 | Improving the tensile properties of carbon fiber reinforced cemeng by ozone treatment of the fiber显示文摘 | Fu X L Lu W M Chung D D L | 1996 | Cement and Conrete Research1996，26，10： | 1 |
| 19 | Removal of Pb(11) using the modified lawny grass: mechanism, kinetics, equilibrium and thermodynamic studies 显示文摘 | LU D CAO Q CAO X | 2009 | J Hazard Mater2009，166，： | 1 |
| 20 | Silver phosphate crystal growth by screw dislocation driven of dynamic-template 显示文摘 | Wang J D Liu J K Luo C X Lu Y Yang X H | 2013 | Crystal Growth & Design2013，13，11： | 1 |
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