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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Visualizing the microtubule-associated protein tau in the nucleus显示文摘Although tau is mainly known as an axonal microtubule-associated protein,many studies indicate that it is not restricted to this subcellular compartment.Assessing tau’s subcellular distribution,however,is not trivial as is evident from transgenic mouse studies.When human tau is over-expressed,it can be immunohistochemically localized to axons and the somatodendritic domain,modeling what is found in neurodegenerative diseases such as Alzheimer’s disease.Yet,in wild-type mice,despite its abundance,tau is difficult to visualize even in the axon.It is even more challenging to detect this protein in the nucleus,where tau has been proposed to protect DNA from damage.To establish a framework for future studies into tau’s nuclear functions,we compared several methods to visualize endogenous nuclear tau in cell lines and mouse brain.While depending on the fixation and permeabilization protocol,we were able to detect nuclear tau in SH-SY5Y human neuroblastoma cells,we failed to do so in N2a murine neuroblastoma cells.As a second method we used subcellular fractionation of mouse tissue and found that in the nucleus tau is mainly present in a hypophosphorylated form.When either full-length or truncated human tau was expressed,both accumulated in the cytoplasm,but were also found in the nuclear fraction.Because subcellular fractionation methods have their limitations,we finally isolated nuclei to probe for nuclear tau and found that the nuclei were free of cytoplasmic contamination.Together our analysis identifies several protocols for detecting tau in the nucleus where it is found in a less phosphorylated form. | LU Jing LI Ting HE RongQiao BARTLETT Perry F GTZ Jürgen | 2014 | Science China(Life Sciences)2014，57，4： | 11 |
| 3 | Role of the crystallite phase of TiO2 in heterogeneous photocatalysis for phenol oxidation in water显示文摘 | Ding Z Lu G Q Greenfield P F | 2000 | J Phys Chem B2000，104，19： | 1 |
| 4 | GRAdient broabcast: A Robust Data Delivery Protoeol for Large Scale Sensor Networks显示文摘 | YE F ZHONG G LU S | 2005 | ACM Wireless Networks2005，11，3： | 1 |
| 5 | Some theoretical considerations on wich structures under the dynamic response of sand impulsive loading显示文摘 | Zhu F Wang Z H Lu G X Nurick G | 2010 | Interna tional Journal of Impact Engineering2010，37，6： | 1 |
| 6 | Characteristics of or-ganic,nitrogen and phosphorus species released from ultra-sonic treatment of waste activated sludge显示文摘 | Wang X X Qiu Z F Lu S G | 2009 | Journal of Haz-ardous Materials2009，176，3： | 1 |
| 7 | Gene expression of manganese - contai- ning superoxidedismutase as a biomarker of manganese bioavailabihty for manganesesources in broilers显示文摘 | Luo X G Li S F Lu L | 2007 | Poult Sci2007，86，5： | 1 |
| 8 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 9 | 显示文摘 | Lin H F Lu W Chen G H | 2007 | Physical B2007，400，： | 1 |
| 10 | A new type of DC arc plasma torch for low cost large area diamond deposition显示文摘 | Lu F X Zhong G F | 1998 | Diamond and Related Materials1998，76，： | 1 |
| 11 | Predictors of HIV infection and prevalence for syphilis infection among injection drug users in China: Community-based surveys along major drug trafficking routes 显示文摘 | Jia YJ Lu F Zeng G | 2008 | Harm Reduct J2008，5，： | 1 |
| 12 | Low-temperature- plasma-catalytic oxidation of formaldehyde in atmospheric- pressure gas streams 显示文摘 | DING H X ZHU A M LU F G | 2006 | Journal of Physics D: Applied- Physics2006，39，16： | 1 |
| 13 | Synthesis and dye separation performance of ferromagnetic hierarchical porous carbon显示文摘 | Wang D W Li F Lu G Q | 2008 | Carbon2008，46，12： | 1 |
| 14 | Vertical migration of sound scatters in the southern Yellow Sea in summer显示文摘 | LU L G L1U J YU F | 2007 | Ocean Science Journa2007，42，1： | 1 |
| 15 | Frontal polymerization synthesis of monolithic macroporous polymers显示文摘 | Yah Q Z Lu G D Zhang W F | 2007 | Advanced Functional Materials2007，17，16： | 1 |
| 16 | Highly flexible polyelectrolyte nanotu bes 显示文摘 | Ai S F Lu G He Q | 2003 | J Am Chem Soc2003，125，11： | 1 |
| 17 | An analysis of expressed sequence tags of developing castor endosperm using a full - length cDNA library 显示文摘 | Lu C F Wallis J G Browse J | 2007 | BMC Plant biology2007，7，： | 1 |
| 18 | Compressive behaviour of aluminium foams at low and medium strain rates 显示文摘 | Ruan D Lu G Chen F L | 2002 | Composite Structures2002，57，14： | 1 |
| 19 | Preclinical lymphatic imaging显示文摘 | Zhang F Niu G Lu G | 2011 | Mol Imaging Biol2011，13，4： | 1 |
| 20 | Role of the crystallite phase of TiO2 in heterogeneous photocatalysis for phenol oxidation in water显示文摘 | Ding Z Lu G Q Greenfield P F | 2000 | JPhys Chem B2000，104，19： | 1 |
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