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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Selection of optimal window length using STFT for quantitative SNR analysis of LFM signal显示文摘An adaptive approach to select analysis window parameters for linear frequency modulated(LFM) signals is proposed to obtain the optimal 3 dB signal-to-noise ratio(SNR) in the shorttime Fourier transform(STFT) domain.After analyzing the instantaneous frequency and instantaneous bandwidth to deduce the relation between the window length and deviation of the Gaussian window,high-order statistics is used to select the appropriate window length for STFT and get the optimal SNR with the right time-frequency resolution according to the signal characteristic under a fixed sampling rate.Computer simulations have verified the effectiveness of the new method. | Qingbo Yin Liran Shen Mingyu Lu Xiangyang Wang Zhi Liu | 2013 | Journal of Systems Engineering and Electronics2013，24，1： | 11 |
| 3 | Linear FM Signal Parameter Estimation Using STFT and FRFT显示文摘 | SHEN Liran YIN Qingbo LU Mingyu ZHANG Qi GUO Lili SHEN Tianen ZHAO Guoku NING Shushi | 2013 | Chinese Journal of Electronics2013，22，2： | 8 |
| 4 | Hybrid nano-scale Au with ITO structure for a high-performance near-infrared silicon-based photodetector with ultralow dark current显示文摘An internal photoemission-based silicon photodetector detects light below the silicon bandgap at room temperature and can exhibit spectrally broad behavior,making it potentially suited to meet the need for a near-infrared pure Si photodetector.In this work,the implementation of a thin Au insertion layer into an ITO/n-Si Schottky photodetector can profoundly affect the barrier height and significantly improve the device performance.By fabricating a nanoscale thin Au layer and an ITO electrode on a silicon substrate,we achieve a well-behaved ITO/Au/n-Si Schottky diode with a record dark current density of 3.7×10^(−7) A/cm^(2) at−1 V and a high rectification ratio of 1.5×10^(8) at±1 V.Furthermore,the responsivity has been obviously improved without sacrificing the dark current performance of the device by decreasing the Au thickness.Such a silicon-based photodetector with an enhanced performance could be a promising strategy for the realization of a monolithic integrated pure silicon photodetector in optical communication. | Xinxin Li Zhen Deng Jun Li Yangfeng Li Linbao Guo Yang Jiang Ziguang Ma Lu Wang Chunhua Du Ying Wang Qingbo Meng Haiqiang Jia Wenxin Wang Wuming Liu Hong Chen | 2020 | Photonics Research2020，8，11： | 4 |
| 5 | Dynamic flow resistivity based model for sound absorption of multi-layer sintered fibrous metals显示文摘The sound absorbing performance of the sintered fibrous metallic materials is investigated by employing a dynamic flow resistivity based model,in which the porous material is modeled as randomly distributed parallel fibers specified by two basic physical parameters:fiber diameter and porosity.A self-consistent Brinkman approach is applied to the calculation of the dynamic resistivity of flow perpendicular to the cylindrical fibers.Based on the solved flow resistivity,the sound absorption of single layer fibrous material can be obtained by adopting the available empirical equations.Moreover,the recursion formulas of surface impedance are applied to the calculation of the sound absorption coefficient of multi-layer fibrous materials.Experimental measurements are conducted to validate the proposed model,with good agreement achieved between model predictions and tested data.Numerical calculations with the proposed model are subsequently performed to quantify the influences of fiber diameter,porosity and backed air gap on sound absorption of uniform(single-layer)fibrous materials.Results show that the sound absorption increases with porosity at higher frequencies but decreases with porosity at lower frequencies.The sound absorption also decreases with fiber diameter at higher frequencies but increases at lower frequencies.The sound absorption resonance is shifted to lower frequencies with air gap.For multi-layer fibrous materials,gradient distributions of both fiber diameter and porosity are introduced and their effects on sound absorption are assessed.It is found that increasing the porosity and fiber diameter variation improves sound absorption in the low frequency range.The model provides the possibility to tailor the sound absorption capability of the sintered fibrous materials by optimizing the gradient distributions of key physical parameters. | MENG Han AO QingBo TANG HuiPing XIN FengXian LU TianJian | 2014 | Science China(Technological Sciences)2014，57，11： | 3 |
| 6 | A Modified Differential Evolution for Constrained Optimization显示文摘 | Zhang Xueliang Lu Qingbo | 2008 | ICIC- EL2008，2，2： | 1 |
| 7 | Selection ofoptimal window length using STFT for quantitative SNR a-nalysis of LFM signal 显示文摘 | Yin Qingbo Shen Liran Lu Mingyu | 2013 | IEEE Transactions on Journalof Systems Engineering and Electronics2013，24，1： | 1 |
| 8 | Genome-wide analysis of GH3 gene family in soybean( Glycine max)显示文摘 | Wei ZHAO Xinjie SHEN Wei GUO Qingbo YOU Yanjie YAO Jianhua LU Juncheng ZHANG Lei HUANG Bingbing DUAN Huarong LV Aili BAO Yongqing JIAO | 2016 | Oil Crop Science2016，1，2： | 1 |
| 9 | Bridgman growth and characterization of Bi 4 (Ge x Si 1? x ) 3 O 12 mixed crystals显示文摘 | Yan Zhang Jiayue Xu Qingbo He Baoliang Lu | 2013 | Journal of Crystal Growth2013，，： | 1 |
| 10 | On a Priori C^1,σ and W^2,ρ Estimates for a Parabolic Monge-Ampere Equation in the Gauss Curvature Flows 显示文摘 | HUANG Qingbo LU Guozhen | 2006 | Amer J Math2006，128，2： | 1 |
| 11 | A Comprehensive Overview of the Role of Visual Cortex Malfunction in Depressive Disorders: Opportunities and Challenges显示文摘Major depressive disorder(MDD)is a highly heterogeneous mental disorder,and its complex etiology and unclear mechanism are great obstacles to the diagnosis and treatment of the disease.Studies have shown that abnormal functions of the visual cortex have been reported in MDD patients,and the actions of several antidepressants coincide with improvements in the structure and synaptic functions of the visual cortex.In this review,we critically evaluate current evidence showing the involvement of the malfunctioning visual cortex in the pathophysiology and therapeutic process of depression.In addition,we discuss the molecular mechanisms of visual cortex dysfunction that may underlie the pathogenesis of MDD.Although the precise roles of visual cortex abnormalities in MDD remain uncertain,this undervalued brain region may become a novel area for the treatment of depressed patients. | Fangfang Wu Qingbo Lu Yan Kong Zhijun Zhang | 2023 | Neuroscience Bulletin2023，39，9： | 1 |
| 12 | FCS-MPC Strategy for PV Grid-Connected Inverter Based on MLD Model显示文摘In the process of grid-connected photovoltaic power generation,there are high requirements for the quality of the power that the inverter breaks into the grid.In this work,to improve the power quality of the grid-connected inverter into the grid,and the output of the system can meet the grid-connected requirements more quickly and accurately,we exhibit an approach toward establishing a mixed logical dynamical(MLD)model where logic variables were introduced to switch dynamics of the single-phase photovoltaic inverters.Besides,based on the model,our recent efforts in studying the finite control set model predictive control(FCS-MPC)and devising the output current full state observer are exciting for several advantages,including effectively avoiding the problem of the mixed-integer quadratic programming(MIQP),lowering the THD value of the output current of the inverter circuit,improving the quality of the power that the inverter breaks into the grid,and realizing the current output and the grid voltage same frequency and phase to meet grid connection requirements.Finally,the effectiveness of the mentioned methods is verified by MATLAB/Simulink simulation. | Xiaojuan Lu Qingbo Zhang | 2021 | Energy Engineering2021，118，6： | 0 |
| 13 | Synthesis of amorphous Pd-based nanocatalysts for efficient alcoholysis of styrene oxide and electrochemical hydrogen evolution显示文摘Amorphous nanomaterials with long-range disordered structures could possess distinct properties and promising applications,especially in catalysis,as compared with their conventional crystalline counterparts.It is imperative to achieve the controlled preparation of amorphous noble metal-based nanomaterials for the exploration of their phase-dependent applications.Here,we report a facile wet-chemical reduction strategy to synthesize various amorphous multimetallic Pd-based nanomaterials,including PdRu,PdRh,and PdRuRh.The phase-dependent catalytic performances of distinct Pd-based nanomaterials towards diverse catalytic applications have been demonstrated.Specifically,the usage of PdRu nanocatalysts with amorphous and crystalline face-centered cubic(fcc)phases can efficiently switch the ring-opening route of styrene oxide to obtain different products with high selectivity through alcoholysis reaction and hydrogenation reaction,respectively.Moreover,when used as an electrocatalyst for hydrogen evolution reaction(HER),the synthesized amorphous PdRh nanocatalyst exhibits low overpotential and high turnover frequency values,outperforming its crystalline fcc counterpart and most of the reported Pd-based HER electrocatalysts. | Yiyao Ge Jingjie Ge Biao Huang Xixi Wang Guigao Liu Xiang-Huan Shan Lu Ma Bo Chen Guanghua Liu Songmo Du An Zhang Hongfei Cheng Qingbo Wa Shiyao Lu Lujiang Li Qinbai Yun Kuo Yuan Qinxin Luo Zhichuan J.Xu Yonghua Du Hua Zhang | 2023 | Nano Research2023，16，4： | 0 |
| 14 | Experimental Investigation of Flame Structure and Combustion Limit During Premixed Methane/Air Jet Flame and Sidewall Interaction显示文摘The effects of inlet gas parameters and sloping sidewall angle on the flame structure and combustion limit with and without sidewall were experimentally investigated.Flame height and impact angle were obtained by chemiluminescence intensity analysis of CH*distribution.First,the combustion characteristics of flame with and without sidewall at different equivalence ratios were explored;then,the influence of Reynolds number and inlet gas temperature on flame structure and combustion limit of v-shaped flame with sidewall were analyzed,and the results with sidewall were compared with those without sidewall.Finally,the variation trend of flame parameters with different sloping sidewall angles was analyzed.The experimental results show that the existence of sidewall makes flame shape change from“M-shaped”to“inverted N-shaped”,and conical shape to trapezoidal shape.The inhibition effect of sidewall on flame stretching downstream is strengthened with the increase in Reynolds number;but as the temperature of the inlet gas increases,the inhibitory effect is obviously weakened.When sloping sidewall angle decreases from 90°to 55°at 5°intervals,flame height and impact angle of v-shaped flame reach the extreme value whenβ=80°.Compared with the case without sidewall,the range of v-shaped flame with sidewall has no obvious trend of broadening or shrinking when inlet gas temperature is increased;however,as sloping sidewall angle decreases,the range of the v-shaped flame shrinks obviously and flammability limit increases significantly. | Ying Chen Jianfeng Pan Qingbo Lu Yu Wang Chenxin Zhang | 2021 | Energy Engineering2021，118，1： | 0 |
| 15 | Antisite defect types and temporal evolution characteristics of D0_(22)-Ni_3V structure:Studied by the microscopic phase field显示文摘Microscopic phase field simulation is performed to study antisite defect type and temporal evolution characteristic of D022-Ni3V structure in Ni75AlxV25-x ternary system.The result demonstrates that two types of antisite defect VNi and NiV coexist in D022 structure;however,the amount of NiV is far greater than VNi;when precipitates transform from D022 singe phase to two phases mixture of D022 and L12 with enhanced Al:V ratio,the amount of VNi has no evident response to the secondary L12 phase,while NiV exhibits a definitely contrary variation tendency:NiV rises without L12 structure precipitating from matrix but declines with it;temporal evolution characteristic and temperature dependent antisite defect VNi,NiV are also studied in this paper:The concentrations of the both defects decline from high antistructure state to equilibrium level with elapsed time but rise with elevated temperature;the ternary alloying element aluminium atom occupies both α and β sublattices of D022 structure with a strong site preference of substituting α site. | ZHANG Jing,CHEN Zheng,ZHANG MingYi,LAI QingBo,LU YanLi & WANG YongXin School of Material Science and Engineering,Northwestern Polytechnical University,Xi’an 710072,China | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，8： | 0 |
| 16 | Effects of human activities on mercury in the environment in Xi’an area, China显示文摘 | Yongqing JIN Xiaojuan WANG Chengxiao ZHANG Julia LU Qingbo DUAN | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 17 | Research on Mixed Logic Dynamic Modeling and Finite Control Set Model Predictive Control of Multi-Inverter Parallel System显示文摘Parallel connection of multiple inverters is an important means to solve the expansion,reserve and protection of distributed power generation,such as photovoltaics.In view of the shortcomings of traditional droop control methods such as weak anti-interference ability,low tracking accuracy of inverter output voltage and serious circulation phenomenon,a finite control set model predictive control(FCS-MPC)strategy of microgrid multiinverter parallel system based on Mixed Logical Dynamical(MLD)modeling is proposed.Firstly,the MLD modeling method is introduced logical variables,combining discrete events and continuous events to form an overall differential equation,which makes the modeling more accurate.Then a predictive controller is designed based on the model,and constraints are added to the objective function,which can not only solve the real-time changes of the control system by online optimization,but also effectively obtain a higher tracking accuracy of the inverter output voltage and lower total harmonic distortion rate(Total Harmonics Distortion,THD);and suppress the circulating current between the inverters,to obtain a good dynamic response.Finally,the simulation is carried out onMATLAB/Simulink to verify the correctness of the model and the rationality of the proposed strategy.This paper aims to provide guidance for the design and optimal control of multi-inverter parallel systems. | Xiaojuan Lu Mengqiao Chen Qingbo Zhang | 2023 | Energy Engineering2023，120，3： | 0 |
| 18 | Magneto-mechanical effect of magnetic microhydrogel for improvement of magnetic neuro-stimulation显示文摘Superparamagnetic iron oxide(SPIO)nanoparticles play an important role in mediating precise and effective magnetic neurostimulation and can help overcome limitations related to penetration depth and spatial resolution.However,nanoparticles readily diffuse in vivo,decreasing the spatial resolution and activation efficiency.In this study,we employed a microfluidic means to fabricate injectable microhydrogels encapsulated with SPIO nanoparticles,which significantly improved the stability of nanoparticles,increased the magnetic properties,reinforced the stimulation effectivity.The fabricated magnetic microhydrogels were highly uniform in size and sphericity,enabling minimally invasive injection into brain tissue.The long-term residency in the cortex up to 22 weeks and the safety of brain tissue were shown using a mouse model.In addition,we quantitatively determined the magneto-mechanical force yielded by only one magnetic microhydrogel using a video-based method.The force was found to be within 7–8 pN under 10 Hz magnetic stimulation by both theoretical simulation and experimental measurement.Lastly,electrophysiological measurement of brain slices showed that the magnetic microhydrogels offer significant advantages in terms of neural activation relative to dissociative SPIO nanoparticles.A universal strategy is thus offered for performing magnetic neuro-stimulation with an improved prospect for biomedical translation. | Le Xue Qing Ye Linyuan Wu Dong Li Siyuan Bao Qingbo Lu Sha Liu Dongke Sun Zonghai Sheng Zhijun Zhang Ning Gu Jianfei Sun | 2023 | Nano Research2023，16，5： | 0 |
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