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| 1 | Simulation of oasis breeze circulation in the arid region of the Northwestern China显示文摘 | LU Shihua, AN Xingqin & CHEN YuchunCold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 730000, China | 2004 | Science China Earth Sciences2004，47，z1： | 12 |
| 2 | Estimation of Turbulent Fluxes Using the Flux-Variance Method over an Alpine Meadow Surface in the Eastern Tibetan Plateau显示文摘流动变化类似关系和数量的垂直转移在表面的不同类型上展出不同,导致在估计用流动变化方法的狂暴的流动的数量之中的相对运输效率的不同 parameterization 途径。我们调查了在雨季期间在中间的水文学条件下面在夏天在东方西藏的高原在一块开、同类、扁平的草地上使用 eddycovariance 大小的这些问题。处于不稳定的条件,温度,水蒸汽,和 CO2 跟随了流动变化类似关系,但是没出现在精确一样的方法由于不同角色(活跃或被动) 这些数量。温度,水蒸汽和 CO2 的类似常数被发现分别地是 1.12, 1.19 和 1.17。热交通比水蒸汽和 CO2 更有效。基于估计的理智的热流动,到水蒸汽和 CO2 的热的相对运输效率的五个 parameterization 方法被检验估计潜伏的热和 CO2 流动。流动变化类似关系的本地决心的策略为潜伏的热和 CO2 流动的评价被推荐。这条途径对代表平均相对运输效率更好,并且对技术上更容易适用,与另外的更复杂的相比。 | WANG Shaoying ZHANG Yu LU Shihua LIU Heping SHANG Lunyu | 2013 | Advances in Atmospheric Sciences2013，30，2： | 11 |
| 3 | 寨卡病毒引起小鼠睾丸损伤并导致雄性不育显示文摘虽然寨卡病毒与其他黄病毒属成员,如登革热病毒、乙型脑炎病毒和两尼罗病毒都是通过蚊媒传播,但是前人的研究发现寨卡病毒在精液中存在数月之久,暗示其性接触传播的可能性。本研究表明寨卡病毒影响雄性生殖系统,提示了其对男性健康的潜在危害。 | Wenqiang Ma Shihua Li Shuoqian Ma Lina Jia Fuchun Zhang Yong Zhang Jingyuan Zhang Gary Wong Shanshan Zhang Xuancheng Lu Mei Liu Jinghua Yan Wei Li Chuan Qin Daishu Han Chengfeng Qin Na Wang 李向东 高福 | 2017 | 科学新闻2017，19，4： | 5 |
| 4 | HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia显示文摘Dear Editor,β-Thalassemia is a common severe genetic disease caused by mutations in HBB and affects approximately 1.5% of the global population (Origa, 2017). In southern China, the carrier rate of β-thalassemia is as high as 6.43%, creating a high socio-economic burden (Xiong et al., 2010). In adult humans, there are three types of hemoglobin: HbA1 (~97%), HbA2 (~2%) and HbF (~1%). HbA1 (α2β2) is composed of two a-globin and two β-globi n sub units en coded by HBA and HBB, respectively;HbF (α2β2)is made up of two α-globin subunits and two β-globin sub units en coded by HBG. Mutations in the coding region or regulatory region of HBB are involved in β-thalassemia pathogenesis. Except for some rare dominant mutations, most HBB mutations are recessive (Origa, 2017). Depending on the mutation type, the β-globin level will either be reduced or completely depleted, resulting in α-globin accumulation and precipitation. These α-globin precipitates lead to red blood cell death, resulting in anemia and tissue damage, and even death in thalassemia major patients. Blood transfusions can help slow disease progression but lead to iron overload, ultimately resulting in iron toxicity. Bone marrow transfer is the only cure in the clinic and is available only to a small percentage of patients with human leukocyte antigervmatched donors. Recently, gene therapy and gene editing therapy have shown great promise in curing β-thalassemia (Glaser et al., 2015;Thompson et al., 2018). However, no appropriate animal models are available for evaluating the safety and efficacy of such advanced therapeutic strategies in vivo.β-thalassemia mice are the sole animal model available for research. However, substantial differences have been reported between the types and expressi on patter ns of human and mouse globins (McColl and Vadolas, 2016). Moreover, mice contain no fetal globin gene equivalent, and homozygous mutations of HBB in mouse for early models of β-thalassemia major or Cooley anemia are all embryonic lethal (Huo et al., 2009). Recently, significant phenotype and physiology differences have been reported between SIRT6- null mice and the non-human primate model (Zhang et al., 2018). Thus, an appropriate non-human primate model is needed for human β-thalassemia studies and treatments. | Yan Huang Chenhui Ding Puping Liang Duanduan Li Yu Tang Wei Meng Hongwei Sun Hongyu Lu Yu Chen Xueying Chen Qunshan Huang Jianpei Fang Canquan Zhou Shihua Yang Junjiu Huang | 2019 | Protein & Cell2019，10，7： | 4 |
| 5 | Offline experiment of land surface processes in Qinghai-Xizang Plateau显示文摘 | ZHANG Yanwu, LU Shihua, FENG Qi, HUANG Jing & HU ZeyongCold and Arid Regions Environmental and Engineering Institute, Chinese Academy of Sciences, Lanzhou 730000, China Resource Environment College, Lanzhou University, Lanzhou 730000, China | 2004 | Science China Earth Sciences2004，47，z1： | 2 |
| 6 | Tumor-associated macrophages provide a suitable microenvironment for non-small lung cancer invasion and progression显示文摘 | Rui Wang Jie Zhang Sufeng Chen Meng Lu Xiaoyang Luo Shihua Yao Shilei Liu Ying Qin Haiquan Chen | 2011 | Lung Cancer2011，，2： | 2 |
| 7 | Diagnostic Accuracy of Three-Dimensional Whole-Heart Magnetic Resonance Angiography to Detect Coronary Artery Disease with Invasive Coronary Angiography as a Reference:A Meta-Analysis显示文摘Objective:We aimed to evaluate the diagnostic performance of three-dimensional whole-heart magnetic resonance coronary angiography(MRCA)in detecting coronary artery disease(CAD)with invasive coronary angiography as the reference standard.Methods:We searched PubMed and Embase for studies evaluating the diagnostic performance of three-dimensional whole-heart MRCA for the diagnosis of CAD with invasive coronary angiography as the reference standard.The bivariate mixed-effects regression model was applied to synthesize available data.The clinical utility of whole-heart MRCA was calculated by the posttest probability based on Bayes’s theorem.Results:Eighteen studies were included,of which 16 provided data at the artery level.Patient-based analysis revealed a pooled sensitivity of 0.90(95%confi dence interval[CI]0.87–0.93)and specifi city of 0.79(95%CI 0.73–0.84),while the pooled estimates were 0.86(95%CI 0.82–0.89)and 0.89(95%CI 0.84–0.92),respectively,at the artery level.The areas under the summary receiver operating characteristic curve were 0.93(95%CI 0.90–0.95)and 0.92(95%CI 0.90–0.94)at the patient and artery levels,respectively.With a pretest probability of 50%,the patients’posttest probabilities of CAD were 81%for positive results and 11%for negative results.Conclusions:Whole-heart MRCA can be an alternative noninvasive method for diagnosis and assessment of CAD. | Shiqin Yu Chen Cui Minjie Lu Shihua Zhao | 2020 | Cardiovascular Innovations and Applications2020，，1： | 2 |
| 8 | Correlation and Significance of Midkine and Estrogen Receptor Beta Protein Expression in Non-Small Cell Lung Cancer显示文摘OBJECTIVE Midkine (MK),a new member of the heparin-binding growth factor family,was found recently to have a highexpression level in many carcinoma specimens,including thoseof the esophagus,gall bladder,pancreas,colorectum,breast andlung.Estrogen receptor beta (ER-β),a recently cloned estrogenreceptor subtype,was also found to be highly expressed in lungtumor tissue,in contrast to a lower level of expression in normallung tissue.However,few relevant studies on these proteins havebeen published.The aims of our study were to investigate theexpression of midkine and ER-β proteins in non-small cell lungcancer (NSCLC) and to examine the relationship between theirexpression and the clinicopathologic data as well as to analyse thecorrelation of their expression in NSCLC.METHODS By immunohistochemistry,MK and ER-β were ex-amined in 24 surgically resected cases of NSCLC with their corre-sponding paraneoplastic and normal lung tissues.RESULTS MK and ER-β were overexpressed in NSCLC.Thelevels of MK and ER-β expression in NSCLC were found to be sig-nificantly negatively correlated with the pathological classification(P=0.042 and 0.021,respectively),and their expression decreasedwith a raise in the classification.Spearman's correlation analysisshowed that the correlation of their expression in NSCLC wasstrong (correlation coefficient[r_s]= 0.535,P=0.007<0.01).CONCLUSION The expression levels of MK and ER-β to someextent reflect the malignant degree of NSCLC,and their combineddetection may be of great value in early diagnosis,treatments ofpatients with NSCLC and can predict the prognoses. | Shihua Zhang Guangfeng Zhao Qingling Wang Kaihua Lu Yayi Hou | 2008 | Chinese Journal of Clinical Oncology2008，5，6： | 2 |
| 9 | Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy显示文摘Chimeric antigen receptor-based T-cell immunotherapy is a promising strategy for treatment of hematological malignant tumors;however,its efficacy towards solid cancer remains challenging.We therefore focused on developing nanobody-based CAR-T cells that treat the solid tumor.CD105 expression is upregulated on neoangiogenic endothelial and cancer cells.CD105 has been developed as a drug target.Here we show the generation of a CD105-specific nanobody,an anti-human CD105 CAR-T cells,by inserting the sequences for anti-CD105 nanobody-linked standard cassette genes into AAVS1 site using CRISPR/Cas9 technology.Co-culture with CD105+target cells led to the activation of anti-CD105 CAR-T cells that displayed the typically activated cytotoxic T-cell characters,ability to proliferate,the production of pro-inflammatory cytokines,and the specific killing efficacy against CD105+target cells in vitro.The in vivo treatment with anti-CD105 CAR-T cells significantly inhibited the growth of implanted CD105+tumors,reduced tumor weight,and prolonged the survival time of tumor-bearing NOD/SCID mice.Nanobody-based CAR-T cells can therefore function as an antitumor agent in human tumor xenograft models.Our findings determined that the strategy of nanobody-based CAR-T cells engineered by CRISPR/Cas9 system has a certain potential to treat solid tumor through targeting CD105 antigen. | Fengzhen Mo Siliang Duan Xiaobing Jiang Xiaomei Yang Xiaoqiong Hou Wei Shi Cueva Jumbo Juan Carlos Aiqun Liu Shihua Yin Wu Wang Hua Yao Zihang Yu Zhuoran Tang Shenxia Xie Ziqiang Ding Xinyue Zhao Bruce D.Hammock Xiaoling Lu | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 2 |
| 10 | 23,24-Dihydrocucurbitacin B induces G2/M cell-cycle Arrest and Mitochondria Dependent Apoptosis in Human Breast Cancer Cells(Bcap37) 显示文摘 | Yang Lu Wu Shihua Zhang Qiuhui | 2007 | Cancer Letters2007，256，： | 1 |
| 11 | NUMERICAL SIMULATION FOR LASER BENDING OF SHEET METAL显示文摘0INTRODUCTIONLaserbendingofsheetmetalisanewflexibleformingtechnologyinrecentyears,whichdependsononlynonuniformheatingbutnot... | Li Weimin Lu Xiuchun Liu Zhubai Li Shihua Mechanical Engineering Institute, Yanshan University | 1998 | Chinese Journal of Mechanical Engineering1998，11，4： | 1 |
| 12 | Synchronization of an uncertain unified chaotic system via adaptive control显示文摘 | Chen Shihua Lu Jinhu | 2002 | Chaos Solitions and Fractals2002，14，2： | 1 |
| 13 | Atmospheric effects on winter SO 2 pollution in Lanzhou, China显示文摘 | Peter C. Chu Yuchun Chen Shihua Lu | 2008 | Atmospheric Research2008，，4： | 1 |
| 14 | Synchronization of an uncertain unified chaotic system via adaptive control 显示文摘 | Shihua Chert Jinhu Lu | 2002 | Chaos Solitions and Fractals (S0960-0779)2002，14，2： | 1 |
| 15 | A Coastal Air-Ocean Coupled System (CAOCS) Evaluated Using an Airborne Expendable Bathythermograph (AXBT) Data Set显示文摘 | PETER C CHU SHIHUA LU and YUCHUN CHEN | 1999 | Journal of Oceanography1999，55，： | 1 |
| 16 | Numerical simulation and data assimilation of the water-energy cycle over semiarid northeastern China显示文摘The default fractional vegetation cover and terrain height were replaced by the estimated fractional vegetation cover, which was calculated by the Normalized Difference Vegetation Index(NDVI) of Earth Observing System Moderate-Resolution Imaging Spectroradiometer(EOS-MODIS) and the Digital Elevation Model of the Shuttle Radar Topography Mission(SRTM) system. The near-surface meteorological elements over northeastern China were assimilated into the three-dimensional variational data assimilation system(3DVar) module in the Weather Research and Forecasting(WRF) model. The structure and daily variations of air temperature, humidity, wind and energy fields over northeastern China were simulated using the WRF model. Four groups of numerical experiments were performed, and the simulation results were analyzed of latent heat flux, sensible heat flux, and their relationships with changes in the surface energy flux due to soil moisture and precipitation over different surfaces. The simulations were compared with observations of the stations Tongyu, Naiman, Jinzhou, and Miyun from June to August, 2009. The results showed that the WRF model achieves high-quality simulations of the diurnal characteristics of the surface layer temperature, wind direction, net radiation, sensible heat flux, and latent heat flux over semiarid northeastern China in the summer. The simulated near-surface temperature, relative humidity, and wind speed were improved in the data assimilation case(Case 2) compared with control case(Case 1). The simulated sensible heat fluxes and surface heat fluxes were improved by the land surface parameterization case(Case 3) and the combined case(Case 4). The simulated temporal variations in soil moisture over the northeastern arid areas agree well with observations in Case 4, but the simulated precipitation should be improved in the WRF model. This study could improve the land surface parameters by utilizing remote sensing data and could further improve atmospheric elements with a data assimilation system. This work provides an effective attempt at combining multi-source data with different spatial and temporal scales into numerical simulations. The assimilation datasets generated by this work can be applied to research on climate change and environmental monitoring of arid lands, as well as research on the formation and stability of climate over semiarid areas. | WEN XiaoHang LIAO XiaoHan YUAN WenPing YAN XiaoDong WEI ZhiGang LIU HuiZhi FENG JinMing LU ShiHua DONG WenJie | 2014 | Science China Earth Sciences2014，57，10： | 1 |
| 17 | Wind-driven South China Sea deep basin warm-core/cool-core eddies显示文摘 | Peter C. Chi Yuchun Chen Shihua Lu | 1998 | Journal of Oceanography1998，，4： | 1 |
| 18 | Particulate air pollution in Lanzhou China显示文摘 | Peter C. Chu Yuchun Chen Shihua Lu Zhenchao Li Yaqiong Lu | 2007 | Environment International2007，，5： | 1 |
| 19 | An hourly solar radiation model under actual weather and terrain conditions: A case study in Heihe river basin 显示文摘 | Chen Rensheng Lu Shihua Kang Ersi | 2007 | Energy2007，32，： | 1 |
| 20 | Construction of a single chain variable fragment antibody (scFv) against tetrodotoxin (TTX) and its interaction with TTX显示文摘 | Rongzhi Wang Ailing Huang Licai Liu Shuangshuang Xiang Xiufeng Li Sumei Ling Lei Wang Tun Lu Shihua Wang | 2014 | Toxicon2014，，： | 1 |
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