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| 1 | ERCP in acute pancreatitis:What takes place in routine clinical practice?显示文摘AIM:To evaluate the data from a survey carried out in Italy regarding the endoscopic approach to acute pancreatitis in order to obtain a picture of what takes place after the release of an educational project on acute pancreatitis sponsored by the Italian Association for the Study of the Pancreas.METHODS:Of the 1 173 patients enrolled in our survey,the most frequent etiological category was biliary forms(69.3%) and most patients had mild pancreatitis(85.8%).RESULTS:344/1 173(29.3%) underwent endoscopic retrograde cholangiopancreatography(ERCP).The mean interval between the onset of symptoms and ERCP was 6.7 ± 5.0 d;only 89 examinations(25.9%) were performed within 72 h from the onset of symptoms.The main indications for ERCP were suspicion of common bile duct stones(90.3%),jaundice(44.5%),clini cal worsening of acute pancreatitis(14.2%) and cho langitis(6.1%).Biliary and pancreatic ducts were visua lized in 305 patients(88.7%) and in 93 patients(27.0%) respectively.The success rate in obtaining a cholangio gram was statistically higher(P = 0.003) in patients with mild acute pancreatitis(90.6%) than in patients with severe disease(72.2%).Biliary endoscopic sphinc terotomy was performed in 295 of the 305 patients(96.7%) with no difference between mild and severe disease(P = 0.985).ERCP morbidity was 6.1% and mortality was 1.7%;the mortality was due to the complications of acute pancreatitis and not the endoscopic procedure.CONCLUSION:The results of this survey,as with those carried out in other countries,indicate a lack of compliance with the guidelines for the indications for interventional endoscopy. | Armando Gabbrielli Raffaele Pezzilli Generoso Uomo Alessandro Zerbi Luca Frulloni Paolo De Rai Laura Castoldi Guido Costamagna Claudio Bassi Valerio Di Carlo | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，9： | 14 |
| 2 | Schwann cell development,maturation and regeneration:a focus on classic and emerging intracellular signaling pathways显示文摘The development,maturation and regeneration of Schwann cells(SCs),the main glial cells of the peripheral nervous system,require the coordinate and complementary interaction among several factors,signals and intracellular pathways.These regulatory molecules consist of integrins,neuregulins,growth factors,hormones,neurotransmitters,as well as entire intracellular pathways including protein-kinase A,C,Akt,Erk/MAPK,Hippo,mTOR,etc.For instance,Hippo pathway is overall involved in proliferation,apoptosis,regeneration and organ size control,being crucial in cancer proliferation process.In SCs,Hippo is linked to merlin and YAP/TAZ signaling and it seems to respond to mechanic/physical challenges.Recently,among factors regulating SCs,also the signaling intermediates Src tyrosine kinase and focal adhesion kinase(FAK)proved relevant for SC fate,participating in the regulation of adhesion,motility,migration and in vitro myelination.In SCs,the factors Src and FAK are regulated by the neuroactive steroid allopregnanolone,thus corroborating the importance of this steroid in the control of SC maturation.In this review,we illustrate some old and novel signaling pathways modulating SC biology and functions during the different developmental,mature and regenerative | Luca Franco Castelnovo Veronica Bonalume Simona Melfi Marinella Ballabio Deborah Colleoni Valerio Magnaghi | 2017 | Neural Regeneration Research2017，12，7： | 9 |
| 3 | Peliosis hepatis: Personal experience and literature review显示文摘Peliosis hepatis(PH) is a disease characterized by multiple and small,blood-filled cysts within the parenchymatous organs. PH is a very rare disease,more common in adults,and when it affects the liver,it comes to the surgeon's attention only in an extremely urgent situation after the lesion's rupture with the resulting hemoperitoneum. This report describes the case of a 29-year-old woman affected by recurring abdominal pain. Computed tomography scans showed a hepatic lesion formed by multiple hypodense areas,which showed an early acquisition of the contrast during the arterial phase. Furthermore,it remained isodense with the remaining parenchyma during the late venous phase. We decided on performing a liver resection of segment Ⅶ while avoiding a biopsy for safety reasons. The histopathologic examination confirmed the diagnosis of focal PH. PH should always be considered in the differential diagnosis of hepatic lesions. Clinicians should discuss the possible causes and issues related to the differential diagnosis in addition to the appropriate therapeutic approach. The fortuitous finding of a lesion,potentially compatible with PH,requires elective surgery with diagnostic and therapeutic intents. The main aim is to prevent the risk of a sudden bleeding that,in absence of properly equipped structures,may have a fatal outcome. | Daniele Crocetti Andrea Palmieri Giuseppe Pedullà Vittorio Pasta Valerio D'Orazi Gian Luca Grazi | 2015 | World Journal of Gastroenterology2015，21，46： | 7 |
| 4 | Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis显示文摘AIM To characterize natural history of cryptogenic cirrhosis(CC) and compare its clinical features and outcomes to those of hepatitis C virus(HCV)-related cirrhosis.METHODS A prospective cohort of 102 consecutive patients at their first diagnosis of CC were enrolled in this study. The clinical data and outcomes were compared to an ageand Child-pugh class-matched cohort of 110 patients with HCV-related cirrhosis. Diagnosis of cirrhosis was based on compatible clinical and laboratory parameters, ultrasound/endoscopic parameters and, whenever possible, on histological grounds and transient elastography. All cases of cirrhosis without a definite etiology were enrolled in the CC group. The parameters assessed were:(1) severity of liver disease at the time of first diagnosis;(2) liver decompensation during follow-up;(3) hepatocellular carcinoma(HCC);(4) orthotopic liver transplantation; and(5) death. The independent associated factors were evaluated by multiple logistic regression analysis, and survival and its determinants by the Kaplan-Meier model, log-rank test and Cox regression.RESULTS At the first observation, median age was 66 and 65 years and male gender was 36% and 58% for CC and HCV cirrhosis, respectively. CC showed Child-pugh class A/B/C of 47%/31%/22%, respectively. Compared to HCV cirrhosis, CC exhibited a significantly higher prevalence of metabolic syndrome(12% vs 54%, respectively), overweight/obesity, high BMI, impaired glucose tolerance, high blood pressure, dyslipidemia, hyperuricemia, cardiovascular diseases, extrahepatic cancer, and gallstones. Over a median period of 42 mo of follow-up, liver decompensation, HCC development and death for CC and HCV-related cirrhosis were 60.8%, and 54.4%, 16.7% and 17.2%, 39.2% and 30%, respectively. The median survival was 60 mo for CC. Independent predictors of death were age and Childpugh class at diagnosis. CC showed an approximately twofold higher incidence of HCC in Child-pugh class A.CONCLUSION Undiagnosed nonalcoholic fatty liver disease has an etiologic role in CC that is associated with a poor prognosis, early HCC development, high risk of cardiovascular disease and extrahepatic cancer. | Luca Rinaldi Fabio Nascimbeni Mauro Giordano Chiara Masetti Barbara Guerrera Annalisa Amelia Maria Chiara Fascione Stefano Ballestri Dante Romagnoli Rosa Zampino Riccardo Nevola Enrica Baldelli Natalina Iuliano Valerio Rosato Amedeo Lonardo Luigi Elio Adinolfi | 2017 | World Journal of Gastroenterology2017，23，8： | 5 |
| 5 | Microscopic colitis显示文摘Microscopic colitis may be defined as a clinical syndrome, of unknown etiology, consisting of chronic watery diarrhea, with no alterations in the large bowel at the endoscopic and radiologic evaluation. Therefore, a definitive diagnosis is only possible by histological analysis. The epidemiological impact of this disease has become increasingly clear in the last years, with most data coming from Western countries. Microscopic colitis includes two histological subtypes [collagenous colitis (CC) and lymphocytic colitis (LC)] with no differences in clinical presentation and management. Collagenous colitis is characterized by a thickening of the subepithelial collagen layer that is absent in LC. The main feature of LC is an increase of the density of intra-epithelial lymphocytes in the surface epithelium. A number of pathogenetic theories have been proposed over the years, involving the role of luminal agents, autoimmunity, eosinophils, genetics (human leukocyte antigen), biliary acids, infections, alterations of pericryptal fibroblasts, and drug intake; drugs like ticlopidine, carbamazepine or ranitidine are especially associated with the development of LC, while CC is more frequently linked to cimetidine, non-steroidal antiinflammatory drugs and lansoprazole. Microscopic colitis typically presents as chronic or intermittent watery diarrhea, that may be accompanied by symptoms such as abdominal pain, weight loss and incontinence. Recent evidence has added new pharmacological options for the treatment of microscopic colitis:the role of steroidal therapy, especially oral budesonide, has gained relevance, as well as immunosuppressive agents such as azathioprine and 6-mercaptopurine. The use of anti-tumor necrosis factoragents, infliximab and adalimumab, constitutes a new, interesting tool for the treatment of microscopic colitis, but larger, adequately designed studies are needed to confirm existing data. | Gianluca Ianiro Giovanni Cammarota Luca Valerio Brigida Eleonora Annicchiarico Alessandro Milani Massimo Siciliano Antonio Gasbarrini | 2012 | World Journal of Gastroenterology2012，18，43： | 4 |
| 6 | A 360-Degree Overview Of Paediatric Nafld: Recent Insights显示文摘 | Valerio Nobili Gianluca Svegliati-Baroni Anna Alisi Luca Miele Luca Valenti Pietro Vajro | 2012 | Journal of Hepatology2012，，： | 3 |
| 7 | Laparoscopic Versus Open Colorectal Surgery: A Randomized Trial on Short-Term Outcome显示文摘 | Marco Braga Andrea Vignali Luca Gianotti Walter Zuliani Giovanni Radaelli Paola Gruarin Paolo Dellabona Valerio Di Carlo | 2002 | Annals of Surgery2002，，6： | 2 |
| 8 | Altered microperfusion at the rectal stump is predictive for rectal anastomotic leak显示文摘 | Andrea Vignali Luca Gianotti Marco Braga Giovanni Radaelli Leopoldo Malvezzi Valerio Di Carlo | 2000 | Diseases of the Colon & Rectum2000，，1： | 2 |
| 9 | Altered microperfusion at the rectal stump is predictive for rectal anastomotic leak显示文摘 | Andrea Vignali M.D. Luca Gianotti M.D. Ph.D. Dr. Marco Braga M.D. Giovanni Radaelli M.B. Leopoldo Malvezzi M.D. Valerio Di Carlo M.D | 2000 | Diseases of the Colon & Rectum2000，，1： | 2 |
| 10 | The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies显示文摘 | Ahmad Al-Serri Quentin M. Anstee Luca Valenti Valerio Nobili Julian B.S. Leathart Paola Dongiovanni Julia Patch Anna Fracanzani Silvia Fargion Christopher P. Day Ann K. Daly | 2011 | Journal of Hepatology2011，，2： | 2 |
| 11 | Immunonutrition in gastric cancer surgical patients显示文摘 | Marco Braga Luca Gianotti Andrea Vignali Valerio Di Carlo | 1998 | Nutrition1998，，11： | 1 |
| 12 | SSJD14101300034250显示文摘 | Federica Domati Stefania Maffei Shaniko Kaleci Carmela Gregorio Monica Pedroni Luca Roncucci Piero Benatti Giulia Magnani Luigi Marcheselli Luca Reggiani Bonetti Francesco Mariani Antonio Maria Alberti Valerio Rossi Maurizio Ponz de Leon | 2014 | Internal and Emergency Medicine2014，，6： | 1 |
| 13 | The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver显示文摘 | Luca Valenti Valerio Nobili Ahmad Al-Serri Raffaela Rametta Julian B.S. Leathart Marco A. Zappa Paola Dongiovanni Anna L. Fracanzani Arianna Alterio Giancarlo Roviaro Ann K. Daly Silvia Fargion Christopher P. Day | 2011 | Journal of Hepatology2011，，6： | 1 |
| 14 | A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer显示文摘 | Luca Gianotti Marco Braga Luca Nespoli Giovanni Radaelli Aldo Beneduce Valerio Di Carlo | 2002 | Gastroenterology2002，，7： | 1 |
| 15 | A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer显示文摘 | Luca Gianotti Marco Braga Luca Nespoli Giovanni Radaelli Aldo Beneduce Valerio Di Carlo | 2002 | Gastroenterology2002，，7： | 1 |
| 16 | Analysis of Prognostic Factors Influencing Long-term Survival After Hepatic Resection for Metastatic Colorectal Cancer显示文摘 | Marcella Arru Luca Aldrighetti Renato Castoldi Saverio Di Palo Elena Orsenigo Marco Stella Carlo Pulitanò Francesca Gavazzi Gianfranco Ferla Valerio Di Carlo Carlo Staudacher | 2008 | World Journal of Surgery2008，，1： | 1 |
| 17 | Metabolic and Functional Results After Laparoscopic Colorectal Surgery: A Randomized, Controlled Trial显示文摘 | Marco Braga Andrea Vignali Walter Zuliani Giovanni Radaelli Luca Gianotti Carla Martani Gilles Toussoun Valerio Di Carlo | 2002 | Diseases of the Colon & Rectum2002，，： | 1 |
| 18 | A 4-Polymorphism Risk Score Predicts Steatohepatitis in Children With Nonalcoholic Fatty Liver Disease显示文摘 | Valerio Nobili Benedetta Donati Nadia Panera Apirom Vongsakulyanon Anna Alisi Bruno Dallapiccola Luca Valenti | 2014 | Journal of Pediatric Gastroenterology and Nutrition2014，，5： | 1 |
| 19 | Does Resection Line Involvement Affect Prognosis in Early Gastric Cancer Patients? An Italian Multicentric Study显示文摘 | Paolo Morgagni MD Domenico Garcea MD Daniele Marrelli MD Giovanni Manzoni MD Giovanni Natalini MD Hayato Kurihara MD Alberto Marchet MD Giovanni Vittimberga MD Luca Saragoni MD Franco Roviello MD Alberto Di Leo MD Francesco Santis MD Valerio Panizza MD Do | 2006 | World Journal of Surgery2006，，4： | 1 |
| 20 | The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies显示文摘 | Ahmad Al-Serri Quentin M. Anstee Luca Valenti Valerio Nobili Julian B.S. Leathart Paola Dongiovanni Julia Patch Anna Fracanzani Silvia Fargion Christopher P. Day Ann K. Daly | 2011 | Journal of Hepatology2011，，2： | 1 |
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