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| 1 | Endoscopic submucosal dissection in dogs in a World Gastroenterology Organisation training center显示文摘AIM: To evaluate if canine models are appropriate for teaching endoscopy fellows the techniques of endoscopic submucosal dissection (ESD). METHODS: ESD was performed in 10 canine models under general anesthesia, on artificial lesions of the esophagus or stomach marked with coagulation points. After ESD, each canine model was euthanized and surgical resection of the esophagus or stomach was carried out according to 'The Principles of Humane Experimental Technique, Russel and Burch'. The ESD specimens were fixed with needles on cork submerged in a formol solution with the esophagus or stomach, and delivered to the pathology department to be analyzed. RESULTS: ESD was completed without complications using the Hook-knife in five esophageal areas, with a procedural duration of 124 ± 19 min, a length of 27.4 ± 2.6 mm and a width of 21 ± 2.4 mm. ESD was also completed without complications using the IT-knife2 in five gastric areas, with a procedural duration of 92.6 ± 19 min, a length of 32 ± 2.5 mm and a width of 18 ± 3.7 mm. CONCLUSION: ESD is feasible in the normal esopha- gus and stomach of canine models, which are appropriate for teaching this technique. | Miguel A Tanimoto Gonzalo Torres-Villalobos Rikiya Fujita Patricio Santillan-Doherty Jorge Albores-Saavedra German Gutierrez Luis A Martin-del-Campo Carlos Bravo-Reyna Octavio Villanueva Jose J Villalobos Misael Uribe Miguel A Valdovinos | 2010 | World Journal of Gastroenterology2010，16，14： | 7 |
| 2 | Manufacture and characterization of graphene membranes with suspended silicon proof masses for MEMS and NEMS applications显示文摘Graphene’s unparalleled strength,chemical stability,ultimate surface-to-volume ratio and excellent electronic properties make it an ideal candidate as a material for membranes in micro-and nanoelectromechanical systems(MEMS and NEMS).However,the integration of graphene into MEMS or NEMS devices and suspended structures such as proof masses on graphene membranes raises several technological challenges,including collapse and rupture of the graphene.We have developed a robust route for realizing membranes made of double-layer CVD graphene and suspending large silicon proof masses on membranes with high yields.We have demonstrated the manufacture of square graphene membranes with side lengths from 7µm to 110µm,and suspended proof masses consisting of solid silicon cubes that are from 5µm×5µm×16.4µm to 100µm×100µm×16.4µm in size.Our approach is compatible with wafer-scale MEMS and semiconductor manufacturing technologies,and the manufacturing yields of the graphene membranes with suspended proof masses were>90%,with>70%of the graphene membranes having>90%graphene area without visible defects.The measured resonance frequencies of the realized structures ranged from tens to hundreds of kHz,with quality factors ranging from 63 to 148.The graphene membranes with suspended proof masses were extremely robust,and were able to withstand indentation forces from an atomic force microscope(AFM)tip of up to~7000nN.The proposed approach for the reliable and large-scale manufacture of graphene membranes with suspended proof masses will enable the development and study of innovative NEMS devices with new functionalities and improved performances. | Xuge Fan Anderson D.Smith Fredrik Forsberg Stefan Wagner Stephan Schroder Sayedeh Shirin Afyouni Akbari Andreas C.Fischer Luis Guillermo Villanueva Mikael Ostling Max C.Lemme Frank Niklaus | 2020 | Microsystems & Nanoengineering2020，6，1： | 4 |
| 3 | Avoiding transduction-induced heating in suspended microchannel resonators using piezoelectricity显示文摘Calorimetry of single biological entities remains elusive.Suspended microchannel resonators(SMRs)offer excellent performance for real-time detection of various analytes and could hold the key to unlocking pico-calorimetry experiments.However,the typical readout techniques for SMRs are optical-based,and significant heat is dissipated in the sensor,altering the measurement and worsening the frequency noise.In this manuscript,we demonstrate for the first time full on-chip piezoelectric transduction of SMRs on which we focus a laser Doppler vibrometer to analyze its effect.We demonstrate that suddenly applying the laser to a water-filled SMR causes a resonance frequency shift,which we attribute to a local increase in temperature.When the procedure is repeated at increasing flow rates,the resonance frequency shift diminishes,indicating that convection plays an important role in cooling down the device and dissipating the heat induced by the laser.We also show that the frequency stability of the device is degraded by the laser source.In comparison to an optical readout scheme,a low-dissipative transduction method such as piezoelectricity shows greater potential to capture the thermal properties of single entities. | Damien Maillard Annalisa De Pastina Amir Musa Abazari Luis Guillermo Villanueva | 2021 | Microsystems & Nanoengineering2021，7，2： | 2 |
| 4 | Learning Curve in a Western Training Center of the Circumferential En Bloc Esophageal Endoscopic Submucosal Dissection in an In Vivo Animal Model显示文摘 | Miguel A. Tanimoto Gonzalo Torres-Villalobos Rikiya Fujita Patricio Santillan-Doherty Jorge Albores-Saavedra Fredy Chable-Montero Luis A. Martin-del-Campo Lucia Vasquez Carlos Bravo-Reyna Octavio Villanueva Jose J. Villalobos Misael Uribe Miguel A. Valdov | 2011 | Diagnostic and Therapeutic Endoscopy2011，，： | 1 |
| 5 | Propranolol plus placebo versus propranolol plus isosorbide-5-mononitrate in the prevention of a first variceal bleed: A double-blind RCT显示文摘 | Juan Carlos Garc??a-Pagán Rosa Morillas Rafael Ba?ares Agustin Albillos Candido Villanueva Carme Vila Joan Genescà Manuel Jimenez Manuel Rodriguez Jose Luis Calleja Joaquin Balanzó Fernando Garcáa-Durán Ramón Planas Jaume Bosch | 2003 | Hepatology2003，，6： | 1 |
| 6 | Contribution of 111In-pentetreotide SPECT/CT imaging to conventional somatostatin receptor scintigraphy in the detection of neuroendocrine tumours显示文摘 | Aurora Sainz-Esteban Roberto Olmos Manuel González-Sagrado María Luisa González María ángeles Ruiz Paloma García-Talavera Claudia Gamazo Juan Gabriel Villanueva Amparo Cobo Daniel de Luis | 2015 | Nuclear Medicine Communications2015，，： | 1 |
| 7 | The role of human papilloma virus in the molecular biolo- gy of cervical carcinogenesis显示文摘 | Motoyama S Ladines-Llave CA Luis VillanuevaS | 2004 | KobeJ Med Sci2004，50，12： | 1 |
| 8 | Resistless fabrication of nanoimprint lithography (NIL) stamps using nano-stencil lithography显示文摘 | Luis Guillermo Villanueva Oscar Vazquez-Mena Cristina Martin-Olmos | 2013 | Micromaehines2013，4，4： | 1 |
| 9 | The Role of Human Papilloma Virus in the Molecular Biology of Cervical Carcinogenesis显示文摘 | Motoyama S Ladines-Llave CA Luis Villanueva S | 2004 | Kobe J Med Sci2004，50，12： | 1 |
| 10 | Oncocytome rénal multiple bilatéral Revue de la littérature à propos d’un cas显示文摘 | Antonio Villanueva Pe?a Antonio Roca Edreira Enrique De Diego Rodríguez Rafa?l Hernández Rodríguez J. Luis Gutiérrez Ba?os Carmen Aguilera Tubet | 2007 | Progres en Urologie2007，，5： | 1 |
| 11 | Fusobacteri-um nucleatum in endodontic flare-ups 显示文摘 | Luis Eduardo Ch6vez de Paz Villanueva G?teborg | 2002 | Oral Surg Oral Med OralPathol Oral Radiol Endod2002，93，： | 1 |
| 12 | Baseline for PAHs and metals in NW Gulf of Mexico related to the Deepwater Horizon oil spill显示文摘 | Alfonso V. Botello Luis A. Soto Guadalupe Ponce-Vélez Susana Villanueva F | 2014 | Estuarine, Coastal and Shelf Science2014，，： | 1 |
| 13 | The role of human papilloma virus in the molecular biology of cervical carcinogenesis显示文摘 | Motoyama S Ladines-Llave CA Luis Villanueva S | 2004 | Kobe J Med Sci2004，50，12： | 1 |
| 14 | The role ofhuman papilloma virus in the molecular biology of cervical carcinogen-esis显示文摘 | Motoyama S Ladines-Llave CA Luis Villanueva S | 2004 | Kobe J Med Sci2004，50，12： | 1 |
| 15 | The role of human papillomavirus in the molecular biology of cervical carcinogenesis显示文摘 | Motoyama S Ladines-Llave CA Luis Villanueva S | 2004 | Kobe J Med Sci2004，50，12： | 1 |
| 16 | Prevalence of hepatitis B virus genotypes in chronic carriers in Santiago, Chile显示文摘 | Mauricio Venegas Gabriela Mu?oz Carmen Hurtado Luis Alvarez Marta Velasco Rodrigo A. Villanueva Javier Brahm | 2008 | Archives of Virology2008，，11： | 1 |
| 17 | Management of cancer patients during COVID-19 pandemic at developing countries显示文摘Cancer patient care requires a multi-disciplinary approach and multiple medical and ethical considerations.Clinical care during a pandemic health crisis requires prioritising the use of resources for patients with a greater chance of survival,especially in developing countries.The coronavirus disease 2019 crisis has generated new challenges given that cancer patients are normally not prioritised for admission in critical care units.Nevertheless,the development of new cancer drugs and novel adjuvant/neoadjuvant protocols has dramatically improved the prognosis of cancer patients,resulting in a more complex decision-making when prioritising intensive care in pandemic times.In this context,it is essential to establish an effective and transparent communication between the oncology team,critical care,and emergency units to make the best decisions,considering the principles of justice and charity.Concurrently,cancer treatment protocols must be adapted to prioritise according to oncologic response and prognosis.Communication technologies are powerful tools to optimise cancer care during pandemics,and we must adapt quickly to this new scenario of clinical care and teaching.In this new challenging pandemic scenario,multi-disciplinary work and effective communication between clinics,technology,science,and ethics is the key to optimising clinical care of cancer patients. | Jaime González-Montero Guillermo Valenzuela Mónica Ahumada Olga Barajas Luis Villanueva | 2020 | World Journal of Clinical Cases2020，8，16： | 0 |
| 18 | Micro 3D printing of a functional MEMS accelerometer显示文摘Microelectromechanical system(MEMS)devices,such as accelerometers,are widely used across industries,including the automotive,consumer electronics,and medical industries.MEMS are efficiently produced at very high volumes using large-scale semiconductor manufacturing techniques.However,these techniques are not viable for the costefficient manufacturing of specialized MEMS devices at low-and medium-scale volumes.Thus,applications that require custom-designed MEMS devices for markets with low-and medium-scale volumes of below 5000–10,000 components per year are extremely difficult to address efficiently.The 3D printing of MEMS devices could enable the efficient realization and production of MEMS devices at these low-and medium-scale volumes.However,current micro-3D printing technologies have limited capabilities for printing functional MEMS.Herein,we demonstrate a functional 3D-printed MEMS accelerometer using 3D printing by two-photon polymerization in combination with the deposition of a strain gauge transducer by metal evaporation.We characterized the responsivity,resonance frequency,and stability over time of the MEMS accelerometer.Our results demonstrate that the 3D printing of functional MEMS is a viable approach that could enable the efficient realization of a variety of custom-designed MEMS devices,addressing new application areas that are difficult or impossible to address using conventional MEMS manufacturing. | Simone Pagliano David E.Marschner Damien Maillard Nils Ehrmann Göran Stemme Stefan Braun Luis Guillermo Villanueva Frank Niklaus | 2022 | Microsystems & Nanoengineering2022，8，5： | 0 |
| 19 | Design and fabrication of a vigorous“cavitation-on-a-chip”device with a multiple microchannel configuration显示文摘Hydrodynamic cavitation is one of the major phase change phenomena and occurs with a sudden decrease in the local static pressure within a fluid.With the emergence of microelectromechanical systems(MEMS),high-speed microfluidic devices have attracted considerable attention and been implemented in many fields,including cavitation applications.In this study,a new generation of‘cavitation-on-a-chip’devices with eight parallel structured microchannels is proposed.This new device is designed with the motivation of decreasing the upstream pressure(input energy)required for facile hydrodynamic cavitation inception.Water and a poly(vinyl alcohol)(PVA)microbubble(MB)suspension are used as the working fluids.The results show that the cavitation inception upstream pressure can be reduced with the proposed device in comparison with previous studies with a single flow restrictive element.Furthermore,using PVA MBs further results in a reduction in the upstream pressure required for cavitation inception.In this new device,different cavitating flow patterns with various intensities can be observed at a constant cavitation number and fixed upstream pressure within the same device.Moreover,cavitating flows intensify faster in the proposed device for both water and the water–PVA MB suspension in comparison to previous studies.Due to these features,this next-generation‘cavitation-on-a-chip’device has a high potential for implementation in applications involving microfluidic/organ-on-a-chip devices,such as integrated drug release and tissue engineering. | Farzad Rokhsar Talabazar Mohammad Jafarpour Merve Zuvin Hongjian Chen Moein Talebian Gevari Luis Guillermo Villanueva Dmitry Grishenkov Ali Koşar Morteza Ghorbani | 2021 | Microsystems & Nanoengineering2021，7，3： | 0 |
| 20 | 通过残留水再利用绿化干旱城市:智利北部的多学科项目显示文摘本文描述了智利北部的一个项目,其目的是促进处于普遍缺水及土壤和水中含盐量高条件下的干旱地区适当绿地和花园的发展。现场研完试验了选定的本地和引入的观赏植物的适合性。植物生长,水和土壤质量、海洋飞沫、气候、废水处理以及灌溉作业问题等是专门研究和探讨的课题。 | Luis Cáceres Villanueva Jose Delatorre Fernando De La Riva Vinka Monardes 林宝法 | 2003 | AMBIO-人类环境杂志2003，32，4： | 0 |
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