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| 1 | Performance value of high risk factors in colorectal cancer screening in China显示文摘AIM:To analyze the performance value of high risk factors in population-based colorectal cancer(CRC) screening in China.METHODS:We compared the performance value of the immunochemical fecal occult blood test(iFOBT) and other high risk factors questionnaire in a population sample of 13 214 community residents who completed both the iFOBT and questionnaire investigation.Patients with either a positive iFOBT and/or questionnaire were regarded as a high risk population and those eligible were asked to undergo colonoscopy.RESULTS:The iFOBT had the highest positive predictive value and negative predictive value in screening for advanced neoplasia.The iFOBT had the highest sensitivity,lowest number of extra false positive results associated with the detection of one extra abnormality for screening advanced neoplasias and adenomas.A history of chronic cholecystitis or cholecystectomy,chronic appendicitis or appendectomy,and chronic diarrhea also had a higher sensitivity than a history of adenomatous polyps in screening for advanced neoplasias and adenomas.The sensitivity of a history of chronic cholecystitis or cholecystectomy was highest among the 10 high risk factors in screening for nonadenomatous polyps.A history of chronic appendicitis or appendectomy,chronic constipation,chronic diarrhea,mucous and bloody stool,CRC in first degree relatives,malignant tumor and a positive iFOBT also had higher sensitivities than a history of adenomas polyps in screening for non-adenomatous polyps.Except for a history of malignant tumor in screening for non-adenomatous polyps,the gain in sensitivity was associated with an increase in extra false positive results associated with the detection of one extra abnormality.CONCLUSION:The iFOBT may be the best marker for screening for advanced neoplasias and adenomas.Some unique high risk factors may play an important role in CRC screening in China. | Wen Meng Shan-Rong Cai Lun Zhou Qi Dong Shu Zheng Su-Zhan Zhang | 2009 | World Journal of Gastroenterology2009，15，48： | 41 |
| 2 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 3 | Serum vascular endothelial growth factor is a potential biomarker of metastatic recurrence after curative resection of hepatocellular carcinoma显示文摘INTRODUCTIONHepatocellular carcinoma(HCC)is one of the mostcommon malignancies in China.To date,surgery is stillthe best solution to it.However,metastatic recurrencesafter curative hepatic resections are very common.Tang etal have reported that recurrence rate within 5 years | Qi Niu Zhao You Tang Zeng Chen Ma Lun Xiu Qin Lian Hai Zhang | 2000 | World Journal of Gastroenterology2000，6，4： | 20 |
| 4 | Two New Group 3 LEA Genes of Wheat and Their Functional Analysis in Yeast显示文摘The group 3 late embryogenesis abundant (LEA) proteins are thought to protect cells from stresses associated with dehydration during periods of water deficit. To investigate the functions of different members of the group 3 LEA genes, we isolated and characterized two new group 3 LEA genes, namely TaLEA2 and TaLEA3, from wheat (Triticum aestivum L.) and introduced TaLEA2 and TaLEA3 into Saccharmyces cerevisiae to examine the effect of these genes on yeast cell tolerance to osmotic, salt, and cold stresses. The TaLEA2 gene encoded a protein of 211 amino acids and possessed five repeats of 11-mer amino acid motifs. The TaLEA3 gene encoded a polypeptide of 211 amino acids with nine repeated units.Overexpression of TaLEA2 and TaLEA3 improved stress tolerance in transgenic yeast cells when cultured in medium containing sorbitol, salt and-20 ℃ freezing treatments respectively. However, the yeast transformants with TaLEA2 seemed to be more tolerant to hyperosmotic and freezing stress than transformants with TaLEA3. This implies that a close relationship exists between function and the number of repeats of the 11-mer amino acid motif in the group 3 LEA protein. | Jia-Ning YU Jin-Song ZHANG Lun SHAN Shou-Yi CHEN | 2005 | Journal of Integrative Plant Biology2005，47，11： | 19 |
| 5 | A Review on Metal-Organic Framework-Derived Porous Carbon-Based Novel Microwave Absorption Materials显示文摘The development of microwave absorption materials(MAMs) is a considerable important topic because our living space is crowed with electromagnetic wave which threatens human’s health.And MAMs are also used in radar stealth for protecting the weapons from being detected.Many nanomaterials were studied as MAMs,but not all of them have the satisfactory performance.Recently,metal-organic frameworks(MOFs) have attracted tremendous attention owing to their tunable chemical structures,diverse properties,large specific surface area and uniform pore distribution.MOF can transform to porous carbon(PC) which is decorated with metal species at appropriate pyrolysis temperature.However,the loss mechanism of pure MOF-derived PC is often relatively simple.In order to further improve the MA performance,the MOFs coupled with other loss materials are a widely studied method.In this review,we summarize the theories of MA,the progress of different MOF-derived PC-based MAMs,tunable chemical structures incorporated with dielectric loss or magnetic loss materials.The different MA performance and mechanisms are discussed in detail.Finally,the shortcomings,challenges and perspectives of MOF-derived PC-based MAMs are also presented.We hope this review could provide a new insight to design and fabricate MOF-derived PC-based MAMs with better fundamental understanding and practical application. | Zhiwei Zhang Zhihao Cai Ziyuan Wang Yaling Peng Lun Xia Suping Ma Zhanzhao Yin Yi Huang | 2021 | Nano-Micro Letters2021，13，4： | 17 |
| 6 | Nitrous oxide emissions from a maize field during two consecutive growing seasons in the North China Plain显示文摘Nitrous oxide (N 2 O) emissions from a maize field in the North China Plain (Wangdu County,Hebei Province,China) were investigated using static chambers during two consecutive maize growing seasons in the 2008 and 2009.The N 2 O pulse emissions occurred with duration of about 10 days after basal and additional fertilizer applications in the both years.The average N 2 O fluxes from the CK (control plot,without crop,fertilization and irrigation),NP (chemical N fertilizer),SN (wheat straw returning plus chemical N fertilizer),OM- 1/2N (chicken manure plus half chemical N fertilizer) and OMN (chicken manure plus chemical N fertilizer) plots in 2008 were 8.51,72.1,76.6,101,107 ng N/(m 2 ·sec),respectively,and in 2009 were 33.7,30.0 and 35.0 ng N/(m 2 ·sec) from CK,NP and SN plots,respectively.The emission factors of the applied fertilizer as N 2 O-N (EFs) were 3.8% (2008) and 1.1% (2009) for the NP plot,3.2% (2008) and 1.2% (2009) for the SN plot,and 2.8% and 2.2% in 2008 for the OM-1/2N and OMN plots,respectively.Hydromorphic properties of the investigated soil (with gley) are in favor of denitrification.The large differences of the soil temperature and water-filled pore space (WFPS) between the two maize seasons were suspected to be responsible for the significant yearly variations.Compared with the treatments of NP and SN,chicken manure coupled with compound fertilizer application significantly reduced fertilizer loss rate as N 2 O-N. | Yuanyuan Zhang Junfeng Liu Yujing Mu Zhu Xu Shuwei Pei Xiaoxiu Lun Ying Zhang | 2012 | Journal of Environmental Sciences2012，24，1： | 15 |
| 7 | Genome of Wild Mandarin and Domestication History of Mandarin显示文摘官员(柠檬 reticulata ) 是世界范围的最重要的柠檬庄稼之一。它的驯服被相信发生在华南,它是四几千年的官员耕作的中心之一。我们在 Nanling 区域附近收集了官员的自然野人口并且在附近栽培了 landraces。我们发现柠檬性的酸水平戏剧性地在栽培官员被减少。理解 ? 官员驯服的基因基础,我们 de novo 装配了野官员的一个草稿染色体并且分析了一套 104 个柠檬染色体。我们发现 Mangshan 官员是一种原始类型并且二个独立驯服事件发生了,分别地导致在北方和南方 Nanling 山的二组栽培官员(MD1 和 MD2 ) 。二个瓶颈和有效人口尺寸的二扩大为栽培官员的 MD1 组被识别。然而,在 MD2 组织 ? 在人口尺寸有长、连续的减少。MD1 和 MD2 官员从栽培 pummelo 种类显示出种间的基因渗入的不同模式。我们在官员的驯服期间在选择下面可能在基因在柠檬酸盐内容的规定包含了的 aconitate hydratase (ACO ) 识别了高分叉的一个区域,它是。这研究为现存野官员人口的地理起源提供具体基因证据并且使驯服和官员的进化历史清楚些。 | Lun Wang Fa He Yue Huang Jiaxian He Shuizhi Yang Jiwu Zeng Chongling Deng Xiaolin Jiang Yiwen Fang Shaohua Wen Rangwei Xu Huiwen Yu Xiaoming Yang Guangyan Zhong Chuanwu Chen Xiang Yan Changfu Zhou Hongyan Zhang Zongzhou Xie Robert M. Larkin Xiuxin Deng Qiang Xu | 2018 | Molecular Plant2018，11，8： | 14 |
| 8 | Efficacy of Leflunomide, Telmisartan, and Clopidogrel for Immunoglobulin A Nephropathy: A Randomized Controlled Trial显示文摘 | Jie Wu Shu-Wei Duan Xue-Feng Sun Wen-Ge Li Ya-Ping Wang Wen-Hu Liu Jian-Rong Zhang Li-De Lun Xue-Mei Li Chun-Hua Zhou Ji-Jun Li Shu-Wen Liu Yuan-Sheng Xie Guang-Yan Cai Lu Ma Wen Huang Hua Wu Qiang Jia Xiang-Mei Chen | 2016 | Chinese Medical Journal2016，，16： | 13 |
| 9 | Change of water use efficiency and its relation with root system growth in wheat evolution显示文摘Raising crop water use efficiency (WUE) is the physiological basis to implement crop high efficiently using water. The present soil column and field experiments are designed to investigate the change of wheat WUE (Triticum aestivum L.) at whole plant level and root system growth in evolution and the relationship between WUE and its root system growth using 10 wheat evolution genotypes with different ploidy chromosomes sets. Results show that in wheat evolution from 2n→6n, WUE at whole plant level increases with the increase of ploidy chromosomes, and root system growth (root weight, root length) and root/shoot ratio of wheat decrease with the increase of ploidy chromosomes under dry and irrigated conditions. WUE is negatively correlated with root weight and root/shoot ratio of wheat in evolution, significantly. Root system growth has an adverse redundancy for WUE in wheat evolution, and the root redundancy reduces with the increase of ploidy chromosomes, which result in the increase of wheat WUE at | ZHANG Suiqi SHAN Lun DENG Xiping | 2002 | Chinese Science Bulletin2002，47，22： | 13 |
| 10 | Application of biochar-based materials in environmental remediation:from multi-level structures to specific devices显示文摘The development of biochar has triggered a hot-spot in various research fields including agriculture,energy,environment,and materials.Biochar-based materials provide a novel approach against environmental challenging issues.Considering the rapid development of biochar materials,this review serves as a valuable platform to summarize the recent progress on the theoretical investigation and engineering applications of biochar materials in environmental remediation.For a better understanding of the structure-application relationships,the structural properties of biochar from macroscopic and microscopic aspects are summarized.The multilevel structures including elements,phases,surface chemistry,and molecular are highlighted to elucidate the multi-functional properties of biochars.Sorption,catalysis,redox reaction,and biological activity of biochar are briefly illustrated,which influence the transport,transformation,and removal of organic and inorganic pollutants in the environments.According to the multi-level structures and structure-application relationships of biochar,specific biochar-based materials and devices have been designed for practical environmental application.The important progress on the functionalization and device of biochar-based materials,including magnetic biochars,2D and 3D biochar-based macrostructures,immobilized microorganism on biochar,and biochar-amended biofilters are highlighted.The environmental friendliness and sustainability of biochar-based materials,considering the whole cycle from synthesis to application,are evaluated. | Lun Lu Wentao Yu Yaofeng Wang Kun Zhang Xiaomin Zhu Yuecan Zhang Yajing Wu Habib Ullah Xin Xiao Baoliang Chen | 2020 | Biochar2020，2，1： | 11 |
| 11 | Efficacy and safety of the long-acting fusion inhibitor albuvirtide in antiretroviral-experienced adults with human immunodeficiency virus-1:interim analysis of the randomized,controlled,phase 3,non-inferiority TALENT study显示文摘Background:Albuvirtide is a once-weekly injectable human immunodeficiency virus(HIV)-1 fusion inhibitor.We present interim data for a phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral drugs.Methods:We carried out a 48-week,randomized,controlled,open-label non-inferiority trial at 12 sites in China.Adults on the World Health Organization(WHO)-recommended first-line treatment for>6 months with a plasma viral load>1000 copies/mL were enrolled and randomly assigned(1:1)to receive albuvirtide(once weekly)plus ritonavir-boosted lopinavir(ABT group)or the WHO-recommended second-line treatment(NRTI group).The primary endpoint was the proportion of patients with a plasma viral load below 50 copies/mL at 48 weeks.Non-inferiority was prespecified with a margin of 12%.Results:At the time of analysis,week 24 data were available for 83 and 92 patients,and week 48 data were available for 46 and 50 patients in the albuvirtide and NRTI groups,respectively.At 48 weeks,80.4%of patients in the ABT group and 66.0%of those in the NRTI group had HIV-1 RNA levels below 50 copies/mL,meeting the criteria for non-inferiority.For the per-protocol population,the superiority of albuvirtide over NRTI was demonstrated.The frequency of grade 3 to 4 adverse events was similar in the two groups;the most common adverse events were diarrhea,upper respiratory tract infections,and grade 3 to 4 increases in triglyceride concentration.Renal function was significantly more impaired at 12 weeks in the patients of the NRTI group who received tenofovir disoproxil fumarate than in those of the ABT group.Conclusions:The TALENT study is the first phase 3 trial of an injectable long-acting HIV drug.This interim analysis indicates that once-weekly albuvirtide in combination with ritonavir-boosted lopinavir is well tolerated and non-inferior to the WHO-recommended second-line regimen in patients with first-line treatment failure.Trial registration:ClinicalTrials.gov Identifier:NCT02369965;http://gffzz90ed6ce9d87f4798sukb0fuw9kwqx65xp.ffgz.tsg.suse.edu.cn Clinical Trial Registry No.ChiCTR-TRC-14004276;http://gffzz62a03ee25e6f4a77hukb0fuw9kwqx65xp.ffgz.tsg.suse.edu.cn/enindex.aspx. | Bin Su Cheng Yao Qing-Xia Zhao Wei-Ping Cai Min Wang Hong-Zhou Lu Yuan-Yuan Chen Li Liu Hui Wang Yun He Yu-Huang Zheng Ling-Hua Li Jin-Feng Chen Jian-Hua Yu Biao Zhu Min Zhao Yong-Tao Sun Wen-Hui Lun Wei Xia Li-Jun Sun Li-Li Dai Tai-Yi Jiang Mei-Xia Wang Qing-Shan Zheng Hai-Yan Peng Yao Wang Rong-Jian Lu Jian-Hua Hu Hui Xing Yi-Ming Shao Dong Xie Tong Zhang Fu-Jie Zhang Hao Wu TALENT Study Team | 2020 | Chinese Medical Journal2020，，24： | 10 |
| 12 | Liquid-FEP-based U-tube triboelectric nanogenerator for harvesting water-wave energy显示文摘收获周围的机械精力是为认识到自我动力的电子学的一种关键技术。与稳定性和耐久性的优点, liquid-solid-based 摩擦电 nanogenerator (TENG ) 最近引起了许多注意。然而, TENG 表演和相关工作原则上的液体性质的影响仍然是不清楚的。我们此处基于液体固体模式装配了 U 试管 TENG 并且使用了 11 液体在 TENG 输出性能上学习液体性质的效果。结果证实影响产量的关键因素是极性,绝缘的常数,和与氟化的乙烯丙烯(FEP ) 的亲密关系。在 11 液体之中,纯以水为基的U试管 TENG 与开电路的电压展出了最好的产量( V 81.7 V 和电线走火电流的 oc )(我 为摇晃的模式( 0.5 Hz )的 0.26 A 的 sc ),它能推进增加到 93.0 V 和 0.48 A ,分别地为水平变模式( 1.25 Hz )。U 试管 TENG 能与比 92% 高的精确性为一个水的答案作为一个自我动力的集中传感器(部件集中或 metalion 集中) 被利用。最后,升级的像三明治的 water-FEP U 试管 TENG 被使用收获水波浪精力,显示出有 V 350 V 的 oc ,我 1.75 A 的 sc ,和 2.04 W/m 3 的力量密度。我们成功地照亮了 60 LEDs 并且动力一温度湿度米。给它的高输出性能, water-FEP U 试管 TENG 是为为自我动力的电子学收获水波浪精力的一条很有希望的途径。 | Lun Pan Jiyu Wang Peihong Wang Ruijie Gao Yi-Cheng Wang Xiangwen Zhang Ji-Jun zou Zhong Lin Wang | 2018 | Nano Research2018，11，8： | 10 |
| 13 | WIP1 Phosphatase Plays a Critical Neuroprotective Role in Brain Injury Induced by High-Altitude Hypoxic Inflammation显示文摘The hypobaric hypoxic environment in highaltitude areas often aggravates the severity of inflammation and induces brain injury as a consequence. However, the critical genes regulating this process remain largely unknown. The phosphatase wild-type p53-induced phosphatase 1(WIP1) plays important roles in various physiological and pathological processes, including the regulation of inflammation in normoxia, but its functions in hypoxic inflammation-induced brain injury remain unclear.Here, we established a mouse model of this type of injury and found that WIP1 deficiency augmented the release of inflammatory cytokines in the peripheral circulation and brain tissue, increased the numbers of activated microglia/macrophages in the brain, aggravated cerebral histological lesions, and exacerbated the impairment of motor and cognitive abilities. Collectively, these results provide the first in vivo evidence that WIP1 is a critical neuroprotector against hypoxic inflammation-induced brain injury. | Dahu Li Lijun Zhang Xin Huang Lili Liu Yunling He Lun Xu Yiyao Zhang Tong Zhao Liying Wu Yongqi Zhao Kuiwu Wu Yan Wu Ming Fan Lingling Zhu | 2017 | Neuroscience Bulletin2017，33，3： | 9 |
| 14 | MoSe2 porous microspheres comprising monolayer flakes with high electrocatalytic activity显示文摘综合的一条灵巧的胶体的线路 MoSe < 潜水艇 class= “ a-plus-plus ” > 2 有由 MoSe 组成的 400600 nm 的直径的多孔的 microspheres < 潜水艇 class= “ a-plus-plus ” > 2 个 单层薄片在厚度的 0.7 nm 被报导。溶剂 trioctylamine TOA 和 oleylamine 操作维护管理被发现在 MoSe 的形成起重要作用 < 潜水艇 class= “ a-plus-plus ” > 2 microspheres, TOA 由此决定三维的 3D microspherical 形态学和操作维护管理,指导 MoSe 的形成 < 潜水艇 class= “ a-plus-plus ” > 2 个 单层薄片。柔韧的 3D MoSe <潜水艇class=“ a-plus-plus ”> 2 microspheres 展览为 electrocatalytic 氢进化反应的显著活动和耐久性她在酸,维持 77 mV 的小发作过电位并且为 5 妈/厘米的当前的密度保留 100 mV 的小过电位<啜class=“ a-plus-plus ”>在 1,000 以后的 2 骑车。另外,类似的 3D WSe < 潜水艇 class= “ a-plus-plus ” > 2 microspheres 能被使用这个方法也准备。我们期望这条灵巧的胶体的线路能进一步被扩展综合将在域例如里发现应用的另外的多孔的结构在精力存储,催化作用,并且察觉到。 | Yejun Zhang Qiufang Gong Lun Li Hongchao Yang Yanguang Li Qiangbin Wang | 2015 | Nano Research2015，8，4： | 9 |
| 15 | Paleomagnetic data from the Late Carboniferous-Late Permian rocks in eastern Tibet and their implications for tectonic evolution of the northern Qiangtang-Qamdo block显示文摘We report paleomagnetic results from the Late Carboniferous-Late Permian strata in eastern Tibet (China), and aim to clarify the tectonic and paleogeographic evolution of the northern Qiangtang-Qamdo block, which is the key to the study of plate boundary between the Gondwanaland and the Eurasia during the late Paleozoic. Two hundred and nineteen samples-including limestone, muddy siltstone, basalt, lava, and tuff-were collected at 24 sites in the Upper Carboniferous and Middle-Upper Permian successions. A systematic study of rock magnetism and paleomagnetism yields three reliable paleomagnetic pole positions. Both hematite and magnetite occurred in the Late Carboniferous limestone samples. The demagnetization curve shows a characteristic double-component, with the remanent magnetization (ChRM) exhibiting a positive polarity (negative inclination). In the Late Permian limestone, tuff, and basalt, magnetic information were recorded primarily in magnetite, although a small fraction of them was found in hematite in basalt. The demagnetization curve illustrates a double or single component, with the ChRM showing a negative polarity (positive inclination), which has passed the classic fold test successfully. The single polarity features of the ChRM directions of the Late Carboniferous and Middle-Late Permian rocks are respectively related to the Kiaman positive and reversed polarities under the stratigraphic coordinates. This, in turn, indicates that both ChRMs directions represent the original remanence directions. By comparison with the previously published paleomagnetic results from the late Paleozoic rocks in the northern Qiangtang Range, we suggest that: (1) Qamdo and northern Qiangtang block were independent of each other during the Late Carboniferous to the Early Permian periods. The north Lancangjiang ocean basin between the two blocks may have closed before the Middle Permian and been involved in the continent-continent collision stage in the Late Permian-Early Triassic periods. (2) The northern Qiangtang-Qamdo Block paleogeographically was situated at low to intermediate latitudes in the Southern Hemisphere in the Late Carboniferous-Late Permian periods, and began to displace northward in the Early Triassic, with an amount of more than 5000 km northward transport from its current location. | CHENG Xin WU HanNing DIAO ZongBao WANG HaiJun MA Lun ZHANG XiaoDong YANG Gang HONG JingJing JI WenHua LI RongShe CHEN ShouJian ZHAO ZhenMing | 2013 | Science China Earth Sciences2013，56，7： | 8 |
| 16 | Nicotinamide overload may play a role in the development of type 2 diabetes显示文摘AIM: To investigate whether nicotinamide overload plays a role in type 2 diabetes. METHODS: Nicotinamide metabolic patterns of 14diabetic and 14 non-diabetic subjects were compared using HPLC. Cumulative effects of nicotinamide and N1-methylnicotinamide on glucose metabolism, plasma H2O2 levels and tissue nicotinamide adenine dinucleotide (NAD) contents of adult Sprague-Dawley rats were observed. The role of human sweat glands and rat skin in nicotinamide metabolism was investigated using sauna and burn injury, respectively. RESULTS: Diabetic subjects had significantly higher plasma N 1-methylnicotinamide levels 5 h after a 100-mg nicotinamide load than the non-diabetic subjects (0.89 ± 0.13 μmol/L vs 0.6 ± 0.13 μmol/L, P < 0.001). Cumulative doses of nicotinamide (2 g/kg) significantly increased rat plasma N 1-methy lnico-tinamide concentrations associated with severe insulin resistance, which was mimicked by N1-methy-lnicotinamide. Moreover, cumulative exposure to N1-methylnicotinamide (2 g/kg) markedly reduced rat muscle and liver NAD contents and erythrocyte NAD/NADH ratio, and increased plasma H2O2 levels. Decrease in NAD/NADH ratio and increase in H2O2 generation were also observed in human erythrocytes after exposure to N1-methylnicotinamide in vitro. Sweating eliminated excessive nicotinamide (5.3-fold increase in sweat nicotinamide concentration 1 h after a 100-mg nicotinamide load). Skin damage or aldehyde oxidase inhibition with tamoxifen or olanzapine, both being notorious for impairing glucose tolerance, delayed N1-methylnicotinamide clearance. CONCLUSION: These f indings suggest that nicotinamide overload, which induced an increase in plasma N 1-methylnicotinamide, associated with oxidative stress and insulin resistance, plays a role in type 2 diabetes. | Shi-Sheng Zhou Da Li Wu-Ping Sun Ming Guo Yong-Zhi Lun Yi-Ming Zhou Fu-Cheng Xiao Li-Xin Jing Shen-Xia Sun Li-Bin Zhang Ning Luo Fu-Ning Bian Wei Zou Lai-Bin Dong Zhi-Gang Zhao Sheng-Fan Li Xiao-Jie Gong Zeng-Guo Yu Chang-Bin Sun Cong-Long Zheng Dong-Ju Jiang Zheng-Ning Li | 2009 | World Journal of Gastroenterology2009，15，45： | 8 |
| 17 | THE STRUCTURE OF ARMILLARIZIN,A NEW PROTOILLUDANE SESQUITERPENOID AROMATIC ESTER FROM ARMILLARIA MELLEA(VAHL.EX FR)QUEL.显示文摘A new protoilludane sesquiterpenoid aromatic ester,named armillarizin(1)has been isolated from the artificially cultured mycelium of Armillaria me-llea(Vahl.ex Fr)Quel.(Tricholomataceae).Its structure was deduced on the ba-sis of spectral analyses.The relative configuration was established from thenuclear Overhauser effects and from the values of ~1H-~1H coupling constants. | Jun Shan YANG Ya Lun SU Yu Lan WANG Xiao Zhang FENG De Quan YU Xiao Tian LIANG Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing,100050 | 1990 | Chinese Chemical Letters1990，1，2： | 8 |
| 18 | Porosity models for determining the pore-size distribution of rocks and soils and their applications显示文摘Previous porosity models have been shown to be unable to accurately describe the pore-size distribution of rocks and soils.Three new porosity models are developed in this study.Pore-size distributions of soft clay and ecotypic revetment material were obtained using a scanning electron microscope(SEM)in two-dimensional space,and with the mercury intrusion method in three-dimensional space.The results show that the new porosity models are valid in predicting the accumulative porosity of rock and soil samples.Based on the new porosity models,a new microstructure soil consolidation model was developed and the error of the compression strain prediction was less than 0.007 under low pressure.Several models for soil water retention curve were founded,which in form comprise previous models developed by other researchers,and they may be more accurate than previous models because of the valid mean for determining the fractal dimension.In addition,we obtain an expression for the relationship between soil cohesion and the test specimen size,as well as between the bulk density of rocks and soils and the test specimen size. | ZHANG JiRu TAO GaoLiang HUANG Li YUAN Lun | 2010 | Chinese Science Bulletin2010，55，34： | 8 |
| 19 | Influence of granulocyte-macrophage colonystimulating factor and tumor necrosis factor on anti-hepatoma activities of human dendritic cells显示文摘INTRODUCTIONDendritic cells (DCs) play a key regulatory role inantitumor immunity,especially in its immuneaccessory role via MHC-Ⅰ molecules.We haverecently reported that DCs were able to enhance thekilling activity of Lymphokine and PHA activatedkiller (LPAK) cells in vitro.In the presentstudy,we evaluated the effects of GM-CSF andTNF upon antitumor activities of freshly | Jin Kun Zhang Jin Lun Sun Hai Bin Chen Yang Zeng Yao Jun Qu | 2000 | World Journal of Gastroenterology2000，6，5： | 8 |
| 20 | Evaluating the safety of forsythin from Forsythia suspensa leaves by acute and sub-chronic oral administration in rodent models显示文摘Objective: To access the toxicity of forsythin from Forsythia suspensa leaves and evaluate its safety,Methods: Acute toxicity was determined by oral administration of a single dose of 18 100 mg/kg forsythin in NIH mice,Sub-chronic toxicity was evaluated by oral administration of several doses of forsythin for 30 days at does of 0,540,1 620,and 6 480 mg/kg in SD rats.Results: In the acute toxicity study,mortality was not observed after 14 days,In addition,clinically relevant adverse effects,or variations in body weight or food consumption were not observed,Similarly,after 30 days in the sub-chronic toxicity study,no mortality or significant toxicological effects such as decreased food consumption,body weight,biochemical parameters and vital organs etc,were noticed,Conclusion: The results revealed that the forsythin from Forsythia suspensa leaves has low or no toxicity via oral administration,and therefore is suitable for further development and applications. | Zhong Han Xia-Ling Lei Hong Zhang Lu Liu Zhi-Sen Chen Wei Yang Zhao-Rong Lun | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，1： | 8 |
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