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| 1 | Efficacy and safety of the long-acting fusion inhibitor albuvirtide in antiretroviral-experienced adults with human immunodeficiency virus-1:interim analysis of the randomized,controlled,phase 3,non-inferiority TALENT study显示文摘Background:Albuvirtide is a once-weekly injectable human immunodeficiency virus(HIV)-1 fusion inhibitor.We present interim data for a phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral drugs.Methods:We carried out a 48-week,randomized,controlled,open-label non-inferiority trial at 12 sites in China.Adults on the World Health Organization(WHO)-recommended first-line treatment for>6 months with a plasma viral load>1000 copies/mL were enrolled and randomly assigned(1:1)to receive albuvirtide(once weekly)plus ritonavir-boosted lopinavir(ABT group)or the WHO-recommended second-line treatment(NRTI group).The primary endpoint was the proportion of patients with a plasma viral load below 50 copies/mL at 48 weeks.Non-inferiority was prespecified with a margin of 12%.Results:At the time of analysis,week 24 data were available for 83 and 92 patients,and week 48 data were available for 46 and 50 patients in the albuvirtide and NRTI groups,respectively.At 48 weeks,80.4%of patients in the ABT group and 66.0%of those in the NRTI group had HIV-1 RNA levels below 50 copies/mL,meeting the criteria for non-inferiority.For the per-protocol population,the superiority of albuvirtide over NRTI was demonstrated.The frequency of grade 3 to 4 adverse events was similar in the two groups;the most common adverse events were diarrhea,upper respiratory tract infections,and grade 3 to 4 increases in triglyceride concentration.Renal function was significantly more impaired at 12 weeks in the patients of the NRTI group who received tenofovir disoproxil fumarate than in those of the ABT group.Conclusions:The TALENT study is the first phase 3 trial of an injectable long-acting HIV drug.This interim analysis indicates that once-weekly albuvirtide in combination with ritonavir-boosted lopinavir is well tolerated and non-inferior to the WHO-recommended second-line regimen in patients with first-line treatment failure.Trial registration:ClinicalTrials.gov Identifier:NCT02369965;http://gffzz90ed6ce9d87f4798sox6x0bxp0w0w6fvp.ffgz.tsg.suse.edu.cn Clinical Trial Registry No.ChiCTR-TRC-14004276;http://gffzz62a03ee25e6f4a77hox6x0bxp0w0w6fvp.ffgz.tsg.suse.edu.cn/enindex.aspx. | Bin Su Cheng Yao Qing-Xia Zhao Wei-Ping Cai Min Wang Hong-Zhou Lu Yuan-Yuan Chen Li Liu Hui Wang Yun He Yu-Huang Zheng Ling-Hua Li Jin-Feng Chen Jian-Hua Yu Biao Zhu Min Zhao Yong-Tao Sun Wen-Hui Lun Wei Xia Li-Jun Sun Li-Li Dai Tai-Yi Jiang Mei-Xia Wang Qing-Shan Zheng Hai-Yan Peng Yao Wang Rong-Jian Lu Jian-Hua Hu Hui Xing Yi-Ming Shao Dong Xie Tong Zhang Fu-Jie Zhang Hao Wu TALENT Study Team | 2020 | Chinese Medical Journal2020，，24： | 10 |
| 2 | Consensus by Chinese Expert Panel on Chlamydia trachomatis-Resistant and Chlamydia trachomatis-Persistent Infection显示文摘 | Man-Li Qi Yuan-Li Guo Qian-Qiu Wang Xiang-Sheng Chen Jian-De Han Xiao-Hong Su Wen-Hui Lun Hao Cheng Jin-Hua Xu Hong-Qing Tian Li Che Zhi-Yuan Ya Wen-Li Feng Juan Jiang Ping-Yu Zhou Xian-Biao Zo Hong-Hui Xu Wei-Min Shi Jun Liu Lin Zhu Quan-Zhong Liu | 2017 | Chinese Medical Journal2017，，23： | 7 |
| 3 | Increased Chondrocyte Apoptosis in Kashin-Beck Disease and Rats Induced by T-2 Toxin and Selenium Deficiency显示文摘Objective To investigate chondrocyte apoptosis and the expression of biochemical markers associated with apoptosis in Kashin-Beck disease(KBD) and in an established T-2 toxin-and selenium(Se) deficiency-induced rat model. Methods Cartilages were collected from the hand phalanges of five patients with KBD and five healthy children. Sprague-Dawley rats were administered a selenium-deficient diet for 4 weeks prior to T-2 toxin exposure. The apoptotic chondrocytes were observed by terminal deoxynucleotidyl transferase d UTP nick end labeling staining. Caspase-3, p53, Bcl-2, and Bax proteins in the cartilages were visualized by immunohistochemistry, their protein levels were determined by Western blotting, and m RNA levels were determined by real-time reverse transcription polymerase chain reaction. Results Increased chondrocyte apoptosis was observed in the cartilages of children with KBD. Increased apoptotic and caspase-3-stained cells were observed in the cartilages of rats fed with normal and Se-deficient diets plus T-2 toxin exposure compared to those in rats fed with normal and Se-deficient diets. Caspase-3, p53, and Bax proteins and m RNA levels were higher, whereas Bcl-2 levels were lower in rats fed with normal or Se-deficiency diets supplemented with T-2 toxin than the corresponding levels in rats fed with normal diet. Conclusion T-2 toxin under a selenium-deficient nutritional status induces chondrocyte death, which emphasizes the role of chondrocyte apoptosis in cartilage damage and progression of KBD. | YANG Hao Jie ZHANG Ying WANG Zhi Lun XUE Sen Hai LI Si Yuan ZHOU Xiao Rong ZHANG Meng FANG Qian WANG Wen Jun CHEN Chen DENG Xiang Hua CHEN Jing Hong | 2017 | Biomedical and Environmental Sciences2017，30，5： | 7 |
| 4 | Recent Advancements on Photothermal Conversion and Antibacterial Applications over MXenes-Based Materials显示文摘The pernicious bacterial proliferation and emergence of super-resistant bacteria have already posed a great threat to public health,which drives researchers to develop antibiotic-free strategies to eradicate these fierce microbes.Although enormous achievements have already been achieved,it remains an arduous challenge to realize efficient sterilization to cut off the drug resistance generation.Recently,photothermal therapy(PTT)has emerged as a promising solution to efficiently damage the integrity of pathogenic bacteria based on hyperthermia beyond their tolerance.Until now,numerous photothermal agents have been studied for antimicrobial PTT.Among them,MXenes(a type of two-dimensional transition metal carbides or nitrides)are extensively investigated as one of the most promising candidates due to their high aspect ratio,atomic-thin thickness,excellent photothermal performance,low cytotoxicity,and ultrahigh dispersibility in aqueous systems.Besides,the enormous application scenarios using their antibacterial properties can be tailored via elaborated designs of MXenes-based materials.In this review,the synthetic approaches and textural properties of MXenes have been systematically presented first,and then the photothermal properties and sterilization mechanisms using MXenes-based materials are documented.Subsequently,recent progress in diverse fields making use of the photothermal and antibacterial performances of MXenes-based materials are well summarized to reveal the potential applications of these materials for various purposes,including in vitro and in vivo sterilization,solar water evaporation and purification,and flexible antibacterial fabrics.Last but not least,the current challenges and future perspectives are discussed to provide theoretical guidance for the fabrication of efficient antimicrobial systems using MXenes. | Shuyan Hao Hecheng Han Zhengyi Yang Mengting Chen Yanyan Jiang Guixia Lu Lun Dong Hongling Wen Hui Li Jiurong Liu Lili Wu Zhou Wang Fenglong Wang | 2022 | Nano-Micro Letters2022，14，11： | 4 |
| 5 | Assessment of circulating tumor DNA in cerebrospinal fluid by whole exome sequencing to detect genomic alterations of glioblastoma显示文摘Background:Cerebrospinal fluid(CSF)has been demonstrated as a better source of circulating tumor DNA(ctDNA)than plasma for brain tumors.However,it is unclear whether whole exome sequencing(WES)is qualified for detection of ctDNA in CSF.The aim of this study was to determine if assessment of ctDNA in CSF by WES is a feasible approach to detect genomic alterations of glioblastoma.Methods:CSFs of ten glioblastoma patients were collected pre-operatively at the Department of Neurosurgery,Sun Yat-sen University Cancer Center.ctDNA in CSF and genome DNA in the resected tumor were extracted and subjected to WES.The identified glioblastoma-associated mutations from ctDNA in CSF and genome DNA in the resected tumor were compared.Results:Due to the ctDNA in CSF was unqualified for exome sequencing for one patient,nine patients were included into the final analysis.More glioblastoma-associated mutations tended to be detected in CSF compared with the corresponding tumor tissue samples(3.56±0.75 vs.2.22±0.32,P=0.097),while the statistical significance was limited by the small sample size.The average mutation frequencies were similar in CSF and tumor tissue samples(74.1%±6.0%vs.73.8%±6.0%,P=0.924).The R132H mutation of isocitrate dehydrogenase 1 and the G34V mutation of H3 histone,family 3A(H3F3A)which had been reported in the pathological diagnoses were also detected from ctDNA in CSF by WES.Patients who received temozolomide chemotherapy previously or those whose tumor involved subventricular zone tended to harbor more mutations in their CSF.Conclusion:Assessment of ctDNA in CSF by WES is a feasible approach to detect genomic alterations of glioblastoma,which may provide useful information for the decision of treatment strategy. | Hao Duan Ji-Long Hu Zheng-He Chen Jue-Hui Li Zhen-Qiang He Zhen-Ning Wang Guan-Hua Zhang Xiao-Yu Guo Lun Liang Yong-Gao Mou | 2020 | Chinese Medical Journal2020，，12： | 3 |
| 6 | Atmospheric isoprene and monoterpenes in a typical urban area of Beijing: Pollution characterization, chemical reactivity and source identification显示文摘Continuous observation of isoprene, α-pinene and β-pinene was carried out in a typical urban area of Beijing from March 2014 to February 2015, using an AirmoV OC online analyzer. Based on the analysis of the ambient level and variation characteristics of isoprene, α-pinene and β-pinene, the chemical reactivity was studied, and their sources were identified. Results showed that the concentrations of isoprene, α-pinene and β-pinene in the urban area of Beijing were lower than those in richly vegetated areas; the concentrations of isoprene were at a moderate level compared with those of previous studies of Beijing. Concentrations of isoprene, α-pinene and β-pinene showed different seasonal, monthly, daily and diurnal variations, and all of the three species showed higher level at night than those in the daytime as a whole, the variations of isoprene, α-pinene and β-pinene mainly influenced by emission of sources, photochemical reaction, and meteorological parameters. Isoprene was the largest contributor to the total OFP values than α-pinene and β-pinene. α-Pinene was the largest contributor to the total SOAFP values than isoprene and β-pinene in autumn, while isoprene was the largest one in other seasons. Isoprene, α-pinene and β-pinene were derived mainly from biological sources; and α-pinene level were also affected by industrial sources. To reduce the concentrations of isoprene, α-pinene and β-pinene, it is necessary to scientifically select urban green plant species, and more strict control measures should be taken to reduce the emission of α-pinene from industrial sources, such as artificial flavors and resins synthesis processes. | Xi Cheng Hong Li Yujie Zhang Yuping Li Weiqi Zhang Xuezhong Wang Fang Bi Hao Zhang Jian Gao Fahe Chai Xiaoxiu Lun Yizhen Chen Junyi Lv | 2018 | Journal of Environmental Sciences2018，30，9： | 3 |
| 7 | Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients显示文摘 | Lun Cai Zheng Zhang Lin Zhou Haiyan Wang Junliang Fu Shuye Zhang Min Shi Hui Zhang Yongping Yang Hao Wu Po Tien Fu-Sheng Wang | 2008 | Clinical Immunology2008，，： | 1 |
| 8 | Predictors of in‐hospital mortality after acute variceal bleeding in patients with hepatocellular carcinoma and concurrent main portal vein thrombosis显示文摘 | Ming‐Lun Han Chieh‐Chang Chen Shih‐Hao Kuo Wen‐Feng Hsu Jyh‐Ming Liou Ming‐Shiang Wu Hsiu‐Po Wang | 2014 | J Gastroenterol Hepatol2014，，2： | 1 |
| 9 | Long noncoding RNA HOTAIR involvement in cancer显示文摘 | Yansheng Wu Li Zhang Yang Wang Hui Li Xiubao Ren Feng Wei Wenwen Yu Xudong Wang Lun Zhang Jinpu Yu Xishan Hao | 2014 | Tumor Biology2014，，10： | 1 |
| 10 | Safflower Yellow Compounds Alleviate Okadaic Acid-Induced Impairment of Neurite Outgrowth in Differentiated SH-SY5Y Cells显示文摘The dynamic assembly of microtubules plays a key role in maintaining structural and functional integrity of eukaryotic cel s,especial y with regard to neuronal differentiation or neurite outgrowth and synaptic plasticity,which contribute to the development of the nervous system and memory formation. | WANG Zhen Hua SHI Xiao Bing LI Gang HAO Xue Yan YUAN Zhen Zhen CAO Xiao Hai WANG Hong Lun LI Ji MA Cheng Jun | 2020 | Biomedical and Environmental Sciences2020，33，10： | 1 |
| 11 | Heat‐shock protein 27: A potential biomarker for hepatocellular carcinoma identified by serum proteome analysis显示文摘 | Ju‐TaoFeng Yin‐KunLiu Hai‐YanSong ZhiDai Lun‐XiuQin Mohamad RadwanAlmofti Cai‐YunFang Hao‐JieLu Peng‐YuanYang Zhao‐YouTang | 2005 | Proteomics2005，，17： | 1 |
| 12 | Heat‐shock protein 27: A potential biomarker for hepatocellular carcinoma identified by serum proteome analysis显示文摘 | Ju‐TaoFeng Yin‐KunLiu Hai‐YanSong ZhiDai Lun‐XiuQin Mohamad RadwanAlmofti Cai‐YunFang Hao‐JieLu Peng‐YuanYang Zhao‐YouTang | 2005 | Proteomics2005，，17： | 1 |
| 13 | SNAIL Regulates Interleukin-8 Expression, Stem Cell–Like Activity, and Tumorigenicity of Human Colorectal Carcinoma Cells显示文摘 | Wei–Lun Hwang Muh–Hwa Yang Ming–Long Tsai Hsin–Yi Lan Shu–Han Su Shih–Ching Chang Hao–Wei Teng Shung–Haur Yang Yuan–Tzu Lan Shih–Hwa Chiou Hsei–Wei Wang | 2011 | Gastroenterology2011，，1： | 1 |
| 14 | Structure and species composition of tree stands on verges and slopes along a major highway in Hong Kong显示文摘Arboricultural research focusing on transport land use was lacking in Hong Kong.Some highway slopes were registered in the Systematic Identification of Maintenance Responsibility of Slopes in the Territory(SIMAR),abbreviated as SIMAR slopes.We aimed to analyze patterns in the structure and species composition of the tree stock along a highway in Hong Kong and examined how a slope registration system could help explain the characteristics of urban forests.The 53 slopes and 52 verges along San Tin Highway,Hong Kong were randomly selected.The trees on each slope and verge were collectively sampled as a tree stand.Six variables,namely tree abundance,species richness,maximum tree height,Shannon-Wiener diversity,Simpson's dominance,and Pielou's evenness were measured for each stand.In addition,a limited visual tree risk assessment was performed.The 7,209 trees in 23 species were recorded.Species richness was low,ranging from one to eight species per stand.SIMAR and non-SIMAR slopes were compared.SIMAR slopes had significantly higher species richness,diversity,evenness but lower dominance,with mean difference of 1.41 species,0.17,0.17 and-0.28respectively.SIMAR slopes were associated with lower tree risk rating.When training regression models,boosting as an ensemble method arbitrarily raised the explanatory power and the predictive accuracy of some models.Slope height,length,angle and area could be significant predictors of the biodiversity-related variables.Future research can sample more habitat characteristics related to the structure and species composition of slopes and verges which were important components of urban forestry. | Louis Shing Him Lee Hao Zhang Kathy Tze Kwun Ng Shun Cheong Lo Alan Siu Lun Yu | 2023 | Journal of Forestry Research2023，34，5： | 0 |
| 15 | A Unified Deep Learning Method for CSI Feedback in Massive MIMO Systems显示文摘A unified deep learning(DL)based algorithm is proposed for channel state information(CSI)compression in massive multipleinput multipleoutput(MIMO)systems.More importantly,the element filling strategy is investigated to address the problem of model redesign⁃ing and retraining for different antenna typologies in practical systems.The results show that the proposed DL-based algorithm achieves better performance than the enhanced TypeⅡalgorithm in Release 16 of 3GPP.The proposed element filling strategy enables onetime training of a unified model to compress and reconstruct different channel state matrices in a practical MIMO system. | GAO Zhengguang LI Lun WU Hao TU Xuezhen HAN Bingtao | 2022 | ZTE Communications2022，20，4： | 0 |
| 16 | Inferring Requirement Goals from Model Implemented in UML显示文摘UML is used widely in many software development processes.However,it does not make explicit requirement goals. Here is a method tending to establish the semantic relationship between requirements goals and UML models.Before the method is introduced, some relevant concepts are described. | Tang Sheng qun, Liu Wei, Ma Jie, Xia Lun xian, Jiang Hao lan State Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072, China | 2001 | Wuhan University Journal of Natural Sciences2001，6，Z1： | 0 |
| 17 | A new facile synthesis of shikalkin显示文摘A short and convergent approach for the synthesis of shikalkin (dl-shikonin) is presented. Stobbe reaction was employed to construct the aromatic skeleton 6. This is followed by a practical method to prepare the key epoxides 9 from aldehydes 8 in high yield. Finally, shikalkin is achieved by Grignard reaction and oxidation. | Qun Lu Hao Lun Tang Yan Qiang Shao Jun Chao Cai | 2008 | Chinese Chemical Letters2008，19，2： | 0 |
| 18 | Effect of pH on the Hydrothermal Synthesis of BN Nanocrystals显示文摘一氮化硼(蒽铬黄 BN ) 用试验性的结果显示出的热水的 synthesismethod.The 被综合了反应答案的最适 PH 价值在蒽铬黄 BN 的收益和阶段上有重要效果,这取样。当最适 PH 价值减少了, cBN 的内容增加了,收益改善了。cBN 内容的增加从 oBN 的变换被结果进 cBNunder cBN nanocrystals may 的热水的状况,和生长由于减少在在那里行动速度,当最适 PH 价值减少了时,因此,蒽铬黄 BN 的水晶的完美改善了。 | Wei FANG Xiao Peng HAO Ning LUN Xian ZHAO De Liang CUI Xu Tang TAO Min Hua JIANG | 2006 | Chinese Chemical Letters2006，17，4： | 0 |
| 19 | Observations of the solar corona during the total solar eclipse on 21 August 2017显示文摘The Sun’s tenuous outer atmosphere,the corona,emits only about one-millionth as much light as the solar surface.In ancient times the corona was observed by human beings only during total solar eclipses,when the strong emission of visible light from the photosphere was completely blocked by the Moon.In 1931, | Hui Tian ZhongQuan Qu YaJie Chen LinHua Deng ZhengHua Huang Hao Li Yue Zhong Yu Liang JingWen Zhang YiGong Zhang BaoLi Lun XiangMing Cheng XiaoLi Yan ZhiKe Xue YuXin Xin ZhiMing Song YingJie Zhu Tanmoy Samanta | 2017 | Earth and Planetary Physics2017，1，1： | 0 |
| 20 | The Coude Echelle Spectrograph for the Lijiang 1.8 m telescope显示文摘The Coude Echelle Spectrograph(CES)was originally mounted on Xinglong 2.16 m telescope in 1994.When the High Resolution Fiber-fed Spectrograph(HRS)was commissioned at Xinglong 2.16 m telescope,the red path of CES was moved to Lijiang 1.8 m telescope,following some redesign and reinstallation.The CES of Lijiang 1.8 m telescope has the spectral resolution(R=λ/?λ)ranging from 20000 to 50000 corresponding to different slit widths.With a 2 k×2 k PI CCD,CES has a wavelength coverage between 570 nm to 1030 nm.In particular,the resolution of 37000 at 0.5 mm slit corresponds to 1.3′′on the sky.The limiting magnitude is V=11.5 with the use of the tip-tilt feedback system,and the S/N is about 40 for 1 hour exposure at 600 nm(R=37000).During the installation of CES,the tip-tilt mirror technology had successfully fulfilled high precision guiding and tracking for high resolution spectral observation and significantly improved the observation efficiency. | Xiao-Li Wang Liang Chang Lei Wang Hang-Xin Ji Hao Xian Zhen Tang Yu-Xin Xin Chuan-Jun Wang Shou-Sheng He Ju-Jia Zhang Bao-Li Lun Kai Wei Xi-Qi Li Xiao-Jun Jiang Hui-Juan Wang Hong-Bin Li Ji-Rong Mao | 2020 | Research in Astronomy and Astrophysics2020，20，3： | 0 |
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