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| 1 | Complete chloroplast genome sequence of Magnolia grandiflora and comparative analysis with related species显示文摘Magnolia grandiflora is an important medicinal,ornamental and horticultural plant species.The chloroplast(cp) genome of M.grandiflora was sequenced using a 454 sequencing platform and the genome structure was compared with other related species.The complete cp genome of M.grandiflora was 159623 bp in length and contained a pair of inverted repeats(IR) of 26563 bp separated by large and small single copy(LSC,SSC) regions of 87757 and 18740 bp,respectively.A total of 129 genes were successfully annotated,18 of which included introns.The identity,number and GC content of M.grandiflora cp genes were similar to those of other Magnoliaceae species genomes.Analysis revealed 218 simple sequence repeat(SSR) loci,most composed of A or T,contributing to a bias in base composition.The types and abundances of repeat units in Magnoliaceae species were relatively conserved and these loci will be useful for developing M.grandiflora cp genome vectors.In addition,results indicated that the cp genome size in Magnoliaceae species and the position of the IR border were closely related to the length of the ycf1 gene.Phylogenetic analyses based on 66 shared genes from 30 species using maximum parsimony(MP) and maximum likelihood(ML) methods provided strong support for the phylogenetic position of Magnolia.The availability of the complete cp genome sequence of M.grandiflora provides valuable information for breeding of desirable varieties,cp genetic engineering,developing useful molecular markers and phylogenetic analyses in Magnoliaceae. | LI XiWen GAO HuanHuan WANG YiTao SONG JingYuan HENRY Robert WU HeZhen HU ZhiGang YAO Hui LUO HongMei LUO Kun PAN HongLin CHEN ShiLin | 2013 | Science China(Life Sciences)2013，56，2： | 17 |
| 2 | Metal Sealing Performance of Subsea X-tree Wellhead Connector Sealer显示文摘The metal sealing performance of subsea X-tree wellhead connectors is crucial for the safety and reliability of subsea X-trees. In order to establish the theoretical relation between metal sealing ring's contact stress and its structural parameters and working pressure, a mechanical analysis method for double-cone sealing of high pressure vessels is applied in analyzing the metal sealing ring under the condition of preload and operation. As a result, the formula of the unit sealing load for the metal sealing ring under operation with residual preload is shown in this paper, which ensures that the metal sealing ring has an excellent sealing effect and can prevent the metal sealing ring from yielding. Besides, while analyzing the sealing process of the metal sealing ring, the change rule of contact stress and working pressure is concluded here, putting forward that the structural parameters of the metal sealing ring are the major factors affecting the change rule. Finally, the analytical solution through theoretical analysis is compared with the simulation result through finite element analysis in a force feedback experiment, and both are consistent with each other, which fully verifies for the design and calculation theory on metal sealing ring's contact stress and its structural parameters and working pressure deduced in this paper. The proposed research will be treated as an applicable theory guiding the design of metal seal for subsea X-tree wellhead connectors. | ZHAO Honglin CHEN Rui LUO Xiaolan DUAN Menglan LU Yinghui FU Guowei TIAN Hongping YE Daohui | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 9 |
| 3 | Symmetry breaking of photonic spin-orbit interactions in metasurfaces显示文摘Spin-orbit optical phenomena pertain to the wider class of electromagnetic effects originating from the interaction of the photon spin with the spatial structure and propagation characteristics of an optical wave,mediated by suitable optical media.There are many emerging photonic applications of spin-orbit interactions(SOI)of light,such as control of the optical wave propagation via the spin,enhanced optical manipulation,and generation of structured optical fields.Unfortunately,current applications are based on symmetric SOI,that is,the behaviours of polarized photons with two opposite spins are opposite,leading to the limit of spin-based multiplexers.The symmetry of SOI can be broken in our proposed metasurfaces,consisting of spatially varying birefringence,which can arbitrarily and independently build SOI for two opposite spins without reduction of optical energy usage.We obtain three kinds of dual-functional metasurfaces at visible and infrared wavelengths with high efficiency.Our concept of generation of asymmetric SOI for two spins,using anisotropic metasurfaces,will open new degrees of freedoms for building new types of spin-controlled multifunctional shared-aperture devices for the generation of complex structured optical fields. | Fei Zhang Mingbo Pu Jun Luo Honglin Yu Xiangang Luo | 2017 | 光电工程2017，44，3： | 8 |
| 4 | Autoantigen Microarray for High-throughput Autoantibody Profiling in Systemic Lupus Erythematosus显示文摘Systemic lupus erythematosus(SLE) is a complex autoimmune disease characterized by the production of autoantibodies to a broad range of self-antigens. Profiling the autoantibody repertoire using array-based technology has emerged as a powerful tool for the identification of biomarkers in SLE and other autoimmune diseases. Proteomic microarray has the capacity to hold large number of self-antigens on a solid surface and serve as a high-throughput screening method for the determination of autoantibody specificities. The autoantigen arrays carrying a wide variety of self-antigens, such as cell nuclear components(nucleic acids and associated proteins), cytoplasmic proteins, phospholipid proteins, cell matrix proteins, mucosal/secreted proteins, glomeruli, and other tissue-specific proteins, have been used for screening of autoantibody specificities associated with different manifestations of SLE. Arrays containing synthetic peptides and molecular modified proteins are also being utilized for identification of autoantibodies targeting to special antigenic epitopes. Different isotypes of autoantibodies, including Ig G, Ig M, Ig A, and Ig E, as well as other Ig subtypes, can be detected simultaneously with multi-color labeled secondary antibodies. Serum and plasma are the most common biologic materials for autoantibody detection, but other body fluids such as cerebrospinal fluid, synovial fluid, and saliva can also be a source of autoantibody detection.Proteomic microarray as a multiplexed high-throughput screening platform is playing an increasingly-important role in autoantibody diagnostics.In this article,we highlight the use of autoantigen microarrays for autoantibody exploration in SLE. | Honglin Zhu Hui Luo Mei Yan Xiaoxia Zuo Quan-Zhen Li | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 6 |
| 5 | Simultaneous determination of brominated phenols in soils显示文摘Brominated phenols(BPs),a widely used group of emerging flame retardants,are important environmental contaminants and exhibit endocrine disrupting potential.Method for simultaneous determination of tetrabromobisphenol A(TBBPA),tribromophenol(TBP),dibromophenols(DBPs)and monobromophenols(MBPs)in soils using gas chromatography-mass spectrometry analysis(GC/MS)was successfully developed.Cleanup methods for soil extracts including several solid-phase extraction cartridges and diferent elution solvents were compared and optimized.Florisil cartridge with dichloromethane as the elution reagent was selected for sample cleanup owing to its high and reproducible recoveries of the target analytes in soils.Derivatization conditions were tested and the optimal conditions were obtained with 20μL silylation reagent at room temperature.The chromatographic separation was optimized with diferent columns and DB-XLB column was selected for its excellent separation of the analytes.The limits of detection for the target compounds were from 0.04 to 0.19 ng/g.Mean recoveries of the compounds from spiked soils exceeded 84%with a good reproducibility,excepting that the recovery of 2-bromophenol was relatively poor(lower than 55%)due to its instability.The developed method was applied to the determination of the BPs in the soils collected from e-waste sites.The contents of BPs in the soils were at ng/g levels with TBBPA and TBP the most frequently detected.To our knowledge,this is the first report for the simultaneous determination of TBBPA,TBP,DBPs and MBPs in soils. | Wei Han Sen Wang Honglin Huang Lei Luo Shuzhen Zhang | 2013 | Journal of Environmental Sciences2013，25，11： | 5 |
| 6 | Regulation of REGγ cellular distribution and function by SUMO modification显示文摘新兴的调整 REG 的蛋白质的发现在多重生物过程作为一条重要小径加重了 REG-proteasome,包括细胞生长,细胞周期规定,和 apoptosis。然而,很少对 REG-proteasome 小径的规定被知道。这里,我们证明 REG 能是在 vitro 并且在由 SUMO-1, SUMO-2,和 SUMO-3 的 vivo 的 SUMOylated。激活的 STAT (PIAS ) 的 SUMO-E3 蛋白质禁止者 1 身体上与 REG 联系并且支持 REG 的 SUMOylation。REG 的 SUMOylation 被发现发生在多重地点,包括 K6, K14,和 K12。变化分析显示这些相扑地点同时在房间贡献了 REG 的 SUMOylation 地位。由相扑变化形式的 REG 的 Posttranslational 修正被揭示调停 REG 并且到原因的 cytosolic translocation 增加了这 proteasome 使活跃之物的稳定性。显示的 SUMOylation 缺乏的 REG 稀释了能力降级 p21Waf//Cip1 由于为 p21 的 REG SUMOylation 有缺点的异种的减少的亲密关系。一起拿,我们报导调整 proteasome 使活跃之物 REG 的活动的以前未被认出的机制。这规章的机制可以使 REG 能与一个更宽广的底层系列在蛋白质降级作为一个更多的有势力因素工作。 | Yan Wu Lu Wang Ping Zhou Guangqiang Wang Yu Zeng Ying Wang Jian Liu Bianhong Zhang Shuang Liu Honglin Luo Xiaotao Li | 2011 | Cell Research2011，21，5： | 4 |
| 7 | Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac function显示文摘Enteroviral 感染能导致扩大心肌症(DCM ) ,它是世界范围的心血管的死亡的一个主要原因。然而,病原的机制充分没被阐明。浆液反应因素(SRF ) 是控制许多目标基因的表示的一个心脏充实抄写管理者,包括涉及可收缩的仪器和立即的早反应的那些,以及 microRNAs 那沉默心脏的规章的因素的表示。在心的 SRF 的大美人导致心脏的可收缩的基因表示的 downregulation 和 DCM 的开发。这研究的目标是在导致 enterovirus 的心脏的机能障碍和前进理解 SRF 的角色到 DCM。这里,我们报导 SRF 被劈开跟随老鼠心和有教养的 cardiomyocytes 的 enteroviral 感染。这劈开被心脏特定的可收缩、规章的基因的损害心脏的功能和 downregulation 伴随。由印射的抗体 epitope 和指导地点的 mutagenesis 的进一步的调查证明那 SRF 劈开通过编码病毒的朊酶 2A 的行动发生在它的 transactivation 领域的区域。而且,我们证明 SRF 的那劈开分裂它从 DNA 有约束力的领域的 transactivation 领域,导致调停 SRF 的基因 transactivation 的混乱。除了功能的 SRF 的损失,最后,我们报导 SRF 劈开产品的 N 终端碎片能也充当一个主导否定的抄写因素,它多半为 DNA 绑定与本国的 SRF 竞争。我们的结果建议病毒感染由损害心功能的机制并且可以提供新治疗学的策略改善 DCM 的心肌的损坏和前进。 | Jerry Wong Jingchun Zhang Bobby Yanagawa Zongshu Luo Xiangsheng Yang Jiang Chang Bruce McManus Honglin Luo | 2012 | Cell Research2012，22，2： | 3 |
| 8 | Layer-by-Layer Assembled Bacterial Cellulose/Graphene Oxide Hydrogels with Extremely Enhanced Mechanical Properties显示文摘Uniform dispersion of two-dimensional(2 D) graphene materials in polymer matrices remains challenging. In this work, a novel layer-by-layer assembly strategy was developed to prepare a sophisticated nanostructure with highly dispersed 2 D graphene oxide in a three-dimensional matrix consisting of onedimensional bacterial cellulose(BC) nanofibers. This method is a breakthrough, with respect to the conventional static culture method for BC that involves multiple in situ layer-by-layer assembly steps at the interface between previously grown BC and the culture medium. In the as-prepared BC/GO nanocomposites, the GO nanosheets are mechanically bundled and chemically bonded with BC nanofibers via hydrogen bonding,forming an intriguing nanostructure. The sophisticated nanostructure of the BC/GO leads to greatly enhanced mechanical properties compared to those of bare BC. This strategy is versatile, facile, scalable, and can be promising for the development of high-performance BC-based nanocomposite hydrogels. | Honglin Luo Jiaojiao Dong Fanglian Yao Zhiwei Yang Wei Li Jie Wang Xinhua Xu Jian Hu Yizao Wan | 2018 | Nano-Micro Letters2018，10，3： | 2 |
| 9 | Leakage tests of the stainless steel vessels of the antineutrino detectors in the Daya Bay reactor neutrino experiment显示文摘The antineutrino detectors for the Daya Bay reactor neutrino experiment are liquid scintillator detectors designed to detect electron anti-neutrino via inverse beta interactions with high efficiency and low backgrounds.Since the antineutrino detector will be installed and immerged in water Cherenkov detector and will run for 3 to 5 years,water tightness is critical to the successful operation of the antineutrino detectors.A special seal technique was used for this purpose.Three leak checking methods have been employed to ensure the seal quality.This paper describes the sealing method and leakage testing results. | CHEN XiaoHui LUO XiaoLan HENG YueKun WANG LingShu TANG Xiao MA XiaoYan ZHUANG HongLin BAND Henry R. CHERWINKA Jeff J. XIAO Qiang HEEGER Karsten M. | 2013 | Science China(Technological Sciences)2013，56，1： | 2 |
| 10 | Interplay between the cellular autophagy machinery and positive-stranded RNA viruses显示文摘Autophagy 是在维持细胞的动态平衡充当一个关键管理者的一个保存细胞的过程。最近的研究含有为在由搬迁入侵病原体并且通过 modulating 的感染和免疫的 autophagy 的一个重要角色天生、适应的有免疫力的回答。然而,几病原体,一些尤其是积极海滨的 RNA 病毒,破坏了 autophagy 到他们的自己的目的。在这评论,我们总结有一个积极海滨的 RNA 染色体的病毒怎么与主人 autophagy 机械交往控制他们的复制并且传播的当前的理解。我们考察位于 autophagy 的正式就职下面的机制并且讨论支持 viral 和 autophagy 和包含的潜在的机制的抗病毒的功能。 | Junyan Shi Honglin Luo | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 2 |
| 11 | Synthesis of ZnO by Chemical Bath Deposition in the Presence of Bacterial Cellulose显示文摘The control of the morphology of zinc oxide(ZnO) crystals is very important in science and industry.This article reports the influence of bacterial cellulose(BC) on the morphology of ZnO prepared by chemical bath deposition.ZnO nanostructures synthesized with and without adding BC to the aqueous solution of zinc acetate and ammonia were characterized by scanning electron microscopy,transmission electron microscopy,and X-ray diffraction.The results reveal that the presence of BC in the aqueous solution changes the morphology from spindle to flower,which is ascribed to the interactions between –OH on BC nanofibers and Zn2?in the solution.In addition,optical property of the two ZnO nanostructures was compared. | Guangyao Xiong Honglin Luo Jing Zhang Jun Jin Yizao Wan | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，4： | 2 |
| 12 | Human umbilical cord mesenchymal stem cells for psoriasis:a phase 1/2a,single-arm study显示文摘Psoriasis is a common,chronic immune-mediated systemic disease that had no effective and durable treatment.Mesenchymal stem cells(MSCs)have immunomodulatory properties.Therefore,we performed a phase 1/2a,single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs(UMSCs)in the treatment of psoriasis and to preliminarily explore the possible mechanisms.Seventeen patients with psoriasis were enrolled and received UMsC infusions.Adverse events,laboratory parameters,PASl,and PGA were analyzed.We did not observe obvious side effects during the treatment and 6-month follow-up.A total of 47.1%(8/17)of the psoriasis patients had at least 40%improvement in the PASl score,and 17.6%(3/17)had no sign of disease or minimal disease based on the PGA score.And the efficiency was 25%(2/8)for males and 66.7%(6/9)for females.After UMSC transplantation(UMSCT),the frequencies of Tregs and CD4^(+)memory T cells were significantly increased,and the frequencies of T helper(Th)17 and CD4^(+)naive T cells were significantly decreased in peripheral blood(PB)of psoriasis patients.And all responders showed significant increases in Tregs and CD4^(+)memory T cells,and significant decreases in Th17 cells and serum IL-17 level after UMsCT.And baseline level of Tregs in responders were significantly lower than those in nonresponders.In conclusion,allogeneic UMSCT is safe and partially effective in psoriasis patients,and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT.Trial registration Clinical Trials NCT03765957. | Lamei Cheng Siqi Wang Cong Peng Xiao Zou Chao Yang Hua Mei Chuang Li Xian Su Na Xiao Qi Ouyang Mi Zhang Qiaolin Wang Yan Luo Minxue Shen Qun Qin Honglin Wang Wu Zhu Guangxiu Lu Ge Lin Yehong Kuang Xiang Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 13 | Air DBD plasma treatment on three-dimensional braided car- bon fiber-reinforced PEEK composites for enhancement of in vitro bioactivity 显示文摘 | Luo Honglin Xiong Guangyao Ren Kaijing | 2014 | Surface and Coatings Techno- logy2014，242，： | 1 |
| 14 | Evolu- tion of morphology of bacterial cellulose scaffolds during early culture 显示文摘 | Luo Honglin Zhang Jing Xiong Guangyao | 2014 | Carbohydr Polym2014，111，： | 1 |
| 15 | Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope显示文摘Apoptotic 原子核包括原子收缩,染色质冷凝作用和 DNA 破碎经历不同词法、生物化学的变化,它被归因于象 lamins 那样的几原子底层的调停 caspase 的劈开。当大多数活跃 caspases 居住在细胞质,原子细胞质的障碍的混乱是必要的让 caspases 到达他们的原子目标。占优势建议机制是 caspases 导致的原子毛孔的渗透的增加允许 caspases 和另外的 apoptotic 因素扩散进原子核,从而导致原子破坏。这里,我们报导原子信封(NE ) 的物理破裂发生在 apoptosis 的早阶段的新奇观察。我们发现 NE 破裂被 C53/LZAP 的调停 caspase 的劈开引起,在各种各样的发信号的小径被含有的蛋白质,包括 NF-κ发信号的 B 和 DNA 损坏反应,以及 tumorigenesis 和转移。我们也证明 C53/LZAP 间接地跳了到微导管(MT ) ,并且 C53/LZAP 劈开产品的表示引起了反常 MT 捆绑和 NE 破裂。一起拿,我们的调查结果在 apoptotic 房间死亡期间在 MT 动力学和 NE 结构的规定建议 C53/LZAP 的一个新奇角色。我们的学习可以在 apoptosis 期间为原子细胞质的障碍的混乱提供另外的机制。 | Jianchun Wu Hai Jiang Shouqing Luo Mingsheng Zhang Yinghua Zhang Fei Sun Shuang Huang Honglin Li | 2013 | Cell Research2013，23，5： | 1 |
| 16 | Interfacial polymerized polyaniline/graphite oxide nanocomposites toward electrochemical energy storage显示文摘 | Jiahua Zhu Minjiao Chen Honglin Qu Xi Zhang Huige Wei Zhiping Luo Henry A. Colorado Suying Wei Zhanhu Guo | 2012 | Polymer2012，，25： | 1 |
| 17 | Preparation and characterization of a new biomedical magnesium-calcium alloy显示文摘 | Wan Yizao Xiong Guangyao Luo Honglin | 2008 | Materials and Design2008，29，0： | 1 |
| 18 | Influence of Glomus etunicatum / Zea mays mycorrhiza on atrazine degradation, soil phosphatase and dehydrogenase activities, and soil microbial community structure显示文摘 | Honglin Huang Shuzhen Zhang Naiying Wu Lei Luo Peter Christie | 2009 | Soil Biology and Biochemistry2009，，4： | 1 |
| 19 | Characterization of TEMPO-oxidized bacterial cellulose scaffolds for tissue engineering applications显示文摘 | Luo Honglin Xiong Guangyao Hu Da | 2013 | Materials Chemistry and Physics2013，143，： | 1 |
| 20 | MicroRNA-21 in Scleroderma Fibrosis and its Function in TGF-β- Regulated Fibrosis-Related Genes Expression显示文摘 | Honglin Zhu Hui Luo Yisha Li Yaou Zhou Ying Jiang Jin Chai Xianzhong Xiao Yunhui You Xiaoxia Zuo | 2013 | Journal of Clinical Immunology2013，，6： | 1 |
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