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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Metal Sealing Performance of Subsea X-tree Wellhead Connector Sealer显示文摘The metal sealing performance of subsea X-tree wellhead connectors is crucial for the safety and reliability of subsea X-trees. In order to establish the theoretical relation between metal sealing ring's contact stress and its structural parameters and working pressure, a mechanical analysis method for double-cone sealing of high pressure vessels is applied in analyzing the metal sealing ring under the condition of preload and operation. As a result, the formula of the unit sealing load for the metal sealing ring under operation with residual preload is shown in this paper, which ensures that the metal sealing ring has an excellent sealing effect and can prevent the metal sealing ring from yielding. Besides, while analyzing the sealing process of the metal sealing ring, the change rule of contact stress and working pressure is concluded here, putting forward that the structural parameters of the metal sealing ring are the major factors affecting the change rule. Finally, the analytical solution through theoretical analysis is compared with the simulation result through finite element analysis in a force feedback experiment, and both are consistent with each other, which fully verifies for the design and calculation theory on metal sealing ring's contact stress and its structural parameters and working pressure deduced in this paper. The proposed research will be treated as an applicable theory guiding the design of metal seal for subsea X-tree wellhead connectors. | ZHAO Honglin CHEN Rui LUO Xiaolan DUAN Menglan LU Yinghui FU Guowei TIAN Hongping YE Daohui | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 9 |
| 3 | QSobel:A novel quantum image edge extraction algorithm显示文摘Edge extraction is an indispensable task in digital image processing. With the sharp increase in the image data, real-time problem has become a limitation of the state of the art of edge extraction algorithms.In this paper, QSobel, a novel quantum image edge extraction algorithm is designed based on the flexible representation of quantum image(FRQI) and the famous edge extraction algorithm Sobel. Because FRQI utilizes the superposition state of qubit sequence to store all the pixels of an image, QSobel can calculate the Sobel gradients of the image intensity of all the pixels simultaneously. It is the main reason that QSobel can extract edges quite fast. Through designing and analyzing the quantum circuit of QSobel, we demonstrate that QSobel can extract edges in the computational complexity of O(n2) for a FRQI quantum image with a size of2 n × 2n. Compared with all the classical edge extraction algorithms and the existing quantum edge extraction algorithms, QSobel can utilize quantum parallel computation to reach a significant and exponential speedup.Hence, QSobel would resolve the real-time problem of image edge extraction. | ZHANG Yi LU Kai GAO YingHui | 2015 | Science China(Information Sciences)2015，58，1： | 8 |
| 4 | Crosstalk-free achromatic full Stokes imaging polarimetry metasurface enabled by polarization-dependent phase optimization显示文摘Imaging polarimetry is one of the most widely used analytical technologies for object detection and analysis.To date,most metasurface-based polarimetry techniques are severely limited by narrow operating bandwidths and inevitable crosstalk,leading to detrimental effects on imaging quality and measurement accuracy.Here,we propose a crosstalkfree broadband achromatic full Stokes imaging polarimeter consisting of polarization-sensitive dielectric metalenses,implemented by the principle of polarization-dependent phase optimization.Compared with the single-polarization optimization method,the average crosstalk has been reduced over three times under incident light with arbitrary polarization ranging from 9μm to 12μm,which guarantees the measurement of the polarization state more precisely.The experimental results indicate that the designed polarization-sensitive metalenses can effectively eliminate the chromatic aberration with polarization selectivity and negligible crosstalk.The measured average relative errors are 7.08%,8.62%,7.15%,and 7.59%at 9.3,9.6,10.3,and 10.6μm,respectively.Simultaneously,the broadband full polarization imaging capability of the device is also verified.This work is expected to have potential applications in wavefront detection,remote sensing,light-field imaging,and so forth. | Yaxin Zhang Mingbo Pu Jinjin Jin Xinjian Lu Yinghui Guo Jixiang Cai Fei Zhang Yingli Ha Qiong He Mingfeng Xu Xiong Li Xiaoliang Ma Xiangang Luo | 2022 | Opto-Electronic Advances2022，5，11： | 6 |
| 5 | Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition显示文摘Astronauts are under high stress for a long time because of the microgravity condition,which leads to anxiety,affects their learning and memory abilities,and seriously impairs the health of astronauts.Aromatherapy can improve the physical and mental health of astronauts in a way that moisturizes them softly and silently.However,the strong volatility of fragrances and inconvenience of aroma treatment greatly limit their application in the field of spaceflight.In this study,reactive mesoporous silica nanoparticles were prepared to encapsulate and slowly release limonene.The limonene loaded nanoparticles were named limonene@mesoporous silica nanoparticles-cyanuric chloride(LE@MSNs-CYC).LE@MSNs-CYC were then applied to wallpaper to improve the convenience of aromatherapy.LE@MSNs-CYC could chemically react with the wallpaper,thus firmly adsorbed on the wallpaper.In the following,the mice were treated with hindlimb unloading(HU)to simulate a microgravity environment.The results showed that 28-day HU led to an increase in the level of anxiety and declines in learning,memory,and physical health in mice.LE@MSNs-CYC showed significant relief effects on anxiety,learning,memory,and physical health of HU treated mice.Subsequently,the molecular mechanisms were explored by hypothalamic-pituitary-adrenal axis related hormones,immune-related cytokines,learning,and memory-related neurotransmitters and proteins. | Zhiguo Lu Jianze Wang Lina Qu Guanghan Kan Tianlu Zhang Jie Shen Yan Li Jun Yang Yunwei Niu Zuobing Xiao Yinghui Li Xin Zhang | 2020 | Bioactive Materials2020，5，4： | 5 |
| 6 | Variability of microphysical characteristics in the “21·7” Henan extremely heavy rainfall event显示文摘In this study, significant rainfall microphysical variability is revealed for the extremely heavy rainfall event over Henan Province in July 2021(the “21·7” Henan EHR event) using a dense network of disdrometers and two polarimetric radars.The broad distributions of specific drop size distribution(DSD) parameters are identified in heavy rainfall from the disdrometer observations, indicating obvious microphysical variability on the surface. A K-means clustering algorithm is adopted to objectively classify the disdrometer datasets into separate groups, and distinct DSD characteristics are found among these heavy rainfall groups. Combined with the supporting microphysical structures obtained through radar observations, comprehensive microphysical features of the DSD groups are derived. An extreme rainfall group is dominantly formed in the deep convection over the plain regions, where the high number of concentrations and large mean sizes of surface raindrops are underpinned by both active ice-phase processes and efficient warm-rain collision-coalescence processes in the vertical direction. Convection located near orographic regions is characterized by restricted ice-phase processes and high coalescence efficiency of liquid hydrometeors, causing the dominant DSD group to comprise negligible large raindrops. Multiple DSD groups can coexist within certain precipitation episodes at the disdrometer stations, indicating the potential microphysical variability during the passage of convective system on the plain regions. | Gang CHEN Kun ZHAO Yinghui LU Yuanyuan ZHENG Ming XUE Zhe-Min TAN Xin XU Hao HUANG Haonan CHEN Fen XU Ji YANG Shushi ZHANG Xueqi FAN | 2022 | Science China Earth Sciences2022，65，10： | 4 |
| 7 | Blind spectrum sensing based on the ratio of mean square to variance显示文摘Anderson-Darling(AD) sensing, characteristic function(CF) sensing and order statistic(OS) sensing are three common spectrum sensing(SS) methods based on goodness of fit(GOF) testing. However, AD and OS sensing needs the prior information of noise variance; CF and OS sensing have high computation complexity. To circumvent those difficulties, in this paper, the ratio of the mean square to variance(RM2V) of the samples, after deriving its probability density function(PDF), is employed as a test statistic to detect the availability of the vacant spectrum in the cognitive radio(CR) system. Then a blind SS method based on RM2 V is proposed, which is dubbed as RM2 V sensing, and its exact theoretical threshold is obtained via the derived PDF of RM2 V. The performance of RM2 V sensing is evaluated by theoretical analysis and Monte Carlo simulations. Comparing with the conventional energy detection(ED), AD, CF and OS sensing, RM2 V sensing, with no need of noise variance, has advantages from the aspect of computation complexity and detection performance. | Ye Yinghui Lu Guangyue | 2016 | The Journal of China Universities of Posts and Telecommunications2016，23，1： | 4 |
| 8 | Systematic biomedical research of the NASA Twins Study facilitates the hazard risk assessment of long-term spaceflight missions显示文摘With the extension of the deep space exploration program, the boundaries of human exploration will be pushed forward to the surface of Mars. Over the past nearly 60 years manned spaceflight and experimental fin dings dem on strated that spaceflight induced bone loss, muscle atrophy, cardiovascular remodeling and space-related medical problems (Durante and Cucinotta, 2008). | Zhongquan Dai Xiaohua Lei Chao Yang Lei Zhao Liang Lu Yinghui Li | 2019 | Protein & Cell2019，10，9： | 3 |
| 9 | Oxygen Vacancy-Rich 2D TiO_(2) Nanosheets:A Bridge Toward High Stability and Rapid Hydrogen Storage Kinetics of Nano-Confined MgH_(2)显示文摘MgH_(2) has attracted intensive interests as one of the most promising hydrogen storage materials.Nevertheless,the high desorption temperature,sluggish kinetics,and rapid capacity decay hamper its commercial application.Herein,2D TiO_(2) nanosheets with abundant oxygen vacancies are used to fabricate a flower-like MgH_(2)/TiO_(2) heterostructure with enhanced hydrogen storage performances.Particularly,the onset hydrogen desorption temperature of the MgH_(2)/TiO_(2) heterostructure is lowered down to 180℃(295℃ for blank MgH_(2)).The initial desorption rate of MgH_(2)/TiO_(2) reaches 2.116 wt% min^(-1) at 300℃,35 times of the blank MgH_(2) under the same conditions.Moreover,the capacity retention is as high as 98.5% after 100 cycles at 300℃,remarkably higher than those of the previously reported MgH_(2)-TiO_(2) composites.Both in situ HRTEM observations and ex situ XPS analyses confirm that the synergistic effects from multi-valance of Ti species,accelerated electron transportation caused by oxygen vacancies,formation of catalytic Mg-Ti oxides,and stabilized MgH_(2) NPs confined by TiO_(2) nanosheets contribute to the high stability and kinetically accelerated hydrogen storage performances of the composite.The strategy of using 2D substrates with abundant defects to support nano-sized energy storage materials to build heterostructure is therefore promising for the design of high-performance energy materials. | Li Ren Wen Zhu Yinghui Li Xi Lin Hao Xu Fengzhan Sun Chong Lu Jianxin Zou | 2022 | Nano-Micro Letters2022，14，9： | 2 |
| 10 | Broadband high-efficiency polymerized liquid crystal metasurfaces with spin-multiplexed functionalities in the visible显示文摘Traditional optical components are usually designed for a single functionality and narrow operation band,leading to the limited practical applications.To date,it is still quite challenging to efficiently achieve multifunctional performances within broadband operating bandwidth via a single planar optical element.Here,a broadband high-efficiency polarization-multiplexing method based on a geometric phase polymerized liquid crystal metasurface is proposed to yield the polarization-switchable functionalities in the visible.As proofs of the concept,two broadband high-efficiency polymerized liquid crystal metalenses are designed to obtain the spin-controlled behavior from diffraction-limited focusing to sub-diffraction focusing or focusing vortex beams.The experimental results within a broadband range indicate the stable and excellent optical performance of the planar liquid crystal metalenses.In addition,low-cost polymerized liquid crystal metasurfaces possess unique superiority in large-scale patterning due to the straightforward processing technique rather than the point-by-point nanopatterning method with high cost and low throughput.The high-efficiency liquid crystal metasurfaces also have unrivalled advantages benefiting from the characteristic with low waveguide absorption.The proposed strategy paves the way toward multifunctional and high-integrity optical systems,showing great potential in mobile devices,optical imaging,robotics,chiral materials,and optical interconnections. | XINJIAN LU XIAOYIN LI YINGHUI GUO MINGBO PU JIANGYU WANG YAXIN ZHANG XIONG LI XIAOLIANG MA XIANGANG LUO | 2022 | Photonics Research2022，10，6： | 2 |
| 11 | Numerical implementation of matching Pursuit for the Analysis of complex ultrasonic signals 显示文摘 | Yinghui lu Jennifer E | 2008 | IEEE Transactions on Ultrasonics Ferroelectrics and Fre- quencyControl2008，55，1： | 1 |
| 12 | A methodology for structural health monitoring with diffuse ultrasonicwaves in the presence of temperature variations显示文摘 | Yinghui Lu Jennifer E Michaels | 2005 | Ultrasonics2005，43，： | 1 |
| 13 | Iaso: an autonomous fault-tolerant management system for supercomputers显示文摘 | Kai LU Xiaoping WANG Gen LI Ruibo WANG Wanqing CHI Yongpeng LIU Hongwei TANG Hua FENG Yinghui GAO | 2014 | Frontiers of Computer Science2014，8，3： | 1 |
| 14 | Advances with RNA interference in Alzheimer’s disease research显示文摘 | Weien Yuan Yinghui Chen Xue-mei Ge Shun Chen Zhenguo Liu Nan Lu | 2013 | Drug Design Development and Therapy (default)2013，，： | 1 |
| 15 | Numerical Implementation of Matching Pursuit for the Analysis of Complex Ultrasonic Signals显示文摘 | Michaels J E Lu Yinghui | | 0，，01： | 1 |
| 16 | Regulatory considerations for animal studies of biomaterial products显示文摘Animal studies play a vital role in validating the concept,feasibility,safety,performance and efficacy of biomaterials products during their bench-to-clinic translation.This article aims to share regulatory considerations for animal studies of biomaterial products.After briefly emphasizing the importance of animal studies,issues of animal studies during biomaterial products’translation are discussed.Animal studies with unclear purposes,flawed design and poor reporting quality could significantly reduce the translation efficiency and create regulatory challenges.Regulatory perspectives on the purpose,principle,quality and regulatory science of animal studies are also presented.Animal studies should have clear purposes,follow principles of 3R+DQ(replacement,reduction,refinement,design and quality)and execute under an efficiently operating quality management system.With the advancement of regulatory science,National Medical Products Administration of China has been developing a series of standards and guidance documents on animal studies of medical devices.Case studies of making decisions on whether to conduct animal studies are provided in the end with drug-eluting stents as examples.In summary,animal studies of biomaterial products should pay close attention to the rationale,design and quality in order to achieve their purposes. | Maobo Cheng Wenbo Liu Jiazhen Zhang Song Zhang Zhaojun Guo Lu Liu Jiaxin Tian Xiangmei Zhang Jin Cheng Yinghui Liu Gang Deng Guobiao Gao Lei Sun | 2022 | Bioactive Materials2022，7，5： | 1 |
| 17 | Border collision bifurcations in 3D piecewise smooth chaotic circuit显示文摘A variety of border collision bifurcations in a three-dimensional(3D) piecewise smooth chaotic electrical circuit are investigated. The existence and stability of the equilibrium points are analyzed. It is found that there are two kinds of non-smooth fold bifurcations. The existence of periodic orbits is also proved to show the occurrence of non-smooth Hopf bifurcations. As a composite of non-smooth fold and Hopf bifurcations,the multiple crossing bifurcation is studied by the generalized Jacobian matrix. Some interesting phenomena which cannot occur in smooth bifurcations are also considered. | Yinghui GAO Xiangying MENG Qishao LU | 2016 | Applied Mathematics and Mechanics(English Edition)2016，37，9： | 1 |
| 18 | Diagnosis value of serum B7-H3 expression in non-small cell lung cancer显示文摘 | Guangbo Zhang Yuehua Xu Xudong Lu Haitao Huang Yinghui Zhou Binfeng Lu Xueguang Zhang | 2009 | Lung Cancer2009，，： | 1 |
| 19 | Burdens Attributable to Intimate Partner Violence in Women Aged 15 Years or Older—China,1990–2019显示文摘Summary What is already known about this topic?Intimate partner violence(IPV)represents a significant global public health concern.What is added by this report?The burden of HIV/AIDS related to IPV demonstrated an upward trend from 1990 to 2019,exhibiting an annual growth of 4.66%in age-standardized death rates(ASDR)and 4.42%in age-standardized disabilityadjusted life years(DALYs)rates.Notably,the age groups 30–34 and 50–54 experienced a higher IPV burden compared to other age groups.What are the implications for public health practice?There is a pressing need for public health policymakers to develop efficacious interventions aimed at bolstering the surveillance and prevention of IPV targeted at women in China. | Leiwen Fu Tian Tian Zhen Lu Bingyi Wang Xinyi Li Weijie Zhang Yanxiao Gao Yinghui Sun Huachun Zou | 2023 | China CDC weekly2023，5，16： | 0 |
| 20 | Nanostructuring of Mg-Based Hydrogen Storage Materials:Recent Advances for Promoting Key Applications显示文摘With the depletion of fossil fuels and global warming,there is an urgent demand to seek green,low-cost,and high-efficiency energy resources.Hydrogen has been considered as a potential candidate to replace fossil fuels,due to its high gravimetric energy density(142 MJ kg^(-1)),high abundance(H_(2)O),and environmentalfriendliness.However,due to its low volume density,effective and safe hydrogen storage techniques are now becoming the bottleneck for the'hydrogen economy'.Under such a circumstance,Mg-based hydrogen storage materials garnered tremendous interests due to their high hydrogen storage capacity(~7.6 wt%for MgH_(2)),low cost,and excellent reversibility.However,the high thermodynamic stability(ΔH=-74.7 kJ mol^(-1)H_(2))and sluggish kinetics result in a relatively high desorption temperature(>300℃),which severely restricts widespread applications of MgH_(2).Nano-structuring has been proven to be an effective strategy that can simultaneously enhance the ab/de-sorption thermodynamic and kinetic properties of MgH_(2),possibly meeting the demand for rapid hydrogen desorption,economic viability,and effective thermal management in practical applications.Herein,the fundamental theories,recent advances,and practical applications of the nanostructured Mg-based hydrogen storage materials are discussed.The synthetic strategies are classified into four categories:free-standing nano-sized Mg/MgH_(2)through electrochemical/vapor-transport/ultrasonic methods,nanostructured Mg-based composites via mechanical milling methods,construction of core-shell nano-structured Mg-based composites by chemical reduction approaches,and multi-dimensional nano-sized Mg-based heterostructure by nanoconfinement strategy.Through applying these strategies,near room temperature ab/de-sorption(<100℃)with considerable high capacity(>6 wt%)has been achieved in nano Mg/MgH_(2)systems.Some perspectives on the future research and development of nanostructured hydrogen storage materials are also provided. | Li Ren Yinghui Li Ning Zhang Zi Li Xi Lin Wen Zhu Chong Lu Wenjiang Ding Jianxin Zou | 2023 | Nano-Micro Letters2023，15，7： | 0 |
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