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| 1 | Antagonism of Protease-Activated Receptor 4 Protects Against Traumatic Brain Injury by Suppressing Neuroinflammation via Inhibition of Tab2/NF-κB Signaling显示文摘Traumatic brain injury(TBI)triggers the activation of the endogenous coagulation mechanism,and a large amount of thrombin is released to curb uncontrollable bleeding through thrombin receptors,also known as protease-activated receptors(PARs).However,thrombin is one of the most critical factors in secondary brain injury.Thus,the PARs may be effective targets against hemorrhagic brain injury.Since the PAR1 antagonist has an increased bleeding risk in clinical practice,PAR4 blockade has been suggested as a more promising treatment.Here,we explored the expression pattern of PAR4 in the brain of mice after TBI,and explored the effect and possible mechanism of BMS-986120(BMS),a novel selective and reversible PAR4 antagonist on secondary brain injury.Treatment with BMS protected against TBI in mice.mRNA-seq analysis,Western blot,and qRT-PCR verification in vitro showed that BMS significantly inhibited thrombin-induced inflammation in astrocytes,and suggested that the Tab2/ERK/NF-κB signaling pathway plays a key role in this process.Our findings provide reliable evidence that blocking PAR4 is a safe and effective intervention for TBI,and suggest that BMS has a potential clinical application in the management of TBI. | Jianing Luo Xun Wu Haixiao Liu Wenxing Cui Wei Guo Kang Guo Hao Guo Kai Tao Fei Li Yingwu Shi Dayun Feng Hao Yan Guodong Gao Yan Qu | 2021 | Neuroscience Bulletin2021，37，2： | 5 |
| 2 | Acrolein Induces Systemic Coagulopathy via Autophagy-dependent Secretion of von Willebrand Factor in Mice after Traumatic Brain Injury显示文摘Traumatic brain injury(TBI)-induced coagulopathy has increasingly been recognized as a significant risk factor for poor outcomes,but the pathogenesis remains poorly understood.In this study,we aimed to investigate the causal role of acrolein,a typical lipid peroxidation product,in TBI-induced coagulopathy,and further explore the underlying molecular mechanisms.We found that the level of plasma acrolein in TBI patients suffering from coagulopathy was higher than that in those without coagulopathy.Using a controlled cortical impact mouse model,we demonstrated that the acrolein scavenger phenelzine prevented TBI-induced coagulopathy and recombinant ADAMTS-13 prevented acrolein-induced coagulopathy by cleaving von Willebrand factor(VWF).Our results showed that acrolein may contribute to an early hypercoagulable state after TBI by regulating VWF secretion.mRNA sequencing(mRNA-seq)and transcriptome analysis indicated that acrolein over-activated autophagy,and subsequent experiments revealed that acrolein activated autophagy partly by regulating the Akt/mTOR pathway.In addition,we demonstrated that acrolein was produced in the perilesional cortex,affected endothelial cell integrity,and disrupted the blood-brain barrier.In conclusion,in this study we uncovered a novel pro-coagulant effect of acrolein that may contribute to TBI-induced coagulopathy and vascular leakage,providing an alternative therapeutic target. | Wenxing Cui Xun Wu Dayun Feng Jianing Luo Yingwu Shi Wei Guo Haixiao Liu Qiang Wang Liang Wang Shunnan Ge Yan Qu | 2021 | Neuroscience Bulletin2021，37，8： | 3 |
| 3 | Nanoencapsulation via Interfacially Confined Reversible Addition Fragmentation Transfer (RAFT) Miniemulsion Polymerization显示文摘 | Luo Yingwu Gu Hongyan | 2007 | Polymer2007，48，11： | 1 |
| 4 | Polyurethane acrylate microgel synthesized by emulsion polymerization using unsaturated self-emulsified polymer显示文摘 | Wei Yanyan Luo Yingwu Li Baofang | 2006 | Colloid polymer Science2006，284，10： | 1 |
| 5 | Nanoen-capsulation of a hydrophobic compound by a miniemulsion polymerization process 显示文摘 | Luo Yingwu Zhou Xingdong | 2004 | J Polym Sci2004，，42： | 1 |
| 6 | Miniemulsion polymerization显示文摘 | Schork F Joseph Luo Yingwu | 2005 | Advanced Polymer Sciences2005，，175： | 1 |
| 7 | Nanoencapsulation of a hy- drophobic compound by a miniemulsion polymerization proce- ss显示文摘 | LUO Yingwu ZHOU Xiangdong | 2004 | Journal of Polymer Science Part A: Polymer Chemi- stry2004，42，9： | 1 |
| 8 | Polyurethane acrylate microgel synthesized by emulsion polymerization using unsaturated self-emulsified polymer 显示文摘 | WEI YANYAN LUO YINGWU LI BAOFANG | 2006 | Colloid polymer Science2006，284，10： | 1 |
| 9 | RAFT miniemulsion polymerization targeting to polymer of higher molecular weight显示文摘 | Luo Yingwu Li Bogeng | 2005 | Journal of Polymer Science Part A:Polymer Chemistry2005，43，20： | 1 |
| 10 | The influence of surfactant coverage of the minidroplets on RAFT miniemulsion polymerization显示文摘 | Lei Luo Yingwu Li Bogeng | 2006 | Journal of Polymer Science Part A:Polymer Chemistry2006，44，7： | 1 |
| 11 | Polystyrene-bloc k-poly(n-butyl acrylate)-block-polystyrene triblock copolymer the rmoplastic elastomer synthesized via RAFT emulsion polymeriza tion 显示文摘 | Yingwu Luo Xiaoguang Wang Yue Zhu | 2010 | Macromolecules2010，43，： | 1 |
| 12 | A facile route to synthe- size highly uniform nanocapsules: Use of amphiphilic poly(acrylic acid)-block-polystyrene RAFT agents to interfa- cially confine miniemulsion polymerization 显示文摘 | Lu Fujun Luo Yingwu Li Bogeng | 2007 | Maeromol Rapid Commun2007，28，7： | 1 |
| 13 | Surfactant-regulated acetylpyrene assemblies as fluorescent probes for identifying heme proteins in an aqueous solution显示文摘Heme proteins play various important roles in a variety of physiological and pathological processes.Surfactant assemblies have drawn great attention in fabricating fluorescent sensors to detect and identify proteins.In this study,an acetylpyrene fluorophore containing imidazole HP-1 was synthesized,and it could be well modulated by an anionic surfactant sodium dodecyl sulfate(SDS).The selected ensemble based on HP-1/SDS assemblies exhibited selective fluorescence sensing performance towards the heme proteins,including neuroglobin(Ngb),myoglobin(Mb)and cytochrome c(Cyt c).Besides,phospholipid DMPC vesicles as membrane models were particularly explored the association process between the heme protein Mb and membrane.The present work showed that Mb induced the lysis of DMPC liposomes visualized by transmission electron microscopy and optical microscope. | Binbin Yuan Shuangshuang Long Huamin Wang Qing Luo Ke Zeng Shuqin Gao Yingwu Lin | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 14 | Temperature-mediated structural evolution of vapor–phase deposited cyclosiloxane polymer thin films for enhanced mechanical properties and thermal conductivity显示文摘Polymer-derived ceramic(PDC) thin films are promising wear-resistant coatings for protecting metals and carbon-carbon composites from corrosion and oxidation.However,the high pyrolysis temperature hinders the applications on substrate materials with low melting points.We report a new synthesis route for PDC coatings using initiated chemical vapor deposited poly(1,3,5-trivinyl-1,3,5-trimethylcyclotrisiloxane)(pV_3D_3) as the precurs or.We investigated the changes in siloxane moieties and the network topology,and proposed a three-stage mechanism for the thermal annealing process.The rise of the connectivity number for the structures obtained at increased annealing temperatures was found with strong correlation to the enhanced mechanical properties and thermal conductivity.Our PDC films obtained via annealing at 850℃ exhibit at least 14.6% higher hardness than prior reports for PDCs synthesized below 1100℃.Furthermore,thermal conductivity up to 1.02 W(mK)^(-1) was achieved at the annealing temperature as low as 700℃,which is on the same order of magnitude as PDCs obtained above 1100℃.Using minimum thermal conductivity models,we found that the thermal transport is dominated by diffusons in the films below the percolation of rigidity,while ultra-short mean-free path phonons contribute to the thermal conductivity of the films above the percolation threshold.The findings of this work provide new insights for the development of wear-resistant and thermally conductive PDC thin films for durable protection coatings. | Weiwei Du Jing Tu Mingjun Qiu Shangyu Zhou Yingwu Luo Wee-Liat Ong Junjie Zhao | 2023 | International Journal of Extreme Manufacturing2023，5，2： | 0 |
| 15 | Death after discharge:prognostic model of 1-year mortality in traumatic brain injury patients undergoing decompressive craniectomy显示文摘Background:Despite advances in decompressive craniectomy(DC)for the treatment of traumatic brain injury(TBI),these patients are at risk of having a poor long-term prognosis.The aim of this study was to predict 1-year mortality in TBI patients undergoing DC using logistic regression and random tree models.Methods:This was a retrospective analysis of TBI patients undergoing DC from January 1,2015,to April 25,2019.Patient demographic characteristics,biochemical tests,and intraoperative factors were collected.One-year mortality prognostic models were developed using multivariate logistic regression and random tree algorithms.The overall accuracy,sensitivity,specificity,and area under the receiver operating characteristic curves(AUCs)were used to evaluate model performance.Results:Of the 230 patients,70(30.4%)died within 1 year.Older age(OR,1.066;95%CI,1.045-1.087;P<0.001),higher Glasgow Coma Score(GCS)(OR,0.737;95%CI,0.660-0.824;P<0.001),higherD-dimer(OR,1.005;95%CI,1.001-1.009;P=0.015),coagulopathy(OR,2.965;95%CI,1.808-4.864;P<0.001),hypotension(OR,3.862;95%CI,2.176-6.855;P<0.001),and completely effaced basal cisterns(OR,3.766;95%CI,2.255-6.290;P<0.001)were independent predictors of 1-year mortality.Random forest demonstrated better performance for 1-year mortality prediction,which achieved an overall accuracy of 0.810,sensitivity of 0.833,specificity of 0.800,and AUC of 0.830 on the testing data compared to the logistic regression model.Conclusions:The random forest model showed relatively good predictive performance for 1-year mortality in TBI patients undergoing DC.Further external tests are required to verify our prognostic model. | Wenxing Cui Shunnan Ge Yingwu Shi Xun Wu Jianing Luo Haixiao Lui Gang Zhu Hao Guo Dayun Feng Yan Qu | 2022 | Chinese Neurosurgical Journal2022，8，1： | 0 |
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