|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A general alternate loading technique and its applications in the inverse designs of centrifugal and mixed-flow pump impellers显示文摘For the inverse designs of centrifugal and mixed-flow pump impellers,clarifying the generation process of secondary flows and putting forward corresponding suppression measures is an important approach to improve the impeller performance.In this paper,to provide a better qualitative insight into the generation mechanism of secondary flows in the impeller,a simple kinematic equation is derived based on the ideal assumptions,which indicates that the potential rothalpy gradient(PRG)is the most important dynamic source that actively induces secondary vortical flows.Induced by the natural adverse PRG on the S1 and S2 stream surfaces,two typical secondary flows,H-S and P-S secondary flows,are clearly presented.To specially suppress these typical secondary flows,a general alternate loading technique(GALT)is proposed,aiming to adjust the real blade loadingδp to control the PRG features.At the blade fore part,theδp on the hub streamline should be slowly increased to avoid breakneck growth of the potential rothalpy to reduce adverse streamwise PRG on the S2 streamsurface.At the blade middle part,theδp should be moderately decreased to reduce adverse streamwise PRG on the S1 streamsurface.At the blade aft part,the difference in theδp between the shroud and hub streamlines should be decreased faster to control the exit uniformity.By applying the GALT to the impeller designs of three typical pump types in hydraulic engineering,the organizational effect of the PRG on fundamental flow structures is proven.The GALT can effectively control the PRG distributions and suppress the secondary flows,thereby widening the pump’s high-efficiency zone,improving flow uniformity and suppressing pressure fluctuations.Compared with the current Z-G method and the ALT,the GALT can meet the requirements of'de-experience'better,thereby enabling the designers to obtain good products explicitly and quickly. | WANG ChaoYue WANG FuJun AN DongSen YAO ZhiFeng XIAO RuoFu LU Li HE ChengLian ZOU ZhiChao | 2021 | Science China(Technological Sciences)2021，64，4： | 7 |
| 2 | Preparation of monoclonal antibody against human KIAA0100 protein and Northern blot analysis of human KIAA0100 gene显示文摘Monoclonal antibodies(MAbs) are important tools for the study of proteins′ function and structure. But there has been no report on the preparation of MAbs against human KIAA0100 protein up to date. Here, first, we generated the mouse MAb against human KIAA0100 protein using purified recombinant 6×Histidinc(6×His)-tagged human KIAA0100 protein segment(1557–2234) as an antigen; then, the m RNA expression of human KIAA0100 gene was detected in U937 cells using Northern blot analysis. The results showed that the mouse MAb against human KIAA0100 protein could sensitively recognize the human KIAA0100 protein using Western blot analysis and immunocytochemistry analysis. Besides, Western blot analysis revealed that human KIAA0100 gene possibly encoded two different protein products(254 k Da and < 250 k Da) in U937 cells. Moreover,Northern blot analysis confirmed that human KIAA0100 gene might produced two different m RNA products(6000–10000 bp and 5000–6000 bp) in U937 cells. The results provide a basis for large-scale production of the MAb against human KIAA0100 protein, which will be useful for the study of human KIAA0100 protein′s function/structure and MAb-targeted drugs in the future. | He Cui Xi Lan Shemin Lu Fujun Zhang Wanggang Zhang | 2017 | Journal of Pharmaceutical Analysis2017，7，3： | 4 |
| 3 | Development of a polycaprolactone/poly(p-dioxanone)bioresorbable stent with mechanically self-reinforced structure for congenital heart disease treatment显示文摘Recent progress in bioresorbable stents(BRSs)has provided a promising alternative for treating coronary artery disease.However,there is still lack of BRSs with satisfied compression and degradation performance for pediatric patients with congenital heart disease,leading to suboptimal therapy effects.Here,we developed a mechanically self-reinforced composite bioresorbable stent(cBRS)for congenital heart disease application.The cBRS consisted of poly(p-dioxanone)monofilaments and polycaprolactone/poly(p-dioxanone)core-shell composite yarns.Interlacing points in cBRS structure were partially bonded,offering the cBRS with significantly higher compression force compared to typical braids and remained good compliance.The suitable degradation profile of the cBRS can possibly preserve vascular remodeling and healing process.In addition,the controllable structural organization provides a method to customize the performance of the cBRS by altering the proportion of different components in the braids.The in vivo results suggested the cBRS supported the vessel wall similar to that of metallic stent.In both abdominal aorta and iliac artery of porcine,cBRS was entirely endothelialized within 1 month and maintained target vessels with good patency in the 12-month follow-up.The in vivo degradation profile of the cBRS is consistent with static degradation results in vitro.It is also demonstrated that there is minimal impact of pulsatile pressure of blood flow and variation of radial force on the degradation rate of the cBRS.Moreover,the lumen of cBRS implanted vessels were enlarged after 6 months,and significantly larger than the vessels implanted with metallic stent in 12 months. | Fan Zhao Jing Sun Wen Xue Fujun Wang Martin W.King Chenglong Yu Yongjie Jiao Kun Sun Lu Wang | 2021 | Bioactive Materials2021，6，9： | 3 |
| 4 | 14.46% Efficiency small molecule organic photovoltaics enabled by the well trade-off between phase separation and photon harvesting显示文摘Small molecule organic photovoltaics(SMPVs) were prepared by utilizing liquid crystalline donor material BTR-Cl and two similar optical bandgap non-fullerene acceptor materials BTP-BO-4 F and Y6.The BTPBO-4 F and Y6 have the similar optical bandgap and different absorption coefficients.The corresponding binary SMPVs exhibit different short circuit current density(/sc)(20.38 vs.23.24 mA cm^(-2)),and fill factor(FF)(70.77% vs.67.21%).A 14.46% power conversion efficiency(PCE) is acquired in ternary SMPVs with 30 wt% Y6,companied with a JSC of 24.17 mA cm^(-2) a FF of 68.78% and an open circuit voltage(Voc) of 0.87 V.The improvement on PCE of ternary SMPVs should originate from the well trade-off between phase separation and photon harvesting of ternary active layers by incorporating 30 wt% Y6 in acceptors.This work may deliver insight onto the improved performance of SMPVs by superposing the superiorities of binary SMPVs with similar optical bandgap acceptors into one ternary cell. | Chunyu Xu Haiyan Chen Zijin Zhao Jinhua Gao Xiaoling Ma Shirong Lu Xiaoli Zhang Zeyun Xiao Fujun Zhang | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 5 | Ultrathin,elastic,and self-adhesive nanofiber bio-tape:An intraoperative drug-loading module for ureteral stents with localized and controlled drug delivery properties for customized therapy显示文摘During the postoperative management of urinary diseases,oral or intravenous administration of drugs and implanting ureteral stents are usually required,making localized drug delivery by ureteral stent a precise and effective medication strategy.In the traditional drug loading method,the drug was premixed in the implants in production lines and the versatility of drugs was restricted.However,the complex situation in the urinary system fails the possibility of finding a“one fits all”medication plan,and the intraoperative drug-loading of implants is highly desired to support customized therapy.Here,we designed an ultrathin(8μm),elastic,and self-adhesive nanofiber bio-tape(NFBT)that can easily encapsulate drugs on the stent surface for controllable localized drug delivery.The NFBT exhibited high binding strength to a ureteral stent,a sustained release over 7 d in PBS for hydrophilic drug,and a zero-order release curve over 28 days for the hydrophobic drug nitrofurantoin(NFT).Further in vivo experiments using a porcine ureteral tract infection model demonstrated that NFBT loaded with NFT could significantly reduce the bacterial concentration in urine.The total amount of NFT delivered by the NFBT was about 2.68 wt%of the recommended dose for the systemic administration. | Liheng Gao Mingxi Xu Wenshuo Zhao Ting Zou Fujun Wang Jun Da Yiwei Wang Lu Wang | 2022 | Bioactive Materials2022，7，12： | 2 |
| 6 | Dynamic features of near-inertial oscillations in the Northwestern Pacific derived from mooring observations from^2015 to 2018显示文摘Near-inertial oscillation is an important physical process transferring surface wind energy into deep ocean.We investigated the near-inertial kinetic energy(NIKE)variability using acoustic Doppler current profiler measurements from a mooring array deployed in the tropical western Pacific Ocean along 130°E at 8.5°N,11°N,12.6°N,15°N,and 17.5°N from September 2015 to January 2018.Spatial features,decay timescales,and significant seasonal variability of the observed NIKE were described.At the mooring sites of 17.5°N,15°N,and 12.6°N,the NIKE peaks occurred in boreal autumn and the NIKE troughs were observed in boreal spring.By contrast,the NIKE at 11°N and 8.5°N showed peaks in winter and troughs in summer.Tropical cyclones and strong wind events played an important role in the emergence of high-NIKE events and explained the seasonality and latitudinal characteristics of the observed NIKE. | HU Shijian LIU Lingling GUAN Cong ZHANG Linlin WANG Jianing WANG Qingye MA Jie WANG Fujun JIA Fan FENG Junqiao LU Xi WANG Fan HU Dunxin | 2020 | Journal of Oceanology and Limnology2020，38，4： | 2 |
| 7 | Experimental and numerical investigation on temperature characteristics of high-speed railway’s embankment in seasonal frozen regions显示文摘 | Hua Liu Fujun Niu Yonghong Niu Zhanju Lin Jiahao Lu Jing Luo | 2012 | Cold Regions Science and Technology2012，，： | 1 |
| 8 | Characteristics of thermokarst lakes and their influence on permafrost in Qinghai–Tibet Plateau显示文摘 | Fujun Niu Zhanju Lin Hua Liu Jiahao Lu | 2011 | Geomorphology2011，，3： | 1 |
| 9 | Ultrastretchable and wearable conductive multifilament enabled by buckled polypyrrole structure in parallel显示文摘Stretchable conductive fibers have attracted much attention due to their potential use in wearable electronics.However,the ultrahigh strain insensitive conductivity is hindered by mechanical mismatch in Young’s modulus and failure of stretchable structures under large deformation.This challenge is addressed with a conductive and elastic multifilament made of the polyurethane monofilaments that are surface-coated with buckled polypyrrole(PPy)of which flexibility is improved by sodium sulfosalicylate.Such parallel conductive monofilaments with PPy buckling on surface reduce the influence of cracks in the conductive coating on the overall conductivity,displaying an ultra-high strain insensitive behavior(quality factor Q=10.9).Remarkably,various complex forms of wearable electronic textiles made by this conductive multifilament maintain the strain-insensitive behavior of the original multifilament,even upon the large deformation of human joint.This multifilament with wrinkled PPy has attractive advantages in the application of super-stretched wearable electronic devices. | Yimeng Li Yaya Gao Lizhen Lan Qian Zhang Leqian Wei Mengqi Shan Lamei Guo Fujun Wang Jifu Mao Ze Zhang Lu Wang | 2022 | npj Flexible Electronics2022，6，1： | 1 |
| 10 | Combination of radiofrequency ablation with transarterial chemoembolization for hepatocellular carcinoma: an up-to-date meta-analysis显示文摘 | Zhenyin Liu Fei Gao Guang Yang Sristi Singh Mingjian Lu Tao Zhang Zhihui Zhong Fujun Zhang Rijie Tang | 2014 | Tumor Biology2014，，8： | 1 |
| 11 | Customized and in situ fenestrated stent-grafts:A reinforced poly-ε-caprolactone branch cuff designed to prevent type III endoleaks and enhance hemodynamics显示文摘Superior long-term anchorage of the bridging stent-grafts from the fenestrated main body endograft could be achieved with the addition of a flared cuff,capable of preventing the previously observed fabric fraying around the fenestration as a result of the balloon angioplasty of the seal zone.This novel stent cuff design will also facilitate more complete biointegration of the devices,eliminate the hemodynamic variation as well as significantly reduce the possibility of a Type III endoleak.The feasibility of this concept is demonstrated by observations made from in-situ tests performed in a Beta endograft design.Flared cuffs made of poly(ε-caprolactone)supported with a weft-knitted polyester structure can be manufactured with various configurations to optimize the transition from the main body of the endograft,thus preventing the currently marketed designs’hemodynamic perturbation while also promoting endograft biointegration.This concept represents an evolution in branch graft design,which may enhance the long-term durability of customized fenestrations and open new applications for in-vivo graft fenestration in the near future.Further ongoing investigation to optimize its structure,X-ray opacity,fixation to the flared stent,and material biocompatibility are still required to build upon this concept’s proof. | Fujun Wang Chaojing Li Robert Guidoin Abedalwafa Mohammed Graeham Douglas Fan Zhao Guy Dionne Ze Zhang Haripriya Ramesh Lu Wang Mark Nutley | 2021 | Medicine in Novel Technology and Devices2021，，1： | 1 |
| 12 | Flared textile cuff to be apposed on the proximal sealing zone in fenestrated stent-grafts 显示文摘 | WANG Fujun LI Chaojing WANG Lu | 2014 | Textile Research Journal2014，84，3： | 1 |
| 13 | A facile route to synthe- size highly uniform nanocapsules: Use of amphiphilic poly(acrylic acid)-block-polystyrene RAFT agents to interfa- cially confine miniemulsion polymerization 显示文摘 | Lu Fujun Luo Yingwu Li Bogeng | 2007 | Maeromol Rapid Commun2007，28，7： | 1 |
| 14 | miR-200b suppresses cell proliferation, migration and enhances chemosensitivityin prostate cancer by regulating Bmi-1显示文摘 | Junjie Yu Youyi Lu Di Cui Enhui Li Yipin Zhu Yuyang Zhao Fujun Zhao Shujie Xia | 2014 | Oncology Reports2014，，2： | 1 |
| 15 | Bioinformatic prediction and functional characterization of human KIAA0100 gene显示文摘Our previous study demonstrated that human KIAA0100 gene is a novel acute monocytic leukemia-associated antigen(MLAA) gene. But the functional characterization of human KIAA0100 gene has remained unknown to date. Here, firstly, bioinformatic prediction of human KIAA0100 gene was carried out using online software;Secondly, human KIAA0100 gene expression was downregulated by the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated(Cas) 9 system in U937 cells. Cell proliferation and apoptosis were next evaluated in KIAA0100-knockdown U937 cells. The bioinformatic prediction showed that human KIAA0100 gene was located on 17q11.2, and human KIAA0100 protein was located in the secretory pathway. Besides, human KIAA0100 protein contained a signal peptide, a transmembrane region, three types of secondary structures(alpha helix, extended strand, and random coil), and four domains from mitochondrial protein 27(FMP27). The observation on functional characterization of human KIAA0100 gene revealed that its downregulation inhibited cell proliferation, and promoted cell apoptosis in U937 cells. To summarize, these results suggest human KIAA0100 gene possibly comes within mitochondrial genome; moreover, it is a novel anti-apoptotic factor related to carcinogenesis or progression in acute monocytic leukemia, and may be a potential target for immunotherapy against acute monocytic leukemia. | He Cui Xi Lan Shemin Lu Fujun Zhang Wanggang Zhang | 2017 | Journal of Pharmaceutical Analysis2017，7，1： | 1 |
| 16 | Conductive fibers for biomedical applications显示文摘Bioelectricity has been stated as a key factor in regulating cell activity and tissue function in electroactive tissues.Thus,various biomedical electronic constructs have been developed to interfere with cell behaviors to promote tissue regeneration,or to interface with cells or tissue/organ surfaces to acquire physiological status via electrical signals.Benefiting from the outstanding advantages of flexibility,structural diversity,customizable mechanical properties,and tunable distribution of conductive components,conductive fibers are able to avoid the damage-inducing mechanical mismatch between the construct and the biological environment,in return to ensure stable functioning of such constructs during physiological deformation.Herein,this review starts by presenting current fabrication technologies of conductive fibers including wet spinning,microfluidic spinning,electrospinning and 3D printing as well as surface modification on fibers and fiber assemblies.To provide an update on the biomedical applications of conductive fibers and fiber assemblies,we further elaborate conductive fibrous constructs utilized in tissue engineering and regeneration,implantable healthcare bioelectronics,and wearable healthcare bioelectronics.To conclude,current challenges and future perspectives of biomedical electronic constructs built by conductive fibers are discussed. | Leqian Wei Shasha Wang Mengqi Shan Yimeng Li Yongliang Wang Fujun Wang Lu Wang Jifu Mao | 2023 | Bioactive Materials2023，，4： | 1 |
| 17 | CT-guided implantation of radioactive 125 I seed in advanced non-small-cell lung cancer after failure of first-line chemotherapy显示文摘 | Tao Zhang Mingjian Lu Sheng Peng Weidong Zhang Guang Yang Zhenyin Liu Sristi Singh Yadi Yang Fujun Zhang Fei Gao | 2014 | Journal of Cancer Research and Clinical Oncology2014，，8： | 1 |
| 18 | Characteristics of roadbed settlement in embankment-bridge transition section along the Qinghai-Tibet Railway in permafrost regions 显示文摘 | Niu Fujun Lin Zhanju Lu Jiahao | 2011 | Cold Re- gions Science and Technology2011，65，： | 1 |
| 19 | Recent development of conjugated oligomers for high-efficiency bulk-heterojunction solar cells显示文摘 | Weihua Tang Jiefeng Hai Yun Dai Zongjun Huang Bingqin Lu Fei Yuan Jian Tang Fujun Zhang | 2010 | Solar Energy Materials and Solar Cells2010，，12： | 1 |
| 20 | Curcumin up‐regulates phosphatase and tensin homologue deleted on chromosome 10 through micro RNA ‐mediated control of DNA methylation – a novel mechanism suppressing liver fibrosis显示文摘 | Jianjian Zheng Cunzao Wu Zhuo Lin Yong Guo Liang Shi Peihong Dong Zhongqiu Lu Shenmeng Gao Yi Liao Bicheng Chen Fujun Yu | 2014 | FEBS J2014，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员