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| 1 | Effects of lysedEnterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model显示文摘In the current study,we sought to investigate whether lysed Enterococcus faecalis FK-23(LFK),a heat-killed probiotic preparation,attenuated eosinophil influx into the upper airway and had immunomodulatory activity in a murine allergic rhinitis model.Eighteen BALB/c mice were divided into three groups;the ovalbumin(OVA)-sensitized/challenged group,which received saline orally for 6 weeks(OVA group),the OVA-sensitized/challenged group,which received LFK orally for 6 weeks(LFK-fed group),and the non-sensitized group,which received saline for 6 weeks(saline control group).Nasal rubbing and sneezing were monitored during the study.After the final challenge,interleukin(IL)-4,interferon(IFN)-γ,and OVA-specific IgE levels in the sera and splenocyte culture supernatants were determined,eosinophilic infiltrate into the upper airway was quantified,and splenic CD4+CD25+ regulatory T cells(Tregs) were examined by flow cytometry.We found that nasal rubbing was significantly reduced in LFK-fed mice compared to the OVA group on d 27 and 35,and sneezing was significantly inhibited by LFK administration for 35 d.LFK-fed mice had significantly less eosinophil influx into the nasal mucosa than the OVA group.There were no significant differences between the LFK-fed group and OVA group in the serum and splenocyte culture supernatant levels of IL-4,IFN-γ,and OVA-specific IgE.Interestingly,the LFK-fed mice had a significantly greater percentage of splenic CD4+CD25+ Tregs than OVA group.Our results indicate that oral administration of LFK may alleviate nasal symptoms,reduce nasal eosinophilia,and increase the percentage of CD4+CD25+ Tregs in experimental allergic rhinitis. | Luping Zhu Takashi Shimada Ruoxi Chen Meiping Lu Qingzhao Zhang Wenmin Lu Min Yin Tadao Enomoto Lei Cheng | 2012 | The Journal of Biomedical Research2012，26，3： | 11 |
| 2 | 病理性近视患者视乳头周围脱离的特征显示文摘目的:在一组高度近视患者中,评估新近认识的视乳头周围病变。即病理性近视视乳头周围脱离(PD-PM)的患病率和临床特征。
方法:共纳入324位高度近视患者(632只眼)。在这些患者中观察PDPMD的发病率、病变范围、荧光素和吲哚青绿造影检查结果及OCT结果。并对有PDPM的患者进行视野检查(Goldmann动态视野检查法和Humphrey 30-2程序)。结果:632只高度近视眼中有31只眼(4.9%)存在视乳头周围脱离。PDPM病变部位的OCT扫描显示视神经邻近部位视网膜色素上皮层的局限性脱离。PDPM常位于视盘下方。但一些患者的病变几乎环绕整个视盘。邻近PDPM的下方近视弧形斑有陡峭的凹陷。且颞下视网膜静脉在跨过PDPM和凹陷的近视弧形斑时明显弯曲。PDPM眼常被检出存在青光眼性视野缺损(71.0%)。
结论:本研究表明PDPM在高度近视眼中并非罕见。虽然其发病机制和病理学意义尚需进一步分类。高度近视PDPM的出现提示可能存在视野缺损。 | Noriaki Shimada Kyoko Ohno-Matsui Takeshi Yoshida Kenjiro Yasuzumi Ariko Kojima Kanako Kobayashi Soh Futagami Takashi Tokoro Manabu Mochizuki 刘亮(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，4： | 9 |
| 3 | 胆道肿瘤临床实践指南(英文第三版)显示文摘日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确定推荐意见、推荐强度以及推荐说明。根据证据推荐分级的评估、制订与评价(GRADE)系统,推荐强度被分为1级(强)或者2级(弱)。英文第三版胆道肿瘤临床实践指南中提出的31个临床问题涵盖:(1)预防性治疗;(2)诊断;(3)胆道引流;(4)外科治疗;(5)化疗;(6)放疗。31个临床问题中,14个问题给予推荐强度为强的推荐意见,14个问题给予推荐强度为弱的推荐意见,剩余的3个问题未给予推荐意见。每条推荐意见都进行推荐强度说明。最新版指南基于循证医学证据,为临床提供了重要建议。未来与癌症登记数据库协作将是评估指南和建立新证据的关键。 | Masato Nagino Satoshi Hirano Hideyuki Yoshitomi Taku Aoki Katsuhiko Uesaka Michiaki Unno Tomoki Ebata Masaru Konishi Keiji Sano Kazuaki Shimada Hiroaki Shimizu Ryota Higuchi Toshifumi Wakai Hiroyuki Isayama Takuji Okusaka Toshio Tsuyuguchi Yoshiki Hirooka Junji Furuse Hiroyuki Maguchi Kojiro Suzuki Hideya Yamazaki Hiroshi Kijima Akio Yanagisawa Masahiro Yoshida Yukihiro Yokoyama Takashi Mizuno Itaru Endo 杨翼飞(译) 仇毓东(译) 赵梦珂(译) 伏旭(译) 蔡正华(译) 毛凉(审校) | 2021 | 中华消化外科杂志2021，20，4： | 7 |
| 4 | Prophylactic lateral pelvic lymph node dissection in stage Ⅳ low rectal cancer显示文摘AIM To assess the clinical significance of prophylactic lateral pelvic lymph node dissection (LPLND) in stage Ⅳ low rectal cancer.METHODS We selected 71 consecutive stage Ⅳ low rectal cancer patients who underwent primary tumor resection,and enrolled 50 of these 71 patients without clinical LPLN metastasis.The patients had distant metastasis such as liver,lung,peritoneum,and paraaortic LN.Clinical LPLN metastasis was defined as LN with a maximum diameter of 10 mm or more on preoperative pelvic computed tomography scan.All patients underwent primary tumor resection,27 patients underwent total mesorectal excision(TME) with LPLND(LPLND group),and 23 patients underwent only TME(TME group).Bilateral LPLND was performed simultaneously with primary tumor resection in LPLND group.R0 resection of both primary and metastatic sites was achieved in 20 of 50 patients.We evaluated possible prognostic factors for 5-year overall survival (OS),and compared 5-year cumulative local recurrence between the LPLND and TME groups.RESULTS For OS,univariate analyses revealed no significant benefit in the LPLND compared with the TME group (28.7% vs 17.0%,P = 0.523); multivariate analysis revealed that R0 resection was an independent prognostic factor.Regarding cumulative local recurrence,the LPLND group showed no significant benefit compared with TME group (21.4% vs 14.8%,P = 0.833).CONCLUSION Prophylactic LPLND shows no oncological benefits in patients with Stage Ⅳ low rectal cancer without clinical LPLN metastasis. | Hiroshi Tamura Yoshifumi Shimada Hitoshi Kameyama Ryoma Yagi Yosuke Tajima Takuma Okamura Mae Nakano Masato Nakano Masayuki Nagahashi Jun Sakata Takashi Kobayashi Shin-ichi Kosugi Hitoshi Nogami Satoshi Maruyama Yasumasa Takii Toshifumi Wakai | 2017 | World Journal of Clinical Oncology2017，8，5： | 4 |
| 5 | Application of highwall mining system in weak geological condition显示文摘 | Takashi Sasaoka Tri Karian Akihiro Hamanaka Hideki Shimada Kikuo Matsui | 2016 | International Journal of Coal Science & Technology2016，3，3： | 3 |
| 6 | Performance of 18-fluoro-2-deoxyglucose positron emission tomography for esophageal cancer screening显示文摘AIM To evaluate the performance of 18-fluoro-2-deoxyglucose positron emission tomography(FDG-PET) for esophageal cancer(EC) screening.METHODS We retrospectively analyzed the data of consecutive asymptomatic individuals who underwent FDG-PET and esophagogastroduodenoscopy(EGD) simultaneously for cancer screening at our institution from February 2004 to March 2013. In total, 14790 FDG-PET and EGD procedures performed for 8468 individuals were included in this study, and the performance of FDGPET for EC screening was assessed by comparing the results of FDG-PET and EGD, considering the latter as the reference.RESULTS Thirty-two EC lesions were detected in 28 individuals(31 squamous cell carcinomas and 1 adenocarcinoma). The median tumor size was 12.5 mm, and the depths of the lesions were as follows: Tis(n = 12), T1a(n = 15), and T1b(n = 5). Among the 14790 FDG-PET procedures, 51 examinations(0.3%) showed positive findings in the esophagus; only 1 was a true-positive finding. The screen sensitivity, specificity, positive predictive value, and negative predictive value of FDGPET for ECs were 3.6%(95%CI: 0.1-18.3), 99.7%(95%CI: 99.6-99.7), 2.0%(95%CI: 0.0-10.4), and 99.8%(95%CI: 99.7-99.9), respectively. Of the 50 FDG-PET false-positive cases, 31 were observed in the lower esophagus, and gastroesophageal reflux disease was observed in 17 of these 31 cases.CONCLUSION This study is the first to clarify the FDG-PET performance for EC screening. Based on the low screen sensitivity, FDG-PET is considered to be difficult to use as a screening modality for ECs. | Masau Sekiguchi Takashi Terauchi Yasuo Kakugawa Naoki Shimada Yutaka Saito Takahisa Matsuda | 2017 | World Journal of Gastroenterology2017，23，15： | 3 |
| 7 | Effect of Application of Pipe Roof Method by Using Pipe Jacking on Behavior of Surrounding Soil显示文摘 | Hideki Shimada Akihiro Hamanakal Takashi Sasaoka Kikuo Matsui Toru Sato | 2013 | Journal of Physical Science and Application2013，3，6： | 2 |
| 8 | Hepatocyte growth factor and transforming growth factor β1 contribute to regeneration of small-for-size liver graft immediately after transplantation显示文摘 | Mizuki Ninomiya Noboru Harada Satoko Shiotani Shoji Hiroshige Ryosuke Minagawa Yuji Soejima Taketoshi Suehiro Takashi Nishizaki Mitsuo Shimada Keizo Sugimachi | 2003 | Transplant International2003，，11： | 2 |
| 9 | Treatment response and prognosis of patients after recurrence of esophageal cancer显示文摘 | Hideaki Shimada Hiroyuki Kitabayashi Yoshihiro Nabeya Shin-ichi Okazumi Hisahiro Matsubara Yutaka Funami Yukimasa Miyazawa Tooru Shiratori Takashi Uno Hisao Itoh Takenori Ochiai | 2003 | Surgery2003，，1： | 2 |
| 10 | Surface subsidence due to underground mining operation under weak geological condition in Indonesia显示文摘Subsidence analysis and prediction with measured data have been conducted and applied to local strata and mining conditions worldwide. Underground coal mines chose the most suitable analysis and prediction method for them. However, there was no study based on the measured data of subsidence induced by underground mining operation in Indonesia. This paper describes the condition of underground coal mine in Indonesia and then discusses the subsidence behavior due to longwall mining operation based on measured data in Balikpapan coal-bearing formation in Indonesia. | Takashi Sasaoka Hiroshi Takamoto Hideki Shimada Jiro Oya Akihiro Hamanaka | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，3： | 2 |
| 11 | Outcomes of Adult-to-Adult Living Donor Liver Transplantation: A Single Institution?s Experience With 335 Consecutive Cases显示文摘 | Daisuke Morioka Hiroto Egawa Mureo Kasahara Takashi Ito Hironori Haga Yasutsugu Takada Hiroshi Shimada Koichi Tanaka | 2007 | Annals of Surgery2007，，2： | 2 |
| 12 | Study on control of rock fragmentation at limestone quarry显示文摘The size distribution of a muck pile depends not on only the blasting standard but also on the mechanical properties,joint system,and crack density of the rock mass. As,the cracks in the rock masses are especially heavily developed at the limestone quar- ries in Japan,they,along with the joints,have a large impact on the effects of blasting, such as the size of the muck pile.Therefore,if the joint system and/or crack density in a rock mass can be determined and quantitatively evaluated,the blasting operation can be conducted more effectively,efficiently and safely.However,guidelines for designing ap- propriate blasting standards based on the rock mass conditions have not yet been scien- tifically developed.Therefore,blasting tests were conducted on different mines and faces, under different geological conditions and blasting standards,in order to determine the im- pacts of each factor on the effects of blasting.Summarized the results of a series of blast- ing tests and described the impacts of geological conditions on the size of the muck pile produced by blast. | SASAOKA Takashi SHIMADA Hideki SASAKI Takayuki ICHINOSE Masatomo MATSUI Kikuo | 2008 | Journal of Coal Science & Engineering(China)2008，14，3： | 2 |
| 13 | Identification and Dynamics of Arabidopsis Adaptor Protein-2 Complex and Its Involvement in Floral Organ Development[W]显示文摘 | Shohei Yamaoka Yuki Shimono Makoto Shirakawa Yoichiro Fukao Takashi Kawase Noriyuki Hatsugai Kentaro Tamura Tomoo Shimada Ikuko Hara-Nishimura | 2013 | The Plant Cell2013，，8： | 1 |
| 14 | Enzymatic synthesis of steryl esters of polyunsaturated fatty acids显示文摘 | Yuji Shimada Yoshinori Hirota Takashi Baba | 1999 | JAOCS1999，76，： | 1 |
| 15 | Evaluating the human likeness of an android by comparing gaze behaviors elicited by the android and a person 显示文摘 | Takashi minato Miehihiro shimada Shoji itakura | 2006 | Advanced Robotics2006，20，10： | 1 |
| 16 | Immunomodulation effects of heat-treated Enterococcus faecalis FK-23(FK-23) in mice显示文摘Objective:The purpose of this study was to evaluate the effects of Enterococcus faecalis FK-23(FK-23) on the immune function in mice. Methods:Mice were treated with three doses of the FK-23(0.05,0.1,0.2,0.6 g/kg body weight) for 30 days. Delayed type hypersensitivity (DTH),monocyte phagocytic function,serum hemolysis antibody and natural killer cell activity were studied. Results:The significant increases in mice treated with 0.6 g/kg bw were found in DTH,phagocytic function of monocyte,serum hemolysis antibody and natural killer cell activity. Conclusion:The results from the present study suggest that FK-23 could improve both specific and nonspecific immune function. | Takashi Shimada Yunqing Cai Lei Cheng Chie Motonaga Kazutake Fukada Yoshihisa Kitamura Jieshu Wu | 2009 | Journal of Nanjing Medical University2009，23，3： | 1 |
| 17 | The effects of the Kampo medicine (Japanese herbal medicine) “Daikenchuto” on the surgical inflammatory response following laparoscopic colorectal resection显示文摘 | Kozo Yoshikawa Mitsuo Shimada Masanori Nishioka Nobuhiro Kurita Takashi Iwata Shinya Morimoto Tomohiko Miyatani Masato Komatsu Hideya Kashihara Chie Mikami | 2012 | Surgery Today2012，，7： | 1 |
| 18 | The clinicopathologic features of serum CA 19-9-positive colorectal cancers显示文摘 | Takashi Ueda Etsuji Shimada Tomoaki Urakawa | 1994 | Surgery Today1994，，6： | 1 |
| 19 | Identification and characterization of Arabidopsis gibberellin receptors显示文摘 | Nakajimal M Shimada A Takashi Y | | 0，，05： | 1 |
| 20 | Phase II study of S-1 as first-line treatment for elderly patients over 75 years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，： | 1 |
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