|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Flavonoid content and radical scavenging activity in fruits of Chinese dwarf cherry(Cerasus humilis) genotypes显示文摘The Chinese dwarf cherry(Cerasus humilis(Bge.) Sok.) is a small shrub with edible fruits. It is native to northern and western China. This species was included as a medicinal plant in the ‘‘Chinese Pharmacopeia'' and has emerged as an economically important crop for fresh fruit consumption, processing into juice and wine and nutraceutical products as well. To gain a better understanding of flavonoid biosynthesis and help develop value added products and better cultivars with greater health benefits, we analyzed total flavonoid content(TFC), composition, and radical scavenging activities in fruit extracts of 16 Chinese dwarf cherry genotypes. Fruit peel TFC ranged from 33.5 to72.8 mg/g REáFW(RE: rutin equivalent, FW: fresh weight)while fruit flesh TFC ranged from 4.3 to 16.9 mg/g REáFW.An HPLC analysis revealed that fruit extracts contained 14 flavonoids with considerable variation in their profiles across genotypes. The most abundant flavonoids in most genotypes were proanthocyanidin B1(PA-B1), proanthocyanidin B2(PA-B2), phloretin 20-O-glucoside(PG), and phloretin 20,40-O-diglucoside(PDG). Principal component analysis showed that PG, PA-B1, and PA-B2 had large,positive factor loading values in the first principal component for each genotype. Increased scavenging activity of2,2-diphenyl-1-picrylhydrazyl(DPPH) radicals was apparent in genotypes ‘Nongda 4', ‘Nongda 3', ‘Nongda 6',‘Wenfenli', and '10-32', suggesting promising applications in the production of nutraceutical products. In summary, our results will aid in breeding, fruit processing, and developing medicinal uses of the Chinese dwarf cherry. | Pengfei Wang Xiaopeng Mu Junjie Du Yu Gary Gao Donghai Bai Luting Jia Jiancheng Zhang Haiyan Ren Xiaofang Xue | 2018 | Journal of Forestry Research2018，29，1： | 8 |
| 2 | The intragastrointestinal fate of paclitaxel-loaded micelles:Implications on oral drug delivery显示文摘The goal of the present study is to elucidate the intragastrointestinal fate of micellar delivery systems by monitoring fluorescently labeled different micelles and the model drug paclitaxel(PTX).Both in vitro and ex vivo leakage studies showed fast PTX release in fluids while micelles remained intact,except in fedstate simulated intestinal fluid and fasted-state pig intestinal fluid,thus referring to the intact absorption of micelles and PTX leakage in the gastrointestinal tract with D-a-tocopherol polyethylene glycol 1000 succinate(TPGS)micelles showing higher stability than other micelles.All groups of micelles were absorbed intact in Caco-2 and Caco-2/HT29-MTX cell models and the absorption of TPGS micelles was found to be higher than other micelles.The transport of the micelles across Caco-2/Raji(1.6%-3.5%),Caco-2(0.8%-1%),and Caco-2/HT29-MTX(0.58%-1%)cell monolayers further verified the absorption of micelles and their subsequent transport;however,more TPGS micelles transported across cell monolayers than other groups.Moreover,the histological examination also confirmed that micelles ente red the enterocytes and were transported to basolateral tissues and TPGS showed the stronger ability of penetration than other groups.Thus,these results are succinctly presenting the absorption of intact micelles in GIT confirmed by imaging evidence with prior leakage of the drug,upta ke by enterocytes and the transport of micelles that survive the digestion by enterocytes and mainly by microfold cells in material nature dependent way with TPGS showing better results than other groups.In conclusion,these results identify the mechanism by which the gastrointestinal tract processes micelles and point to the likely use of this approach in the design of micelles-based therapies. | Iqbal Zoya Haisheng He Luting Wang Jianping Qi Yi Lu Wei Wu | 2021 | Chinese Chemical Letters2021，32，4： | 3 |
| 3 | A study of nonocrystalline TiO2 preparation with inorganotitanates and gelatin dispersant: thermal analysis of complex gel显示文摘 | Xiaoheng Liu Xin Wang Jiangrun Zhang Xi Hu Lute Lu | 1999 | Thermochimica Acta1999，，324： | 1 |
| 4 | Integrative analysis of transcript and metabolite profiling data sets to evaluate the regulation of biochemical pathways during photomorphogenesis显示文摘 | Ghassemian M Lutes J Tepperman J.M Chang H.S Zhu T Wang X Quail P.H and Lange B | | 0，，： | 1 |
| 5 | Versatile den- drimer-derived nanocrystal microreactors towards fluorescence colloidal photonic crystals显示文摘 | Zhang Jing Ling Luting Wang Caifeng | 2014 | Journal of Materials Chemistry C2014，2，18： | 1 |
| 6 | Analytical methods of non-Gaussian stochastic response of offshore structures 显示文摘 | Wang J Lutes L D | 1997 | International Journal of Offshore and Polar Engineering1997，7，3： | 1 |
| 7 | Materials Project显示文摘 | Tian Sugui Zhang Luting Wang Guihua | 2000 | 10(1):252000，10，1： | 1 |
| 8 | Neuroprotective effects of ProBeptigen/CMI-168 on aging-induced cognitive decline and neuroinflammation in mice:a comparison with essence of chicken显示文摘Neuroinflammation and cognitive decline are the key pathological features in aging that bring detrimental impacts upon quality of life.However,there is no effective anti-aging pharmacological therapy thus far.Dietary supplements in particular essence of chicken(EC)has been found to be an effective remedy for alleviating mental stress and improving memory.In addition,a novel hydrolyzed chicken extract,ProBeptigen/CMI-168(PB),showed beneficial effects on cognitive ability.However,the antiaging effect and possible mechanism of PB and EC are still unknown.Here,we investigated the antiaging effects of PB and EC on hippocampus-related cognitive decline and neuroinflammation in aged mice.PB and EC were administered for 16 weeks in 10-month-old mice.Both PB and EC treatments ameliorated age-related deterioration of learning and memory,and attenuated oxidative stress and inflammation in the hippocampus.These results were associated with decreased inflammatory cytokine levels and increased neurotransmitter levels in the hippocampus.The overall effects of improving aging-induced cognitive decline were more robust in PB-treated mice,while EC was effective in decreasing oxidative stress and inflammation.Moreover,alterations in the diversity and composition of the gut microbiota in aged mice were also regulated by both PB and EC,which induced distinguished features in the gut microbiota and their related functions.This study showed that PB exerts neuroprotective effects in aged mice,the mechanism of which might be different from that of EC.Therefore,PB has a potential as dietary supplement for ameliorating cognitive dysfunction and neuroinflammation in elderly individuals. | Yinhua Ni Liyang Ni Lingyan Ma Zhe Wang Yufeng Zhao Luting Hu Liujie Zheng Zhengwei Fu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 0 |
| 9 | Waterborne sub-lethal exposure to perfluorobutanesulfonate causes intestinal dysbiosis in tadpoles of Lithobates catesbeianus显示文摘Perfluorobutanesulfonate (PFBS) is a ubiquitous pollutant in the aquatic environment, but its toxic effects andmechanisms on amphibian species remain largely unknown. In the present study, tadpoles (Lithobates catesbeianus) were exposed to various concentrations of PFBS (0, 1, 3, 10, and 30 μg/L) for 14 days, with the goal ofunveiling the impairment of intestinal health. Histopathological examination showed that sub-lethal exposure oftadpoles to PFBS at concentrations as low as 3 μg/L could result in the injury of intestinal structures. In a clearconcentration-dependent manner, the expressions of epithelial barrier components (i.e., Claudin 1 gene and tightjunction protein 2) were significantly decreased in PFBS-exposed intestines, while the intestinal content oflipopolysaccharide (LPS) and transcriptions of downstream responsive genes (e.g., TLR4, MyD88, and NF-κB) wereconcurrently significantly increased by exposure to 3, 10, and 30 μg/L of PFBS. As a consequence, the number ofeosinophils and expression of pro-inflammatory cytokines (e.g., IL-1β and TNF-α) were increased therein.Furthermore, PFBS exposure induced oxidative stress in intestinal tissues by increasing the level of reactive oxygen species (ROS) and suppressing antioxidant capacity. The transcriptional levels of CytoC and Bax genes aswell as activities of caspase 9 and caspase 3 enzymes were remarkably increased, while the transcript abundanceof Bcl-2 was down-regulated significantly after PFBS exposure, thereby favoring apoptosis in tadpole intestines.PFBS sub-lethal exposure also drove the composition of intestinal microbiota to a dysbiosis status. Correlationanalysis further revealed that the relative abundance of members of the genus Bosea was positively related withthe contents of LPS and IL-1β. Overall, the present study provides the first evidence for pronounced impacts ofPFBS on amphibian intestinal ecology, highlighting the susceptibility of tadpoles to the environmental risks ofPFBS. | Yilin Shu Luting Wei Huiling Jiang Wenchao Wang Huijuan Zhang Lizhu Tang Jun He Kanghua Jiang Hailong Wu Lianguo Chen | 2022 | Water Biology and Security2022，1，4： | 0 |
| 10 | Transcriptome-wide association analysis identified candidate susceptibility genes for nasopharyngeal carcinoma显示文摘Dear Editor,Nasopharyngeal carcinoma(NPC)is a common malignancy in East and Southeast Asia,especially in South China.The etiology of NPC has been linked to genetic susceptibility,Epstein-Barr virus(EBV)infection,and environmental factors.Accumulated evidence including multiple genome-wide association studies(GWASs)has revealed robust genetic predisposition of NPC.However,GWAS-identified genetic variants collectively account for only 8.2%of NPC heritability[1].The underlying inherited predisposition is largely undetermined.The strongest genetic signal for NPC consistently hits the human leukocyte antigen(HLA)region on 6p21[2].However,the highly polymorphic nature and complicated long-range linkage disequilibrium(LD)in the HLA region particularly obscure the causal variants driving the association.In addition,most genetic variants located in introns or intergenic regions.The causal genes mediating genetic effects on NPC risk have rarely been ascertained by GWAS alone. | Yong-Qiao He Wen-Qiong Xue Dan-Hua Li Tong-Min Wang Zhi-Ming Mai Da-Wei Yang Chang-Mi Deng Ying Liao Wen-Li Zhang Ruo-Wen Xiao Luting Luo Hua Diao Xiating Tong Yanxia Wu Jiang-Bo Zhang Ting Zhou Xi-Zhao Li Pei-Fen Zhang Xiao-Hui Zheng Shao-Dan Zhang Ye-Zhu Hu Minzhong Tang Yuming Zheng Yonglin Cai Ellen T.Chang Zhe Zhang Guangwu Huang Su-Mei Cao Qing Liu Lin Feng Ying Sun Maria Li Lung Hans-Olov Adami Weimin Ye Tai-Hing Lam Wei-Hua Jia | 2022 | Cancer Communications2022，42，9： | 0 |
| 11 | Genomes and evolutionary genomics of animals显示文摘 | Luting SONG Wen WANG | 2013 | Current Zoology2013，59，1： | 0 |
| 12 | The long-circulating effect of pegylated nanoparticles revisited via simultaneous monitoring of both the drug payloads and nanocarriers显示文摘The long-circulating effect is revisited by simultaneous monitoring of the drug payloads and nanocarriers following intravenous administration of doxorubicin(DOX)-loaded methoxy polyethylene glycol-polycaprolactone(mPEG-PCL) nanoparticles. Comparison of the kinetic profiles of both DOX and nanocarriers verifies the long-circulating effect, though of limited degree, as a result of pegylation. The nanocarrier profiles display fast clearance from the blood despite dense PEG decoration;DOX is cleared faster than the nanocarriers. The nanocarriers circulate longer than DOX in the blood, suggesting possible leakage of DOX from the nanocarriers. Hepatic accumulation is the highest among all organs and tissues investigated, which however is reversely proportionate to blood circulation time. Pegylation and reduction in particle size prove to extend circulation of drug nanocarriers in the blood with simultaneous decrease in uptake by various organs of the mononuclear phagocytic system. It is concluded that the long-circulating effect of mPEG-PCL nanoparticles is reconfirmed by monitoring of either DOX or the nanocarriers, but the faster clearance of DOX suggests possible leakage of a fraction of the payloads. The findings of this study are of potential translational significance in design of nanocarriers towards optimization of both therapeutic and toxic effects. | Wufa Fan Haixia Peng Zhou Yu Luting Wang Haisheng He Yuhua Ma Jianping Qi Yi Lu Wei Wu | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员