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| 1 | Dissipative particle dynamics simulation of flow through periodic arrays of circular micropillar显示文摘Flow through arrays of micropillar embedded inside microfluidic chip systems is important for various microfluidic devices. It is critical to accurately predict the mass flow rate through pillar arrays based on the pillar design. This work presents a dissipative particle dynamics(DPD) model to simulate a problem of flow across periodic arrays of circular micropillar and investigates the permeability of two types of micropillar arrays.The flow fields including horizontal and vertical velocity fields, the number density field,and the streamline of the flow are analyzed. The predicted solid volumes by the presented DPD simulation of both types of arrays are quite close to the actual counterparts. These quantitative agreements show usefulness and effectiveness of the DPD model in simulating arrays of micropillar. By comparing two types of micropillar arrangement patterns, we find that the arrangement pattern of micropillar does not have significant influence on the permeability of the array. | Luwen ZHOU Yuqian ZHANG Xiaolong DENG Moubin LIU | 2016 | Applied Mathematics and Mechanics(English Edition)2016，37，11： | 1 |
| 2 | Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1αpathways显示文摘Accumulating evidence has confirmed the links between transfer RNA(tRNA)modifications and tumor progression.The present study is the first to explore the role of tRNA methyltransferase 5(TRMT5),which catalyzes the m1G37 modification of mitochondrial tRNAs in hepatocellular carcinoma(HCC)progression.Here,based on bioinformatics and clinical analyses,we identified that TRMT5 expression was upregulated in HCC,which correlated with poor prognosis.Silencing TRMT5 attenuated HCC proliferation and metastasis both in vivo and in vitro,which may be partially explained by declined extracellular acidification rate(ECAR)and oxygen consumption rate(OCR).Mechanistically,we discovered that knockdown of TRMT5 inactivated the hypoxia-inducible factor-1(HIF-1)signaling pathway by preventing HIF-1αstability through the enhancement of cellular oxygen content.Moreover,our data indicated that inhibition of TRMT5 sensitized HCC to doxorubicin by adjusting HIF-1α.In conclusion,our study revealed that targeting TRMT5 could inhibit HCC progression and increase the susceptibility of tumor cells to chemotherapy drugs.Thus,TRMT5 might be a carcinogenesis candidate gene that could serve as a potential target for HCC therapy. | Qiong ZHAO Luwen ZHANG Qiufen HE Hui CHANG Zhiqiang WANG Hongcui CAO Ying ZHOU Ruolang PAN Ye CHEN | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，1： | 1 |
| 3 | Flow field analyses of a porous membrane-separated,double-layered microfluidic chip for cell co-culture显示文摘Organs-on-chips composed of a porous membrane-separated,double-layered channels are used widely in elucidating the effects of cell co-culture and flow shear on biological functions.While the diversity of channel geometry and membrane permeability is applied,their quantitative correlation with flow features is still unclear.Immersed boundary methods(IBM)simulations and theoretical modelling were performed in this study.Numerical simulations showed that channel length,height and membrane permeability jointly regulated the flow features of flux,penetration velocity and wall shear stress(WSS).Increase of channel length,lower channel height or membrane permeability monotonically reduced the flow flux,velocity and WSS in upper channel before reaching a plateau.While the flow flux in lower channel monotonically increased with the increase of each factor,the WSS surprisingly exhibited a biphasic pattern with first increase and then decrease with increase of lower channel height.Moreover,the transition threshold of maximum WSS was sensitive to the channel length and membrane permeability.Theoretical modeling,integrating the transmembrane pressure difference and inlet flow flux with chip geometry and membrane permeability,was in good agreement with IBM simulations.These analyses provided theoretical bases for optimizing flow-specified chip design and evaluating flow microenvironments of in vivo tissue. | Shenbao Chen Jian Xue Jinrong Hu Qihan Ding Luwen Zhou Shiliang Feng Yuhong Cui Shouqin Lu Mian Long | 2020 | Acta Mechanica Sinica2020，36，3： | 1 |
| 4 | Discussion problems in calculation of canal seepage 显示文摘 | ZHOU Luwen | 2003 | Gansu Water Conservancy and Hydropower Technology2003，，2： | 1 |
| 5 | Discussion on the Application of Industry-Finance Integration in Warehousing Enterprises显示文摘In recent years,the transformation of warehousing enterprises has garnered widespread attention.The integration of industry and finance in management accounting can provide financial management support for the transformation of warehousing enterprises,deliver accurate and effective financial and business information,facilitate managers’decision-making,and achieve the benign development of enterprises.This paper discusses the problems in the application of industry-finance integration in warehousing enterprises,including the low degree of informatization,inefficient internal cost control,and mismatched staff quality,and then proposes corresponding measures,such as establishing and improving information systems,establishing a comprehensive budget management system,and establishing management measures for the integration of industry and finance in warehousing enterprises,so as to strengthen the application of industry-finance integration in warehousing enterprises. | Luwen Zhong Nanyan Zhou Zhizheng Wang | 2022 | Proceedings of Business and Economic Studies2022，5，4： | 0 |
| 6 | Versatile photonic molecule switch in multimode microresonators显示文摘Harnessing optical supermode interaction to construct artificial photonic molecules has uncovered a series of fundamental optical phenomena analogous to atomic physics.Previously,the distinct energy levels and interactions in such two-level systems were provided by coupled microresonators.The reconfigurability is limited,as they often require delicate external field stimuli or mechanically altering the geometric factors.These highly specific approaches also limit potential applications.Here,we propose a versatile on-chip photonic molecule in a multimode microring,utilizing a flexible regulation methodology to dynamically control the existence and interaction strength of spatial modes.The transition between single/multi-mode states enables the“switched-off/on”functionality of the photonic molecule,supporting wider generalized applications scenarios.In particular,“switched-on”state shows flexible and multidimensional mode splitting control in aspects of both coupling strength and phase difference,equivalent to the a.c.and d.c.Stark effect.“Switched-off”state allows for perfect low-loss single-mode transition(Qi~10 million)under an ultra-compact bend size(FSR~115 GHz)in a foundry-based silicon microring.It breaks the stereotyped image of the FSR-Q factor trade-off,enabling ultra-wideband and high-resolution millimeter-wave photonic operations.Our demonstration provides a flexible and portable solution for the integrated photonic molecule system,extending its research scope from fundamental physics to real-world applications such as nonlinear optical signal processing and sixth-generation wireless communication. | Zihan Tao Bitao Shen Wencan Li Luwen Xing Haoyu Wang Yichen Wu Yuansheng Tao Yan Zhou Yandong He Chao Peng Haowen Shu Xingjun Wang | 2024 | Light(Science & Applications)2024，13，3： | 0 |
| 7 | Aqueous Phase Synthesis and Fluorescence Properties of Inverted Core/Shell ZnSe/CdSe Nanocrystals显示文摘We report a facile aqueous phase synthesis for prepar-ing water-soluble inverted core/shell ZnSe/CdSe semiconductor nanocrystals. The samples were characterized by X-ray diffraction (XRD),transmission electron microscopy (TEM),and their optical properties were investigated by using UV-vis-NIR spectropho-tometer and fluorescence spectrophotometer. The results indicate that the synthesized ZnSe/CdSe nanocrystals are inverted core/shell structure with diameter of about 5 nm. Furthermore,their absorption band-edge is red-shifted with the growth of CdSe shell; correspondingly,their emission wavelength can be tuned from 460 nm to 604 nm. | ZHOU Jing, JIANG Luwen, GUO Wen, JIANG Hai, HAO Zhonghua School of Physics and Technology, Wuhan University/Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, Wuhan 430072, Hubei, China | 2010 | Wuhan University Journal of Natural Sciences2010，15，4： | 0 |
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