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| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | Haze insights and mitigation in China: An overview显示文摘The present article provides an overview of the chemical and physical features of haze in China, focusing on the relationship between haze and atmospheric fine particles, and the formation mechanism of haze. It also summarizes several of control technologies and strategies to mitigate the occurrence of haze. The development of instruments and the analysis of measurements of ambient particles and precursor concentrations have provided important information about haze formation. Indeed, the use of new instruments has greatly facilitated current haze research in China. Examples of insightful results include the relationship between fine particles and haze, the chemical compositions and sources of particles, the impacts of the aging process on haze formation, and the application of technologies that control the formation of haze. Based on these results, two relevant issues need to be addressed: understanding the relationship between haze and fine particles and understanding how to control PM2.5. | Xuliang Zhuang Yuesi Wang Hong He Jianguo Liu Xinming Wang Tingyu Zhu Maofa Ge Ju Zhou Guiqian Tang Jinzhu Ma | 2014 | Journal of Environmental Sciences2014，26，1： | 12 |
| 3 | On the automobile lightweight显示文摘The significance,description parameters,evaluation method,implement way and design for lightweight of automobile are comprehensively reviewed.The relationship among the performances of auto parts & components,the properties of materials and application of advanced technologies is also elaborated.According to recently related progress of lightweight and authors' research and developing work,lightweight of automobile is comprehensively and systematically overviewed. | Ma Mingtu Yi Hongliang Lu Hongzhou Wan Xinming | 2012 | Engineering Sciences2012，10，2： | 8 |
| 4 | Distinct potential aerosol masses under different scenarios of transport at a suburban site of Beijing显示文摘In order to evaluate the secondary aerosol formation potential at a suburban site of Beijing,in situ perturbation experiments in a potential aerosol mass(PAM) reactor were carried out in the winter of 2014.The variations of secondary aerosol formation as a function of time,OH exposure,and the concentrations of gas phase pollutants and particles were reported in this study.Two periods with distinct secondary aerosol formation potentials,marked as Period Ⅰ and Period Ⅱ,were identified during the observation.In Period Ⅰ,the secondary aerosol formation potential was high,and correlated well to the air pollutants,i.e.,SO_2,NO_2,and CO.The maximal secondary aerosol formation was observed with an aging time equivalent to about 3 days of atmospheric oxidation.In period Ⅱ,the secondary aerosol formation potential was low,with no obvious correlation with the air pollutants.Meanwhile,the aerosol mass decreased,instead of showing a peak,with increasing aging time.Backward trajectory analysis during the two periods confirmed that the air mass in Period Ⅰwas mainly from local sources,while it was attributed mostly to long distance transport in Period Ⅱ.The air lost its reactivity during the long transport and the particles became highly aged,resulting in a low secondary aerosol formation potential.Our experimental results indicated that the in situ measurement of the secondary aerosol formation potential could provide important information for evaluating the contributions of local emission and long distance transport to the aerosol pollution. | Biwu Chu Yongchun Liu Qingxin Ma Jinzhu Ma Hong He Gang Wang Shuiyuan Cheng Xinming Wang | 2016 | Journal of Environmental Sciences2016，28，1： | 5 |
| 5 | Histogram analysis of apparent diffusion coefficient predicts response to radiofrequency ablation in hepatocellular carcinoma显示文摘Objective: The aim of this study was to predict tumor progression in patients with hepatocellular carcinoma(HCC) treated with radiofrequency ablation(RFA) using histogram analysis of apparent diffusion coefficients(ADC).Methods: Breath-hold diffusion weighted imaging(DWI) was performed in 64 patients(33 progressive and 31 stable) with biopsy-proven HCC prior to RFA. All patients had pre-treatment magnetic resonance imaging(MRI)and follow-up computed tomography(CT) or MRI. The ADC values(ADC_(10), ADC_(30_, ADC_(median) and ADC_(max))were obtained from the histogram's 10 th, 30 th, 50 th and 100 th percentiles. The ratios of ADC_(10), ADC_(30_,ADCmedian and ADCmax to the mean non-lesion area-ADC(RADC_(10), RADC_(30_, RADC_(median), and RADC_(max)) were calculated. The two patient groups were compared. Key predictive factors for survival were determined using the univariate and multivariate analysis of the Cox model. The Kaplan-Meier survival analysis was performed, and pairs of survival curves based on the key factors were compared using the log-rank test.Results: The ADC_(30_, ADCmedian, ADCmax, RADC_(30_, RADC_(median), and RADC_(max) were significantly larger in the progressive group than in the stable group(P<0.05). The median progression-free survival(PFS) was 22.9 months for all patients. The mean PFS for the stable and progressive groups were 47.7±1.3 and 9.8±1.3 months,respectively. Univariate analysis indicated that RADC_(10), RADC_(30_, and RADC_(median) were significantly correlated with the PFS [hazard ratio(HR)=31.02, 43.84, and 44.29, respectively, P<0.05 for all]. Multivariate analysis showed that RADCmedian was the only independent predictor of tumor progression(P=0.04). And the cutoff value of RADC_(median) was 0.71.Conclusions: Pre-RFA ADC histogram analysis might serve as a useful biomarker for predicting tumor progression and survival in patients with HCC treated with RFA. | Xiaohong Ma Han Ouyang Shuang Wang Meng Wang Chunwu Zhou Xinming Zhao | 2019 | Chinese Journal of Cancer Research2019，31，2： | 5 |
| 6 | Hospital-Based Phenotypic Features and Treatment Outcomes of Chinese Women with Polycystic Ovary Syndrome: The Effect of Body Mass Index and Geographic Distribution显示文摘Genetic,lifestyle,and environmental factors contribute to the etiology of polycystic ovary syndrome(PCOS).Increased body mass index(BMI)exacerbates the reproductive and metabolic parameters and reduces the fecundity of women with PCOS.This is a secondary analysis of a large-sample,multicenter,randomized controlled trial conducted at 21 sites in Chinese mainland.A total of 1000 women diagnosed with PCOS were enrolled in this trial.Of these,998 women with PCOS were included in the analysis.Increased BMI was associated with more severe menstrual irregularities,elevated testosterone level,higher prevalence of metabolic syndrome,and poorer quality of life.The rates of ovulation per woman for the normal,overweight,and obese BMI groups were 83.0%,78.2%,and 63.6%,respectively(P<0.001),and the rates of live birth were 23.6%,18.1%,and 15.3%(P=0.030).Northern PCOS patients showed more severe reproductive,glucose,and lipid profiles;less exercise;and lower total ovulation rates compared with PCOS patients from Southern China(74.8%vs 81.2%,absolute difference 6.4%,95%confidence interval 1.2%–11.5%).The results show the typical phenotypic features of Han women with PCOS in Northern and Southern China.The women living in Northern China showed a higher BMI,more severe glycolipid metabolism profiles,and subsequently worse clinical outcomes by the same interventions than those living in Southern China.The difference in phenotypic features can be explained mostly by differences in BMI and the resulting difference in ovulation. | Jingshu Gao Hongli Ma Yu Wang Xinming Yang Yijuan Cao Bei Zhang Conghui Han Xiaoke Wua | 2021 | Engineering2021，7，2： | 3 |
| 7 | Secondary aerosol formation and oxidation capacity in photooxidation in the presence of Al_2O_3 seed particles and SO_2显示文摘To investigate the sensitivity of secondary aerosol formation and oxidation capacity to NOx in homogeneous and heterogeneous reactions, a series of irradiated toluene/NOx/air and ?-pinene/NOx/air experiments were conducted in smog chambers in the absence or presence of Al2O3 seed particles. Various concentrations of NOx and volatile organic compounds(VOCs) were designed to simulate secondary aerosol formation under different scenarios for NOx. Under 'VOC-limited' conditions, the increasing NOx concentration suppressed secondary aerosol formation, while the increasing toluene concentration not only contributed to the increase in secondary aerosol formation, but also led to the elevated oxidation degree for the organic aerosol. Sulfate formation was suppressed with the increasing NOx due to a decreased oxidation capacity of the photooxidation system. Secondary organic aerosol(SOA) formation also decreased with the presence of high concentration of NOx, because organo-peroxy radicals(RO2) react with NOx instead of with peroxy radicals(RO2 or HO2), resulting in the formation of volatile organic products. The increasing concentration of NOx enhanced the formation of sulfate, nitrate and SOA under 'NOx-limited' conditions, in which the heterogeneous reactions played an important role. In the presence of Al2O3 seed particles, a synergetic promoting effect of mineral dust and NOx on secondary aerosol formation in heterogeneous reactions was observed in the photooxidation. This synergetic effect strengthened the positive relationship between NOx and secondary aerosol formation under 'NOx-limited' conditions but weakened or even overturned the negative relationship between NOx and secondary aerosol formation under 'VOC-limited' conditions. Sensitivity of secondary aerosol formation to NOx seemed different in homogeneous and heterogeneous reactions, and should be both taken into account in the sensitivity study. The sensitivity of secondary aerosol formation to NOx was further investigated under 'winter-like' and NH3-rich conditions. No obvious difference for the sensitivity of secondary aerosol formation except nitrate to NOx was observed. | Biwu Chu Tengyu Liu Xiao Zhang Yongchun Liu Qingxin Ma Jinzhu Ma Hong He Xinming Wang Junhua Li Jiming Hao | 2015 | Science China Chemistry2015，58，9： | 3 |
| 8 | Preparation of SiC Porous Ceramics by Crystalline Silicon Cutting Waste显示文摘SiC porous ceramics were prepared at 1 400 ℃ for4 h with crystalline silicon cutting waste and activated carbon as main starting materials and NH_4HCO_3 as the pore-forming agent. Effects of NH_4HCO_3 additions( 0,20%,30%,40%,by mass) on the phase composition,microstructure,sintering properties,cold compressive strength and thermal shock resistance of as-prepared Si C porous ceramics were investigated. The results show that:( 1) addition of NH_4HCO_3 remarkably influences the apparent porosity and cold compressive strength of specimens. The apparent porosity achieves its maximum value( 63. 40%) when 40% NH_4HCO_3 is added,while the minimum cold compressive strength is 4. 77 MPa;( 2) the specimen with 40% NH_4HCO_3 has the best thermal shock resistance. The thermal cycling times between1 000 ℃ to room temperature reach 62;( 3) the addition of NH_4HCO_3 does not remarkably affect the phase composition of the specimens;( 4) the specimens include a large number of SiC particles and a small amount of SiC whiskers. | ZHANG Yaran MA Beiyue YU Jingyu SU Chang REN Xinming QIAN Fan LIU Guoqi LI Hongxia YU Jingkun | 2018 | China's Refractories2018，27，4： | 3 |
| 9 | Effect of Starch Addition on Properties of Corundum-mullite Porous Ceramics显示文摘Corundum-mullite porous ceramics(CMPCs)were fabricated using fly ash and aluminum ash as the raw materials,adding different amounts of starch(0,10%,20%,and 30%,by mass)as the pore-forming agent,molding and firing at 1200℃ for 1 h.The apparent porosity,the bulk density,the cold compressive strength,the thermal shock resistance and the thermal conductivity of the CMPCs were tested.The phase composition and the microstructure of the CMPCs were characterized by XRD and SEM.The effect of the starch addition on the properties of the CMPCs was studied.The results show that:(1)the CMPCs with high porosity can be successfully prepared by adding starch as the pore-forming agent and firing at 1200℃ for 1 h;(2)with the starch addition increasing,the porosity increases;the cold compressive strength and the number of the quenching cycles of the CMPCs decrease,but they remain at high levels;meanwhile,the thermal conductivity decreases;(3)generally,when adding 20 mass%starch,the CMPC has the apparent porosity of 48.6%,the cold compressive strength of 52.1 MPa,the quenching cycles of 5 and the thermal conductivity of 1.63 W·m-1·K-1 and 1.52 W·m-1·K-1,respectively,at 25℃ and 500℃,showing good performance. | SU Chang MA Beiyue REN Xinming LIU Guoqiang ZHU Qiang | 2020 | China's Refractories2020，29，4： | 2 |
| 10 | Effects of Pore-forming Agents on Properties of Silicon Carbide Porous Ceramics Prepared from Crystalline Silicon Cutting Waste显示文摘SiC powder was rapidly synthesized in an induction furnace with crystalline silicon cutting waste and active carbon as raw materials,and then SiC porous ceramics were prepared at 1600 t for 4 h with carbon embedded using the powder as raw material,the starch and the graphite as pore-forming agents.Effects of additions of different pore-forming agents on the phase composition,microstructures,physical properties,and cold crushing strength of the porous ceramics were investigated.The results show that the main crystalline phases of the synthetic powder areα-S iC(6H-SiC)andβ-SiC(3C-SiC).The phase composition of the porous ceramics includesα-S iC(6H-SiC),β-SiC(3C-SiC),FeSi,quartz and Si2N20.The apparent porosity and closed porosity of the porous ceramics prepared by adding starch are higher,and the cold compressive strength of the porous ceramics added with graphite is higher.As increasing the additions of the starch,the apparent porosity,closed porosity and linear shrinkage ratio of the porous ceramics increase,and the bulk density decreases correspondingly.When 20 mass%starch is added,the apparent porosity,closed porosity,linear shrinkage ratio and cold compressive strength are 57.05%,2.03%,5.10%and 10.20 MPa,respectively. | MA Beiyue WU Hua GAO Zhi REN Xinming ZHANG Yaran | 2019 | China's Refractories2019，28，4： | 1 |
| 11 | Semen Analysis and Fecundity Association Among Women with Polycystic Ovary Syndrome Experiencing Ovulatory Dysfunction Treated by Ovulation Induction显示文摘In this study,normal values of semen analysis were set for a general infertile population of couples among which most women had normal ovulation.The predictive capacity values of sperm quality,including concentration,motile count,progressive motile count,and morphology,are unclear for women with polycystic ovary syndrome(PCOS).A secondary analysis was conducted based on a randomized controlled trial investigating infertility among women with PCOS experiencing ovulatory disorder between 2011 and 2016 in China.A total of 1000 women received ovulation induction(acupuncture and clomiphene).We randomized the women with PCOS in 27 hospitals in China who received one of four interventions(acupuncture plus clomiphene,sham acupuncture plus clomiphene,acupuncture plus placebo,or sham acupuncture plus placebo).Semen analysis was performed for every male partner according to the World Health Organization(WHO)criteria.The outcomes included conception,clinical pregnancy,and live birth.Logistic regression was used to evaluate the predictive value of semen analysis among ovulatory women for conception,clinical pregnancy,and live birth.Among the 1000 couples,the number of couples who attained ovulation,conception,clinical pregnancy,and live birth were 780,320,235,and 205,respectively.Semen volume and motility were applied and used as prediction parameters for conception(area under the curve(AUC)of 0.62(95%confidence interval(CI),0.55–0.69)),clinical pregnancy(AUC of 0.67(95%CI:0.61–0.73)),and live birth(AUC of 0.57(95%CI:0.50–0.64)).No poor calibration was shown for these models in Hosmer–Lemeshow tests.The predictive capacity of semen analysis for treatment outcome in PCOS women with PCOS experiencing with ovulatory dysfunction is limited. | Jingshu Gao Yu Wang Mubai Li Mengyi Zhu Xuekui Liu Hongli Ma Yijuan Cao Lu Li Xinming Yang Xiaoke Wu | 2021 | Engineering2021，7，11： | 1 |
| 12 | UBE3A alleviates isoproterenol-induced cardiac hypertrophy through the inhibition of the TLR4/MMP-9 signaling pathway显示文摘Cardiac hypertrophy is considered to be a leading factor in heart function-related deaths.In this study,we explored the potential mechanism underlying cardiac hypertrophy induced by isoproterenol.Our results showed that isoproterenol induced cardiac hypertrophy in AC16 cells,as reflected by the increased cell surface area and increased hypertrophic markers,which was accompanied by increased ubiquitin-protein ligase E3a(UBE3A)expression.Moreover,UBE3A knockdown by siRNAs accelerated cardiac hypertrophy,suggesting that increased UBE3A expres sion induced by isoproterenol might be a protective response and UBE3A might be a protective factor against cardiac hypertrophy.Our study also revealed that UBE3A knockdown increased the protein expression of the TLR4/MMP-9 pathway that has been shown to be associated with cardiac hypertrophy,which suggested that UBE3A-mediated protection is likely to be associated with the blockade of the TLR4/MMP-9 signaling pathway.UBE3A might be thus a potential target gene for the treatment of cardiac hypertrophy. | Yanfei Li Linlin Ma Sijie Gu Jiewen Tian Yilin Cao Zi Jin Jingyi Chen Bingbing Gu Jiayin Tu Zhixiao Wang Xinming Li Zhongping Ning Yueling Jin | 2020 | Acta Biochimica et Biophysica Sinica2020，52，1： | 1 |
| 13 | The Existence and Significance of Two Kinds of Effective Reservoirs in Deep Water Area of the Western Qaidam Basin显示文摘Objective Deep-water deposit has become one of the greatest potential and economic areas for petroleum exploration.In the western Qaidam Basin,the deep-water sedimentary area account for nearly 2/3 of the basin area,but the related reports is less.Scholars generally believed that the salt water medium can inhibit the extension of the sand(Qian et al.,1984). | SHI Yajun XU Li HUANG Chenggang WANG Liqun MA Xinming | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 1 |
| 14 | Development of P genome-specific SNPs and their application in tracing Agropyron cristatum introgressions in common wheat显示文摘As an important wild relative of wheat, Agropyron cristatum has been successfully used for wheat improvement. Currently, a few useful agronomic traits of A. cristatum, such as high grain number per spike and resistance to diseases, have been transferred into common wheat.However, the effective detection of small A. cristatum segmental introgressions in common wheat is still difficult. The objective of this study was to identify A. cristatum-specific single nucleotide polymorphisms(SNPs) for the detection of small alien segments in wheat. The transcriptome sequences of A. cristatum were aligned against wheat coding DNA sequences(CDS) for SNP calling. As a result, we discovered a total of 167,613 putative SNPs specific to the P genome of A. cristatum compared with the common wheat genomes. Among 230 selected SNPs with functional annotations related to inflorescence development and stress resistance,68 were validated as P genome-specific SNPs in multiple wheat backgrounds using Kompetitive Allele Specific PCR(KASP) assays. Among them, 55 SNPs were assigned to six homoeologous groups of the P genome using wheat-A. cristatum addition lines, and 6 P-specific SNP markers were further physically mapped on different segments of chromosome 6 P in 6 P translocation lines. The P genome-specific SNPs were also validated by Sanger sequencing and used to detect the P chromatin in wheat-A. cristatum cryptic introgression lines. Two SNP markers(Unigene20217-182 and Unigene20307-1420) were detected in two wheat-A. cristatum introgression lines that showed enhanced grain number per spike and high resistance to powdery mildew. Together, the developed P genome-specific SNP markers will accelerate the detection of large numbers of wheat-A. cristatum derivatives and will be helpful for marker-assisted transfer of desirable traits from A. cristatum into adapted wheat cultivars in wheat breeding programs. | Huihui Ma Jinpeng Zhang Jing Zhang Shenghui Zhou Haiming Han Weihua Liu Xinming Yang Xiuquan Li Lihui Li | 2019 | The Crop Journal2019，7，2： | 1 |
| 15 | Research Progress on Porous Ceramics Prepared from Industrial Solid Wastes显示文摘The situation of porous ceramics prepared from industrial waste slag(fly ash,red mud,metallurgical slag,tailings,etc.)was summarized.It was pointed out that the preparation of porous ceramics from industrial waste slag can bring long-term economic and social benefits.The development trend of secondary utilization of industrial waste slag was also prospected. | GAO Zhi REN Xinming MA Beiyue YU Jingkun LIU Guoqi | 2019 | China's Refractories2019，28，3： | 1 |
| 16 | A Maximal Clique Based Packet Scheduling Algorithm in Ad Hoc Wireless Networks 显示文摘 | Tao MA Xinming ZHANG and Guoliang CHEN | 2004 | IEEEICN'' 042004，，： | 1 |
| 17 | Rough set and ensemble learn- ing based semi-supervised algorithm for text classification显示文摘 | SHI Lei MA Xinming XI Lei | 2011 | Expert Systems with Applications2011，38，5： | 1 |
| 18 | Application of smog chambers in atmospheric process studies显示文摘Smog chamber experimental systems,which have been widely used in laboratory simulation for studying atmospheric processes,are comprehensively reviewed in this paper.The components,development history,main research topics and main achievements of smog chambers are introduced.Typical smog chambers in the world,including their volumes,wall materials,light sources and features,are summarized and compared.Key factors of smog chambers and their influences on the simulation of the atmospheric environment are discussed,including wall loss,wall emission and background pollutants.The features of next-generation smog chambers and their application prospect in future studies of the atmospheric environment are also outlined in this paper. | Biwu Chu Tianzeng Chen Yongchun Liu Qingxin Ma Yujing Mu Yonghong Wang Jinzhu Ma Peng Zhang Jun Liu Chunshan Liu Huaqiao Gui Renzhi Hu Bo Hu Xinming Wang Yuesi Wang Jianguo Liu Pinhua Xie Jianmin Chen Qian Liu Jingkun Jiang Junhua Li Kebin He Wenqing Liu Guibin Jiang Jiming Hao Hong He | 2022 | National Science Review2022，9，2： | 1 |
| 19 | Cadmium pollution on the influence of content of tobacco leaf ultrastructure and some elements显示文摘 | Yuan Zuli Ma Xinming Han Jinfeng | 2012 | Acta Ecologica Sinica2012，11，2： | 1 |
| 20 | A study on hyperspectral estimating models of tobacco leaf area index显示文摘 | Zhang ZhengYang Ma XinMing Liu Guoshun | 2011 | African Journal of Agricultural Research2011，6，2： | 1 |
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