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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans——Qingdao City,Shandong Province,China,September 2020显示文摘Summary What is already known about this topic?Though coronavirus disease 2019(COVID-19)has largely been controlled in China,several outbreaks of COVID-19 have occurred from importation of cases or of suspected virus-contaminated products.Though several outbreaks have been traced to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)isolated on the outer packaging of cold chain products,live virus has not been obtained. | Huilai Ma Zhaoguo Wang Xiang Zhao Jun Han Yong Zhang Hong Wang Cao Chen Ji Wang Fachun Jiang Jie Lei Jingdong Song Shaofeng Jiang Shuangli Zhu Huihui Liu Dongyan Wang Yao Meng Naiying Mao Yanhai Wang Zhen Zhu Zhixiao Chen Bingling Wang Qinqin Song Haijun Du Qun Yuan Dong Xia Zhiqiang Xia Peipei Liu Yuchao Wu Zijian Feng Ruqin Gao George F.Gao Wenbo Xu | 2021 | China CDC weekly2021，3，30： | 13 |
| 3 | Hyperhomocysteinemia induces cardiac injury by up-regulation of p53-dependent Noxa and Bax expression through the p53 DNA methylation in ApoE-/- mice显示文摘Hyperhomocysteinemia (HHcy ) 是为心血管的疾病的一个风险因素并且与心失败有强壮的关联。然而,心脏的织物上的 HHcy 的效果仍然保持不太好理解。阐明在导致 HHcy 的心脏的损害的 p53 依赖的 apoptosis 的角色,我们用高蛋氨酸饮食喂了 ApoE/ 老鼠建立 HHcy 模型。浆液 Hcy,心脏的酶,和类脂化合物被测量。Noxa, DNMT1, caspases-3/9,和 p53 的蛋白质层次被连接酶的 immunosorbent 试金决定。Bcl-2 和 Bax 蛋白质被染色的 immunohistochemistry 检测。S-adenosyl 蛋氨酸和 S-adenosyl homocysteine 集中被高效的液体层析决定。p53 和 DNMT1 的 mRNA 层次被即时聚合酶链反应(PCR ) 分析, p53 的 methylation 层次被嵌套的 methylation-specific-PCR 分析。我们的数据证明浆液 Hcy 和类脂化合物的集中与 N 控制组相比在 Meth 组被增加,它显示模型成功地被建立。p53 和 Noxa 的表示层次在 Meth 组被增加,当 p53 的 methylation 地位是 hypomethylation 时。caspase-3/9 的活动与 N 控制组相比在 Meth 组被增加。另外,染色的 immunohistochemistry 证明 Bax 的表示显著地与 N 控制组相比在 Meth 和 Meth-F 组被增加。在摘要, HHcy 由 p53 依赖的 pro-apoptotic 的起来规定导致心脏的损害联系了基因 Noxa 和 Bax,当 p53 DNA hypomethylation 是在 HHcy 导致的病理学的过程的关键分子的机制时。 | ShengchaoMa Huiping Zhang Weiwei Sun HuiHui Gong YanhuaWang Changjian Ma Ju Wang Chengjian Cao Xiaoling Yang Jue Tian Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 12 |
| 4 | Concise and efficient direct-view generation of arbitrary cylindrical vector beams by a vortex half-wave plate显示文摘A concise, efficient, and practical direct-view scheme is presented to generate arbitrary cylindrical vector(CV)beams, including CV beams, vortex beams, and cylindrical vector vortex(CVV) beams, by a vortex half-wave plate(VHP). Six kinds of first-order and other high-order CV beams, such as azimuthally polarized(AP) beams, antivortex radial polarization mode beams, and three-order AP beams, are formed by simply rotating a half-wave plate. The Stokes parameters and double-slit interference of multitype CV beams are investigated in detail.The polarization parameters, including degree of polarization, polarization azimuth, and ellipticity, are obtained,which demonstrates the efficient generation of CV beams. In addition, the double-slit interference experiment is introduced in the setup, and fringe misplacement and tilt appear for CVV beams, in which the misplacement number M is 2P+1 for P ≤ 2 and 2P-1 for P ≥ 3, where P is the polarization order number, and the fringe tilt offset is positively related to the topological charge number l of CVV beams. In addition, new types of VHPs can be formed by cascading two or more VHPs when the types of available VHPs are limited, assisting in more flexible generation of multitype CV beams. It is experimentally demonstrated that arbitrary CV beams with high quality are effectively achieved by the proposed setup, and the double-slit interference method can be utilized to determine and analyze CV beams rapidly and concisely by practical performance, which shows the potential to be implemented as a commercial device. | JUNLI QI WEIHUA WANG BO SHI HUI ZHANG YANAN SHEN HAIFEI DENG WENJING PU XIN LIU HUIHUI SHAN XIAOMIN MA LIANQIANG ZHANG WEI LU MEICHENG FU XIUJIAN LI | 2021 | Photonics Research2021，9，5： | 4 |
| 5 | Mutations in EZH2 are associated with poor prognosis for patients with myeloid neoplasms显示文摘EZH2 is a component of the polycomb repressive complex 2(PRC2),which is a highly conserved histone methyltransferase that methylates lysine 27 of histone 3.EZH2 mutations are associated with oncogenesis and progression of cancers.However,the relationship between the clinical outcome of patients with myeloid malignancies and EZH2 mutations is controversial.Therefore,we performed a meta-analysis of 8 studies(n Z 2243 patients)that evaluates the correlation between EZH2 mutations and overall survival(OS)in patients with myeloid neoplasms.EZH2 mutations were associated with significantly worse OS(hazard ratio[HR]Z 2.37,95%confidential interval(CI),1.48e3.79).In a word,EZH2 mutations indicate a poor prognosis for patients with myeloid neoplasms. | Qi Zhang Qi Han Jie Zi Jinlong Ma Huihui Song Yulu Tian Mary McGrath Chunhua Song Zheng Ge | 2019 | Genes & Diseases2019，6，3： | 3 |
| 6 | Decomposition of mixed rare earth concentrate by NaOH roasting and kinetics of hydrochloric acid leaching process显示文摘A new clean extraction technology for the decomposition of Bayan Obo mixed rare earth concentrate by NaOH roasting is proposed.The process mainly includes NaOH roasting to decompose rare earth concentrate and HCl leaching roasted ore.The effects of roasting temperature,roasting time,NaOH addition amount on the extraction of rare earth and factors such as HCl concentration,liquid-solid ratio,leaching temperature and leaching time on the dissolution kinetics of roasted ore were studied.The experimental results show that when the roasting temperature is 550℃and the roasting time is 60 min,the mass ratio of NaOH:rare earth concentrate is 0.60:1,the concentration of HCl is 6.0 mol/L,the ratio of liquid to solid(L/S)6.0:1.0,and the leaching temperature 90℃,leaching time 45 min,stirring speed 200 r/min,and the extraction of rare earth can reach 92.5%.The relevant experimental data show that the process of HCl leaching roasted ore conforms to the shrinking core model,but the control mechanism of the che mical reaction process is different when the leaching temperature is different.When the leaching temperature is between 40 and 70℃,the chemical reaction process is controlled by the diffusion of the product through the residual layer of the inert material.The average surface activation energy of the rare earth element is E_a=9.96 kJ/mol.When the leaching temperature is 75-90℃,the chemical reaction process is controlled by the interface transfer across the product layer(product layer interface mass transfer)and diffusion.The average surface activation energy of rare earth elements is E_a=41.65 kJ/mol.The results of this study have certain significance for the green extraction of mixed rare earth ore. | Mei Li Jianfei Li Dongliang Zhang Kai Gao Huihui Wang Wei Xu Jinlong Geng Xiaoyan Zhang Xiufen Ma | 2020 | Journal of Rare Earths2020，38，9： | 2 |
| 7 | Decrease of NH_4^+-N by bacterioplankton accelerated the removal of cyanobacterial blooms in aerated aquatic ecosystem显示文摘We used aerated systems to assess the influence of the bacterioplankton community on cyanobacterial blooms in algae/post-bloom of Lake Taihu, China. Bacterioplankton community diversity was evaluated by polymerase chain reaction-denaturing gradient gel electrophoresis(PCR-DGGE) fingerprinting. Chemical analysis and nitrogen dynamic changes illustrated that NH4+-N was nitrified to NO2-N and NO3-N by bacterioplankton. Finally, NH4+-N was exhausted and NO3-N was denitrified to NO2-N, while the accumulation of NO2-N indicated that bacterioplankton with completely aerobic denitrification ability were lacking in the water samples collected from Lake Taihu. We suggested that adding completely aerobic denitrification bacteria(to denitrify NO2-N to N2)would improve the water quality. PCR-DGGE and sequencing results showed that more than 1/3 of the bacterial species were associated with the removal of nitrogen, and Acidovorax temperans was the dominant one. PCR-DGGE, variation of nitrogen, removal efciencies of chlorophyll-a and canonical correspondence analysis indicated that the bacterioplankton significantly influenced the physiological and biochemical changes of cyanobacteria. Additionally, the unweighted pair-group method with arithmetic means revealed there was no obvious harm to the microecosystem from aeration. The present study demonstrated that bacterioplankton can play crucial roles in aerated ecosystems, which could control the impact of cyanobacterial blooms in eutrophicated fresh water systems. | Xi Yang Ping Xie Zhimei Ma Qing Wang Huihui Fan Hong Shen | 2013 | Journal of Environmental Sciences2013，25，11： | 2 |
| 8 | Determination of formaldehyde in foodstuffs by flow injection spectrophotometry using phloroglucinol as chromogenic agent 显示文摘 | LI Ziwei MA Hongbing LU Huihui | 2008 | Talanta2008，74，4： | 1 |
| 9 | Determination of N -methylcarbamate pesticides in vegetables by poly(methacrylic acid- co -ethylene glycol dimethacrylate) monolith microextraction coupled with high performance liquid chromatography显示文摘 | Huihui Ma Wei Feng Miaomiao Tian Qiong Jia | 2013 | Journal of Chromatography B2013，，： | 1 |
| 10 | SCN1A, SCN1B, and GABRG2 gene mutation analysis in Chinese families with generalized epilepsy with febrile seizures plus显示文摘 | Huihui Sun Yuehua Zhang Jianmin Liang Xiaoyan Liu Xiuwei Ma Husheng Wu Keming Xu Jiong Qin Yu Qi Xiru Wu | 2008 | Journal of Human Genetics2008，，8： | 1 |
| 11 | Determination of formaldehyde in foodstuffs by flow injection spectrophotometry using phloroglucinol as chromogenic agent显示文摘 | LI Ziwei MA Hongbing LU Huihui | 2008 | Talanta2008，74，4： | 1 |
| 12 | Development of P genome-specific SNPs and their application in tracing Agropyron cristatum introgressions in common wheat显示文摘As an important wild relative of wheat, Agropyron cristatum has been successfully used for wheat improvement. Currently, a few useful agronomic traits of A. cristatum, such as high grain number per spike and resistance to diseases, have been transferred into common wheat.However, the effective detection of small A. cristatum segmental introgressions in common wheat is still difficult. The objective of this study was to identify A. cristatum-specific single nucleotide polymorphisms(SNPs) for the detection of small alien segments in wheat. The transcriptome sequences of A. cristatum were aligned against wheat coding DNA sequences(CDS) for SNP calling. As a result, we discovered a total of 167,613 putative SNPs specific to the P genome of A. cristatum compared with the common wheat genomes. Among 230 selected SNPs with functional annotations related to inflorescence development and stress resistance,68 were validated as P genome-specific SNPs in multiple wheat backgrounds using Kompetitive Allele Specific PCR(KASP) assays. Among them, 55 SNPs were assigned to six homoeologous groups of the P genome using wheat-A. cristatum addition lines, and 6 P-specific SNP markers were further physically mapped on different segments of chromosome 6 P in 6 P translocation lines. The P genome-specific SNPs were also validated by Sanger sequencing and used to detect the P chromatin in wheat-A. cristatum cryptic introgression lines. Two SNP markers(Unigene20217-182 and Unigene20307-1420) were detected in two wheat-A. cristatum introgression lines that showed enhanced grain number per spike and high resistance to powdery mildew. Together, the developed P genome-specific SNP markers will accelerate the detection of large numbers of wheat-A. cristatum derivatives and will be helpful for marker-assisted transfer of desirable traits from A. cristatum into adapted wheat cultivars in wheat breeding programs. | Huihui Ma Jinpeng Zhang Jing Zhang Shenghui Zhou Haiming Han Weihua Liu Xinming Yang Xiuquan Li Lihui Li | 2019 | The Crop Journal2019，7，2： | 1 |
| 13 | Continuous culture of urine-derived bladder cancer cells for precision medicine显示文摘Dear Editor,Bladder cancer is the most common type of genitourinary cancer in China,with an estimated 80,500 new cases and 32,900 related deaths in 2015 alone(Chen et al.,2016).Unlike many other cancers,there has been no significant improvement in survival rates for bladder cancer over the last three decades.Specific treatment regimens for bladder cancer and their efficacy vary depending not only on clinical stages,but also on associated risk factors and other personal clinical characteristics.Patients with non-muscle invasive bladder cancer(NMIBC)have a high 5-year recurrence rate of 60%-70%(Berdik,2017)and those with muscle invasive bladder cancer(MIBC)has a relatively poor prognosis with approximately 65%risk of death within 5-year follow-up(Kamat et al.,2016).Therefore,there is an urgent need to develop models for bladder cancer to screen for rational treatment strategies by personalized medicine to improve the clinical assessment and treatment of bladder cancer. | Shuai Jiang Jiaqi Wang Chen Yang Renke Tan Jun Hou Yuan Shi Huihui Zhang Shiyu Ma Jianan Wang Mengmeng Zhang George Philips Zengxia Li Jian Ma Wanjun Yu Guohua Wang Yuanming Wu Richard Schlegel Huina Wang Shanbo Cao Jianming Guo Xuefeng Liu Yongjun Dang | 2019 | Protein & Cell2019，10，12： | 1 |
| 14 | Determination of N-methylcarbamate pesticides in vegetables by poly(methacrylic acid-co-ethylene glycol dimethacrylate) monolith microextraction coupled with high performance liquid chromatography显示文摘 | Ma Huihui Feng Wei Tian Miaomiao | 2013 | J Chromatogr B2013，929，： | 1 |
| 15 | Combination of Astragalus membranaceus and Euonymus alatus (THUNB.) SIEB. for treatment of diabetes: A network-based pharmacology research显示文摘Objective:To find the target genes in combination of astragalus root(Astragalus membranaceus)and spindle tree wings(Euonymus alatus(THUNB.)SIEB.)(Qijian Heji)with the function of regulating blood glucose levels in kk mice by real-time fluorescence quantitative PCR(RT-PCR).To achieve the primary exploration on the material basis for Qijian Heji to improve the blood glucose levels of type 2 diabetic kk mice.Methods:We applied RT-PCR to detecting the expression of gene targets in kidney tissues of type 2 diabetes model kk mice.The detected gene targets were predicted by the network pharmacology method in the early stage of the project.Through the observation of the hypoglycemic effect of different ratios of Qijian Heji,the optimal proportion was determined and then used to conduct research of material basis.Results:Continuous administration of Qijian Heji(astragalus root:spindle tree wings Z 3:1)for six weeks resulted in significantly lowering blood glucose levels in mice in the fourth week,dropping from 33.3 to 21.9 mmol/L;this lower level was maintained in the fifth to sixth weeks.Blood glucose values in the positive drug group decreased from 33.3 to 21.85 mmol/L in the fourth week and maintained steady decreasing in the fifth and sixth weeks.Conclusion:Qijian Heji,with proportion of 3:1,could significantly reduce the blood glucose values in kk mice,animal experiment results verified the accurate prediction of network pharmacology,and at the same time,it is verified there was a certain therapeutic effect about the combination of the two herbs on reducing the glucose value.Animal experiments and RT-PCR results showed that Qijian Heji conducted a hypoglycemic effect by modulating estrogen receptor(ESR1)and renin(REN)expression. | Kun Chen Dong Deng Youliang Huang Xiaoyun Ma Xueli Li Wenting Zhang Zhiyong Li Yang Liu Wei Wang Jianxin Chen HuiHui Zhao | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，3： | 1 |
| 16 | Identification of yeast population dynamics of spontaneous fermentation in Beijing wine region,China显示文摘 | Huihui Sun Huiqin Ma Meiling Hao | | 0，，01： | 1 |
| 17 | Genetic dissection of top three leaf traits in rice using progenies from a japonica × indica cross显示文摘The size of the top three leaves of rice plants is strongly associated with yield; thus, it is important to consider quantitative traits representing leaf size(e.g.,length and width) when breeding novel rice varieties.It is challenging to measure such traits on a large scale in the field, and little is known about the genetic factors that determine the size of the top three leaves. In the present study, a population of recombinant inbred lines(RILs) and reciprocal single chromosomal segment substitution lines(SSSLs) derived from the progeny of a japonica Asominori ? indica IR24 cross were grown under four diverse environmental conditions. Six morphological traits associated with leaf size were measured,namely length and width of the flag, second and third leaves. In the RIL population, 49 QTLs were identified that clustered in 30 genomic region. Twenty-three of these QTLs were confirmed in the SSSL population. A comparison with previously reported genes/QTLs revealed eight novel genomic regions that contained uncharacterized ORFs associated with leaf size. The QTLs identified in this study can be used for markerassisted breeding and for fine mapping of novel genetic elements controlling leaf size in rice. | Changbin Yin Huihui Li Zhigang Zhao Zhiquan Wang Shijia Liu Liangming Chen Xi Liu Yunlu Tian Juan Ma Lidong Xu Dashuang Zhang Susong Zhu Danting Li Jianmin Wan Jiankang Wang | 2017 | Journal of Integrative Plant Biology2017，59，12： | 1 |
| 18 | Research on mass transfer of CO2absorption using ammonia solution in spray tower显示文摘 | Ma Shuangchen Zang Bin Song Huihui | 2013 | International Journal of Heat and Mass Transfer2013，67，： | 1 |
| 19 | Biomass-derived nitrogen self-doped porous activation carbon as an effective bifunctional electrocatalysts显示文摘The strategy of adopting cheap precursors or abundant resources,which can be obtained directly from nature,is a simple and excellent method of introducing accessible research into environmentally friendly development.Moreover,this is also an urgent requirement for the sustainable development of green technology.Herein,we introduce a simplistic and expandable method to prepare metal-free biomassderived nitrogen self-doped porous activation carbon(N-PAC) with large specific surface area(S_(BET)=1300.58 m^(2)/g).Moreover,the manufactural electrocatalysts exhibit prominent oxygen reduction reaction(ORR) performance in all PH values.As compared with the commercial Pt/C catalyst,the N-PAC/800 with a positive onset potential at 10 mA/cm^(2)(0.93 V),half-wave potential(0.87 V),and limiting current(6.34 mA/cm^(2)) bring to light excellent catalytic stability,selectivity,and much-enhanced methanol tolerance.Furthermore,the prepared electrocatalysts possess considerable hydrogen evolution reaction(HER) performance with a less onset potential of 0.218 V(acidic medium) and0.271 V(alkaline medium) respectively,which can show similar catalytic activity across the whole pH range.Such bifunctional electrocatalyst,with excellent electrocatalytic properties,resource-rich,low cost,and environmental-friendly,hold a promising application in energy conversion and reserve. | Yuanqing Sun Yiming Ouyang Jiaqing Luo Huihui Cao Xiang Li Jingwen Ma Jian Liu Yuanhao Wang Lin Lu | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 20 | Kinetic experimental study on desorption of decarbonization solution using ammonia method显示文摘 | Ma Shuangchen Wang Mengxuan Han Tingting Song Huihui Zang Bin Lu Dongli Chen Weizhong | 2013 | Chemical Engineering Journal2013，，： | 1 |
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