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| 1 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 2 | Help, hope and hype: ethical considerations of human microbiome research and applications显示文摘 | Yonghui Ma Hua Chen Canhui Lan Jianlin Ren | 2018 | Protein & Cell2018，9，5： | 6 |
| 3 | Genome-wide identification of Gossypium INDETERMINATE DOMAIN genes and their expression profiles in ovule development and abiotic stress responses显示文摘Background:INDETERMINATE DOMAIN(IDD)transcription factors form one of the largest and most conserved gene families in plant kingdom and play important roles in various processes of plant growth and development,such as flower induction in term of flowering control.Till date,systematic and functional analysis of IDD genes remained infancy in cotton.Results:In this study,we identified total of 162 IDD genes from eight different plant species including 65 IDD genes in Gossypium hirsutum.Phylogenetic analysis divided IDDs genes into seven well distinct groups.The gene structures and conserved motifs of GhIDD genes depicted highly conserved exon-intron and protein motif distribution patterns.Gene duplication analysis revealed that among 142 orthologous gene pairs,54 pairs have been derived by segmental duplication events and four pairs by tandem duplication events.Further,Ka/Ks values of most of orthologous/paralogous gene pairs were less than one suggested the purifying selection pressure during evolution.Spatiotemporal expression pattern by qRT-PCR revealed that most of the investigated GhIDD genes showed higher transcript levels in ovule of seven days post anthesis,and upregulated response under the treatments of multiple abiotic stresses.Conclusions:Evolutionary analysis revealed that IDD gene family was highly conserved in plant during the rapid phase of evolution.Whole genome duplication,segmental as well as tandem duplication significantly contributed to the expansion of IDD gene family in upland cotton.Some distinct genes evolved into special subfamily and indicated potential role in the allotetraploidy Gossypium hisutum evolution and development High transcript levels of GhIDD genes in ovules illustrated their potential roles in seed and fiber development Further,upregulated responses of GhIDD genes under the treatments of various abiotic stresses suggested them as important genetic regulators to improve stress resistance in cotton breeding. | ALI Faiza QANMBER Ghulam LI Yonghui MA Shuya LU Lili YANG Zuoren WANG Zhi LI Fuguang | 2019 | Journal of Cotton Research2019，2，1： | 5 |
| 4 | Activating Flux Design for Laser Weldingof Ferritic Stainless Steel显示文摘The behaviors of YAG laser welding process of ferritic stainless steel with activating fluxes were investigatedin this study. Some conventional oxides, halides and carbonates were applied in laser welding. The resultsshowed that the effect of oxides on the penetration depth was more remarkable. Most activating fluxes improved thepenetration more effectively at low power than that at high power. The uniform design was adopted to arrange theformula of multicomponent activating fluxes, showing that the optimal formula can make the penetration depth up to2.23 times as large as that without flux, including 50% ZrO2, 12.09% CaCO3, 10.43% CaO and 27.48% MgO. Throughthe high-speed photographs of welding process, CaF2 can minimize the plasma volume but slightly improve the penetrationcapability. | Ma Li | 2014 | Transactions of Tianjin University2014，20，6： | 3 |
| 5 | Crystal structure determination of nanolaminated Ti_(5)Al_(2)C_(3) by combined techniques of XRPD,TEM and ab initio calculations显示文摘Crystal structure of Ti_(5)Al_(2)C_(3)was determined by means of X-ray powder diffraction(XRPD),transmission electron microscopy(TEM)and ab initio calculations.In contrast to the already known P63/mmc space group that the MAX phases crystallize,it was demonstrated that the R3_m space group could better satisfy the experimental data.The lattice parameters are a=0.30564 nm,c=4.81846 nm in a hexagonal unit cell. | Hui ZHANG Xiaohui WANG Yonghui MA Luchao SUN Liya ZHENG Yanchun ZHOU | 2012 | Journal of Advanced Ceramics2012，1，4： | 3 |
| 6 | Shifting from homogeneous to heterogeneous surfaces in estimating terrestrial evapotranspiration: Review and perspectives显示文摘Terrestrial evapotranspiration(ET)is a crucial link between Earth’s water cycle and the surface energy budget.Accurate measurement and estimation remain a major challenge in geophysical,biological,and environmental studies.Pioneering work,represented by Dalton and Penman,and the development of theories and experiments on turbulent exchange in the atmospheric boundary layer(ABL),laid the foundation for mainstream methodologies in ET estimation.Since the 1990s,eddy covariance(EC)systems and satellite remote sensing have been widely applied from cold to tropical and from arid to humid regions.They cover water surfaces,wetlands,forests,croplands,grasslands,barelands,and urban areas,offering an exceptional number of reports on diverse ET processes.Surface nocturnal ET,hysteresis between ET and environmental forces,turbulence intermittency,island effects on heterogeneous surfaces,and phase transition between underlying surfaces are examples of reported new phenomena,posing theoretical and practical challenges to mainstream ET methodologies.Additionally,based on non-conventional theories,new methods have emerged,such as maximum entropy production and nonparametric approaches.Furthermore,high-frequency on-site observation and aerospace remote sensing technology in combination form multi-scale observations across plant stomata,leaves,plants,canopies,landscapes,and basins.This promotes an insightful understanding of diverse ET processes and synthesizes the common mechanisms of the processes between and across spatial and temporal scales.All the recent achievements in conception,model,and technology serve as the basis for breaking through the known difficulties in ET estimation.We expect that they will provide a rigorous,reliable scientific basis and experimental support to address theoretical arguments of global significance,such as the water-heat-carbon cycle,and solve practical needs of national importance,including agricultural irrigation and food security,precise management of water resources and eco-environmental protection,and regulation of the urban thermal environment and climate change adaptation. | Yuanbo LIU Guoyu QIU Hongsheng ZHANG Yonghui YANG Yinsheng ZHANG Quan WANG Wenzhi ZHAO Li JIA Xibin JI Yujiu XIONG Chunhua YAN Ning MA Shumin HAN Yifan CUI | 2022 | Science China Earth Sciences2022，65，2： | 2 |
| 7 | Genetic architecture of maize yield traits dissected by QTL mapping and GWAS in maize显示文摘The study of yield traits can reveal the genetic architecture of grain yield for improving maize production.In this study, an association panel comprising 362 inbred lines and a recombinant inbred line population derived from X178 × 9782 were used to identify candidate genes for nine yield traits. High-priority overlap(HPO) genes, which are genes prioritized in a genome-wide association study(GWAS), were investigated using coexpression networks. The GWAS identified 51 environmentally stable SNPs in two environments and 36 pleiotropic SNPs, including three SNPs with both attributes. Seven hotspots containing 41 trait-associated SNPs were identified on six chromosomes by permutation. Pyramiding of superior alleles showed a highly positive effect on all traits, and the phenotypic values of ear diameter and ear weight consistently corresponded with the number of superior alleles in tropical and temperate germplasm. A total of 61 HPO genes were detected after trait-associated SNPs were combined with the coexpression networks. Linkage mapping identified 16 environmentally stable and 16 pleiotropic QTL.Seven SNPs that were located in QTL intervals were assigned as consensus SNPs for the yield traits.Among the candidate genes predicted by our study, some genes were confirmed to function in seed development. The gene Zm00001 d016656 encoding a serine/threonine protein kinase was associated with five different traits across multiple environments. Some genes were uniquely expressed in specific tissues and at certain stages of seed development. These findings will provide genetic information and resources for molecular breeding of maize grain yield. | Xiao Zhang Zhiyong Ren Bowen Luo Haixu Zhong Peng Ma Hongkai Zhang Hongmei Hu Yikai Wang Haiying Zhang Dan Liu Ling Wu Zhi Nie Yonghui Zhu Wenzhu He Suzhi Zhang Shunzong Su Yaou Shen Shibin Gao | 2022 | The Crop Journal2022，10，2： | 2 |
| 8 | Microstructure, mechanical and thermo-physical properties of hot-pressed Al2O3-GdAlO3-ZrO2 ceramics with eutectic composition显示文摘A low cost chemical co-precipitation method was employed to fabricate nanoscale Al_2O_3-GdAlO_3-ZrO_2 powder with eutectic composition. A careful control of reaction conditions was required during the preparation. The synthesized nanopowders exhibited a particle size of 20-200 nm, and were highly dispersive and uniform. The results showed that calcination temperature had an important influence on the phase constituents of the nanopowders. With increasing the calcination temperature, a phase transformation from θ-Al_2O_3 to α-Al_2O_3 and a thermal decomposition from Gd_3 Al_5O_(12)(GdAG) to GdAlO_3 and α-Al_2O_3 occurred in sequence. A calcination temperature of 1300 ℃ was needed for the crystallization of α-Al_2 O_3. These nanosized powders were consolidated via hot pressing to produce a fully densified ceramic composite with eutectic composition. The Al_2O_3-GdAlO_3-ZrO_2 ceramic hot-pressed at 1500 ℃ exhibited a relative density of 99.4%, a flexural strength of 485 MPa and a fracture toughness of 6.5 MPa m^(1/2). The ceramic had a thermal conductivity of 1.9 W m K^(-1) at 1200 ℃ and a thermal expansion coefficient of 9.49 ×10^(-6) K^(-1) at 1100 ℃. | Abdelkhalek Henniche Jiahu Ouyang Yonghui Ma Zhigang Wang Zhanguo Liu Yujin Wang Mehdi Derradji Xinyu Liu | 2017 | Progress in Natural Science:Materials International2017，27，4： | 1 |
| 9 | Seven facts and five initiatives for gut microbiome research显示文摘The gut microbiome has attracted increasing attention over the past 15 years.Along with the fast-growing body of research literature and media reports,the public's opinions on the gut microbiome have begun to appear polarized.Some believe that the gut microbiome is at the core of human health and is related to every single disease.To the opposite,some people question the scientific basis of gut microbiome studies and criticize that many of them are farfetched;there is even a joke spreading in the biomedical research field—'keeping gut microbiome in mind,no mechanism is hard to find'. | Danyi Li Chunhui Gao Faming Zhang Ruifu Yang Canhui Lan Yonghui Ma Jun Wang | 2020 | Protein & Cell2020，11，6： | 1 |
| 10 | The influence of premature ventricular contractions on left ventricular function in asymptomatic children without structural heart disease: an echocardiographic evaluation显示文摘 | Yiping Sun Nico A. Blom Yonghui Yu Peiran Ma Yi Wang Xiuzhen Han Cees A. Swenne Ernst E. van der Wall | 2003 | The International Journal of Cardiac Imaging2003，，4： | 1 |
| 11 | Synthesis of core–shell structured zeolite-A@mesoporous silica composites for butyraldehyde adsorption显示文摘 | Haijun Yu Yingying Lv Kuoyan Ma Changguo Wang Zhaoteng Xue Yujuan Zhao Yonghui Deng Ya Dai Dongyuan Zhao | 2014 | Journal of Colloid And Interface Science2014，，： | 1 |
| 12 | Impact of hepatitis B vaccination among children in Guangdong Province, China显示文摘 | Jianpeng Xiao Jikai Zhang Chenggang Wu Xiaoping Shao Guowen Peng Zhiqiang Peng Wenjun Ma Yonghui Zhang Huizhen Zheng | 2012 | International Journal of Infectious Diseases2012，，9： | 1 |
| 13 | Synthesis and thermal stability of selenium-doped hydroxyapatite with different substitutions显示文摘 | Yonghui LIU Jun MA Shengmin ZHANG | 2015 | Frontiers of Materials Science2015，9，4： | 1 |
| 14 | The influence of premature ventricular contractions on left ventricular function in asymptomatic children without structural heart disease: an echocardiographic evaluation显示文摘 | Yiping Sun Nico A. Blom Yonghui Yu Peiran Ma Yi Wang Xiuzhen Han Cees A. Swenne Ernst E. van der Wall | 2003 | The International Journal of Cardiac Imaging2003，，4： | 1 |
| 15 | Anisotropy of thermal conductivity and mechanical properties in Mg–5Zn–1Mn alloy显示文摘 | Jiawei Yuan Kui Zhang Ting Li Xinggang Li Yongjun Li Minglong Ma Ping Luo Guangqiu Luo Yonghui Hao | 2012 | Materials and Design2012，，： | 1 |
| 16 | Low-temperature and stable CO oxidation of Co_(3)O_(4)/TiO_(2) monolithic catalysts显示文摘Highly efficient Co_(3)O_(4)/TiO_(2) monolithic catalysts with enhanced stability were in-situ grown on Ti mesh for CO oxidation,which could completely oxidize CO at 120℃.The comprehensive catalytic performance is competitive to some noble metal catalysts and conventional Co_(3)O_(4) powder catalysts,which holds great potential toward industrial applications.Meanwhile,the in-situ synthesis strategy of Co_(3)O_(4)/TiO_(2) monolithic catalysts on flexible mesh substrate in this work can be extended to the development of a variety of oxide-based monolithic catalysts towards diverse catalysis applications. | Xinyue Tang Junchao Wang Yonghui Ma Jing Li Xinglai Zhang Baodan Liu | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 17 | Observations of TEC Depletion,Periodic Structure of TEC,ROTI and Scintillation Associated with ESF Irregularities over South China显示文摘The observations of Global Positioning System(GPS) scintillation,Total Electron Content(TEC)depletion,the periodic structure of TEC and Rate of TEC Index(ROTI) over south China were presented.Data were collected from GPS observations at stations of Shenzhen and Guangzhou from 2011 to 2012.This study reported that the ratio of simultaneous occurrences of TEC depletions with strong scintillations was higher than that of TEC depletions with weak scintillations in vernal and autumnal equinoxes of 2011 over South China.The number of the periodic structures of TEC with depletion contained was greater than that with no depletion contained corresponding to strong scintillations.The structure of the slab of plasma irregularities could be responsible for the simultaneous occurrences of TEC depletion with strong scintillations and ROTI.Before and during the occurrences of strong scintillation,there was Large-Scale Wave Structure(LSWS) which provided the seed ionization perturbation to trigger ESF irregularities and contributed to the periodic structure of TEC. | DENG Kun MA Yonghui LIU Minbo GUO Zhixiong WANG Shu | 2020 | 空间科学学报2020，40，3： | 1 |
| 18 | Ambient Temperature and Years of Life Lost:A National Study in China显示文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics. | Tao Liu Chunliang Zhou Haoming Zhang Biao Huang Yanjun Xu Lifeng Lin Lijun Wang Ruying Hu Zhulin Hou Yize Xiao Junhua Li Xiaojun Xu Donghui Jin Mingfang Qin Qinglong Zhao Weiwei Gong Peng Yin Yiqing Xu Jianxiong Hu Jianpeng Xiao Weilin Zeng Xing Li Siqi Chen Lingchuan Guo Zuhua Rong Yonghui Zhang Cunrui Huang Yaodong Du Yuming Guo Shannon Rutherford Min Yu Maigeng Zhou Wenjun Ma | 2021 | The Innovation2021，2，1： | 1 |
| 19 | Cross validation of hygrothermal properties of historical Chinese blue bricks with isothermal sorption experiments显示文摘The historical,cultural,and social value of heritage buildings mandates special protection of these structures.Blue brick is one kind of the main construction materials of heritage buildings,which is porous material and easily subject to deterioration due to environmental factors such as humidity.Therefore,determining the dynamic moisture content rule of materials under fluctuant ambient humidity is necessary for preventative conservation.This study measured the equilibrium moisture content of eight types of Chinese blue bricks under isothermal conditions with varying humidity levels.The results show that when ambient humidity increased from 10%to 90%,the moisture sorption of historical Chinese blue bricks tripled,which is 3 times greater than that of modern Chinese blue bricks and 10(at low humidity)to 20 times(at high humidity)greater than that of clay bricks in the international handbook.The results contribute to the improvement of the international building material database and research related to hygrothermal performance of heritage buildings in East Asia.©2021 Higher Education Press Limited Company.Publishing services by Elsevier B.V.on behalf of KeAi Communications Co.Ltd.This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dhbp60qfxp5c6k6x69.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). | Yonghui Li Yan Ma Huarong Xie Jiaomin Li Xinjian Li | 2021 | Frontiers of Architectural Research2021，10，1： | 0 |
| 20 | Detecting benign uterine tumors by autofuorescence lifetime imaging microscopy through adjacent healthy cervical tissues显示文摘The endogenous fluorophores such as reduced nicotinarmide adenine dinucleotide(phosphate)(NAD(P)H)and favin adenine dinucleotide(FAD)in cells and tissues can be imaged by fuo-rescence lifetime imaging microscopy(FLIM)to show the tisute morphology features,as well as the biomolecular changes in microenvironment.The two important coenzymes in cellular metabolism,NAD(P)H and FAD,can be used to monitor the cellular metabolic status.This work proposed a novel method to study the uterine metabolism at the adjacent site of healthy cervix.It was found that the benign uterine tumors such as leiomyomas and adenomyosis with abnormal cell growth can be detected by measuring the fluorescence lifetime of NAD(P)H and FAD in adjacent healthy cervical tisues.This method opened a novel strategy for alicted women to undergo the cervical biopsies instead of hysterectomies for detecting tumors,which can preserve the fertility of patients.The FLIM studying on NAD(P)H and FAD indicated the correlation between metabolism and some diseases,including diabetes,hyperthyroidism and obesity.It was also suggested that the metabolic level might be quite different for a patient with a malignant tumnor history. | Maojia Huang Zixiao Zhang Xinyi Wang Yonghui Xie Yiyan Fei Jiong Ma Jing Wang Li Chen Lan Mi Yulan Wang | 2019 | Journal of Innovative Optical Health Sciences2019，，5： | 0 |
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