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| 1 | Helicobacter pylori-related chronic gastritis as a risk factor for colonic neoplasms显示文摘To summarize the current views and insights on associations between Helicobacter pylori(H. pylori)-related chronic gastritis and colorectal neoplasm, we reviewed recent studies to clarify whether H. pylori infection/H. pylori-related chronic gastritis is associated with an elevated risk of colorectal neoplasm. Recent studies based on large databases with careful control for confounding variables have clearly demonstrated an increased risk of colorectal neoplasm associated with H. pylori infection. The correlation between H. pylori-related chronic atrophic gastritis(CAG) and colorectal neoplasm has only been examined in a limited number of studies. A recent large study using a national histopathological database, and our study based on the stage of H. pylori-related chronic gastritis as determined by serum levels of H. pylori antibody titer and pepsinogen, indicatedthat H. pylori-related CAG confers an increased risk of colorectal neoplasm, and more extensive atrophic gastritis will probably be associated with even higher risk of neoplasm. In addition, our study suggested that the activity of H. pylori-related chronic gastritis is correlated with colorectal neoplasm risk. H. pylori-related chronic gastritis could be involved in an increased risk of colorectal neoplasm that appears to be enhanced by the progression of gastric atrophy and the presence of active inflammation. | Izumi Inoue Jun Kato Hideyuki Tamai Mikitaka Iguchi Takao Maekita Noriko Yoshimura Masao Ichinose | 2014 | World Journal of Gastroenterology2014，20，6： | 25 |
| 2 | Novel risk markers for gastric cancer screening: Present status and future prospects显示文摘Initial identification of populations at high risk of gastric cancer (GC) is important for endoscopic screening of GC. As serum pepsinogen (PG) test-positive subjects with progression of chronic atrophic gastritis (CAG) show a high likelihood of future cancer development, this population warrants careful follow-up observation as a high-risk GC group. By combining the PG test with Helicobacter pylori (HP) antibody titers, the HP-related chronic gastritis stage can be classified, thus identifying not only a GC high-risk group but also a low-risk group. Among PG test-negative patients without CAG, those with high serum PG Ⅱ levels and HP antibody titers are thought to have severe gastric mucosal inflammation and the risk of diffuse-type GC is also high. Meanwhile, in gastric mucosae obtained by endoscopic biopsy, HP infection induces aberrant DNA methylation in CpG islands in multiple gene regions and the extent of methylation clearly correlates with GC risk. By quantifying aberrant DNA methylation in suitable gene markers, we can determine the extent of the epigenetic field for cancerization. These novel concepts and risk markers will have many clinical applications in gastrointestinal endoscopy, including more efficient endoscopic GC screening and a strategic approach to metachronous multiple GCs after endoscopic treatment. | Shotaro Enomoto Takao Maekita Hiroshi Ohata Kimihiko Yanaoka Masashi Oka Masao Ichinose | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，12： | 10 |
| 3 | Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori -related gastritis显示文摘 | Takeichi Yoshida Jun Kato Takao Maekita Satoshi Yamashita Shotaro Enomoto Takayuki Ando Tohru Niwa Hisanobu Deguchi Kazuki Ueda Izumi Inoue Mikitaka Iguchi Hideyuki Tamai Toshikazu Ushijima Masao Ichinose | 2013 | Gastric Cancer2013，，4： | 3 |
| 4 | A case of chronic pancreatitis in which endoscopic ultrasonography was effective in the diagnosis of a pseudoaneurysm显示文摘Endoscopic ultrasonography (EUS) was performed on a patient being treated for chronic pancreatitis because a submucosal tumor was observed in the stomach during gastrointestinal endoscopy. As internal pulsa- tile blood flow on Doppler was present, the diagnosis of an aneurysm was made. The pseudoaneurysm of the left gastric artery was embolized with histoacryl and lipiodol and the splenic artery was embolized with coils at the location of the pseudoaneurysm to prevent hemorrhage. Follow up EUS confirmed the cessation of blood flow from the pseudoaneurysm. Clinicians encountering a gastric submucosal tumor-like protrusion in a patient with chronic pancreatitis should use EUS to investigate the possibility of a pseudoaneurysm, which must be treated as quickly as possible once identified. | Kazuhiro Fukatsu Kazuki Ueda Hiroki Maeda Yasunobu Yamashita Masahiro Itonaga Yoshiyuki Mori Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Izumi Inoue Takao Maekita Mikitaka Iguchi Hideyuki Tamai Jun Kato Masao Ichinose | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 2 |
| 5 | High levels of aberrantDNA methylation in Helicobacter p^/ori-infected gastric mucosaeand its possible association with gastric cancer risk显示文摘 | Maekita T Nakazawa K Mihara M | 2006 | Clin CancerRes2006，12，3： | 1 |
| 6 | Identification of gastric cancer risk markers that are informative in individuals with past H . pylori infection显示文摘 | Sohachi Nanjo Kiyoshi Asada Satoshi Yamashita Takeshi Nakajima Kazuyuki Nakazawa Takao Maekita Masao Ichinose Toshiro Sugiyama Toshikazu Ushijima | 2012 | Gastric Cancer2012，，4： | 1 |
| 7 | Severe complications in hemorrhagic stomach ulcer in the elderly and the therapeutic measures显示文摘 | Ueda K Enomoto S Maekita T | 2010 | Nippon Rinsho2010，68，11： | 1 |
| 8 | DNA methylation as a marker for the past and future显示文摘 | Ushijima T Nakajima T Maekita T | 2006 | J Gastroenterol2006，41，5： | 1 |
| 9 | Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori?associatedchronic atrophic gastritis: A follow?up study of patients with endoscopicallyresected colorectal neoplasia显示文摘 | Izumi Inoue Jun Kato Noriko Yoshimura Yoshimasa Maeda Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Takao Maekita Kazuki Ueda Mikitaka Iguchi Hideyuki Tamai Mitsuhiro Fujishiro Nobutake Yamamichi Tatsuya Takeshita Masao Ichinose | 2013 | Molecular and Clinical Oncology2013，，1： | 1 |
| 10 | Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers显示文摘 | Takada T Yagi Y Maekita T | 2004 | Cancer science2004，95，9： | 1 |
| 11 | DNA methylation as a marker for the past and future显示文摘 | Ushijima T Nakajima T Maekita T | 2006 | J Gastroenterol2006，41，： | 1 |
| 12 | Methylation-associatedsilencing of the Wnt antagonist SFRP1 gene in human ovariancarcinomas显示文摘 | ToshioTakada YukikoYagi Takao Maekita | 2004 | Carcinoma Sci2004，95，9： | 1 |
| 13 | High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk显示文摘 | Maekita T Nakazawa K Mihara M | 2006 | Clin Cancer Res2006，12，3： | 1 |
| 14 | High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk显示文摘 | Maekita T Nakazawa K Mihara M | | 0，，03： | 1 |
| 15 | DNA methylation as a marker for the past and future显示文摘 | USHIJIMA T NAKAJIMA T MAEKITA T | | 0，，05： | 1 |
| 16 | Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis显示文摘 | Mika Watanabe Jun Kato Izumi Inoue Noriko Yoshimura Takeichi Yoshida Chizu Mukoubayashi Hisanobu Deguchi Shotaro Enomoto Kazuki Ueda Takao Maekita Mikitaka Iguchi Hideyuki Tamai Hirotoshi Utsunomiya Nobutake Yamamichi Mitsuhiro Fujishiro Masataka Iwane Ta | 2012 | Int J Cancer2012，，11： | 1 |
| 17 | Methylation-associ ated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers显示文摘 | TAKADA T YAGI Y MAEKITA T | 2004 | Cancer Sci2004，95，9： | 1 |
| 18 | DNA methylafion as a marker for the past and future 显示文摘 | USHJIMA T NAKAJIMA T MAEKITA T | 2006 | J Gastroenterol2006，41，： | 1 |
| 19 | Methylation-associated silencing of the Wnt antagonist SFRP 1 gene in human ovarian cancers 显示文摘 | Takada T Yagi Y Maekita T | 2004 | Cancer Sci2004，95，9： | 1 |
| 20 | DNA methylation as a marker for the past and future显示文摘 | Ushijima T Nakajima T Maekita T | 2006 | J GastroenteroL2006，41，5： | 1 |
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