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| 1 | Changes in growth factor and cytokine expression in biliary obstructed rat liver and their relationship with delayed liver regeneration after partial hepatectomy显示文摘瞄准:在部分肝切除术以后在肝新生上学习妨碍的黄疸的效果。方法: Hepatocyte 生长因素( HGF ),它的受体, 遇见c ,脉管的内皮生长因素( VEGF )和转变生长在肝织物和孤立的肝细胞的 factor-beta1 ( TGF-beta1 ) mRNA 表示被量的反向抄写的聚合酶链反应( RT-PCR )用 LightCycler 在胆汁的阻塞( BO )以后调查。为 desmin 和 alpha 光滑的肌肉肌动朊(alpha-SMA ) 染色的 Immunohistochemical 也被学习。标记的原子抗原(PCNA ) 索引的再生肝重量和增殖的房间,和生长因素表示然后与伴随物在 70% 肝切除术以后被评估在 BO 老鼠或假冒操作老鼠的内部胆汁的排水。结果:肝的 TGF-beta1 mRNA 层次显著地在 BO 以后增加了 14 天,并且进一步与胆汁郁积的持续时间增加了。同时, HGF 和 VEGF 趋于增加,但是不是重要的。在房间孤立, TGF-beta1 mRNA 主要在肝的星形的房间(HSC ) 被发现部分。Immunohistochemical 研究揭示了 HSC (desmin 积极的房间) 的一个增加的数字并且在 BO 以后在门区域激活 HSC (alpha-SMA-positive 房间) 。在一个肝切除术模型,肝新生在 BO 老鼠被推迟,作为与假冒操作老鼠相比。在肝切除术,和更早的 HGF mRNA 山峰沉醉于 BO 老鼠以后, TGF-beta1 mRNA 是显著地起来调整的直到 48 h。结论:BO 导致 HSC 增长和激活,导致 TGF-beta1 mRNA 的起来规定和在肝的 HGF mRNA 的抑制。这些改变的表示模式可以强烈与妨碍的黄疸在肝切除术以后涉及推迟的肝新生。 | Hironobu Makino Hiroaki Shimizu Hiroshi Ito Fumio Kimura Satoshi Ambiru Akira Togawa Masayuki Ohtsuka Hiroyuki Yoshidome Atsushi Kato Hideyuki Yoshitomi Shigeaki Sawada Masaru Miyazaki | 2006 | World Journal of Gastroenterology2006，12，13： | 32 |
| 2 | Effects of Cu,Fe and Co addition on the glass-forming ability and mechanical properties of Zr-Al-Ni bulk metallic glasses显示文摘The thermal stability,glass-forming ability(GFA) and mechanical properties of Zr60Al15Ni25xTMx(TM = Cu,Fe and Co,x = 0-10) bulk metallic glasses(BMGs) were systematically investigated.Additional 5-10 at.% Cu greatly enhances the thermal stability and GFA of the base alloy.Zr60Al15Ni15Cu10 BMG exhibits the largest supercooled liquid region of 104 K and critical diameter of 18 mm.However,addition of 5-10 at.% Fe or Co decrease the thermal stability and GFA.In addition,the plasticity of the BMG can be improved by adding of Cu,while the strength is decreased slightly.Zr60Al15Ni20Cu5 BMG has the largest plastic strain of 5.5% with a yield stress of 1755 MPa and Young's modulus of 83 GPa.Addition of Co brings an increase of strength but a lower of plasticity,and additional Fe reduces the strength and plasticity simultaneously. | LI YanHui ZHANG Wei DONG Chuang AKIHIRO Makino | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 19 |
| 3 | Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma with a false-positive result on fluorodeoxyglucose PET显示文摘Recently, several reports have demonstrated that fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is useful in differentiating between benign and malignant lesions in the gallbladder. However, there is a limitation in the ability of FDG-PET to differentiate between inflammatory and malignant lesions. We herein present a case of xanthogranulomatous cholecystitis misdiagnosed as gallbladder carcinoma by ultrasonography and computed tomography. FDG-PET also showed increased activity. In this case, FDG-PET findings resulted in a false-positive for the diagnosis of gallbladder carcinoma.Recently, several reports have demonstrated that fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is useful in differentiating between benign and malignant lesions in the gallbladder. However, there is a limitation in the ability of FDG-PET to differentiate between inflammatory and malignant lesions. We herein present a case of xanthogranulomatous cholecystitis misdiagnosed as gallbladder carcinoma by ultrasonography and computed tomography. FDG-PET also showed increased activity. In this case, FDG-PET findings resulted in a false-positive for the diagnosis of gallbladder carcinoma. | Isamu Makino Takahiro Yamaguchi Nariatsu Sato Toshiaki Yasui Ichiro Kita | 2009 | World Journal of Gastroenterology2009，15，29： | 11 |
| 4 | Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations显示文摘瞄准:在胃的区分类型的肿瘤澄清在肿瘤区别显型和肿瘤侵略或基因改变之间的关系。方法:我们检验了肿瘤区别在 48 个胃的腺瘤和 171 区分类型的癌的显型,在 APC 和 p53 的变化的存在,和微卫星不稳定性(MSI ) 地位。肿瘤区别显型被检验人的表示决定胃粘蛋白(HGM ) , MUC6, MUC2 和 CD10。肿瘤然后被分类进胃 --(G-) ,胃、肠混合 --( 官方补给 --) ,或肠 --( 我 --) 显型,根据上述标记的免疫确实。在 APC 和 p53 和 MSI 地位的变化的存在也在所有肿瘤被调查。结果:胃的腺瘤显著地与 CD10 表示,我显型肿瘤和 APC 变化的存在被联系,与癌相比(66.7% 对 25.1% , P <
0.0001;56.3% 对 14.6% , P <
0.0001;39.6% 对 14.0% , P <
0.0001,分别地) 并且相反地与 HGM 和 MUC6 和 p53 变化的存在的表情联系了(10.4% 对 62.6% , P <
0.0001;39.6% 对 64.3% , P = 0.003;2.0% 对 26.3% , P = 0.001,分别地) 。APC 变化的频率在比在 HGM 积极的肿瘤, MUC6 积极的肿瘤, CD10 否定的肿瘤和 G 显型肿瘤的 HGM 否定的肿瘤, MUC6 否定的肿瘤, CD10 积极的肿瘤和我显型肿瘤是显著地更高的(32.7% 对 7.1% , P <
0.0001;27.8% 对 14.0% , P = 0.0182;37.3% 对 10.4% , P <
0.0001;并且 38.5% 对 9.5% , P = 0.0017,分别地) 。MSI 的频率在比在 MUC6 否定的肿瘤, CD10 积极的肿瘤和我显型肿瘤的 MUC6 积极的肿瘤, CD10 否定的肿瘤和 G 显型肿瘤是显著地更高的(24.8% 对 6.7% , P = 0.0009;22.2% 对 8.0% , P = 0.0143;并且 28.6% 对 9.6% , P = 0.0353,分别地) 。结论:肿瘤区别显型是仔细与在胃的区分类型的肿瘤的肿瘤侵略和基因改变有关。 | Kimiyasu Yamazaki Yusuke Tajima Reiko Makino Nobukazu Nishino Shigeo Aoki Masanori Kato Masaaki Sakamoto Koji Morohara Tsutomu Kaetsu Mitsuo Kusano | 2006 | World Journal of Gastroenterology2006，12，24： | 9 |
| 5 | 基于紫外-可见-近红外光谱技术的蔬菜细胞ATP含量无损检测研究显示文摘农产品细胞内的ATP含量水平直接反映细胞的活性,在产后贮藏过程中可作为农产品新鲜度和品质的一种评价指标。采用紫外-可见-近红外分光光度计UV-3600获取菠菜叶片样本的光谱数据,并采用常规物理化学方法和萤火虫荧光素酶生物发光技术制备和测定细胞原生质体悬浮液及其细胞原生质体的ATP含量。利用person相关分析确定关键特征波长,并建立基于298nm紫外光和730nm近红外光两个特征波长菠菜叶片光谱反射率的细胞原生质体ATP含量的预测模型。结果分析表明,298nm紫外光和730nm近红外光两个特征波长具有预测细胞原生质体ATP含量的潜力(R2=0.802 9和0.901)。提出的基于光谱技术的蔬菜细胞ATP含量检测方法为准确、快速、无损的蔬菜新鲜度评价提供一种新的技术途径。 | 叶旭君 Seiichi Oshita Yoshio Makino 钱琼秋 何勇 | 2012 | 光谱学与光谱分析2012，32，4： | 8 |
| 6 | 弱粘煤和不粘煤的快速热解及其团聚研究显示文摘对弱粘煤和不粘煤的快速加氢热解及在快速热解情况下发生的团聚现象进行了研究.研究发现,在高温加压快速加热条件下,氢气气氛中,煤的热失重率比煤的挥发分高,而在氮气气氛中,煤的热失重率低于煤的挥发分.同时,在高温加压快速加热条件下,在氮气气氛中的热失重率远低于氢气气氛中的热失重率.大多数弱粘煤和不粘煤,在高温下快速热解,无论在氢气气氛还是在氮气气氛中都发生团聚现象,即煤热解残炭团聚为圆柱状,且有一定的强度.有些煤(如Strongman煤和兴隆煤)在氢气气氛中残炭强度大于氮气气氛中的残炭强度. | 李登新 Makino M 吕俊复 岳光溪 张建胜 | 2003 | 燃烧科学与技术2003，9，5： | 5 |
| 7 | Comparison of percutaneous radiofrequency ablation and CyberKnife®for initial solitary hepatocellular carcinoma:A pilot study显示文摘AIM To compare therapeutic outcomes and adverseevents in initial solitary hepatocellular carcinoma(HCC) treated with radiofrequency ablation (RFA) andCyberKnife?.METHODS: Seventy three consecutive patients withinitial solitary HCC treated with RFA (38 patients;RFA group) and CyberKnife (35 patients; CK group)were enrolled in this study. Background factorswere compared between the two groups. Local andintrahepatic distant recurrence control, and cumulativesurvival rates were compared between the two groups.These were determined using the Kaplan-Meier method,and the significance of differences was analyzed by log-rank test. The presence of more grade 3 on CTCAE ver.4.0 early and late adverse events was investigated.RESULTS: In background factors, age was significantlyhigher (P = 0.005) and the tumor diameter wassignificantly larger (P = 0.001) in the CK group. The1-year local recurrence control rates were 97.4%and 97.1% in the RFA and CK groups, respectively (P= 0.71); the 1-year intrahepatic distant recurrencecontrol rates were 85.6% and 86.1%, respectively (P= 0.91); and the 1-year cumulative survival rates were100% and 95.2%, respectively (P = 0.075), showingno significant difference in any rate between the twogroups. There were no late adverse event in the RFAgroup, but 11.4% in the CK group had late adverseevents. In the CK group, the Child-Pugh score at 12 moafter treatment was significantly higher than that in theRFA group (P = 0.003) and significantly higher than thescore before treatment (P = 0.034).CONCLUSION: The occurrence of adverse events is aconcern, but CyberKnife treatment is likely to becomean important option for local treatment of early HCC. | Kazue Shiozawa Manabu Watanabe Takashi Ikehara Yasushi Matsukiyo Michio Kogame Yui Kishimoto Yusuke Okubo Hiroyuki Makino Nobuhiro Tsukamoto Yoshinori Igarashi Yasukiyo Sumino | 2015 | World Journal of Gastroenterology2015，21，48： | 4 |
| 8 | 在ELT书面作文中学习者的自我纠错显示文摘引言错误分析是二语习得研究领域的主题之一。学习者的错误被看成是学习过程中自然的、必不可少的一部分。它们也被视为是不可避免的,因为学习者需要鼓励钻研目标语。那么,在课堂学习中,教师在处理错误方面起什么作用?怎样纠错(Error Correction)才最有效?在英语书面作文中,教师给予何种提示能使学生纠正自己的错误最有效?自我纠错(Self-correction)有什么作用和怎样鼓励学习者纠正自己的错误?Chaudron(1975) | Taka-Yoshi Makino 李永才 李进 许忠梅 | 1995 | 外语教学理论与实践1995，，2： | 4 |
| 9 | Risk factors for lymph node metastasis in histologically poorly differentiated type early gastric cancer显示文摘 | C. Kunisaki M. Takahashi Y. Nagahori T. Fukushima H. Makino R. Takagawa T. Kosaka H. Ono H. Akiyama Y. Moriwaki A. Nakano | 2009 | Endoscopy2009，，06： | 4 |
| 10 | Clinical and radiological feature of lymphoepithelial cyst of the pancreas显示文摘A lymphoepithelial cyst(LEC)of the pancreas is a rare benign lesion.Because patients with LEC of the pancreas have a good prognosis,it is important that these lesions are accurately differentiated from other more aggressive pancreatic neoplasms for an appropriate treatment strategy.Previous studies have reported that a definitive diagnosis of LEC often cannot be obtained based solely on the findings of preoperative imaging(e.g.,Computed tomography or Magnetic resonance imaging).In this study,we reviewed four cases of pancreatic LECs to investigate the feature of LECs.We reviewed these cases with regard to symptoms,imaging findings,surgical procedures,and other clinical factors.We found that LEC was associated with unique characteristics on imaging findings.A preoperative diagnosisof LEC may be possible by comprehensively evaluating its clinical and imaging findings. | Hirofumi Terakawa Isamu Makino Hisatoshi Nakagawara Tomoharu Miyashita Hidehiro Tajima Hirohisa Kitagawa Takashi Fujimura Dai Inoue Kazuto Kozaka Toshifumi Gabata Tetsuo Ohta | 2014 | World Journal of Gastroenterology2014，20，45： | 4 |
| 11 | Isolated intrapancreatic Ig G4-related sclerosing cholangitis显示文摘Immunoglobulin G4-related sclerosing cholangitis(Ig G4-SC) is frequently associated with type 1 autoimmune pancreatitis(AIP). Association with AIP can be utilized in the diagnosis of Ig G4-SC. However, some cases of Ig G4-SC are isolated from AIP, which complicates the diagnosis. Most of the reported cases of isolated Ig G4-SC displayed hilar biliary strictures, whereas isolated Ig G4-SC with intrapancreatic biliary stricture is very rare. Recently, we have encountered 5 isolated intrapancreatic Ig G4-SC cases that were not associated with AIP, three of which were pathologically investigated after surgical operation. They all were males with a mean age of 74.2 years. The pancreas was not enlarged in any of these cases. No irregular narrowing of the main pancreatic duct was found. Bile duct wall thickening in lesions without luminal stenosis was detected by abdominal computed tomography in all five cases, by endoscopic ultrasonography in two out of four cases and by intraductal ultrasonography in all three cases. In three cases, serum Ig G4 levels were within the normal limits. The mean serum Ig G4 level measured before surgery was 202.1 mg/d L(4 cases). Isolated intrapancreatic Ig G4-SC is difficult to diagnose, especially if the Ig G4 level remains normal. Thus, this type of Ig G4-SC should be suspected in addition to cholangiocarcinoma and pancreatic cancer if stenosis of intrapancreatic bile duct is present. | Takahiro Nakazawa Yushi Ikeda Yoshiaki Kawaguchi Hirohisa Kitagawa Hiroki Takada Yutaka Takeda Isamu Makino Naohiko Makino Itaru Naitoh Atsushi Tanaka | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 12 | Distribution and deposition of respirable PLGA microspheres in lung alveoli显示文摘 | Keiji Hirota Tadafumi Kawamoto Takehisa Nakajima Kimiko Makino Hiroshi Terada | 2013 | Colloids and Surfaces B: Biointerfaces2013，，： | 3 |
| 13 | Remediation of heavy metal(loid)s contaminated soils – To mobilize or to immobilize?显示文摘 | Nanthi Bolan Anitha Kunhikrishnan Ramya Thangarajan Jurate Kumpiene Jinhee Park Tomoyuki Makino Mary Beth Kirkham Kirk Scheckel | 2013 | Journal of Hazardous Materials2013，，： | 3 |
| 14 | A new numerical simulation model for high pressure squeezing moulding显示文摘High pressure squeeze is the most popular moulding process applied in modern moulding machines.Because of the unique characters of moulding sand and nonlinearity of squeezing process,the mechanical model is of key importance for computer simulation.Drucker-Prager/Cap is a typical soil mechanical theory model and it was used to simulate the squeezing process in this study,while ABAQUS software is used to simulate dynamic stress/strain evolution during the process.The simulation agrees well with the experimental results.We conclude that Drucker-Prager/Cap is an appropriate model for the squeezing compaction of moulding sand,and that the associated nonlinearity can be solved well with ABAQUS software. | Li Hua Wu Junjiao Huang Tianyou Makino Hiroyasu | 2011 | China Foundry2011，8，1： | 3 |
| 15 | Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development显示文摘AIM: To investigate factors that accurately predict hepatocellular carcinoma(HCC) development after antiviral therapy in chronic hepatitis C(CHC) patients. METHODS: CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein(AFP) to predict HCC development after interferon(IFN) therapy. RESULTS: Of 1255 patients enrolled, 665 developed sustained virological response(SVR) during mean follow-up period of 5.4 years. HCC was occurred in 89 patients, and 20 SVR patients were included. Proportional hazard models showed that HCC occurred in SVR patients showing AFP ≥ 5 ng/m L before therapy and in non-SVR patients showing AFP ≥ 5 ng/m L before and 1 year after therapy besides older age, and low platelet counts. SVR patients showing AFP ≥ 5 ng/m L before therapy and no decrease in AFP to < 5 ng/m L 1 year after therapy had significantly higher HCC incidence than non-SVR patients showing AFP ≥ 5 ng/m L before therapy and decreased AFP(P = 0.043). AFP ≥ 5 ng/m L before therapy was significantly associated with low platelet counts and high values of alanine aminotransferase(ALT) in stepwise logistic regression analysis. After age, gender, platelet count, and ALT was matched by propensity score, significantly lower HCC incidence was shown in SVR patients showing AFP < 5 ng/m L before therapy than in those showing AFP ≥ 5 ng/m L.CONCLUSION: The criteria of AFP < 5 ng/m L before and 1 year after IFN therapy is a benefical predictor for HCC development in CHC patients. | Yasuto Takeuchi Fusao Ikeda Toshiya Osawa Yasuyuki Araki Kouichi Takaguchi Youichi Morimoto Noriaki Hashimoto Kousaku Sakaguchi Tatsuro Sakata Masaharu Ando Yasuhiro Makino Shuji Matsumura Hiroki Takayama Hiroyuki Seki Shintarou Nanba Yuki Moritou Tetsuya Yasunaka Hideki Ohnishi Akinobu Takaki Kazuhiro Nouso Yoshiaki Iwasaki Kazuhide Yamamoto | 2015 | World Journal of Hepatology2015，7，19： | 3 |
| 16 | Feasibility and Safety of Single-Incision Laparoscopic Colectomy: A Systematic Review显示文摘 | Tomoki Makino Jeffrey W. Milsom Sang W. Lee | 2012 | Annals of Surgery2012，，4： | 2 |
| 17 | A case report of anaplastic carcinoma of the pancreas with remarkable intraductal tumor growth into the main pancreatic duct显示文摘We herein report a case of anaplastic carcinoma of the pancreas with remarkable intraductal tumor growth into the main pancreatic duct.A 76-year-old male was referred to our hospital for treatment of a pancreatic tumor.Preoperative examinations revealed a poorly defined tumor in the main pancreatic duct in the body of the pancreas,accompanied with severe dilatation of the main pancreatic duct,which was diagnosed as an intraductal papillary-mucinous neoplasm.We performed distal pancreatectomy and splenectomy.The pathological examination revealed that the tumor consisted of a mixture of anaplastic carcinoma(giant cell type)and adenocarcinoma in the pancreas.There was a papillary projecting tumor composed of anaplastic carcinoma in the dilated main pancreatic duct.The patient is now receiving chemotherapy because liver metastasis was detected 12 mo after surgery.In this case,we could observe a remarkable intraductal tumor growth into the main pancreatic duct.We also discuss the pathogenesis and characteristics of this rare tumor with specific tumor growth. | Mitsuyoshi Okazaki Isamu Makino Hirohisa Kitagawa Shinichi Nakanuma Hironori Hayashi Hisatoshi Nakagawara Tomoharu Miyashita Hidehiro Tajima Hiroyuki Takamura Tetsuo Ohta | 2014 | World Journal of Gastroenterology2014，20，3： | 2 |
| 18 | Hypoxia-inducible factor 1α regulates branching morphogenesis during kidney development显示文摘 | Kenji Tsuji Shinji Kitamura Hirofumi Makino | 2014 | Biochemical and Biophysical Research Communications2014，，1： | 2 |
| 19 | Intraductal papillary neoplasm of the bile duct accompanying biliary mixed adenoneuroendocrine carcinoma显示文摘We present the first case of an intraductal papillary neoplasm of the bile duct(IPNB) accompanying a mixed adenoneuroendocrine carcinoma(MANEC).A 74-yearold woman presented with fever of unknown cause.Laboratory data revealed jaundice and liver injury.Contrast-enhanced computed tomography revealed a 20 mm polypoid tumor in the dilated distal bile duct,which exhibited early enhancement and papillary growth.Upper gastrointestinal endoscopy revealed mucus production from the papilla of Vater,characterized by its protruding and dilated orifice.Endoscopic ultrasonography visualized the polypoid tumor in the distal bile duct,but no invasive region was suggested by diagnostic imaging.Therefore,the initial diagnosis was IPNB.After endoscopic nasobiliary drainage,a pylorus-preserving pancreaticoduodenectomy was performed.Pathological examination of the resected bile duct revealed papillary proliferation of biliary-type cells with nuclear atypia,indicating pancreaticobiliary-type IPNB.In addition,solid portions comprised of tumor cells with characteristic salt-and-pepper nuclei were evident.Immunohistochemistry revealed expression of the neuroendocrine marker synaptophysin in this solid component,diagnosing it as a neuroendocrine tumor(NET).Furthermore,the MIB-1 proliferation index of NET was higher than that of IPNB,and microinvasion of the NET component was found,indicating neuroendocrine carcinoma(NET G3).This unique case of MANEC,comprising IPNB and NET,provides insight into the pathogenesis of biliary NET. | Ichiro Onishi Hirohisa Kitagawa Kenichi Harada Syogo Maruzen Seisyo Sakai Isamu Makino Hironori Hayashi Hisatoshi Nakagawara Hidehiro Tajima Hiroyuki Takamura Takashi Tani Masato Kayahara Hiroko Ikeda Tetsuo Ohta Yasuni Nakanuma | 2013 | World Journal of Gastroenterology2013，19，20： | 2 |
| 20 | Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury显示文摘 | Kentaro Hayashida Motoaki Sano Ikuroh Ohsawa Ken Shinmura Kayoko Tamaki Kensuke Kimura Jin Endo Takaharu Katayama Akio Kawamura Shun Kohsaka Shinji Makino Shigeo Ohta Satoshi Ogawa Keiichi Fukuda | 2008 | Biochemical and Biophysical Research Communications2008，，1： | 2 |
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