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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 3 | Core stability and its relationship to lower extremity function and injury显示文摘 | WILLSON J D DOUGHERTY C P MARY L I | 2005 | journal of the American Academy of Orthopaedic Surgeons2005，13，5： | 1 |
| 4 | Associations between Recent Exposure to Ambient Fine Particulate Matter and Blood Pressure in the Multi-Ethnic Study of Atherosclerosis (MESA)显示文摘 | Auchincloss Amy H Roux Ana V Diez Dvonch J Timothy Brown Patrick L Barr R Graham Daviglus Martha L Goff David C Kaufman Joel D O’Neill Marie S | 2008 | Environmental Health Perspectives2008，，4： | 1 |
| 5 | New insight into the relationship between molecular effects and the rheological behavior of polymer-thickened lubricants under high pressure显示文摘 | Mary C Philippon D Lafarge L | 2013 | Tribology Letters2013，52，3： | 1 |
| 6 | Molecular circuits shared by placental and cancer cells, and their impli- cations in the proliferative, invasive and migratory capacities of troph- oblasts 显示文摘 | Ferretti C Bruni L Dangles - Marie V Pecking AP Bellet D | 2007 | Hum Reprod Update2007，13，2： | 1 |
| 7 | Fibroblast growth fac- tor 21 regulates energy metabolism by activating the AMPK-SIRTI- PGC-Ict pathway 显示文摘 | MARY D L C JIAPING G QING Y | 2010 | PNAS2010，107，12： | 1 |
| 8 | Increased Platelet Reactivity and Circulating Monocyte-Platelet Aggregates in Patients With Stable Coronary Artery Disease显示文摘 | Mark I Furman Stephen E Benoit Marc R Barnard C.Robert Valeri Marie L Borbone Richard C Becker Herbert B Hechtman Alan D Michelson | 1998 | Journal of the American College of Cardiology1998，，2： | 1 |
| 9 | 显示文摘 | Marie M Z Patricia D L Douglas C C | 2002 | Biotechnology Progress2002，18，4： | 1 |
| 10 | Chromosome 1p and 11q deletions and outcome in neumblastoma显示文摘 | Attiyeh EF London W B Mossé Y P Wang Q Winter C Khazi D McGrady P W Seeger R C Look A T Shirnada H Brodeur G M Cohn S L Matthay K K Maris J M Children's Oncology Group | | 0，，21： | 1 |
| 11 | Pancreatic Resection with Islet Cell Autotransplant for the Treatment of Severe Chronic Pancreatitis/DISCUSSION显示文摘 | Argo Joshua L Contreras Juan L Wesley Mary M Christein John D Borman Karen Vitale Gary C Maxwell Robert | 2008 | The American Surgeon2008，，6： | 1 |
| 12 | Aerobic oxidation of aqueous ethanol using heterogeneous gold catalysts: Efficient routes to acetic acid and ethyl acetate 显示文摘 | Betina J Sofie E C Marie L D T | 2007 | Journal of Catalysis2007，251，2： | 1 |
| 13 | Birth, preweaning and postweaning traits of Angus, Holstein, Simmental and chianina sired calves显示文摘 | Anderson D C O'Mary C C Martin E L | 1978 | J Anim Sci1978，46，： | 1 |
| 14 | Volatile host fruit odors as attractants for the oriental fruit fly (Diptera:Tephritidae)显示文摘 | MARY L C JIAN J D RUSSELL H M | 2000 | Journal of Economic Entomology2000，93，1： | 1 |
| 15 | EU Forum: The CREATE Project : Development of certified reference materials for allergenic products and validation of methods for their quantification 显示文摘 | Van R R Chapman M D Ferreira F Vieths S Bryan D Cromwell O Villalba M Durham S R Becker W M Aalbers M Andr6 C Barber D Bahima A C Custovic A Didierlaurent A Dolman C Dorpema J W Felice G D Eberhardt F Caldas E F Rivas M F Fiebig H Focke M Ft~tisch K Gadermaier G Das R G Mancebo E G Himly M Kinaciyan T Knulst A C Kroon A M Lepp U Marco F M Mari A Moingeon P Monsalve R Neubauer A Notten S Ooievaar-deHeer P Pauli G Pini C Purohit A Quiralte J Rak S Raulf-Heimsoth M Moncin M M S M Simpson B Tsay A Vailes L Wallner M Weber B | 2008 | Allergy2008，63，： | 1 |
| 16 | Increased levels of erucic acid in Brassica carinata by co-suppression and antisense repression of the endogenous FAD2 gene 显示文摘 | Jadhav A Katavic V Mari!lia E F Giblin E M Barton D L Kunaar A Sonntag C Babic V Keller W A Taylor D C | 2005 | Metab Eng2005，7，3： | 1 |
| 17 | Gender-role Orientation as a Determinant of Entrepreneurial Self-efficacy显示文摘 | STEPHEN L M MARY C D | 2008 | Journal of DevelopmentalEntrepreneurship2008，13，1： | 1 |
| 18 | Calpain and cathepsin activities in post mortem fish and meat muscles显示文摘 | Romuald C Chistine D L Marie L-A | 2007 | Food Chemistry2007，101，4： | 1 |
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