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| 1 | In vivo histological diagnosis for gastric cancer using endocytoscopy显示文摘AIM To examine usefulness of virtual biopsy using endocytoscopy by comparing the in vivo endocytoscopic and histopathological images of gastric cancers.METHODS Endocytoscopy was performed in 30 patients with early gastric cancer. Of these, 26 patients showed well differentiated adenocarcinomas, while 4 patients showed poorly differentiated adenocarcinomas(including one signet ring cell carcinoma). Cancerous and non-cancerous areas were observed after double staining with 0.05% crystal violet and 0.1% methylene blue. The endocytoscopic images obtained were evaluated by an expert endoscopist and an expert pathologist without knowledge of patient clinical data, and endocytoscopic and histopathological diagnoses were compared.RESULTS The endocytoscopic images of the cancerous area were assessed as evaluable in 25(83.3%) and 27(90%) patients by endoscopist A and pathologist B, respectively, and those of the non-cancerous area as evaluable in 28(93.3%) and 23(76.7%) patients by the endoscopist and pathologist, respectively. The sensitivity, specificity, and diagnostic accuracy of gastric cancer diagnosis using evaluable endocytoscopic images were 88.0% and 92.9%, and 90.6% by endoscopist A, and 88.9% and 91.3%, and 90.0% by pathologist B, respectively. Evaluation of the diagnostic concordance rate between the endoscopist and the pathologist by inter-observer agreement calculation revealed no significant difference between the two observers. The inter-observer agreement(κ-value) for endocytoscopic diagnosis was 0.745. CONCLUSION Endocytoscopy is useful for the differentiation of cancerous from non-cancerous gastric mucosa, making it a promising tool for virtual biopsy. | Issei Tsurudome Ryoji Miyahara Kohei Funasaka Kazuhiro Furukawa Masanobu Matsushita Takeshi Yamamura Takuya Ishikawa Eizaburo Ohno Masanao Nakamura Hiroki Kawashima Osamu Watanabe Masato Nakaguro Akira Satou Yoshiki Hirooka Hidemi Goto | 2017 | World Journal of Gastroenterology2017，23，37： | 5 |
| 2 | STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation显示文摘 | Hazel Tye Catherine L. Kennedy Meri Najdovska Louise McLeod William McCormack Norman Hughes Anouk Dev William Sievert Chia Huey Ooi Tomo-o Ishikawa Hiroko Oshima Prithi S. Bhathal Andrew E. Parker Masanobu Oshima Patrick Tan Brendan J. Jenkins | 2012 | Cancer Cell2012，，4： | 3 |
| 3 | The carbon content of Japan–US trade显示文摘 | Frank Ackerman Masanobu Ishikawa Mikio Suga | 2007 | Energy Policy2007，，9： | 2 |
| 4 | CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc ? and Thereby Promotes Tumor Growth显示文摘 | Takatsugu Ishimoto Osamu Nagano Toshifumi Yae Mayumi Tamada Takeshi Motohara Hiroko Oshima Masanobu Oshima Tatsuya Ikeda Rika Asaba Hideki Yagi Takashi Masuko Takatsune Shimizu Tomoki Ishikawa Kazuharu Kai Eri Takahashi Yu Imamura Yoshifumi Baba Mitsuyo O | 2011 | Cancer Cell2011，，3： | 2 |
| 5 | Analyses of CO2 emissions embodied in Japan-China trade 显示文摘 | Xianbing Liu Masanobu Ishikawa Can Wang | 2010 | Energy Policy2010，，38： | 1 |
| 6 | The Carbon Content of Japan-US Trade显示文摘 | Frank Aekerman Masanobu Ishikawa and Mikio Suga | 2007 | Energy Policy2007，，3： | 1 |
| 7 | The carbon content of Japan-US trade显示文摘 | FRANK ACKERMAN MASANOBU ISHIKAWA MIKIO SUGA | 2007 | Energy Policy2007，35，： | 1 |
| 8 | Association of the Glu298Asp polymorphism of the eNOS Gene with ischemic heart disease in Japanese diabetic subjects显示文摘 | Hiroyuki Tamemoto San-E Ishikawa Masanobu Kawakami | 2008 | Diabetes Research and Clinical Practice2008，2，5： | 1 |
| 9 | Elevation of serum adiponectin and CD146 levels in diabetic nephropathy显示文摘 | Takako Saito Osamu Saito Takahisa Kawano Hiroyuki Tamemoto Eiji Kusano Masanobu Kawakami San-e Ishikawa | 2007 | Diabetes Research and Clinical Practice2007，，1： | 1 |
| 10 | The carbon content of Japan-US trade显示文摘 | Frank Ackeman Masanobu Ishikawa Mikio Suga | | 0，，35： | 1 |
| 11 | Analyses of CO^2 emissions embodied in Japan - Chi- na trade 显示文摘 | XIANBING LIU MASANOBU ISHIKAWA CAN WANG | 2010 | Energy Policy2010，38，3： | 1 |
| 12 | Analyses of CO 2 emissions embodied in Japan–China trade显示文摘 | Xianbing Liu Masanobu Ishikawa Can Wang Yanli Dong Wenling Liu | 2009 | Energy Policy2009，，3： | 1 |
| 13 | Analyses of CO 2 emissions embodied in Japan–China trade显示文摘 | Xianbing Liu Masanobu Ishikawa Can Wang Yanli Dong Wenling Liu | 2009 | Energy Policy2009，，3： | 1 |
| 14 | A framework for quantified eco-efficiency analysis 显示文摘 | Gjalt Huppes Masanobu Ishikawa | 2005 | Journal of Industrial Ecology2005，9，4： | 1 |
| 15 | Eco-efficiency and its terminology显示文摘 | Gjalt Huppes Masanobu Ishikawa | 2005 | Journal of Industrial Ecology2005，9，4： | 1 |
| 16 | The carbon content of Japan–US trade显示文摘 | Frank Ackerman Masanobu Ishikawa Mikio Suga | 2007 | Energy Policy2007，，9： | 1 |
| 17 | An analysis of the driving forces of CO2 emissions embodied in Japan-China trade 显示文摘 | Yanli Dong Masanobu Ishikawa | 2010 | Energy Policy2010，，2： | 1 |
| 18 | Analysis of CO2 emissions embodied in Japan-China trade显示文摘 | LIU Xianbing MASANOBU Ishikawa WANG Can DONG Yanli LIU Wenling | 2010 | Energy policy2010，，38： | 1 |
| 19 | A Framework for Quantified Ecoefficiency Analysis显示文摘 | Gjalt Huppes Masanobu Ishikawa | | 0，，04： | 1 |
| 20 | A Framework for Quantified Eco-efficiency Analysis 显示文摘 | Gjah Huppes and Masanobu Ishikawa | 2005 | Journal of Industrial Ecology2005，9，4： | 1 |
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