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| 1 | Update on acute myeloid leukemia stem cells:New discoveries and therapeutic opportunities显示文摘The existence of cancer stem cells has been wellestablished in acute myeloid leukemia. Initial proof of the existence of leukemia stem cells(LSCs) was accomplished by functional studies in xenograft models making use of the key features shared with normal hematopoietic stem cells(HSCs) such as the capacity of self-renewal and the ability to initiate and sustain growth of progenitors in vivo. Significant progress has also been made in identifying the phenotype and signaling pathways specific for LSCs. Therapeutically, a multitude of drugs targeting LSCs are in different phases of preclinical and clinical development. This review focuses on recent discoveries which have advanced our understanding of LSC biology and provided rational targets for development of novel therapeutic agents. One of the major challenges is how to target the selfrenewal pathways of LSCs without affecting normal HSCs significantly therefore providing an acceptable therapeutic window. Important issues pertinent to the successful design and conduct of clinical trials evaluating drugs targeting LSCs will be discussed as well. | Maximilian Stahl Tae Kon Kim Amer M Zeidan | 2016 | World Journal of Stem Cells2016，8，10： | 2 |
| 2 | Liquid alkanes with targeted molecular weights from biomass -derived carbohydrates 显示文摘 | RYAN M WEST ZHEN Y LIU MAXIMILIAN PETER et a/ | 2008 | Chem- SusChem2008，1，5： | 1 |
| 3 | Silica-based mesoporous organic-inorganic hybrid materials 显示文摘 | FRANK H MAXIMILIAN C JRGEN M | 2006 | Angew Chew Int Ed2006，45，： | 1 |
| 4 | Training over- head for decoding random linear network codes in wireless net- works 显示文摘 | Maximilian R Sagduyu Y E Honig M L | 2009 | IEEE Journal on Selected Areas in Communications2009，27，5： | 1 |
| 5 | Prognostic significance of the hepatopulmonary syndrome in patients with cirrhosis显示文摘 | Peter Schenk Maximilian Sch?niger-Hekele Valentin Fuhrmann Christian Madl Gerd Silberhumer Christian Müller | 2003 | Gastroenterology2003，，4： | 1 |
| 6 | Hepatocellular carcinoma in Austria: aetiological and clinical characteristics at presentation显示文摘 | Maximilian Sch?niger-Hekele Christian Müller Mathilde Kutilek Christian Oesterreicher Peter Ferenci Alfred Gangl | 2000 | European Journal of Gastroenterology & Hepatology2000，，8： | 1 |
| 7 | Non-physician endoscopists: A systematic review显示文摘AIM:To examine the available evidence on safety, competency and cost-effectiveness of nursing staff providing gastrointestinal(GI) endoscopy services.METHODS:The literature was searched for publications reporting nurse endoscopy using several databases and specific search terms.Studies were screened against eligibility criteria and for relevance.Initial searches yielded 74 eligible and relevant articles; 26 of these studies were primary research articles using original datasets relating to the ability of nonphysician endoscopists.These publications included a total of 28883 procedures performed by non-physician endoscopists.RESULTS:The number of publications in the field of non-specialist gastrointestinal endoscopy reached a peak between 1999 and 2001 and has decreased thereafter.17/26 studies related to flexible sigmoidoscopies,5 to upper GI endoscopy and 6 to colonoscopy.All studies were from metropolitan centres with nurses working under strict supervision and guidance by specialist gastroenterologists.Geographic distribution of publications showed the majority of research was conducted in the United States(43%),the United Kingdom(39%)and the Netherlands(7%).Most studies conclude that after appropriate training nurseendoscopists safely perform procedures.However,in relation to endoscopic competency,safety or patient satisfaction,all studies had major methodological limitations.Patients were often not randomized(21/26studies)and not appropriately controlled.In relation to cost-efficiency,nurse endoscopists were less costeffective per procedure at year 1 when compared to services provided by physicians,due largely to the increased need for subsequent endoscopies,specialist follow-up and primary care consultations.CONCLUSION:Contrary to general beliefs,endoscopic services provided by nurse endoscopists are not more cost effective compared to standard service models and evidence suggests the opposite.Overall significant shortcomings and biases limit the validity and generalizability of studies that have explored safety and quality of services delivered by non-medical endoscopists. | Maximilian Stephens Luke F Hourigan Mark Appleyard George Ostapowicz Mark Schoeman Paul V Desmond Jane M Andrews Michael Bourke David Hewitt David A Margolin Gerald J Holtmann | 2015 | World Journal of Gastroenterology2015，21，16： | 1 |
| 8 | Liquid,h alkanes with targeted molecular weights from biomass -derived carbohydrates 显示文摘 | RYAN M WEST ZHEN Y LIU MAXIMILIAN PETER et a/ | 2008 | Chem- SusChem2008，1，5： | 1 |
| 9 | Frequency-shift offset-QAM for GFDM显示文摘 | IVAN G MAXIMILIAN M NICOLA M | 2015 | IEEE Communication Letters2015，19，8： | 1 |
| 10 | Fettweis,expectation propagation for near-optimum detection of MIMO-GFDM signals显示文摘 | DAN Z LUCIANO L M MAXIMILIAN M | 2016 | IEEE Transactions on Wireless Communications2016，15，2： | 1 |
| 11 | Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit显示文摘 | Hind Medyouf Maximilian Mossner Johann-Christoph Jann Florian Nolte Simon Raffel Carl Herrmann Amelie Lier Christian Eisen Verena Nowak Bettina Zens Katja Müdder Corinna Klein Julia Obl?nder Stephanie Fey Jovita Vogler Alice Fabarius Eva Riedl Henning Roe | 2014 | Cell Stem Cell2014，，6： | 1 |
| 12 | Obesity, Inflammation, and Insulin Resistance - A Mini-Review显示文摘 | Zeyda Maximilian Stulnig Thomas M | 2009 | Gerontology2009，，4： | 1 |
| 13 | Current value of intraoperative sonography during surgery for hepatic neoplasms显示文摘 | Johannes Zacherl M.D. Christian Scheuba M.D. Martin Imhof M.D. Maximilian Zacherl M.D. Friedrich L?ngle M.D. Peter Pokieser M.D. Fritz Wrba M.D. Etienne Wenzl M.D. Ferdinand Mühlbacher M.D. Raimund Jakesz M.D. Rudolf Steininger M.D | 2002 | World Journal of Surgery2002，，5： | 1 |
| 14 | Production and characterization of antibodies against each of the thee subunits of the Bacillus cereus nonhemolytic enterotoxin complex显示文摘 | Richard D Maximilian M Christine B | 2005 | Appliedand Environmental Microbiology2005，71，12： | 1 |
| 15 | Structural MRI correlates for vulnerability and resilience to major depressive disorder显示文摘 | Amico Francesco Meisenzahl Eva Koutsouleris Nicolaos Reiser Maximilian M?ller Hans-Juergen Frodl Thomas | 2011 | Journal of Psychiatry & Neuroscience : JPN2011，，1： | 1 |
| 16 | Differences in hippocampal volume between major depression and schizophrenia: a comparative neuroimaging study显示文摘 | Eva M. Meisenzahl Doerthe Seifert Ronald Bottlender Stefan Teipel Thomas Zetzsche Markus J?ger Nikolaos Koutsouleris Gisela Schmitt Johanna Scheuerecker Bernhard Burgermeister Harald Hampel Tobias Rupprecht Christine Born Maximilian Reiser Hans-Jürgen M?l | 2010 | European Archives of Psychiatry and Clinical Neuroscience2010，，2： | 1 |
| 17 | Silica-based mesoporous organic-inorganic hybrid materials 显示文摘 | Frank H Maximilian C Jiirgen M | 2006 | Angew Chem lnt Ed2006，45，20： | 1 |
| 18 | Leptomeningeal metastasis of an intradural malignant peripheral nerve sheath tumor显示文摘 | Andreas M Stark H Maximilian Mehdorn | 2013 | J Clin Neurosci2013，20，8： | 1 |
| 19 | Obesity, Inflammation, and Insulin Resistance - A Mini-Review显示文摘 | Zeyda Maximilian Stulnig Thomas M | 2009 | Gerontology2009，，4： | 1 |
| 20 | Primary malignant sarco- mas of the heart and great vessels in adult patients-a singlecenter ex- perience 显示文摘 | Frank M Hermann A Maximilian R | 2007 | Oncologist2007，12，9： | 1 |
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