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| 1 | 上海慢性病自我管理项目实施效果的评价显示文摘目的 评价上海慢性病自我管理项目实施 6个月后的效果。方法 按照以社区为基础的随机对照试验研究设计 ,将 95 4名患有高血压病、心脏病、关节炎、中风、哮喘、糖尿病、慢性阻塞性肺病 (COPD)等疾病自愿参加该项目的慢性病人 ,随机分为干预组和对照组。采用协方差的秩和检验 ,比较了有基线和 6个月后 2次问卷调查数据的43 0名干预组病人和 3 49名对照组病人在项目实施 6个月后在自我管理行为、自我效能、健康状况和卫生服务利用等方面的变化。结果 与对照组比较 ,干预组在一种自我管理行为方面明显提高 :6个月内认知性症状、管理方法实践评分 ,干预组平均多增加了 0 3 3分 ;症状管理自我效能和疾病共性管理自我效能评分 6个月的增加值 ,分别比对照组高出 0 69分和 0 63分 ;干预组在健康状况的 9个方面 (整体健康自评、健康担忧、疲劳、气短、疼痛、失能、疾病对病人生活影响、情绪低落及社会活动 /角色受限 ) ,明显好于对照组 (P均 <0 0 5 ) ;干预组 6个月内看急诊次数平均比对照组少 0 0 1次 (P =0 0 2 ) ;干预组 6个月内住院次数平均比对照组减少了 0 12次 (P =0 0 1)。结论 上海慢性病自我管理项目 6个月后可改善参加者的自我管理行为、自我效能、部分健康状况、减少看急诊次数和住院次? | 傅东波 傅华 Patrick McGowan 沈贻谔 朱莉珍 杨惠勤 朱世泰 毛建国 丁永明 卫志华 杨顺英 吴翠娥 | 2003 | 中国公共卫生2003，19，2： | 198 |
| 2 | Differential hepatic features presenting in Wilson disease-associated cirrhosis and hepatitis B-associated cirrhosis显示文摘BACKGROUND Cirrhosis is a chronic late stage liver disease associated with hepatitis viruses,alcoholism, and metabolic disorders, such as Wilson disease(WD). There are no clear markers or clinical features that define cirrhosis originating from these disparate origins. We hypothesized that cirrhosis is not one disease and cirrhosis of different etiology may have differential clinical hepatic features.AIM To delineate the liver features between WD-associated cirrhosis and hepatitis Bassociated cirrhosis in the Chinese population.METHODS In this observational study, we reviewed the medical data of consecutive inpatients who had WD-associated cirrhosis or hepatitis B-associated cirrhosis from January 2010 to August 2018, and excluded patients who had carcinoma,severe heart or pulmonary diseases, or other liver diseases. According to the etiology of cirrhosis, patients were divided into two groups: WD-associated cirrhosis group(60 patients) and hepatitis B-associated cirrhosis group(56 patients). The liver fibrosis degree, liver function indices, and portal hypertension features of these patients were compared between the two groups.RESULTS No inter-group differences were observed in the diagnostic liver fibrosis markers,however, clinical features clearly defined the origin of cirrhosis. WD-associated cirrhosis patients(16-29 years) had lower levels of alanine transaminase,aspartate transaminase, and bilirubin, lower prothrombin time, lower incidence of hepatic encephalopathy, and lower portal vein diameter(P < 0.05), compared to cirrhosis resulting from hepatitis B in older patients(45-62 years). Importantly,they had decreased risks of progression from Child-Pugh grade A to B(odds ratio = 0.046, 95% confidence interval: 0.006-0.387, P = 0.005) and of ascites(odds ratio = 0.08, 95% confidence interval: 0.01-0.48, P = 0.005). Conversely, WDassociated cirrhosis patients had a higher risk of splenomegaly(odds ratio = 4.15,95% confidence interval: 1.38-12.45, P = 0.011).CONCLUSION WD-associated cirrhosis presents a higher risk of splenomegaly associated with leukopenia and thrombocytopenia, although revealing milder liver dysfunction and portal hypertension symptoms, which recommends WD patients to be monitored for associated complications. | Hao-Jie Zhong Huan-Huan Sun Lan-Feng Xue Eileen M McGowan Yu Chen | 2019 | World Journal of Gastroenterology2019，25，3： | 19 |
| 3 | Burden of Gastrointestinal Disease in the United States: 2012 Update显示文摘 | Anne F. Peery Evan S. Dellon Jennifer Lund Seth D. Crockett Christopher E. McGowan William J. Bulsiewicz Lisa M. Gangarosa Michelle T. Thiny Karyn Stizenberg Douglas R. Morgan Yehuda Ringel Hannah P. Kim Marco Dacosta DiBonaventura Charlotte F. Carroll Je | 2012 | Gastroenterology2012，，5： | 15 |
| 4 | 人脐带间充质干细胞移植对支气管哮喘小鼠气道炎症的作用及其机制显示文摘目的 探讨人脐带间充质干细胞(hUC-MSCs)移植对支气管哮喘(简称哮喘)小鼠气道炎症的作用及其机制.方法 将24只BALB/c小鼠按随机数字表法均分为四组:正常对照组、哮喘模型组[用卵白蛋白(OVA)制备过敏性哮喘动物模型]、hUC-MSCs治疗组(在哮喘模型动物气管内注射hUC-MSCs 50μl)和hUC-MSCs对照组(在正常对照动物气管内注射hUC-MSCs 50μl).hUC-MSCs从健康胎儿脐带组织分离培养,经表征检测后,细胞移植到哮喘小鼠气管中,分别对各组小鼠气道的组织病理学变化、支气管肺泡灌洗液(BALF)中白细胞、肥大细胞计数、白细胞介素(IL)-6、转化生长因子β(TGF-β)和IL-17+ CD4+T细胞(Th17细胞)表达水平进行评价.结果 哮喘模型组动物小支气管/气道变小、气道、血管旁有大量炎症细胞浸润,部分气道管腔有黏液堵塞;BALF中白细胞总数计数和肥大细胞计数显著升高(P<0.05).哮喘模型组肺组织中Th17细胞比例显著高于对照组(2.90%比0.76%,P<0.05).正常对照组及hUC-MSCs对照组无气道炎症表现.hUC-MSCs治疗组BALF中白细胞总数、肥大细胞及Th17细胞比例显著低于哮喘模型组(例如Th17细胞:0.24%比2.90%,均P<0.05);肺组织中的IL-6 mRNA和TGF-β mRNA相对表达量均显著低于哮喘模型组(0.23比2.30和0.56比6.60,P<0.01).此外,hUC-MSCs治疗组的肺组织炎性细胞浸润显著轻于哮喘模型组.结论 hUC-MSCs移植可有效地改善OVA诱导的哮喘小鼠的气道炎症反应;其机制可能是通过抑制Th17细胞以及下调炎症因子的分泌. | 任妮娜 陈鸿杰 陈巧林 Eileen McGowan 安军 林宜光 | 2017 | 中华医学杂志2017，97，34： | 6 |
| 5 | 缺氧缺血性脑病新生儿血糖变化与脑损伤的关系显示文摘脑的能量90%由葡萄糖提供,当葡萄糖供应不足时,新生儿产生酮体或脂肪酸等中间代谢产物的能力有限,难以提供足够的能量代偿,故应对缺氧缺血性脑病的新生儿增加葡萄糖的供给以降低缺氧缺血陛脑损伤。然而,对缺氧缺血性脑损伤的成年动物模型和发生卒中的成年患者的研究表明,在窒息初期过度供给葡萄糖反而不利。缺氧后理想的血糖水平并不确切。本文讨论新生儿缺氧缺血性脑病患儿血糖变化与脑损伤的关系。 | 黄久浪 侯新琳 McGowan JE | 2015 | 中国新生儿科杂志2015，30，5： | 5 |
| 6 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 7 | Tumor Necrosis Factor Receptors 1 and 2 Differentially Regulate Survival, Cardiac Dysfunction, and Remodeling in Transgenic Mice With Tumor Necrosis Factor-α–Induced Cardiomyopathy显示文摘 | Yoshihiro Higuchi Charles F. McTiernan Carole B. Frye Brian S. McGowan Tung O. Chan Arthur M. Feldman | 2004 | Circulation: Journal of the American Heart Association2004，，15： | 2 |
| 8 | 深圳证券交易所结构设计显示文摘深圳证券交易所塔楼采用钢梁-型钢混凝土柱组合框架+钢筋混凝土核心筒结构体系,东西两侧外框架在裙楼以下采用转换桁架结构。位于塔楼7-10层的悬臂裙楼最大悬挑距离37m,采用钢桁架结构支承。本项目为超高、超限结构,受地震作用及风荷载影响较大,设计时基于不同性能水准下的抗震性能目标,同时考虑风洞试验风荷载数据,对结构设计方案及整体性能进行了研究。弹性分析采用了两种不同的分析软件进行计算对比,同时对塔楼进行了非线性时程分析。分析结果表明,本工程整体结构性能满足相关规范要求,结构设计安全,构件设计主要由风荷载或重力荷载控制。罕遇地震下结构抗震性能满足"大震不倒"的性能目标。 | 朴才思 Rory McGowan 何伟明 李秀英 张然 | 2014 | 建筑结构2014，44，24： | 2 |
| 9 | A randomized, controlled trial of oral sulfate solution plus polyethylene glycol as a bowel preparation for colonoscopy显示文摘 | Douglas K. Rex John McGowan Mark vB. Cleveland Jack A. Di Palma | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 10 | Treating to New Targets (TNT) Study: does lowering low-density lipoprotein cholesterol levels below currently recommended guidelines yield incremental clinical benefit?显示文摘 | David D Waters John R Guyton David M Herrington Mary P McGowan Nanette K Wenger Charles Shear | 2004 | The American Journal of Cardiology2004，，2： | 2 |
| 11 | Tumor immunogenicity determine the effect of B7-1 costimulation of T cell-mediated tumor immunity显示文摘 | Chen L McGowan P Ashe S | 1994 | J Exp Med1994，179，： | 2 |
| 12 | Identification of stimulating and inhibitory epitopes within the heat shock protein 70 molecule that modulate cytokine production and maturation of dendritic cells显示文摘 | Wang Y Whittall T McGowan E | 2005 | J Immunol2005，174，6： | 1 |
| 13 | Reactive oxygen species as mediators of photoreceptor apoptosis in vitro显示文摘 | Carmody R J McGowan A J Cotter TG | 1999 | Exp Cell Res1999，248，2： | 1 |
| 14 | Extracellular matrix and the regulation of lung development and repair显示文摘 | McGowan SE | 1992 | FASEB J1992，6，11： | 1 |
| 15 | Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls显示文摘 | Kumar-Singh S Pirici D McGowan E | 2005 | Am J Pathol2005，167，2： | 1 |
| 16 | Reactive oxygen species as mediators ofphotoreceptor apoptosis in vitro显示文摘 | Carmody RJ McGowan AJ Cotter TG | 1999 | Exp Cell Res1999，248，52： | 1 |
| 17 | Advances in mucosal immunology显示文摘 | MCGOWAN I CHALMERS A SMITH G R etal | 1997 | Gastroen-terol Clin N Am1997，26，： | 1 |
| 18 | ADAM-17 expmssion in breast cancer correlates with variables of tumor progression显示文摘 | MCGOWAN P M RYAN B M HILL A D | 2007 | Clin Cancer Res2007，13，8： | 1 |
| 19 | IntramurM pregnaney显示文摘 | Mcgowan L | 1965 | JAMA1965，192，： | 1 |
| 20 | Resistance in nonfermenting gram-negative bacteria:multidrug resis tance to the maximum显示文摘 | McGowan JE Jr | 2006 | Am J Med2006，119，6： | 1 |
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