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| 1 | Nosocomial infections:Epidemiology,prevention,control and surveillance显示文摘Nosocomial infections or healthcare associated infections occur in patients under medical care.These infections occur worldwide both in developed and developing countries.Nosocomial infections accounts for 7% in developed and 10% in developing countries.As these infections occur during hospital stay,they cause prolonged stay,disability,and economic burden.Frequently prevalent infections include central line-associated bloodstream infections,catheter-associated urinary tract infections,surgical site infections and ventilator-associated pneumonia.Nosocomial pathogens include bacteria,viruses and fungal parasites.According to WHO estimates,approximately 15% of all hospitalized patients suffer from these infections.During hospitalization,patient is exposed to pathogens through different sources environment,healthcare staff,and other infected patients.Transmission of these infections should be restricted for prevention.Hospital waste serves as potential source of pathogens and about 20%–25% of hospital waste is termed as hazardous.Nosocomial infections can be controlled by practicing infection control programs,keep check on antimicrobial use and its resistance,adopting antibiotic control policy.Efficient surveillance system can play its part at national and international level.Efforts are required by all stakeholders to prevent and control nosocomial infections. | Hassan Ahmed Khan Fatima Kanwal Baig Riffat Mehboob | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，5： | 22 |
| 2 | IFN-γ,establishes interferon-stimulated gene-mediated antiviral state against Newcastle disease virus in chicken fibroblasts显示文摘Newcastle disease virus(NDV)causes severe economic losses through severe morbidity and mortality and poses a significant threat to the global poultry industry.Significant efforts have been made to develop novel vaccines and therapeutics;however,the interaction of NDV with the host is not yet fully understood.Interferons(IFNs),an integral component of innate immune signaling,act as the first line of defense against invading viruses.Compared with the mammalian repertoire of IFNs,limited information is available on the antiviral potential of IFNs in chickens.Here,we expressed chicken IFN-γ(chlFN-γ)using a baculovirus expression vector system,characterized its antiviral potential against NDV,and determined its antiviral potential.Priming of chicken embryo fibroblasts with chlFN-γelicited an antiviral environment in primary cells,which was mainly due to interferon-stimulated genes(ISGs).A genome-wide transcriptomics approach was used to elucidate the possible signaling pathways associated with IFN-γ-induced immune responses.RNA-sequencing(RNA-seq)data revealed significant induction of ISG-associated pathways,activated temporal expression of ISGs,antiviral mediators,and transcriptional regulators in a cascade of antiviral responses.Collectiv(e)ly,we found that IFN-γsignificantly elicited an antiviral response against NDV infection.These data provide a foundation for chlFN-γ-mediated antiviral responses and underpin functional annotation of these important chlFN-γ,-induced antiviral influencers. | Xin Yang Mehboob Arslan Xingjian Liu Haozhi Song Mengtan Du YinüLi Zhifang Zhang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 9 |
| 3 | Nosocomial infections and their control strategies显示文摘Nosocomial infections are also known as hospital-acquired/associated infections. National Healthcare Safety Network along with Centers for Disease Control for surveillance has classified nosocomial infection sites into 13 types with 50 infection sites, which are specific on the basis of biological and clinical criteria. The agents that are usually involved in hospitalacquired infections include Streptococcus spp., Acinetobacter spp., enterococci, Pseudomonas aeruginosa, coagulase-negative staphylococci, Staphylococcus aureus, Bacillus cereus, Legionella and Enterobacteriaceae family members, namely, Proteus mirablis, Klebsiella pneumonia, Escherichia coli, Serratia marcescens. Nosocomial pathogens can be transmitted through person to person, environment or contaminated water and food, infected individuals, contaminated healthcare personnel's skin or contact via shared items and surfaces. Mainly, multi-drug-resistant nosocomial organisms include methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, Pseudomonas aeruginosa and Klebsiella pneumonia, whereas Clostridium difficile shows natural resistance. Excessive and improper use of broadspectrum antibiotics, especially in healthcare settings, is elevating nosocomial infections, which not only becomes a big health care problem but also causes great economic and production loss in the community. Nosocomial infections can be controlled by measuring and comparing the infection rates within healthcare settings and sticking to the best healthcare practices. Centers for Disease Control and Prevention provides the methodology for surveillance of nosocomial infections along with investigation of major outbreaks. By means of this surveillance, hospitals can devise a strategy comprising of infection control practices. | Hassan Ahmed Khan Aftab Ahmad Riffat Mehboob | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，7： | 4 |
| 4 | Primate-specific Long Non-coding RNAs and MicroRNAs显示文摘Non-coding RNAs(ncRNAs) are critical regulators of gene expression in essentially all life forms.Long ncRNAs(lncRNAs) and micro RNAs(miRNAs) are two important RNA classes possessing regulatory functions.Up to date,many primate-specific ncRNAs have been identified and investigated.Their expression specificity to primate lineage suggests primate-specific roles.It is thus critical to elucidate the biological significance of primate or even human-specific ncRNAs,and to develop potential ncRNA-based therapeutics.Here,we have summarized the studies regarding regulatory roles of some key primate-specific lncRNAs and miRNAs. | Hassaan Mehboob Awan Abdullah Shah Farooq Rashid Ge Shan | 2017 | Genomics, Proteomics & Bioinformatics2017，15，3： | 2 |
| 5 | RAPDanalysis of Fusarium isolates causing Mango Malformation disease inPakistan显示文摘 | ZAFAR I MEHBOOB R ALTAF D AHMAD S YUSUF Z | 2006 | World Journal Microbiology and Biotechnology2006，22，11： | 1 |
| 6 | Giant cell turnouts in hand bones 显示文摘 | Minhas MS Mehboob G Ansari I | 2010 | J Coil Physicians Surg Pak2010，20，7： | 1 |
| 7 | Production of liguin peroxidase by Ganoderma leucidum using solid state fermentation显示文摘 | Mehboob N Asad M J Imran M | 2013 | African Journal of Biotechnology2013，10，48： | 1 |
| 8 | Treatment of intertrochanteric femoral fractures with a proximal femoral nail (PFN):a short follow up显示文摘 | Anjum MP Hussain FN Mehboob I | 2009 | Nepal Med Coil J2009，11，4： | 1 |
| 9 | Diagnostic yield of color doopler uhrasonography in deep vein thrombosis 显示文摘 | Naz R Naz S Mehboob M | 2005 | J Coil Physicians Surg Pak2005，15，5： | 1 |
| 10 | A navigation device with MAC supporting multiple physical networks for extended coverage and operations显示文摘 | Ahmed Z Jamal H Mehboob R | 2008 | IEEE Transactions on Consumer Electronics2008，54，3： | 1 |
| 11 | Insulinotropic glucagonlike peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas 显示文摘 | Doris AS Timothy JK Mehboob AH | 2000 | Diabetes2000，49，5： | 1 |
| 12 | FIR filter design methodology for hardware optimized implementation显示文摘 | MEHBOOB R KHAN S A QAMAR R | | 0，，03： | 1 |
| 13 | Giant cell tumours in hand bones显示文摘 | Minhas MS Mehboob G Ansari I | 2010 | J Coil Physicians Surg Pak2010，20，7： | 1 |
| 14 | Meta- analysis: the effects of gut flora modulation using prebiotics, probiotics and synbiotics on mini- mal hepatic encephalopathy 显示文摘 | Shukla S Shukla A Mehboob S et aI | 2011 | Aliment Pharmacol Ther2011，33，6： | 1 |
| 15 | Impaired endothelium- mediated vasodilation in heart failure: clinical evidence and the potential for therapy显示文摘 | Elkayam U Khan S Mehboob A | 2002 | J Card Fail2002，8，1： | 1 |
| 16 | Meta-analysis:the effects of gut flora modulation using prebiotics,probiotics and synbiotics on minimal hepatic encephalopathy显示文摘 | Shukla S Shukla A Mehboob S | 2011 | Aliment Pharmacol Ther2011，33，6： | 1 |
| 17 | On Relay Selection for Decode-and-forward Relaying显示文摘 | F. M. Mehboob U. Murat | | 0，，07： | 1 |
| 18 | FIR filterdesign methodology for hardware optimized implementation 显示文摘 | MEHBOOB R KHAN S A QAMAR R | 2009 | IEEE Trans Consumer Elec2009，55，3： | 1 |
| 19 | Pro-apoptotic effect of fly ash leachates in hepatocytes of freshwater fish ( Channa punctata Bloch)显示文摘 | Mehboob Ali Shakilur Rahman Hasibur Rehman Kanchan Bhatia Rizwan A. Ansari Sheikh Raisuddin | 2006 | Toxicology in Vitro2006，，1： | 1 |
| 20 | Piagnostic yield of color Doppler ultrasonography in deep vein thrombosis显示文摘 | Naz R Naz S Mehboob M | 2005 | J Coil Physicians Surg Pak2005，15，5： | 1 |
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