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| 1 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 2 | Interpretability constraint forfuzzy information granulation显示文摘 | MENC C FANELLI A M | 2008 | Information Sciences2008，178，24： | 1 |
| 3 | Detection of Achromobacter xylosoxidans in Hospital, Domestic, and Outdoor Environmental Samples and Comparison with Human Clinical Isolates显示文摘 | Lucie Amoureux Julien Bador Sakina Fardeheb Cédric Mabille Charlyne Couchot Clémence Massip Anne-Lise Salignon Guillaume Berlie Véronique Varin Catherine Neuwirth | 2013 | Applied and Environmental Microbiology2013，，23： | 1 |
| 4 | Early transpyloric enteral nutrition in critically ill children显示文摘 | César Sánchez Jesús López-Herce Angel Carrillo Santiago Mencía Dolores Vigil | 2007 | Nutrition2007，，1： | 1 |
| 5 | Nutrient-Sensing Mechanisms in the Gut as Therapeutic Targets for Diabetes显示文摘 | Danna M. Breen Brittany A. Rasmussen Clémence D. C?té V. Margaret Jackson Tony K.T. Lam | 2013 | Diabetes2013，，9： | 1 |
| 6 | Larval interference competition between the native Neotropical mosquito Limatus durhamii and the invasive Aedes aegypti improves the fitness of both species显示文摘Interspecific competition with native species during biological invasions can sometimes limit alien expansion.We aimed to determine the potential ecological effects of Limatus durhamii Theobald 1901,a native Neotropical mosquito (Diptera:Culicidae) species,on the invasive species Aedes (Stegomyia)aegypti (Linnaeus 1762)that breeds in the same artificial water containers.Development time and adult dry mass were measured in 3 rearing conditions:control (a single larva),intraspecific competition (2 conspecific larvae),and interspecific competition (2 heterospecific larvae).Food was provided ad libitum to eliminate exploitative competition.For Ae.aegypti,development time was not affected by interspecific interference competition (nonsignificant differences with the control)and the adult dry mass was significantly higher,meaning that individual fitness likely increased.Yet,because previous studies showed longer development time and lighter adults during competition with other invasive mosquitoes,it is likely that Ae.aegypti can express a different phenotype depending on the competing species.The similar pattern found for Li.durhamii females and the nonsignificant difference with the control for males explain in part why this species can compete with Ae.aegypti. | Stanislas Talaga Alain Dejean Clémence Mouza Yves Dumont Céline Leroy | 2018 | Insect Science2018，25，6： | 0 |
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