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| 1 | Are humic substances soil microbial residues or unique synthesized compounds?A perspective on their distinctiveness显示文摘Humic substances(HS),which are defined as a series of highly acidic,relatively high-molecular-weight,and yellow to black colored substances formed during the decay and transformation of plant and microbial remains,ubiquitously occur in nature.Humic substances represent the largest stable organic carbon pool in terrestrial environments and are the central characteristic of the soil.However,the validity of the HS concept and the justification of their extraction procedure have been recently debated.Here,we argue that the traditional humic paradigm is still relevant.Humic substances are distinctive and complex because the extracted HS formed during the humification are chemically distinct from their precursors and are heterogeneous among soils.By reviewing the concept,formation pathways,and stabilization of HS,we propose that the key question facing soil scientists is whether HS are soil microbial residues or unique synthesized compounds.Without revealing the distinctiveness of HS,it is impossible to address this question,as the structure,composition,and reactivity of HS are still poorly known owing to the heterogeneity and geographical variability of HS and the limits of the currently available analytical techniques.In our view,the distinctiveness of HS is fundamental to the soil,and thus further studies should be focused on revealing the distinctiveness of HS and explaining why HS hold this distinctiveness. | Sen DOU Jun SHAN Xiangyun SONG Rui CAO Meng WU Chenglin LI Song GUAN | 2020 | Pedosphere2020，30，2： | 12 |
| 2 | Low Power EEPROM Designed for Sensor Interface Circuit显示文摘 | MENG Xiangyun YANG Sen CHEN Zhongjian LU Wengao ZHANG Yacong HUANG Jingqing LI Haojiong SU Weiguo LI Song | 2012 | Chinese Journal of Electronics2012，21，4： | 1 |
| 3 | Ubiquitin-specific protease 47 regulates intestinal inflammation through deubiquitination of TRAF6 in epithelial cells显示文摘Deubiquitinates(DUBs) alter the stabilities, localizations or activities of substrates by removing their ubiquitin conjugates,which are closely related to the development of inflammatory response. Here, we show that ubiquitin-specific protease 47(USP47) prevents inflammation development in inflammatory bowel disease(IBD). Compared with wild-type mice, Usp47 knockout mice are more susceptible to dextran sodium sulfate(DSS)-induced acute and chronic colitis with higher inflammatory cytokines expression and severe intestinal tissue damage. Chimeric mouse experiments suggest that non-hematopoietic cells mainly contribute to the phenotype. And, DSS-induced colitis of the Usp47 knockout mice depends on commensal bacteria.Mechanistically, down-regulation of USP47 aggravates the activation of NF-κB signaling pathway by increasing the K63-linked poly-ubiquitination of tumor necrosis factor receptor-associated factor 6(TRAF6) in intestinal epithelial cells. Furthermore, the expression of USP47, negatively correlated with the degree of inflammation, is lower at colonic inflammatory lesions than that non-inflammatory sites from the intestine from ulcerative colitis(UC) and Crohn's disease(CD) patients. These data, taken together, indicate that USP47 regulates intestinal inflammation through de-ubiquitination of K63-linked poly-ubiquitination TRAF6 in intestinal epithelial cells. | Hu Lei Li Yang Hanzhang Xu Zhengting Wang Xiangyun Li Meng Liu Yingli Wu | 2022 | Science China(Life Sciences)2022，65，8： | 1 |
| 4 | USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia显示文摘T-cell acute lymphoblastic leukemia(T-ALL)is a highly aggressive leukemia that is primarily caused by aberrant activation of the NOTCH1 signaling pathway.Recent studies have revealed that posttranslational modifications,such as ubiquitination,regulate NOTCH1 stability,activity,and localization.However,the specific deubiquitinase that affects NOTCH1 protein stability remains unestablished.Here,we report that ubiquitin-specific protease 7(USP7)can stabilize NOTCH1.USP7 deubiquitinated NOTCH1 in vivo and in vitro,whereas knockdown of USP7 increased the ubiquitination of NOTCH1.USP7 interacted with NOTCH1 protein in T-ALL cells,and the MATH and UBL domains of USP7 were responsible for this interaction.Depletion of USP7 significantly suppressed the proliferation of T-ALL cells in vitro and in vivo,accompanied by downregulation of the NOTCH1 protein level.Similarly,pharmacologic inhibition of USP7 led to apoptosis of T-ALL cells.More importantly,we found that USP7 was significantly upregulated in human T-ALL cell lines and patient samples,and a USP7 inhibitor exhibited cell cytotoxicity toward primary T-ALL cells,indicating the clinical relevance of these findings.Overall,our results demonstrate that USP7 is a novel deubiquitinase that stabilizes NOTCH1.Therefore,USP7 may be a promising therapeutic target in the currently incurable T-ALL. | Huizhuang Shan Xiangyun Li Xinhua Xiao Yuting Dai Jinyan Huang Junjun Song Meng Liu Li Yang Hu Lei Yin Tong Li Zhou Hanzhang Xu Yingli Wu | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 0 |
| 5 | GRB 220408B:A Three-episode Burst from a Precessing Jet显示文摘Jet precession has previously been proposed to explain the apparently repeating features in the light curves of a few gamma-ray bursts(GRBs).In this paper,we further apply the precession model to a bright GRB 220408B by examining both its temporal and spectral consistency with the predictions of the model.As one of the recently confirmed GRBs observed by our GRID CubeSat mission,GRB 220408B is noteworthy as it exhibits three apparently similar emission episodes.Furthermore,the similarities are reinforced by their strong temporal correlations and similar features in terms of spectral evolution and spectral lags.Our analysis demonstrates that these features can be well explained by the modulated emission of a Fast-Rise-Exponential-Decay(FRED)shape light curve intrinsically produced by a precessing jet with a precession period of 18.4_(-0.2)~(+0.2)s,a nutation period of11.1_(-0.2)~(+0.2)s and viewed off-axis.This study provides a straightforward explanation for the complex yet similar multiepisode GRB light curves. | Zijian Zhang Yi-Han Iris Yin Chenyu Wang Xiangyu Ivy Wang Jun Yang Yan-Zhi Meng Zi-Ke Liu Guo-Yin Chen Xiaoping Fu Huaizhong Gao Sihao Li Yihui Liu Xiangyun Long Yong-Chang Ma Xiaofan Pan Yuanze Sun Wei Wu Zirui Yang Zhizhen Ye Xiaoyu Yu Shuheng Zhao Xutao Zheng Tao Zhou Qing-Wen Tang Qiurong Yan Rong Zhou Zhonghai Wang Hua Feng Ming Zeng Bin-Bin Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，11： | 0 |
| 6 | A class of anomalous diffusion epidemic models based on CTRW and distributed delay显示文摘In recent years,the epidemic model with anomalous diffusion has gained popularity in the literature.However,when introducing anomalous diffusion into epidemic models,they frequently lack physical explanation,in contrast to the traditional reaction-diffusion epidemic models.The point of this paper is to guarantee that anomalous diffusion systems on infectious disease spreading remain physically reasonable.Specifically,based on the continuous-time random walk(CTRW),starting from two stochastic processes of the waiting time and the step length,time-fractional space-fractional diffusion,timefractional reaction-diffusion and fractional-order diffusion can all be naturally introduced into the SIR(S:susceptible,I:infectious and R:recovered)epidemic models,respectively.The three models mentioned above can also be applied to create SIR epidemic models with generalized distributed time delays.Distributed time delay systems can also be reduced to existing models,such as the standard SIR model,the fractional infectivity model and others,within the proper bounds.Meanwhile,as an application of the above stochastic modeling method,the physical meaning of anomalous diffusion is also considered by taking the SEIR(E:exposed)epidemic model as an example.Similar methods can be used to build other types of epidemic models,including SIVRS(V:vaccine),SIQRS(Q:quarantined)and others.Finally,this paper describes the transmission of infectious disease in space using the real data of COVID-19. | Zhenzhen Lu Guojian Ren Yangquan Chen Xiangyun Meng Yongguang Yu | 2023 | International Journal of Biomathematics2023，16，7： | 0 |
| 7 | Convergence analysis of the rectangular Morley element scheme for second order problem in arbitrary dimensions显示文摘We present the convergence analysis of the rectangular Morley element scheme utilised on the second order problem in arbitrary dimensions. Specifically, we prove that the convergence of the scheme is of O(h) order in energy norm and of O(h^2) order in L^2 norm on general d-rectangular triangulations. Moreover, when the triangulation is uniform, the convergence rate can be of O(h^2) order in energy norm, and the convergence rate in L^2 norm is still of O(h^2) order, which cannot be improved. Numerical examples are presented to demonstrate our theoretical results. | MENG XiangYun YANG XueQin ZHANG Shuo | 2016 | Science China Mathematics2016，59，11： | 0 |
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