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| 1 | Coping as a Mechanism Linking Stressful Life Events and Mental Health Problems in Adolescents显示文摘Objective Although stressful life events represent an etiologic factor of mental health problems in adolescents,few studies have been conducted to address mechanisms linking the stress‐psychopathology relation.The present study was designed to examine coping as a mediate factor on the relationship between stressful life events and symptoms of anxiety and depression.Methods The participants were 13 512 students from eight cities of China,who participated in a school‐based survey.Data were collected by a questionnaire comprising coping,stressful life events,anxiety,and depressive symptoms.As a model,a series of regression equations were used to examine whether coping mediated the association between stressful life events and symptoms of anxiety and depression.Results Each dimension of stressful life events showed significant correlation with anxiety,depression and coping (all P<0.001).In the model to analyze mediate effects,all standardized coefficients (β) were significant (all P<0.01),indicating marked mediator effects.Furthermore,negative coping might account for more mediate effects than positive coping on this relationship.Conclusion Coping partially mediated the relationship between stressful life events and mental health during adolescence.This study highlighted an important public health priority for preventive interventions targeting stress‐related psychopathology,and for further promoting adolescents'mental health. | MENG Xiu Hong TAO Fang Biao WAN Yu Hui HU Yan WANG Ren Xi | 2011 | Biomedical and Environmental Sciences2011，24，6： | 16 |
| 2 | Synthesis and characterization of magnetic and luminescent Fe_3O_4/CdTe nanocomposites using aspartic acid as linker显示文摘在这研究,新有点磁性、光的 Fe3O4/CdTe nanocomposites 的准备被表明。Superparamagnetic Fe3O4 nanoparticles 被铁、铁的离子的热水的一起沉淀首先综合,与丁氨二酸酸与 tetramethylammonium 氢氧化物(TMAOH ) 和化学激活由他们的表面的修正列在后面。修改表面的 Fe3O4 nanoparticles 当时与 CdTe 量点(QD ) 是 covalently 涂的,它与 mercaptoacetic 酸(MPA ) 被修改,到通过 Fe3O4 和 carboxyl 的表面上的氨基的组的协作的 Fe3O4/CdTe 磁性、光的 nanocomposites 在 CdTe QD 上组织的形式。同样综合的 nanocomposites 的结构和性质被描绘。nanocomposites 与 40-50 nm,黄绿色的排放特征和房间温度强磁性的一条平均直径拥有了结构,这被显示。荧光和 nanocomposites 的紫外力的吸收系列显示出 CdTe QD 与那些作比较的蓝移动。蓝移动的机制被介绍。nanocomposites 与 8.9 emu/g 的浸透磁化保留了铁磁性的性质。 | Xiu Ling Wang Lu Wei Guan Hong Tao Meng Qiong Huang | 2011 | Chinese Chemical Letters2011，22，2： | 8 |
| 3 | Malnutrition Increases the Risk of Mortality in Hospitalized Lung Cancer Patients显示文摘Background The Global Leadership Initiative on Malnutrition(GLIM)recently developed a new set of diagnostic criteria for identifying patients with malnutrition.Because the GLIM criteria were only introduced a little over 3 years ago,additional validation and reliability testing are needed in a variety of populations.Methods We performed an observational,multicenter cohort study.From July 2013 to October 2018,lung cancer patients were recruited from the Daping Hospital of Army Medical University and the First Hospital of Jilin University as part of the INSCOC project.Previously-established cut-off values for the calf circumference(CC,male<30 cm,female<29.5 cm)were applied as the reduced muscal mass of phenotypic criteria to establish the GLIM diagnosis.Multivariate Cox regression analyses were performed to analyze the association between the GLIM criteria and survival.Results A total of 1219 patients with lung cancer were studied as subjects.Their age was 58.81±9.92 years old,and 820 were male and 399 were female.According to the GLIM diagnostic criteria using the CC as a muscle mass measurement,303 patients(24.9%)were categorized as malnourished,142 patients(23.1%)in the adult group(18≤age<60)and 161 patients(26.7%)in the older group(age≥60 years).The patients with malnutrition had a higher incidence of anemia than the nourished patients(P=0.012).The QLQ-C30 score and KPS score indicating that the malnourished patients had a consistently worse quality of life compared to the nourished group(all P<0.001).The median survival of the malnutrition group was 42(95%CI:34-50)months,which was much shorter than the 62(95%CI:57-66)months in the nourished group(P<0.001).In the adult group,the median survival decreased from 65(95%CI:55-72)months in nourished group to 34(95%CI:25-48)months in the patients with malnutrition(P<0.001).In the older group,it decreased from 61(95%CI:55-67)months to 48(95%CI:39-59)months(P=0.001).A Cox regression analysis showed that GLIM-diagnosed malnutrition was associated with an increased risk of death among adult group(HR=1.670,95%CI:1.29-2.16),older group(HR=1.332,95%CI:1.05-1.69)and overall(HR=1.453,95%CI:1.22-1.72).Conclusion All of these results demonstrate that GLIM-diagnosed malnutrition is associated with a poorer survival for all lung cancer patients,independent of age. | Fei Fei Chong Liang Yu Yin Jie Liu Na Li Jing Guo Yang Fan Meng Yuan Zhang Ling Zhang Xiu Mei He Hong Mei Zhang Mu Li Shi Wei Li Hong Xia Xu | 2022 | Journal of Nutritional Oncology2022，7，1： | 4 |
| 4 | The rs2227481 C>T Polymorphism in the IL22 Gene Promoter Significantly Reduces the Risk of Liver,Lung,and Gastric Cancer in a Han Chinese Population显示文摘Cancer is a serious threat to public health and the economy worldwide.Statistical data from the World Health Organization(WHO)in 2018 have demonstrated that lung cancer is the most commonly diagnosed cancer(11.6%of the total cases)and the leading cause of cancer death(18.4%of the total cancer deaths),closely followed bygastric cancer(5.7%and 8.2%),and liver cancer(4.7%and 8.2%). | CHAI Long Long XIAO Ying Xuan MENG Ling Han WANG Huan FENG Xian Hong GU Xiu Li LI Qi Chang XIONG Qian Tao CHEN Bi Feng | 2021 | Biomedical and Environmental Sciences2021，34，7： | 1 |
| 5 | Screening of Genes with Unique Mutations of Microcus显示文摘Yersinia pestis is the causative agent of bubonic and pneumonic plagues.Strains of Y.pestis are classified into four biovars:antiqua,mediaevalis,orientalis,and microtus[1].There are two microtus-related plague foci in China:the Microtus brandti plague focus in the Xilin Gol Grassland(focus L)and the Microtus fuscus plague focus in the Qinghai-Tibet Plateau(focus M).Microtus strains are avirulent to humans,and experiments have shown that strains isolated from Microtus brandti in Inner Mongolia are virulent | SHEN Xiao Na XIA Lian Xu HAI Rong LIANG Ying XU Dong Lei CAI Hong WANG Yu Meng ZHENG Xiao WANG Yan Hua ZHANG Zhi Kai WEI Jian Chun FU Xiu Ping ZHANG En Min ZHANG Hui Juan YU Dong Zheng | 2013 | Biomedical and Environmental Sciences2013，26，9： | 0 |
| 6 | Synthesis and in vitro activities on anti-platelet aggregation of N,N'-di(2-substituted-phenyl)-4-methoxyisophthalamides and benzene- 1,3-disulfonamides显示文摘在寻找 SAR 并且获得聚集药的新奇 antiplatelet 的propose 上,我们在衍生物的二个系列的 antiplatelet 聚集上在 vitro 描述了合成过程和这些活动,它包含两 18 N , 2 系列和九 N 的 N-di ( 2-substitutedphenyl ) -4-methoxyisophthalamides ( 2a2r ), 3 系列的 N-di ( 2-substitutedphenyl ) -4-methoxybenzene-1,3-disulfonamides ( 3a3i )。结果证明三混合物 2e, 2i 和 3g 作为 antiplatelet 聚集,到二参考药 picotamide 和阿司匹林的上级,和八混合物的重要活动出现了 2j, 2k, 2l, 2o, 2p, 2q, 2r 和比 picotamide 仅仅优异的 3i。2 系列经由取代者纳入了二个方面的位的阻碍者增加这些活动是有利的初步的 SAR 表演在 2 位置锁住苯戒指。并且 2 系列的 arylamides 更好比除了 3b 和 3g 各自的 3 系列的 arylsulfonamides 有活动价值。相反,静电的因素不显然作出贡献到二个系列的活动。15 混合物的结构最新综合了被 MS 和 1H NMR 建立了并且是首先在这份报纸报导了。 | Xiu Jie Liu Xin He Cheng Ling Shi Jie Meng Ying Lu Shao Hong Qiang Si Tao Hu | 2011 | Chinese Chemical Letters2011，22，10： | 0 |
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