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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway显示文摘背景 Ursolic 酸(UA ) 是在有在 vitro 并且在 vivo 被显示出的特定的 anticancer 效果的植物王国的一个无所不在的分子。尽管 UA 能禁止肝癌症房间的增长并且导致肿瘤房间的许多类型的 apoptosis,它的 anti-hepatoma 活动的分子的机制仍然不是明确的。这研究的目的是调查禁止的效果,人的 hepatoma 房间上的 UA 的机制衬里 SMMC-7721。在有 UA 的治疗以后的方法, SMMC-7721 细胞的生长抑制被 MTT 估计试金。在他们被 UA 劝诱以后,房间被流动 cytometric 分析,染色的 Wright-Giemasa, Hoechst 33258 染色和传播电子显微镜也评估。DNA microarray 技术被用来调查暴露于 UA 40 pmol/L 的 SMMC-7721 房间的基因表示模式。房间死亡的分子的机制被即时 RT-PCR 和西方的 blotting.Results 分析 SMMC-7721 房间的增长显著地在 UA 治疗以后在一个剂量依赖者和时间依赖者举止被禁止。UA 导致了房间周期拘捕和 apoptosis。DNA microarray 分析显示 64 基因被发现到,包括下面表示的 GDF15, SOD2, ATF3,和 fos 是显著地 up-expressed, 或。西方的弄污的结果显示出 apoptotic 蛋白质 p53,当 anti-apoptotic 蛋白质 Bcl-2 是 down-regulated.Real-time RT-PCR 时, Bax 是起来调整的证实的 UA 能起来调整 GDF15, SOD2, ATF3 和下面调整的 mRNA 表情 fos 的 mRAN 表示。同时,这些效果被预告的处理部分与 p53 小径的 p53 禁止者 Pft-.Conclusion 激活堵住涉及 SMMC-7721 人的 hepatocellular 癌房间生长和 apoptosis 的正式就职的 UA 抑制。 | YU Yan-xia GU Zhen-lun YIN Jiang-lin CHOU Wen-hsien KWOK Chi-yi QIN Zheng-hong LIANG Zhong-qin | 2010 | Chinese Medical Journal2010，，14： | 32 |
| 3 | Portosplenomesenteric vein thrombosis in patients with early-stage severe acute pancreatitis显示文摘AIM To investigate the incidence and risk factors of portosplenomesenteric vein thrombosis(PSMVT) in the early stage of severe acute pancreatitis(SAP).METHODS Patients with SAP in a tertiary care setting from January 2014 to December 2016 were retrospectively reviewed. All contrast-enhanced computed tomography(CT) studies were reassessed and reviewed. Clinical outcome measures were compared between SAP patients with and without PSMVT in the early stage of the disease. Univariate and multivariate logistic regression analyses were sequentially performed to assess potential risk factors for the development of PSMVT in SAP patients. A receiver operating characteristic(ROC) curve was generated for the qualifying independent risk factors.RESULTS Twenty-five of the one hundred and forty(17.86%) SAP patients developed PSMVT 6.19 ± 2.43 d after acute pancreatitis(AP) onset. PSMVT was confirmed by contrast-enhanced CT. Multivariate stepwise logistic regression analyses showed that Balthazar's CT severity index(CTSI) scores [odds ratio(OR): 2.742; 95% confidence interval(CI): 1.664-4.519; P = 0.000], hypoalbuminemia(serum albumin level < 25 g/L)(OR: 32.573; 95%CI: 2.711-391.353; P = 0.006) and gastrointestinal wall thickening(OR: 4.367, 95%CI: 1.218-15.658; P = 0.024) were independent risk factors for PSMVT developed in patients with SAP. The area under the ROC curve for Balthazar's CTSI scores was 0.777(P = 0.000), the sensitivity was 52%, and the specificity was 93% at a cut-off value of 5.5.CONCLUSION High Balthazar's CTSI scores, hypoalbuminemia and gastrointestinal wall thickening are independent risk factors for PSMVT developed in the early stage of SAP. | Ling Ding Feng Deng Chen Yu Wen-Hua He Liang Xia Mi Zhou Xin Huang Yu-Peng Lei Xiao-Jiang Zhou Yin Zhu Nong-Hua Lu | 2018 | World Journal of Gastroenterology2018，24，35： | 20 |
| 4 | A Possible Dynamic Mechanism for Rapid Production of the Extreme Hourly Rainfall in Zhengzhou City on 20 July 2021显示文摘In this study,the unprecedented extreme rainfall event during 19-20 July 2021,which caused devastating flooding in Zhengzhou City and its nearby areas,is examined based on observational data analysis and WRF model 40-h simulations on 1-km horizontal resolution.The results show that the model successfully reproduces(i)major synopticscale weather systems(i.e.,the western Pacific subtropical high,the Tibetan high,two typhoons,and the Huang-Huai cyclone),(ii)convective initiation along the east to north edge of the Songshan Mountain,where orographic lifting is obvious,and(iii)subsequent formation of the convective storm producing the extreme rainfall in Zhengzhou.In particular,the model generates the maximum rainfall rate of 233 mm h^(-1)and 40-h accumulated rainfall of 704 mm,corresponding well to the observed extreme values of 201.9 mm h^(-1)and 818 mm,at nearly observed timing and location.Importantly,the model reproduces an intense quasi-stationary,well-organized meso-γ-scale convective system,surrounded by an arc-shaped convergence zone,allowing the development of convective updrafts in a three-quarter circle around the convective system,in a way similar to“multidirectional pumping,”attracting all associated precipitation overlaid and concentrated into the same trailing region to generate the extreme hourly rainfall over Zhengzhou.Our study emphasizes the significant contribution of the unique dynamic structure of the well-organized meso-γ-scale convective system to the record-high hourly rainfall.A possible dynamic mechanism for short-time extreme rainfall production is proposed.That is,the arc-shaped convergence zone of the mesoscale convective system,acting like multidirectional lifting pumps,transports precipitation from different directions into the same region,and thus produces the extreme rainfall.The results gained herein may shed new light on better understanding and forecasting of short-time extreme rainfall. | Jinfang YIN Haodong GU Xudong LIANG Miao YU Jisong SUN Yanxin XIE Feng LI Chong WU | 2022 | Journal of Meteorological Research2022，36，1： | 17 |
| 5 | Global overview of research progress and development of precision maize planters显示文摘Maize is the most important crop for food and widely used for industrial materials,leading to its increasing demand all over the world.Precision planting is the effective method to increase maize yield.To meet the agronomic requirement of precision planting,different kinds of precision maize planters were developed.However,because of the difference of geographical environment,cropping system,farm scale and economic status among different countries,types of maize planters are various and the technologies involved are at different levels.This paper summarizes the precision maize planters currently available in the world and classifies them into four types:precision planters for tilled-land,minimum/no tilled-land,hilly&small land,and cold&arid land.Detailed characteristics have been provided for some typical precision planters and comparisons were made as to their suitability under particular working conditions.High-efficiency and high-accuracy are the main features of precision planters for tilled-land,while the ability to clean residue from seed rows and prevent planters to be blocked are the important function of precision planters for minimum/no tilled-land.To fit for hilly&small land,planters should be light-weighted and small-sized,and to warm up soil and keep moisture,planters for cold&arid land should be equipped with plastic-film mulching mechanism.Finally,developing trend of precision planting technology was analyzed and suggestions,including policy support and technical improvement,were made for developing countries to make suitable precision maize planters according to the local geographical conditions and cropping systems. | Yang Li Yan Bingxin Cui Tao Yu Yiming He Xiantao Liu Quanwei Liang Zhijie Yin Xiaowei Zhang Dongxing | 2016 | International Journal of Agricultural and Biological Engineering2016，9，1： | 17 |
| 6 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 7 | Environmental Factors Affecting Temporal and Spatial Dynamics of Soil Erosion in Xingguo County, South China显示文摘By using soil erosion maps of four different time periods and a digital elevation model (DEM), in combination withthe remote sensing and GIS technologies, soil erosion dynamics in Xingguo County of Jiangxi Province in South Chinawere analyzed on both temporal and spatial scales in soils of different parent materials, altitudes and slopes. The resultsshowed that from 1958 to 2000 severe soil erosion was coming under control with a decreasing percentage of the land undersevere erosion. It was also found that the soils developed from Quaternary red clay, granite and purple shale were moresusceptible to soil erosion and that areas sitting between 200 to 500 m in altitude with a slope less than 3° or between7° to 20° where human activities were frequent remained to be zones where soil erosion was most likely to occur. Theseareas deserve special attention in monitoring and controlling. | WANG Ku SHI Xue-Zheng YU Dong-Sheng SHI De-Ming CHEN Jing-Ming XU Bin-Bin LIANG Yin LI De-Cheng | 2005 | Pedosphere2005，15，5： | 12 |
| 8 | Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAa receptor and GABAergic neuron in corresponding nuclei显示文摘Propofol is the most commonly used intravenous anesthetic worldwide.It can induce loss of consciousness prior to the occurrence of severe respiratory suppression,which is also a pharmacodynamic feature of all general anesthetics.However,the neural mechanisms underlying this natural phenomenon are controversial and highly related to patient safety.In the present study,we demonstrated that the pharmacodynamic effects of propofol(50 and 100 μM)on suppression of consciousness-related excitatory postsynaptic currents in the medial prefrontal cortex(mPFC)and centromedian nucleus of the thalamus(CMT)were lower than those in the kernel respiratory rhythmogenesis nucleus pre-Botzinger complex(PrBo).Furthermore,we unexpectedly found that the GABAa receptor β3 subunit is the key target for propofol's action and that it is mutually and exclusively expressed in GABAergic neurons.It is also more abundant in the mPFC and CMT,but mainly co-localized with GABAergic neurons in the PrBo.As a result,the differentiated expression pattern should mediate more neuron suppression through the activation of GABAergic neurons in the mPFC and CMT at low doses of propofol(50 μM).However,PrBo GABAergic neurons were only activated by propofol at a high dose(100 μM).These results highlight the detailed pharmacodynamic effects of propofol on consciousness-related and respiration-related nuclei and provide the distinct interaction mechanism between the β3 subunit and GABAergic neurons in mediating the suppression of consciousness compared to the inhibition of respiration. | Junli Jiang Yingfu Jiao Po Gao Wen Yin Wei Zhou Yunchun Zhang Yanjun Liu Daxiang Wen Yuan Wang Liang Zhou Tian Yu Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 11 |
| 9 | Evaluation of a New Real-time PCR Assay for Detection of Mycoplasma Pneumoniae in Clinical Specimens显示文摘Objective To establish and evaluate a real-time PCR assay to detect Mycoplasma pneumoniae (M.pneumoniae) in clinical specimens.Methods By analysing the whole p1 gene sequence of 60 M.pneumoniae clinical isolates in Beijing of China,an optimized real-time PCR assay (MpP1) using p1 gene conserved region was designed.The specificity and sensitivity of this assay were evaluated and compared with other two reported assays (RepMp1 and Mp181) using 40 positive and 100 negative clinical specimens.Results The detection limit of the new assay was 8.1 fg (about 1~3CFU) M.pneumoniae DNA.The sensitivity of MpP1,RepMp1,and Mp181 assays appeared to be 100%,100%,and 85%,respectively.Conclusion MpP1 assay is suitable for the detection of M.pneumoniae in Chinese clinical specimens. | ZHAO Fei CAO Bin HE Li Hua YIN Yu Dong TAO Xiao Xia SONG Shu Fan MENG Fan Liang ZHANG Jian Zhong | 2012 | Biomedical and Environmental Sciences2012，25，1： | 11 |
| 10 | Cbl-b and PI3K/Akt pathway are differently involved in oxygen- glucose deprivation preconditioning in PC12 cells显示文摘 | Zhang Wei Yu Huan Zou Wei Wang Yan-fu Liang Xiao-feng Zhang Bo Kong Jing-jing Li Pai Zhang Duo-duo Yin Lin | 2013 | Chinese Medical Journal2013，，21： | 10 |
| 11 | Stearic acid protects primary cultured cortical neurons against oxidative stress显示文摘瞄准:对氧化压力 inprimary 观察硬脂的酸的效果有教养的外皮的 neurons.Methods:外皮的神经原当面暴露于 glutamate , hydrogenperoxide ( H2O2 ),或 NaN3 侮辱或 corticalneurons 的硬脂的 acid.Cell 生存能力的缺席被 MTT 试金和 LDH release.Endogenous 抗氧化剂 enzymesactivity 决定[ superoxide dismutases (草皮),谷胱甘肽 peroxidase ( GSH-Px ),并且过氧化氢酶(猫)]并且在有教养的外皮的神经原的 lipidperoxidation 用 commercialkits 被评估{3-[ 1 ( p-chloro-benzyl ) -5-(isopropyl)-3-t-butylthiondol-2-yl]-2,2-dimethylpropanoic 酸, Na }[ MK886 ; 5 m 硬脂的酸 dose-dependently 保护了外皮的 neuronsagainst glutamate 或 H2O2 损害并且在有教养的外皮的 neurons.Its neuroprotective 效果在有教养的 neurons.This protectionwas 伴随物增加了 glutamate 举起到类脂化合物 peroxidation 的抑制并且到 Cu/Zn SODand 猫的提升活动被 BADGEand CHX.After 孵化完全为 24 h 与 H2O2 堵住, PPAR gamma 蛋白质的表示 decreasedsignificantly ( P > 0.05 ),并且前上的 H2O2 的禁止的效果硬脂的酸能由增加内部抗氧化剂 enzymes.Its neuroprotective 效果保护外皮的神经原免于 oxidativestress 可以在外皮的神经原是由 PPAR gamma 和新蛋白质合成的激活的 mainlymediated。 | Ze-jian WANG Cui-ling LIANG Guang-mei LI Cai-yi YU Ming YIN | 2007 | Acta Pharmacologica Sinica2007，28，3： | 9 |
| 12 | Hepatitis B virus induces expression of cholesterol metabolism-related genes via TLR2 in HepG2 cells显示文摘AIM:To investigate whether hepatitis B virus(HBV) exacerbates hepatic cholesterol accumulation,and explore the underlying mechanisms.METHODS:HepG2 cells were infected with adenovirus(Ad) containing 1.3-fold overlength HBV genome.Realtime polymerase chain reaction and Western blotting were used to measure mRNA and protein expression of target genes.Cholesterol accumulation was measured by fluorescence microscopy.Cell toxicity due to Ad-HBV treatment was determined by the mitochondrial tetrazolium assay.The protein levels of toll-like receptors(TLRs) were determined by Western blotting.RESULTS:Ad-HBV increased hepatic cholesterol accumulation and enhanced the mRNA and protein levels oflow-density lipoprotein receptor(LDLR) and 3-hydroxy3-methylglutharyl-coenzyme A reductase(HMGCoAr) mRNA and protein expression in HepG2 cells.In addition,these inductive effects were partly offset by suppressing TLR2 expression levels by small interfering RNA in HepG2 cells.CONCLUSION:Ad-HBV increases LDLR and HMGCoAr expression,resulting in exacerbated cholesterol accumulation in HepG2 cells,which was mediated via the TLR2 pathway. | Ying-Ju Li Ping Zhu Yu Liang Wei-Guo Yin Jian-Hua Xiao | 2013 | World Journal of Gastroenterology2013，19，14： | 8 |
| 13 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 14 | Physical design of target station and neutron instruments for China Spallation Neutron Source显示文摘The China Spallation Neutron Source(CSNS)is the first accelerator-based multidiscipline user facility to produce pulsed neutrons by tungsten target under collision of a pulsed proton beam with a beam power of 100 kW at a repetition rate of 25 Hz.In this paper,we focus on the physical design of CSNS target station and neutron instruments.Under optimized design,the flat tungsten target and the compact target-moderator-reflector coupling enhance effective cold and thermal neutron output from moderators.Three wing-type moderators supply four different characteristics of neutrons to 19 beamlines primarily for neutron scattering applications.Layout of neutron instruments are conceptually planned for total 20 beamlines,the configuration and specification have been determined for three day-one neutron instruments.All designs are optimized for the Phase I of 100 kW with a upgradable capacity to 500 kW. | WANG FangWei LIANG TianJiao YIN Wen YU QuanZhi HE LunHua TAO JuZhou ZHU Tao JIA XueJun ZHANG ShaoYing | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，12： | 7 |
| 15 | The Relationship between Polymorphisms at 17 Gene Sites and Hypertension among the Aboriginal Tibetan People显示文摘Objective The incidence of hypertension in Tibet ranks highest among all Chinese provinces. This may be due to genetic changes caused by Tibet's unique natural environment and agrarian lifestyle, prompting us to investigated the relationship between gene polymorphisms and hypertension. Methods Blood samples were collected from 229 hypertensive participants and 372 healthy (control) participants from five Tibetan counties. Seventeen single nucleotide polymorphisms were investigated for their connection to hypertension. Results The C allele at rs2070744 of the NOS3 gene was shown to be significantly associated with hypertension (P=0.0443; OR=1.636). Additionally, the T allele of rs4961 of the ADD gene was correlated with hypertension in women (P=0.03124; OR=1.584). Conclusion In this study we found that the NOS3 and ADD genes were related to a high incidence of hypertension among Tibetans. NOS3 gene plays a role in regulating vascular tone and blood vessel diameter, which may be altered by the low-oxygen environment of Tibet. ADD is involved in water and salt metabolism, which is consistent with the high-salt diet of Tibetans. The correlations elucidated by our study were different from those of other ethnic groups, indicating that these findings may be specific to the Tibetan people. | LI Kui LIANG Yu SUN Yin ZHANG Ling Xia YI Xin CHEN Yong GU SANG LA MU WANG Jian | 2012 | Biomedical and Environmental Sciences2012，25，5： | 6 |
| 16 | The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST显示文摘As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,respectively.The maximum exposure time can be up to20 s due to precise pointing and image stabilization function.Among the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal imaging.We present the up-to-date design for the LST payload. | Bo Chen Hui Li Ke-Fei Song Quan-Feng Guo Pei-Jie Zhang Ling-Ping He Shuang Dai Xiao-Dong Wang Hai-Feng Wang Chun-Long Liu Hong-Ji Zhang Guang Zhang Yunqi Wang Shi-Jie Liu Hong-Xin Zhang Lei Liu Shi-Lei Mao Yang Liu Jia-Hao Peng Peng Wang Liang Sun Yang Liu Zhen-Wei Han Yan-Long Wang Kun Wu Guang-Xing Ding Peng Zhou Xin Zheng Ming-Yi Xia Qing-Wen Wu Jin-Jiang Xie Ya Chen Shu-Mei Song Hong Wang Bo Zhu Chang-Bo Chu Wen-Gang Yang Li Feng Yu Huang Wei-Qun Gan Ying Li Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li Ying Ming-Zhe Sun Cheng Zhu Wei-Min Bao Lei Deng Zeng-Shan Yin | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 6 |
| 17 | A study of the ameliorating effects of carnitine on hepatic steatosis induced by total parenteral nutrition in rats显示文摘INTRODUCTIONLongtermtotalparenteralnutrition(TPN)canfrequentlyleadtothedevelopmentofhepaticsteatosis.Althoughitsincidencehas... | LIANG Li Jian, YIN Xiao Yu, LUO Shi Min, ZHENG Jin Fang, LU Ming De and HUANG Jie Fu | 1999 | World Journal of Gastroenterology1999，5，4： | 6 |
| 18 | Adipocyte-derived SFRP5 inhibits breast cancer cells migration and invasion through Wnt and epithelial-mesenchymal transition signaling pathways显示文摘Objective:Obesity is closely associated with metastasis in breast cancer patients.Secreted frizzled-related protein 5(SFRP5),one of the novel adipokines with anti-inflammatory properties,is associated with obesity.This study aims to study the role of SFRP5 in the crosstalk between obesity and breast cancer metastasis and identify the underlying mechanism.Methods:3T3-L1 pre-adipocytes were differentiated to mature adipocytes and a hypertrophic adipocyte model was induced with palmitic acid(PA).Cell motility was measured in MDA-MB-231 and MCF-7 breast cancer cells co-cultured with adipocytes conditioned medium(CM)with or without SFRP5 protein.Wnt and epithelialmesenchymal transition(EMT)signal pathways were investigated by western blot.Circulating SFRP5 level in 218 breast cancer patients and the association with clinicopathologic characteristics of breast cancer were further determined.Online databases ENCORI and PREDICT Plus were used to exam the link between SFRP5 and prognosis.Results:Reduced SFRP5 level was detected in the hypertrophic adipocyte model.Recombinant SFRP5 protein inhibited MDA-MB-231 and MCF-7 cells invasion and migration induced by PA-treated adipocyte CM,and SFRP5 inhibition by specific antibody reversed the effect of SFRP5.Furthermore,SFRP5 significantly inhibited Wnt and downstream EMT in breast cancer cells.Low circulating SFRP5 level correlated with body mass index(BMI),lymph node(LN)metastasis,TNM stage and high Ki67 expression in breast cancer patients.Increased SFRP5 level was associated with favorable predicted survival.Kaplan-Meier curves showed high SFRP5 level in tumor tissue was associated with better outcome of breast cancer patients.Conclusions:Our findings demonstrated SFRP5 is a vital adipokine that mediates the crosslink between obesity and the metastatic potential of breast cancer.Promotion of SFRP5 expression in the adipose microenvironment may represent a novel approach for preventing breast cancer metastasis. | Wenzhong Zhou Chunmiao Ye Liang Li Liyuan Liu Fei Wang Lixiang Yu Fei Zhou Yujuan Xiang Yongjiu Wang Gengshen Yin Zhongbing Ma Qinye Fu Qiang Zhang Dezong Gao Shuya Huang Zhigang Yu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 5 |
| 19 | Study on a New Ultraviolet Sterilizer to the Surface Disinfection of the Ultrasound Probe显示文摘我们学习了消毒效果一新紫外(紫外) 超声探查上的 sterilizer 和它的利用出现。搬运人量的杀菌测试,模仿的即席试用,和有机物质影响测试被用来执行试验性的观察。人工地感染的探针为比较用 sterilizer 或一盏杀菌的灯被消毒。细菌的全部的数字和类型坚定、识别。我们的结果证明 sterilizer 在医院里在三个不同消毒方法之中有最好的消毒效果。sterilizer 没有超声探查仪器的著名损坏在一个医院背景被使用 2 年了。它有快消毒,高消毒效果,和与超声仪器的好相容性的优点,值得是在医药机构的支持的应用。 | CHEN Gui Qiu CHEN Yu Hao YI Liang YIN Jin GAO Qiong SONG Jiang Nan LI Shi Kang CHEN Pei Hou GUO Gui Ping | 2018 | Biomedical and Environmental Sciences2018，31，2： | 5 |
| 20 | Neutron-induced apoptosis of HR8348 cells in vitro显示文摘INTRODUCTIONTo date ,the major therapy for rectal carcinoma is extensive abdomino-perineal resection[1]. Unfortunately ,after resection of rectal carcinoma ,many patients still die of blood-borne metastases ,usually in the liver or lungs ,or local prlvic recurrence[2,3],which is the major cause of morbidity and mortality in patients with rectal carcinoma .Pre-or postoperative radiotherapy can reduce the incidence of local rdcurrence[4-7]. | Li Ping Wang~1 Ke Liang~2 Yu Shen~2 Wei Bo Yin~2 G.Hans~3 Yan Jun Zeng~1 ~1Biomechanics & Medical Information Institute,Beijing Polytechnic University,Beijng 100022,China ~2Department of Gastrointestinal Surgery,Aalborg University,Denmark ~3Cancer Institute (Hospital),Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100021,ChinaLi Ping Wang graduated from Beijing Polytechnic University in 2000,major in tumor radiotherapy,having 3 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 5 |
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