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| 1 | Differential expression of serum miR-126,miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancer显示文摘Objective:MicroRNAs(miRNAs) have potential as diagnostic biomarkers in cancer.Evaluation of the association between miRNA expression patterns and early detection of liver metastasis in colorectal cancer(CRC) has not been reported.Methods:We investigated the expression of metastasis-associated miRs-31,335,206,141,126,200b,200c,21,Let7a,Let7b and Let7c in localized,liver-metastatic and other organ-metastatic CRC(OM-CRC).Expressions of target miRNAs in serum were evaluated in 116 consecutive localized CRC(L-CRC),72 synchronous liver-metastatic CRC(SLM-CRC) and 36 other OM-CRC by quantitative real-time PCR.Results:Seven of 11 tested miRNAs could be detected from serum.Four miRNAs,miR-126,Let-7a,miR-141 and miR-21 were identified as metastasis-associated miRNAs.Compared with L-CRC,significant upregulated expression was observed for miR-141 and miR-21 in SLM-CRC and OM-CRC,down-regulated expression was observed for miR-126 in SLM-CRC and OM-CRC,and up-regulated expression of Let-7a in OM-CRC.The receiver operating characteristic(ROC) curve showed serum miR-126 had a cut-off [log 10 relative quantity(log 10 RQ)=–0.2005] with 77.78% sensitivity and 68.97% specificity with an area under curve(AUC) of 0.7564,miR-141 had a cut-off(log 10 RQ=–0.2285) with 86.11% sensitivity and 76.11% specificity with an AUC of 0.8279,and miR-21 had a cut-off(log 10 RQ=–0.1310) with 73.61% sensitivity and 66.38% specificity with an AUC of 0.7479.Conclusions:We identified liver metastasis-associated miRNAs,suggesting serum miR-126,miR-141 and miR-21 may be novel biomarkers for clinical diagnosis of early stage liver-metastatic CRC. | Jie Yin Zhigang Bai Jianning Song Yun Yang Jin Wang Wei Han Jun Zhang Hua Meng Xuemei Ma Yao Yang Tingting Wang Weirong Li Zhongtao Zhang | 2014 | Chinese Journal of Cancer Research2014，26，1： | 22 |
| 2 | Cloning and Characterization of miRNAs and Their Targets, Including a Novel miRNA-Targeted NBS-LRR Protein Class Gene in Apple (Golden Delicious)显示文摘MicroRNA (miRNA ) 在植物作为基因表示的一个重要管理者出现了。146 miRNAs 从苹果被识别(Malus domestica cv。金色美味) 由定序的生物信息的分析和 RNA 图书馆。从这些, 135 被保存, 11 是新奇 miRNAs。目标分析预言了新奇 miRNAs 之一, Md-miRLn11 (Malus domestica microRNA Ln11 ) ,指向了一个苹果核苷酸绑定地点(NBS ) 充满白氨酸的重复(LRR ) 班蛋白质编码基因(Md-NBS ) 。5 赛跑试金证实了 Md-miRLn11 的能力在 1112-nt 位置劈开 Md-NBS。Md-miRLn11 和 Md-NBS 的表示的分析在在 40 个苹果变化的最佳侵略时期期间证明在抵抗变化的 Md-NBS 基因的表示比在易受影响的变化高,与为 Md-miRLn11 的一个反的模式。从抵抗苹果变化 JiGuan 的幼苗被用来执行 Agrobacterium 渗入试金,然后与苹果叶点疾病接种。结果在 JiGuan 苹果显示出疾病抵抗的清楚的衰落。相反,与 Md-NBS 基因渗入的易受影响的变化富士在疾病抵抗显示出重要增加。基于上述结果,我们建议 Md-miRLn11 特别地在病原体感染的条件下面调整 Md-NBS 基因表示,并且指向 P 环地点的 Md-miRLn11 可以在木质的植物调整许多 NBSLRR 蛋白质类基因。 | Chao Ma You Lu Songlin Bai Wennan Zhang Xuwei Duan Dong Meng Zhigang Wang Aide Wang Zongshan Zhou Tianzhong Li | 2014 | Molecular Plant2014，7，1： | 19 |
| 3 | Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice显示文摘Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation. | Jiachang Wang Yulong Ren Xi Liu Sheng Luo Xiao Zhang Xin Liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu Zhang Bin Lei Chunlei Zhou Tian Pan Yongfei Wang Mingming Wu Ruonan jing Yang Xu Meng Han Fuqing Wu Cailin Lei Xiuping Guo Zhijun Cheng Xiaoming Zheng Yihua Wang Zhigang Zhao Ling Jiang Xin Zhang Yong-Fei Wang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 10 |
| 4 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 5 | Principles of the roof cut short-arm beam mining method (110 method) and its mining-induced stress distribution显示文摘Since the 1960 s, mining science and technology in China has experienced two technical innovations, i.e.the ‘‘Masonry Beam Theory(MBT)' and ‘‘Transfer Rock Beam Theory(TRBT)'. Based on those theories, the conventional mining method(being called the 121 mining method) was established, consisting of excavating two tunnels with a pillar left for mining a working panel. However, with increasing mining depth,engineering geological disasters in the underground caverns have been frequently encountered. In addition, the use of the coal-pillar mining results in a large amount of coal resources unexploited. In order to address the problems above, the ‘‘Roof Cut Short-Arm Beam Theory(RCSBT), being called the 110 mining method)' was proposed by He Manchao in 2008. The 110 mining method features the mining of one coal seam panel, excavating necessarily only one roadway tunnel and leaving no pillars. Realization of the 110 mining method includes the following steps:(1) directional pre-splitting roof cutting,(2) supporting the roof by using high Constant Resistance Large Deformation bolt/cable(CRLD), and(3) blocking gangue by hydraulic props. This paper presents an overview of the principles, techniques and application of the 110 mining method. Special emphasis is placed on the numerical simulation of the geostress distribution found in the mining panel using the 110 method compared to that of the 121 method. In addition, the stress distribution on the ‘‘short beam' left by the roof cutting when performing the 110 method was also investigated using both numerical simulation and theoretical formulation. | Tao Zhigang Song Zhigang He Manchao Meng Zhigang Pang Shihui | 2018 | International Journal of Mining Science and Technology2018，28，3： | 8 |
| 6 | Characteristics of the Seismic Waves from a New Active Source Based on Methane Gaseous Detonation显示文摘Active seismic sources are critical for obtaining high resolution images of the subsurface.For active imaging in urban areas,environment friendly and green seismic sources are required.In present work,we introduce a new type of green active source based on the gaseous detonation of methane and oxygen.When fired in a closed container,the chemical reaction,i.e.gaseous detonation,will produce high pressure air over 150 MPa.Seismic waves are produced when high pressure air is quickly released to impact the surroundings.The first field experiment of this active source was carried out in December,2017 in Jingdezhen,Jiangxi Province,where a series of active sources were excited to explore their potential in mine exploration.In current work,we analyzed the seismic waves recorded by near-field accelerators and a dense short-period seismic array and compared them with those from a mobile airgun source,another kind of active source by releasing high pressure air into water.The results demonstrate that it can be used for high resolution near surface imaging.Firstly,the gaseous detonation productions are harmless CO2 and water,making it a green explosive source.Secondly,the dominant seismic frequencies are 10-80 Hz and a single shot can be recorded up to 15 km,making it suitable for local structure investigations.Thirdly,it can be excited in vertical wells,similar to traditional powder explosive sources.It can also act as an additional on-land active source to airgun sources,which requires a suitable water body as intermediate media to generate repeating signals.Moreover,the short duration and high frequency signature of the source signals make it safe with no damage to nearby buildings.These make it convenient to excite in urban areas.As a new explosive source,the excitation equipment and conditions,such as gas ratio,sink depth and air-releasing directions,need further investigation to improve seismic wave generation efficiency. | WANG Weitao WANG Xiang MENG Chuanmin DONG Shi WANG Zhigang XIE Junju WANG Baoshan YANG Wei XU Shanhui WANG Tao | 2019 | Earthquake Research in China2019，33，2： | 6 |
| 7 | Viscous-Flow-Based Analysis of Wave Near-Trapped in a Four-Cylinder Structure显示文摘The hydrodynamic analysis of multi-floating bodies is important and widely used in marine engineering. In this study, we systematically simulated the wave diffraction problem of a fixed vertical four-cylinder structure in regular waves in the time domain in a viscous numerical wave tank. The hydrodynamic interaction of waves with a bottom-mounted structure consisting of four vertical cylinders arranged at the corners of a square shows a complicated interference phenomenon. In this paper, we illustrate and analyze the run-up around the structure and the corresponding wave forces. To investigate the viscous effect on the near-trapping phenomenon, we pay particular attention to investigating the waves near-trapped inside the four-cylinder structure,and make a comparative study of the viscous-and inviscid-flow solutions with the experimental measurements. The results show that the maximum wave elevation occurs on the inner side of the leeside cylinder, and that the wave elevations on the outer side of the cylinders are lower than those on the inner side. We can conclude that viscosity has an obvious damping effect on wave elevations inside the structure. The cylinders show a tendency to drift apart from each other when the near-trapping phenomenon occurs. | Zhengke Wang Guanghua He Zhigang Zhang Yanghan Meng | 2018 | Journal of Marine Science and Application2018，17，3： | 5 |
| 8 | Synthesis of Poly (3-acetylpyrrolyl methine) with Azobenzene Side Groups and Study on Its Third-order Nonlinear Optical Property显示文摘A novel soluble 7r-conjugated polymer, poly [(3-acetylpyrrole-2, 5-diyl) p-(N, N-dimethylamino) azobenzylidene] (PA-PDMAABE), was synthesized by condensation of 3-acetylpyrrole with 4-aldehyde-4’-dimethylaminoazobenzene (AD-MAA). The chemical structure of PAPDMAABE was characterized by Fourier transform infrared spectroscopy (FTIR),1H-NMR, and UV-Vis-NIR spectra. Transmission electron microscope (TEM) analysis for PAPDMAABE indicatesthat part of PAPDMAABE is in crystal state, due to the short-range order of the polymer. Thermogravimetric analy-sis (TGA) curve shows that the polymer has good thermal stability and its decomposition temperature is 248°C. Theoptical band gap of PAPDMAABE obtained from the optical absorption spectrum is about 1.73 eV. The resonantthird-order nonlinear optical property of PAPDMAABE at 532 nm was studied using degenerate four-wave mixing(DFWM) technique. The resonant third-order nonlinear optical susceptibility of the polymer is about 7.48×10-8 esu. | Zhigang ZHANG Hongcai WU Lingjie MENG Wenhui YI | 2005 | Journal of Materials Science & Technology2005，21，5： | 4 |
| 9 | Materials Experiment on Tiangong-2 Space Laboratory显示文摘During the China's Tiangong-2(TG-2) flight mission, the experiments of 18 kinds of material samples were conducted in space by using a Multiple Materials Processing Furnace(MMPF) mounted in the orbital module of the TG-2 space laboratory. After the experiments of 12 kinds of samples of the first and second batches were completed successfully, astronauts packed and brought them back to the ground by ShenzhouII spacecraft. By studying processing and formation on semiconductor and optoelectronics materials, metal alloys and metastable materials, functional single-crystal, micro-and nano-composite materials encapsulated in sample ampoules both in space and on Earth, we expect to explore some physical and chemical processes and mechanism of the materials formation that are normally obscured and therefore are difficult to study quantitatively on the ground due to the gravity-induced convection, to obtain the processing and synthesis technology for preparing high quality materials, and lead to the improvement and development of materials processing techniques on Earth, and also develop the experiment device and comprehensive ability for materials experiment in microgravity environment. This report briefly introduces the main points of each research work and preliminary comparative analysis results of 12 samples carried out by scientists undertaking research task. | LI Xiangyang LU Ye MENG Xiangjian WANG Jianlu WANG Reng CHEN Lidong HUA Zile LI Xiaoya SHI Jianlin LIU Jinfeng XU Guisheng WEI Bingbo XIE Wenjun YIN Zhigang ZHANG Xingwang JIANG Hongxiang LI Hong LUO Xinghong ZHANG Haifeng ZHAO Jiuzhou WANG Binbin PAN Mingxiang | 2018 | 空间科学学报2018，38，5： | 4 |
| 10 | Bt protein expression in the transgenic insect-resistant cotton in China显示文摘According to statistics of International Service for the Acquisition of Agri-biotech Applications(ISAAA),18million farmers in 28 countries planted more than 181million hectares of genetically modified(GM)crops in2014,at an annual growth rate of between 3%–4%,with6.3 million ha more than 2013[1].Among these counties,China ranks the sixth with 3.9 million ha.Globally,27kinds of transgenic crops have been approved.The four main food groups for which GM varieties are | Guoqing Sun Dongling Zhang Rui Zhang Yuan Wang Zhigang Meng Tao Zhou Chenzhen Liang Tao Zhu Sandui Guo | 2016 | Science Bulletin2016，61，20： | 3 |
| 11 | Energetic electrons associated with magnetic reconnection in the sheath of interplanetary coronal mass ejection显示文摘Magnetic reconnection is an important universal plasma dissipation process that converts magnetic energy into plasma thermal and kinetic energy,and simultaneously changes the magnetic field topology.In this paper,we report the first observation of energetic electrons associated with asymmetric reconnection in the sheath of an interplanetary coronal mass ejection.The magnetic field shear angle was about 151°,implying guide-field reconnection.The width of the exhaust was about 8×104 km.The reconnection rate was estimated as 0.044-0.08,which is consistent with fast reconnection theory and previous observations.We observed flux enhancements of energetic electrons with energy up to 400 keV in this reconnection exhaust.The region where ener- getic electron fluxes were enhanced is located at one pair of separatrices in the higher density hemisphere.We discuss these observation results,and compare with previous observations and recent kinetic simulations. | HUANG ShiYong DENG XiaoHua ZHOU Meng YUAN ZhiGang LI HuiMin WANG DeDong | 2012 | Chinese Science Bulletin2012，57，12： | 3 |
| 12 | Influenza A Virus(H1N1) Infection Induces Glycolysis to Facilitate Viral Replication显示文摘Viruses depend on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. In this study, we observed that influenza A virus(H1N1), a single-stranded, negative-sense RNA virus with an eight-segmented genome, enhanced glycolysis both in mouse lung tissues and in human lung epithelial(A549) cells. In detail, the expression of hexokinase 2(HK2), the first enzyme in glycolysis, was upregulated in H1N1-infected A549 cells,and the expression of pyruvate kinase M2(PKM2) and pyruvate dehydrogenase kinase 3(PDK3) was upregulated in H1N1-infected mouse lung tissues. Pharmacologically inhibiting the glycolytic pathway or targeting hypoxia-inducible factor 1(HIF-1), the central transcriptional factor critical for glycolysis, significantly reduced H1N1 replication, revealing a requirement for glycolysis during H1N1 infection. In addition, pharmacologically enhancing the glycolytic pathway further promoted H1N1 replication. Furthermore, the change of H1N1 replication upon glycolysis inhibition or enhancement was independent of interferon signaling. Taken together, these findings suggest that influenza A virus induces the glycolytic pathway and thus facilitates efficient viral replication. This study raises the possibility that metabolic inhibitors, such as those that target glycolysis, could be used to treat influenza A virus infection in the future. | Lehao Ren Wanju Zhang Jing Zhang Jiaxiang Zhang Huiying Zhang Yong Zhu Xiaoxiao Meng Zhigang Yi Ruilan Wang | 2021 | Virologica Sinica2021，36，6： | 3 |
| 13 | Increased lateral root formation by CRISPR/Cas9-mediated editing of arginase genes in cotton显示文摘Dear Editor,Proper development of plant roots is critical for primary physiological functions,including water and nutrient absorption and uptake,physical support,and carbohydrate storage(Zhang et al.,2010).Crop root systems act as the key organ for sensing and response to abiotic and biotic stresses.Previous studies of crop root system development suggest that increased lateral root formation(LRF)could | Yanling Wang Zhigang Meng Chengzhen Liang Zhaohong Meng Yuan Wang Guoqing Sun Tao Zhu Yongping Cai Sandui Guo Rui Zhang Yi Lin | 2017 | Science China(Life Sciences)2017，60，5： | 3 |
| 14 | Taking advantage of glass:capturing and retaining the helium gas on the moon显示文摘Helium-3(3He)is a noble gas that has critical applications in scientific research and promising application potential as clean fusion energy.It is thought that the lunar regolith contains large amounts of helium,but it is challenging to extract because most helium atoms are reserved in defects of crystals or as solid solutions.Here,we find large amounts of helium bubbles in the glassy surface layer of ilmenite particles that were brought back by the Chang’E-5 mission.The special disordered atomic packing structure of glasses should be the critical factor for capturing the noble helium gas.The reserves in bubbles do not require heating to high temperatures to be extracted.Mechanical methods at ambient temperatures can easily break the bubbles.Our results provide insights into the mechanism of helium gathering on the moon and offer guidance on future in situ extraction. | Ao Li Xiao Chen Lijian Song Guoxin Chen Wei Xu Juntao Huo Meng Gao Ming Li Lei Zhang Bingnan Yao Min Ji Yan Zhang Shaofan Zhao Wei Yao Yanhui Liu Jun-Qiang Wang Haiyang Bai Zhigang Zou Mengfei Yang Weihua Wang | 2022 | Materials Futures2022，1，3： | 2 |
| 15 | Electron dynamics and wave activities associated with mirror mode structures in the near-Earth magnetotail显示文摘We report the observation of mirror mode structures by Cluster spacecraft at around X^-16 RE in the Earth’s magnetotail.The wavelength of the mirror structure is larger than 7000 km,corresponding to tens of ion gyroradii.Features of the mirror structures are similar to those detected in the magnetosheath:the anti-correlation between the magnetic field strength and plasma density,zero phase velocity in the plasma rest frame and linear polarization.The structures were observed in a region bounded by two dipolarizations during a substorm intensification.Thus,the dipolarization process may provide a plasma condition facilitating the growth of the mirror mode structures.Another interesting feature is the electron dynamics within the mirror structures.Thermal electron energy flux has an enhancement at 0°and 180°pitch angles inside the magnetic dips of the first three mirror structures and an enhancement at 90°pitch angle inside the magnetic dip of the last structure.The different electron distribution inside the mirror structures might be a result of different evolution stages of the mirror wave.The last structure may be in the nonlinear stage of the mirror instability,whereas the three others with quasi-sinusoidal waveforms may be in the linear stage.In addition,we found that intense whistler waves were confined within the magnetic dips.We conjecture that whistler waves observed in the first three dips were generated in a remote region,then they were trapped in the mirror mode troughs and transported toward the spacecraft;while the whistler wave detected in the last dip was excited locally by the electron anisotropy instability. | LI HuiMin ZHOU Meng DENG XiaoHua YUAN ZhiGang HUANG ShiYong | 2014 | Science China(Technological Sciences)2014，57，8： | 2 |
| 16 | Three-layer phosphorene-metal interfaces显示文摘Phosphorene 最近由于它的高级搬运人活动性和悦耳的直接 bandgap 在电子的 nanoscale 和 optoelectronic 设备作为其他的隧道材料吸引了许多注意。与单层(ML ) 相比 phosphorene,很少层(FL ) phosphorene 更容易准备,在实验是更稳定的,并且被期望在 phosphorene 金属接口形成更小的 Schottky 障碍高度(SBH ) 。用 ab initio ,电子结构计算和量搬运模拟,我们执行界面的性质的系统的研究三层( 3L ) phosphorene 领域效果晶体管(联邦货物税)与几普通金属联系了(艾尔, Ag , Au , Cu , Ti , Cr , Ni ,并且 Pd )第一次。从投射乐队在垂直方向获得的 SBH 3L phosphorene 金属系统组织到左 bilayer (2L ) phosphorenes 是可比较的,那些为 2L phosphorene 联邦货物税从量运输模拟在侧面的方向获得了。当分别地, Ag 和 Cu 被用作电极,p类型 Schottky 与 0.05 的洞 SBH 联系时,为 3L phosphorene 联邦货物税的量运输模拟证明 3L phosphorene 在侧面的方向与 0.16 和 0.28 eV 的电子 SBH 形成n类型 Schottky 接触, 0.11 , 0.20 ,在侧面的方向的 0.30 , 0.30 ,和 0.31 eV 当 Cr , Pd , Ni , Ti ,艾尔,和 Au 分别地被用作电极时。3L phosphorene 联邦货物税的计算极性和 SBH 通常与可得到的实验一致。 | Xiuying Zhang Yuanyuan Pan Meng Ye Ruge Quhe Yangyang Wang Ying Guo Han Zhang Yang Dan Zhigang Song Jingzhen Li Jinbo Yang Wanlin Guo Jing Lu | 2018 | Nano Research2018，11，2： | 2 |
| 17 | Photochemical alteration of biogenic particles in wastewater effluents显示文摘Biogenic particles discharged by wastewater treatment plants play important roles in receiving water because of the large specific surface area and good mobility of the particles. In this study, the changes induced in biogenic particles by natural sunlight were investigated to understand the phototransformation of the particles in the receiving waters. The results showed that photoexposure resulted in significant decreases in the sizes of the biogenic particles but that photoexposure did not impact the zeta potentials. In addition, the photodissolution of biogenic particulate organic matter(POM) led to the generation of biogenic dissolved organic matter(DOM). Characterization using excitation–emission matrix(EEM) spectroscopy showed that photoexposure changed both the shapes and the intensities of the EEM spectra of the biogenic POM; the regions of the T1 and T2 peaks were susceptible to photoexposure. Modeling by parallel factor analysis(PARAFAC) decomposed the EEMs of the biogenic POM into four valid components, i.e., terrestrial or microbial humic-like substances, tryptophan-like proteins, tyrosinelike proteins and hydrophobic proteins. The humic-like substances in the biogenic POM from the effluents were subject to lower decreases(17.0 % and 11.6 %).Throughout the entire incubation time, the PARAFAC components in the biogenic DOM were dominated by elimination mechanisms rather than by production through photodissolution of the biogenic POM. | Xiaofang Yang Zengquan Li Fangang Meng Zhigang Wang Li Sun | 2014 | Chinese Science Bulletin2014，59，28： | 2 |
| 18 | Photonic engineering of superbroadband near-infrared emission in nanoglass composites containing hybrid metal and dielectric nanocrystals显示文摘Photonic media containing hybrid noble metal-dielectric nanocrystals(NCs)represent a wonderland of nanophotonics,with a myriad of uncharted optical functions yet to be explored.Capitalizing on the unique phase separation and spontaneous formation of Au-metal NCs in a gallosilicate glass,we fabricated Ni^2+-doped transparent nanoglass composites(GCs)containing Au-metal/γ-Ga2O3-dielectric NCs.Compared with GCs free of Au-metal NCs,the super broadband near-infrared emission of Ni^2+with a full width at half-maximum over280 nm is enhanced twice in the Au-metal/γ-Ga2O3 dual-phase GCs.A comparison is given as to the spontaneous emission(SPE)properties of Ni^2+in the dual-phase GCs when pumped resonantly and off-resonantly with the localized surface plasmon resonance band of the Au-metal NCs.The important role of the Au-metal NCs in the SPE enhancement is revealed by theoretical simulation based on the finite-element method.Combining the photonic engineering effect of hybrid Au-metal/γ-Ga2O3 NCs and the sensitization effect of Yb^3+on Ni^2+,a record-high enhancement factor of over 10 of the Ni^2+NIR emission is achieved,and optical gain is demonstrated in the GCs at the fiber communication wavelength. | ZHIGANG GAO HAIBO ZHU BOCHAO SUN YINGKE JI XIAOSONG LU HAO TIAN JING REN SHU GUO JIANZHONG ZHANG JUN YANG XIANGENG MENG KATSUHISA TANAKA | 2020 | Photonics Research2020，8，5： | 2 |
| 19 | Noninvasive Ultrasound Stimulation of Ventral Tegmental Area Induces Reanimation from General Anaesthesia in Mice显示文摘Evidence in animals suggests that deep brain stimulation or optogenetics can be used for recovery from disorders of consciousness(DOC).However,these treatments require invasive procedures.This report presents a noninvasive strategy to stimulate central nervous system neurons selectively for recovery from DOC in mice.Through the delivery of ultrasound energy to the ventral tegmental area,mice were aroused from an unconscious,anaesthetized state in this study,and this process was controlled by adjusting the ultrasound parameters.The mice in the sham group under isoflurane-induced,continuous,steady-state general anaesthesia did not regain their righting reflex.On insonation,the emergence time from inhaled isoflurane anaesthesia decreased(sham.13.63±0.53 min,ultrasound.1.5±0.19 min,p<0.001).Further,the induction time(sham.12.0±0.6 min,ultrasound.17.88±0.64 min,p<0.001)and the concentration for 50%of the maximal effect(EC50)of isoflurane(sham.0.6%,ultrasound.0.7%)increased.In addition,ultrasound stimulation reduced the recovery time in mice with traumatic brain injury(sham.30.38±1.9 min,ultrasound.7.38±1.02 min,p<0.01).This noninvasive strategy could be used on demand to promote emergence from DOC and may be a potential treatment for such disorders. | Tianyuan Bian Wen Meng Meihong Qiu Zhigang Zhong Zhengrong Lin Junjie Zou Yibo Wang Xiaowei Huang Lisheng Xu Tifei Yuan Zhili Huang Lili Niu Long Meng Hairong Zheng | 2021 | Research2021，，1： | 2 |
| 20 | Chinese Pathogen Identification Net:A Laboratory Network for Surveillance and Response of Bacterial Infectious Diseases显示文摘Infectious diseases are a sustained threat to social development and public health.Bacterial infectious diseases,including plague,cholera,anthrax,brucellosis,typhoid fever,meningitis,and even those caused by antimicrobial-resistant bacteria,have been prevalent around the world for a long time,and still trigger outbreaks and long-term epidemics in different countries or regions nowadays(1),and trans-regional spread of diseases has frequently exhibited epidemic patterns. | Zhigang Cui Haijian Zhou Shuang Meng Xiaoli Du Jianguo Xu Biao Kan | 2022 | China CDC weekly2022，4，12： | 2 |
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