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| 1 | Laparoscopic approach in gastrointestinal emergencies显示文摘This review focuses on the laparoscopic approach to gastrointestinal emergencies and its more recent indications. Laparoscopic surgery has a specific place in elective procedures, but that does not apply in emergency situations. In specific emergencies, there is a huge range of indications and different techniques to apply, and not all of them are equally settle. We consider that the most controversial points in minimally invasive procedures are indications in emergency situations due to technical difficulties. Some pathologies, such as oesophageal emergencies, obstruction due to colon cancer, abdominal hernias or incarcerated postsurgical hernias, are nearly always resolved by conventional surgery, that is, an open approach due to limited intraabdominal cavity space or due to the vulnerability of the bowel. These technical problems have been solved in many diseases, such as for perforated peptic ulcer or acute appendectomy for which a laparoscopic approach has become a wellknown and globally supported procedure. On the other hand, endoscopic procedures have acquired further indications, relegating surgical solutions to a second place; this happens in cholangitis or pancreatic abscess drainage. This endoluminal approach avoids the need for laparoscopic development in these diseases. Nevertheless, new instruments and new technologies could extend the laparoscopic approach to a broader array of potentials procedures. There remains, however, a long way to go. | Rosa M Jimenez Rodriguez Juan José Segura-Sampedro Mercedes Flores-Cortés Francisco López-Bernal Cristobalina Martín Verónica Pino Diaz Felipe Pareja Ciuro Javier Padillo Ruiz | 2016 | World Journal of Gastroenterology2016，22，9： | 5 |
| 2 | Tourism versus nature conservation: reconciliation of common interests and objectives——an analysis through Picos de Europa National Park显示文摘Nature tourism and particularly tourism in national parks have acquired significant importance in contemporary societies. Post-Fordist consumers have reevaluated the meanings of ‘nature' and ‘natural spaces' and now avoid standardization to seek singularity. Tourism in national parks is a consequence of this tendency and has both positive and negative aspects. The purpose of this sociological research is to describe the most relevant conflicts in the Picos de Europa National Park(Spain) involving the park's conservation, local economic development,and tourism. Seven in-depth interviews and three focus groups were addressed to key local stakeholders.In this research were identified three chief areas of existing or potential inter-related conflicts and the main actors interacting with them. The first is on population, particularly, the negative consequences of depopulations on the local socio-economic development and the environment. A second source of conflicts identified is caused by the difficult conciliation between commercial exploitation and conservation of the protected natural area. More precisely, this specific form of tourism positively contributes to the economy of local communities whilst problems can arise for the conservation goals of National Parks. Thirdly, in this research is also analyzed the institutional governance and the inter and intra-governmental conflicts as well as with the Park's management body. These findings provide important information for the improved management of tourism and conflicting interests in natural parks. | LóPEZ Iván PARDO Mercedes | 2018 | Journal of Mountain Science2018，15，11： | 4 |
| 3 | Translational pancreatic cancer research:a comparative study on patient-derived xenograft models显示文摘AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice.METHODS This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreatic adenocarcinoma. Tumour samples from pancreatic cancer patients were transplanted into nude mice in three different locations(intraperitoneal, subcutaneous and pancreatic). Histological analysis(haematoxylin-eosin and Masson's trichrome staining) and immunohistochemical assessment of apoptosis(TUNEL), proliferation(Ki-67), angiogenesis(CD31) and fibrogenesis(α-SMA) were performed. When a tumour xenograft reached the target size, it was reimplanted in a new nude mouse. Three sequential tumour xenograft generations were generated(F1, F2 and F3).RESULTS The overall tumour engraftment rate was 61.1%. The subcutaneous model was most effective in terms of tissue growth(69.9%), followed by intraperitoneal(57.6%) and pancreatic(55%) models. Tumour development was faster in the subcutaneous model(17.7 ± 2.6 wk) compared with the pancreatic(23.1 ± 2.3 wk) and intraperitoneal(25.0 ± 2.7 wk) models(P = 0.064). There was a progressive increase in the tumour engraftment rate over successive generations for all three models(F1 28.1% vs F2 71.4% vs F3 80.9%, P < 0.001). There were no significant differences in tumour xenograft differentiation and cell proliferation between human samples and the three experimental models among the sequential generations of tumour xenografts. However, a progressive decrease in fibrosis, fibrogenesis, tumour vascularisation and apoptosis was observed in the three experimental models compared with the human samples. All three pancreatic patient-derived xenograft models presented similar histological and immunohistochemical characteristics.CONCLUSION In our experience, the faster development andgreatest number of viable xenografts could make the subcutaneous model the best option for experimentation in pancreatic cancer. | Mercedes Rubio-Manzanares Dorado Luis Miguel Marín Gómez Daniel Aparicio Sánchez Sheila Pereira Arenas Juan Manuel Praena-Fernández Juan Jose Borrero Martín Francisco Farfán López Miguel ángel Gómez Bravo Jordi Muntané Relat Javier Padillo Ruiz | 2018 | World Journal of Gastroenterology2018，24，7： | 2 |
| 4 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | Plasma Fatty Acid-Binding Protein 4 Increases with Renal Dysfunction in Type 2 Diabetic Patients without Microalbuminuria显示文摘 | Cabré Anna Lázaro Iolanda Girona Josefa Manzanares Josep M Marimón Francesc Plana Núria Heras Mercedes Masana Lluís | 2008 | Clinical Chemistry2008，，1： | 1 |
| 6 | Solid-phase microextraction and gas chromatography-mass spectrometry of volatile compounds from avocado puree after microwave processing显示文摘 | López Mercedes G Guzmán G R Dorantes A L | 2004 | Journal of Chromatography A2004，1036，1： | 1 |
| 7 | Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation显示文摘 | Juan C. Rodríguez-Sanjuán Francisco González Carlos Juanco Luis A. Herrera Mercedes López-Bautista Mónica González-Noriega Elena García-Somacarrera Javier Figols Manuel Gómez-Fleitas Martín Silván | 2008 | World Journal of Surgery2008，，7： | 1 |
| 8 | Evaluation of ancient structures by GPR (ground penetrating radar): The arch bridges of Galicia (Spain) 显示文摘 | Mercedes S Henrique L Alexandre N | 2011 | Scientific P esearch and Essays2011，6，8： | 1 |
| 9 | Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy 显示文摘 | MERCEDES N L CRISTIAN P MARCOS R | 2007 | Invest Ophthalmol- VisSci2007，48，3： | 1 |
| 10 | Radiological and Pathological Assessment of Hepatocellular Carcinoma Response to Radiofrequency. A Study on Removed Liver after Transplantation显示文摘 | Juan C. Rodríguez-Sanjuán Francisco González Carlos Juanco Luis A. Herrera Mercedes López-Bautista Mónica González-Noriega Elena García-Somacarrera Javier Figols Manuel Gómez-Fleitas Martín Silván | 2008 | World Journal of Surgery2008，，7： | 1 |
| 11 | Predictive factors for mortality in Fournier’s gangrene: A series of 59 cases显示文摘 | Andrés García Marín Fernando Turégano Fuentes Marta Cuadrado Ayuso Juan Antonio Andueza Lillo Juan Carlos Cano Ballesteros Mercedes Pérez López | 2014 | Cirugía Espa?ola (English Edition)2014，，： | 1 |
| 12 | Lead isotope ratios in a soil from a coal carbonization plant显示文摘 | Mercedes Díaz-Somoano Montserrat Calvo M. Antonia López Antón Isabel Suarez-Ruiz Roberto García Sabino R. Moinelo M. Rosa Martínez-Tarazona | 2006 | Fuel2006，，7： | 1 |
| 13 | The role of GLUT1 immunostaining in the diagnosis and classification of liver vascular tumors in children显示文摘 | Francisco Hernández Marta Navarro Jose L. Encinas Juan C. López Gutiérrez Manuel López Santamaría Nuria Leal Leopoldo Martínez Mercedes Patrón Juan A. Tovar | | Journal of Pediatric Surgery0，，： | 1 |
| 14 | Rapid flow injection method for the determination of sulfite in wine using the permanganate–luminol luminescence system显示文摘 | Mercedes Villar Navarrro María Ramos Payán Miguel Angel Bello López Rut Fernández-Torres Manuel Callejón Mochón | 2010 | Talanta2010，，5： | 1 |
| 15 | Dysplasia and colorectal cancer in a patient with ulcerative colitis and primary sclerosing cholangitis: A case report and a short review of the literature显示文摘 | María Chaparro María Trapero-Marugán Mercedes Guijarro Consuelo López Ricardo Moreno-Otero Javier P. Gisbert | 2012 | Journal of Crohn’s and Colitis2012，，： | 1 |
| 16 | COX-2 is involved in vascular oxidative stress and endothelial dysfunction of renal interlobar arteries from obese Zucker rats显示文摘 | Mercedes Mu?oz Ana Sánchez María Pilar Martínez Sara Benedito Maria-Elvira López-Oliva Albino García-Sacristán Medardo Hernández Dolores Prieto | 2015 | Free Radical Biology and Medicine2015，，： | 1 |
| 17 | Phenotypic characterization of idiosyncratic drug‐induced liver injury: The influence of age and sex显示文摘 | M. Isabel Lucena Raúl J. Andrade Neil Kaplowitz Miren García‐Cortes M. Carmen Fernández Manuel Romero‐Gomez Miguel Bruguera Hacibe Hallal Mercedes Robles‐Diaz Jose F. Rodriguez‐González Jose Maria Navarro Javier Salmeron Pedro Martinez‐Odriozola Ramón Pér | 2009 | Hepatology2009，，： | 1 |
| 18 | Fatty acid-binding protein 4 is associated with endothelial dysfunction in patients with type 2 diabetes显示文摘 | Gemma Aragonès Raimon Ferré Iolanda Lázaro Anna Cabré Núria Plana Jordi Merino Mercedes Heras Josefa Girona Lluís Masana | 2010 | Atherosclerosis2010，，1： | 1 |
| 19 | Gastroenterologist-guided sedation with propofol for endoscopic ultrasonography in average-risk and high-risk patients: a prospective series显示文摘 | Eduardo Redondo-Cerezo Antonio Sánchez-Robaina Juan Gabriel Martínez Cara Manuel Ojeda-Hinojosa Ana Matas-Cobos Antonio Damián Sánchez Capilla Mercedes López de Hierro Ruíz Julio Pleguezuelo-Díaz Javier de Teresa | 2012 | European Journal of Gastroenterology & Hepatology2012，，5： | 1 |
| 20 | ECIEN-2020 study:the effect of COVID-19 on admissions for non-COVID-19 diseases显示文摘Background The pandemic caused by severe acute respiratory coronavirus 2(SARS-CoV-2)has had great effects on health systems worldwide,not only in relation to coronavirus disease 2019(COVID-19)cases but also affecting patients with other pathologies.Methods ECIEN-2020 is an observational study conducted in a tertiary referral hospital in Navarra,Spain.It describes the effects of COVID-19 pandemic and the preventive measures adopted,in pediatric admissions for non-COVID-19 diseases.Admissions during March-June 2020(first wave of the COVID-19 pandemic in Spain)are described and compared with the same quarter in 2019.A sub-analysis was performed delving into epidemiology.Patient characteristics(age,sex,past medical history),disease characteristics(symptoms,duration of symptoms,previous consultation in Primary Care Health Center),and admission characteristics(place and average stay)were analyzed.Results A 33% reduction in the number of pediatric hospital admissions was observed,decreasing from 529 hospitaliza-tions in 2019 to 353 in 2020(P<0.001).This highlights a 48% reduction in patients admitted for pulmonary diseases.There were no significant changes in average hospital-stay,percentage of intensive care unit admissions,or in admissions for other reasons.Percentage of patients admitted among those seen in the emergency department rose from 5.1%in 2019 to 10.9% in 2020,whereas the total number of consultations in the emergency department decreased by 68%.Conclusion The pandemic and the measures adopted due to SARS-CoV-2 have significantly decreased pediatric admissions for non-COVID-19 diseases,especially due to a reduction in the hospitalization for respiratory diseases. | Beatriz Ramos-Lacuey Mercedes Herranz Aguirre Clara Calderón Gallego Andrea Ilundain López de Munain Eva Gembero Esarte Laura Moreno-Galarraga | 2021 | World Journal of Pediatrics2021，17，1： | 0 |
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