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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers显示文摘AIM:To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori(H.pylori)-associated,non-steroidal inflammatory drug(NSAID)-associated and idiopathic-gastric ulcers.METHODS:We studied a cohort of randomly selected patients with H.pylori(group 1,n=30),NSAID(group 2,n=18),combined H.pylori and NSAID associated gastric ulcers(group 3,n=24),and patients with idiopathic gastric ulcers(group 4,n=20).Immunohistochemistry for MUC1,MUC4,MUC17,and staining for Erythrina cristagalli agglutinin and Sambucus nigra agglutinin(SNA)lectins was performed on sections from the ulcer margins.RESULTS:Staining intensity of MUC17 was higher in H.pylori ulcers(group 1)than in idiopathic ulcers(group4),11.05±3.67 vs 6.93±4.00 for foveola cells,and10.29±4.67 vs 8.00±3.48 for gland cells,respectively(P<0.0001).In contrast,MUC1 expression was higher in group 4 compared group 1,9.89±4.17 vs 2.93±5.13 in foveola cells and 7.63±4.60 vs 2.57±4.50 for glands,respectively(P<0.0001).SNA lectin staining was increased in group 4,in parallel to elevated MUC1expression,indicating more abundantα2-6 sialylation in that group.CONCLUSION:Cytoplasmic MUC17 staining was sig-nificantly decreased in the cases with idiopathic ulcer.The opposite was observed for both MUC1 and SNA lectin.This observation may reflect important pathogenic mechanisms,since different mucins with altered sialylation patterns may differ in their protection efficiency against acid and pepsin. | Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 3 | Small (Sendai Negative) Branch-Duct IPMNs: Not Harmless显示文摘 | Stefan Fritz Miriam Klauss Frank Bergmann Thilo Hackert Werner Hartwig Oliver Strobel Bogata D. Bundy Markus W. Büchler Jens Werner | 2012 | Annals of Surgery2012，，2： | 3 |
| 4 | Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy eows显示文摘 | Miriam L K Julie R B Debra A D | 1998 | Journal of Nutrition1998，128，： | 1 |
| 5 | Effect of procalcitonin-guded treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trail 显示文摘 | Miriam C Dalana J Roland B | 2004 | Lancet2004，363，： | 1 |
| 6 | Transition Metal Complexes of Boron-synthesis,Structure and Reactivity显示文摘 | HOLGER B MIRIAM C | 2001 | Coordination Chemistry Reviews2001，223，1： | 1 |
| 7 | Reducing pre -hospital delay in acute stroke 显示文摘 | Miriam B Robin L Vincent T | 2009 | Nat Rev Neuro12009，5，9： | 1 |
| 8 | Systematic review of the effectiveness of community pharmacy-based interventions toreduce risk behaviours and risk factors forcoronary heart disease 显示文摘 | Alison B Claire A Miriam A | 2003 | Journal of Public Health Medicine2003，25，2： | 1 |
| 9 | Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia a prospective cohort triM显示文摘 | Fabian M Miriam CC Thomas B | 2010 | Chest2010，135，1： | 1 |
| 10 | Association between high - risk human papilloma virus DNA load and pre - cursor lesions of cervical cancer in Mexican women 显示文摘 | DULCE M H LAURA O B MIRIAM G J | 2003 | Gyne Onco2003，90，： | 1 |
| 11 | Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows 显示文摘 | Miriam L K Julie R B Debra A D | 1998 | Journal of Nutrition1998，128，： | 1 |
| 12 | Correction for light absorption in flurecence studies of proteinligand interactions 显示文摘 | BERRY B RODNEY W K MIRIAM R W | 1983 | Analytical Biochemistry1983，132，： | 1 |
| 13 | Soil enzymeactivities under long-term tillage and crop rotation systems insubtropical agro-ecosystems显示文摘 | Elcio L B Miriam K Amaldo C F | 2004 | Brazilian Journal of Microbiology2004，35，4： | 1 |
| 14 | Osmotic dehydra-tion of tomato in ternary solutions:Influence of process vari-ables on mass transfer kinetics and an evaluation of the re-tention of carotenoids显示文摘 | Renata V T Alessandra F B Miriam D H | 2007 | Journal of Food Engineering2007，，82： | 1 |
| 15 | Association belwen high risk human papillomarirus DNA load and precursor Lesions of lervical cancer in Mexican women显示文摘 | DULEE M H LAURA O B MIRIAM G J | 2003 | Gyno Onco2003，90，： | 1 |
| 16 | Differentiation of pancreas carcinoma from healthy pancreatic tissue using mutipile b-values显示文摘 | Andreas L Frederik B L Miriam K | 2009 | Invest Radiol2009，44，12： | 1 |
| 17 | Novel RGD lipopeptides for the targeting of liposomes to integrin-expressing endothelial and melanoma cells 显示文摘 | PETER H MIRIAM B TINA V | 2004 | Protein Engineering Design and Selection2004，17，5： | 1 |
| 18 | Photocatalytic activity of structured mesoporous TiO2 materials 显示文摘 | MERCEDES A CARMELA A MIRIAM B | 2006 | J Phys Chem: B2006，110，13： | 1 |
| 19 | An assessment of Hg pollution in different gold mining areas, Amazon Brazil显示文摘 | Miriam B O M Wanderley R C Fernando J P B | | 0，，02： | 1 |
| 20 | Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice显示文摘 | Sonveaux Pierre Végran Frédérique Schroeder Thies Wergin Melanie C Verrax Julien Rabbani Zahid N De Saedeleer Christophe J Kennedy Kelly M Diepart Caroline Jordan Bénédicte F Kelley Michael J Gallez Bernard Wahl Miriam L Feron Olivier Dewhir | 2008 | Journal of Clinical Investigation2008，，12： | 1 |
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