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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Analysis of products, mechanisms of reaction, and some functional properties of soy protein hydrolysates 显示文摘 | MOLINA ORTIZ S E ANON M C | 2000 | JAOCS2000，77，： | 1 |
| 3 | Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator显示文摘 | Molina C Ribo M Rubiera M | 2006 | Stroke2006，37，： | 1 |
| 4 | 显示文摘 | Almansa C Molina S M Rodriguez R F | 2004 | Microporous and Mesoporous Materials2004，76，3： | 1 |
| 5 | First genotyping of Giardia lamblia from human and animal feces in Argentina, South America 显示文摘 | Minvielle M C Molina N B Polverino D | 2008 | Mem Inst Oswaldo Cruz2008，103，1： | 1 |
| 6 | Determination oforganophosphorous pesticides in water by SPE followed by LC/ high flow pneumatically assisted electrospray MS显示文摘 | Molina C Honing M Barcelo D | 1994 | Anal Chem1994，66，24： | 1 |
| 7 | Memetic algorithms for continuous optimisation based on local search chains 显示文摘 | Molina D Lozano M Garefa-Martlnez C | 2010 | Evolutionary Computation2010，18，1： | 1 |
| 8 | Physicians' knowledge of inhaler devices and inha- lation techniques remains poor in Spain显示文摘 | Plaza V Sanchis J Roma P Molina J Calle M Quirce S Viejo JL Ca- ballero F Murio C | 2012 | J Aerosol Med Pulm Dm8 Deliv2012，25，1： | 1 |
| 9 | Differentialsynthesis of fermentative aroma compounds of two related commercialwine yeast strains显示文摘 | MOLINA A M GUADALUPE V VARELA C | 2009 | Food Chemistry2009，117，2： | 1 |
| 10 | Review of 64 cases of death in children with Prader-Willi syndrome (PWS) 显示文摘 | Tauber M Diene G Molinas C | 2008 | Am J Med Genet A2008，146，7： | 1 |
| 11 | Tumor markers in response monitoring and prognosis of non small cell lung cancer:preliminary report显示文摘 | Vinolas N Molina R Galan M C Casas F Callejas M A Filella X | 1998 | Anticancer Res1998，18，1： | 1 |
| 12 | Analysis of gene status in cervical dysplastic lesions and squamous cell carcinoma using tissue microarrays显示文摘 | Costa C Espinet B Molina M A | 2009 | Histol Histopathol2009，24，7： | 1 |
| 13 | Effect of Different Non-ionic Surfactants on the Biodegradation of PAHs by Diverse Aerobic Bacteria显示文摘 | Bautista L F Sanz R Molina M C | 2009 | lnt Biodeterior Biodegrad2009，63，7： | 1 |
| 14 | Characterization of Tn1546,a Tn3-related transposon conferring glycopep- tide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147显示文摘 | Arthur M Molinas C Depardieu F | 1993 | J Bacte- rio11993，175，1： | 1 |
| 15 | Platelet function assays in strokemanagement: more study is needed显示文摘 | SELIM M H MOLINA C A | 2010 | Stroke2010，41，10： | 1 |
| 16 | Vectorial diffraction analysis of near-field focusing of perfect black Fresnel zone plates under various polarization states显示文摘 | Lopez L C Molina M P Gonzalez P A | 2011 | Journal of Light Technology2011，29，6： | 1 |
| 17 | Acute hyperglycemia state is as- sociated with lower tpa-induced xecanalization rates in stroke patients 显示文摘 | Ribo M Molina C Montaner J | 2005 | Stroke2005，36，： | 1 |
| 18 | Relationship between structural changes and functional properties of soybean protein isolates-carrageenan systems显示文摘 | Molina Ortiz S E Puppo M C Wagner J R | | 0，，： | 1 |
| 19 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study显示文摘 | Keith C Bible Vera J Suman Julian R Molina Robert C Smallridge William J Maples Michael E Menefee Joseph Rubin Kostandinos Sideras John C Morris Bryan McIver Jill K Burton Kevin P Webster Carolyn Bieber Anne M Traynor Patrick J Flynn Boon Cher Goh Hui Tan | 2010 | Lancet Oncology2010，，10： | 1 |
| 20 | Thermal expansion behaviour of aluminum/SiC composites with bimodal particle distributions显示文摘 | Arpon R Molina J M Saravanan R A Garcia-Cordovilla C Louis E Narciso J | 2003 | Acta Mater2003，51，11： | 1 |
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