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| 1 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Activity of antioxidant en-zymes in response to cadmium in Crotalaria juncea显示文摘 | Pereira G J G Molina S M G Lea P J | 2002 | Plant andSoil2002，239，： | 1 |
| 4 | Peptic peptide mapping by HPLC, on line with photodiode array de- tection, of a hemoglobin hydrolysate produced at pilot- plant scale from an ultrafiltration process 显示文摘 | ZHAO Q Y MOLINA P PIOT J M | 1997 | Journal of Liquid Chromatography & Related Technologies1997，20，11： | 1 |
| 5 | Activity of antioxidant enzymes in response to cadmium in Crotalariajuncea显示文摘 | PEREIRA G J G MOLINA S M G LEA P J | 2002 | Plant and Soil2002，，239： | 1 |
| 6 | Update on medical therapy for obscure gastrointestinal hemorrhage显示文摘 | Molina Infante J Pérez Gallardo B Fernández Bermejo M | 2007 | Revista Espaola de Enfermedades Digestivas2007，99，8： | 1 |
| 7 | The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel显示文摘 | Lovato T L Nguyen T P Molina M R | 2002 | Devel- opment2002，129，21： | 1 |
| 8 | Fused pyrimidines by a tandem aza-wittig/electrocyclic ring closure strategy: synthesis of pyrazolopyrimidine, triaololo pyrimide, and thiazolo pyrimidine derivatives 显示文摘 | Molina P Arques A Vinader M V | 1988 | J Org Chem1988，53，： | 1 |
| 9 | Physicians' knowledge of inhaler devices and inha- lation techniques remains poor in Spain显示文摘 | Plaza V Sanchis J Roma P Molina J Calle M Quirce S Viejo JL Ca- ballero F Murio C | 2012 | J Aerosol Med Pulm Dm8 Deliv2012，25，1： | 1 |
| 10 | 6π-Electrocyclization of Azahexa-1,3,5-trienes: A New Entry to a Regiospecific Synthesis of 3-Aryl (heteroaryl) pyridines显示文摘 | Molina P Pastor A Vilaplana M J | 1993 | Tetrahedron1993，49，35： | 1 |
| 11 | Differential expression of pathogen-responsive genes encoding two types of glycine-rich proteins in barley 显示文摘 | Molina A Mena M Carbonero P | 1997 | Plant Mol Biol1997，33，： | 1 |
| 12 | Vectorial diffraction analysis of near-field focusing of perfect black Fresnel zone plates under various polarization states显示文摘 | Lopez L C Molina M P Gonzalez P A | 2011 | Journal of Light Technology2011，29，6： | 1 |
| 13 | Residue persistence in sheep milk following antibiotic therapy显示文摘 | MOLINA A MOLINA M P ALTHAUS R L | 2003 | The Veterinary Journal2003，165，1： | 1 |
| 14 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study显示文摘 | Keith C Bible Vera J Suman Julian R Molina Robert C Smallridge William J Maples Michael E Menefee Joseph Rubin Kostandinos Sideras John C Morris Bryan McIver Jill K Burton Kevin P Webster Carolyn Bieber Anne M Traynor Patrick J Flynn Boon Cher Goh Hui Tan | 2010 | Lancet Oncology2010，，10： | 1 |
| 15 | Secondary organic aerosol formation from acety-lene (C2H2): seed effect on SOA yield due to organic photochemistry in the aerosol aqueousphase 显示文摘 | Volkamer R Ziemann P J Molina M J | 2009 | Atmospheric Chemistry and Physics2009，9，： | 1 |
| 16 | Antimicrobial Agent Detection in Ewes' Milk by the Microbial Inhibitor Test Brilliant Black Reduction Test-BRT AiM(R)显示文摘 | Molina M P Althaus R L Molina A | 2003 | Int Dairy J2003，13，10： | 1 |
| 17 | Analysis Time and Lactation Stage Influence on Lactoperoxidase System Components in Dairy Ewe Milk 显示文摘 | ALTHAUS R L MOLINA M P | 2001 | J Dairy Sci2001，84，： | 1 |
| 18 | Evaluation of the BRT(R) Method for Detection of β-lactam Antibiotics in Ewe Milk显示文摘 | Althaus R L Molina M P Rodríguez | 2001 | Milchwissenschaft2001，56，10： | 1 |
| 19 | Residue Persistence in Sheep Milk Following Antibiotic Therapy显示文摘 | Molina A Molina M P Althaus R L | 2003 | Vet J2003，165，1： | 1 |
| 20 | Long-term follow-up of patients with post-traumatic refractory high intracranial pressure treated with lumbar drainage显示文摘 | Llompart-Pou J A Abadal J M Pérez-Bárcena J Molina M Brell M Ibá?ez J Raurich J-M Homar J | 2011 | EN2011，，1： | 1 |
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