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| 1 | Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure显示文摘SIRT1,a mammalian ortholog of yeast silent information regulator 2(Sir2),is an NAD+-dependent protein deacetylase that plays a critical role in the regulation of vascular function.The current study aims to investigate the functional significance of deacetylase activity of SIRT1 in heart.Here we show that the early postnatal hearts expressed the highest level of SIRT1deacetylase activity compared to adult and aged hearts.We generated transgenic mice with cardiac-specific expression of a dominant-negative form of the human SIRT1(SIRT1H363Y),which represses endogenous SIRT1 activity.The transgenic mice displayed dilated atrial and ventricular chambers,and died early in the postnatal period.Pathological,echocardiographic and molecular phenotype confirmed the presence of dilated cardiomyopathy.Terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling analysis revealed a greater abundance of apoptotic nuclei in the hearts of transgenic mice.Furthermore,we show that cardiomyocyte apoptosis caused by suppression of SIRT1 activity is,at least in part,due to increased p53acetylation and upregulated Bax expression.These results indicate that dominant negative form of SIRT1(SIRT1H363Y)overexpression in mouse hearts causes cardiomyocyte apoptosis and early-onset heart failure,suggesting a critical role of SIRT1 in preserving normal cardiac development during the early postnatal period. | MU WenLi ZHANG QingJun TANG XiaoQiang FU WenYan ZHENG Wei LU YunBiao LI HongLiang WEI YuSheng LI Li SHE ZhiGang CHEN HouZao LIU DePei | 2014 | Science China(Life Sciences)2014，57，9： | 12 |
| 2 | Adaptive sliding-mode guidance of a homing missile 显示文摘 | Zhou Di Mu Chundi Xu Wenli | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
| 3 | Adaptive Sliding-Mode Guidance of a Homing Missile显示文摘 | Zhou Di Mu Chundi Xu Wenli | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
| 4 | Adaptive Sliding-mode Guidance of a Homing Missile显示文摘 | Zhou Di Mu Chundi Xu Wenli | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
| 5 | Adaptive sliding-mode guidance of a homing missile显示文摘 | Zhou Di Mu Chundi Xu Wenli | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
| 6 | Adaptive Sliding-Mode Guidance of a Homing Missile显示文摘 | Zhou Di Mu Chundi Xu Wenli | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
| 7 | Adaptive sliding-mode guidance of a homing missile显示文摘 | Zhou Di Mu Chundi Xu Wenli | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
| 8 | Regime shift of the dominant factor for halocline depth in the Canada Basin during 1990–2008显示文摘The World Ocean Database(WOD) is used to evaluate the halocline depth simulated by an ice-ocean coupled model in the Canada Basin during 1990–2008. Statistical results show that the simulated halocline is reliable.Comparing of the September sea ice extent between simulation and SSM/I dataset, a consistent interannual variability is found between them. Moreover, both the simulated and observed September sea ice extent show staircase declines in 2000–2008 compared to 1990–1999. That supports that the abrupt variations of the ocean surface stress curl anomaly in 2000–2008 are caused by rapid sea ice melting and also in favor of the realistic existence of the simulated variations. Responses to these changes can be found in the upper ocean circulation and the intermediate current variations in these two phases as well. The analysis shows that seasonal variations of the halocline are regulated by the seasonal variations of the Ekman pumping. On interannual time scale, the variations of the halocline have an inverse relationship with the ocean surface stress curl anomaly after 2000,while this relationship no longer applies in the 1990 s. It is pointed out that the regime shift in the Canada Basin can be derived to illustrate this phenomenon. Specifically, the halocline variations are dominated by advection in the 1990 s and Ekman pumping in the 2000 s respectively. Furthermore, the regime shift is caused by changing Transpolar Drift pathway and Ekman pumping area due to spatial deformation of the center Beaufort high(BH)relative to climatology. | MU Longjiang ZHAO Jinping ZHONG Wenli | 2017 | Acta Oceanologica Sinica2017，36，1： | 1 |
| 9 | Adaptive sliding-mode guidance of a homing missile显示文摘 | Zhou Di Mu Chundi Xu Wenli | | 0，，04： | 1 |
| 10 | Adaptive sliding-mode guidance of a homing missile显示文摘 | Di Zhou Chundi Mu Wenli Xu | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
| 11 | Adaptive sliding mode guidance of a homing missile显示文摘 | Zhou Di Mu Chundi Xu Wenli | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
| 12 | Recent advances on applications and biotechnological production of d-psicose显示文摘 | Wanmeng Mu Wenli Zhang Yinghui Feng Bo Jiang Leon Zhou | 2012 | Applied Microbiology and Biotechnology2012，，6： | 1 |
| 13 | Adaptive sliding-mode guidance of a homing missile显示文摘 | Di Zhou Chundi Mu Wenli Xu | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
| 14 | Adaptive Sliding-Mode Guidance of a Homing Missile 显示文摘 | Mu Chundi Xu Wenli | 1999 | Joumal of Guidance Control and Dynamics1999，22，4： | 1 |
| 15 | Adaptive two-step filter with applications to bearings-only measurement problem显示文摘 | Zhou Di Mu Chundi Xu Wenli | 1999 | Journal of Guidance1999，22，5： | 1 |
| 16 | Adaptive sliding-mode guidance of a homing missile 显示文摘 | ZHOU Di MU Chundi XU Wenli | 1999 | J of Guidance Control and Dynamics1999，22，4： | 1 |
| 17 | Adaptive two-step filter withapplications to bearings-only mrasurement problem显示文摘 | Zhou Di Mu Chundi Xu Wenli | 1999 | Journalof Guidance Control and Dynamics1999，22，5： | 1 |
| 18 | Adaptive Sliding-Mode Guidance of a Homing Missile显示文摘 | Di Zhou Chundi Mu Wenli Xu | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
| 19 | Adaptive slidingmode guidance of a homing missile 显示文摘 | ZHOU Di MU Chundi XU Wenli | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
| 20 | Adaptive sliding-mode guidance of a homing missile显示文摘 | Di Zhou Chundi Mu Wenli Xu | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
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