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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | microRNAs-powerful repression comes from small RNAs显示文摘microRNAs (miRNAs) encode a novel class of small, non-coding RNAs that regulate gene expression post-trancriptionally. miRNAs comprise one of the major non-coding RNA families, whose diverse bio- logical functions and unusual capacity for gene regulation have attracted enormous interests in the RNA world. Over the past 16 years, genetic, biochemical and computational approaches have greatly shaped the growth of the field, leading to the identification of thousands of miRNA genes in nearly all metazoans. The key molecular machinery for miRNA biogenesis and silencing has been identified, yet the precise biochemical and regulatory mechanisms still remain elusive. However, recent findings have shed new light on how miRNAs are generated and how they function to repress gene expression. miRNAs provide a paradigm for endogenous small RNAs that mediate gene silencing at a genome-wide level. The gene silencing mediated by these small RNAs constitutes a major component of gene regu- lation during various developmental and physiological processes. The accumulating knowledge about their biogenesis and gene silencing mechanism will add a new dimension to our understanding about the complex gene regulatory networks. | MA Cong, LIU YuFei & HE Lin 535 LSA, Division of Cell and Developmental Biology, MCB Department, University of California at Berkeley, Berkeley, CA 94720-3200 | 2009 | Science China(Life Sciences)2009，52，4： | 7 |
| 3 | 血管内皮生长因子受体3通过β抑制蛋白1调节内皮功能显示文摘受体信号转导对于维持血管内皮功能至关重要,其在动脉粥样硬化和肺动脉高压(pulmonary arterial hypertension,PAH)等血管疾病中出现失调。内皮功能相关受体信号包括血管内皮生长因子(vascular endothelial growth factor,VEGF)受体(VEGFR)和G蛋白耦联受体(G protein-coupled receptor,GPCR),激活特异的细胞内信号通路和反应。 | 刘青 叶鹏 Ma Z Yu YR Badea CT Kovacs JJ Xiong X Comhair S Piantadosi CA Rajagopal S | 2019 | 中华高血压杂志2019，27，1： | 5 |
| 4 | 尿酸是正常高值血压发展为高血压的一个重要危险标志物显示文摘正常高值血压常发展为高血压,是一个与心血管病和脑卒中高死亡率和高发病率相关的事件。然而,正常高值血压发展成高血压的危险因素仍不清楚。研究者采用年龄(52.1±11.0)岁日本成年高血压患者3584例(2081例为男性)的资料进行前瞻性群体研究,研究对象在2004年被发现处于正常高值血压阶段,并在2009年重新进行检查。 | 黄洁 叶鹏 Kuwabara M Hisatome I Niwa K Hara S Roncal-Jimenez CA Bjornstad P Nakagawa T Andres-Hernando A Sato Y Jensen T Garcia G Rodriguez-Iturbe B Ohno M Lanaspa MA Johnson RJ | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 5 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia 显示文摘 | Hicks CA Ward MA Swettenham JB O'Neill MJ | 1999 | Eur J Pharmacol1999，381，23： | 2 |
| 7 | Prognosis and outcomes of patients with community-acquired pneumonia显示文摘 | Fine MJ Smith MA Carson CA | 1996 | JAMA1996，275，： | 1 |
| 8 | Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial 显示文摘 | Morrison CA Carrick MM Norman MA | 2011 | J Trauma2011，70，3： | 1 |
| 9 | Longitudinal assessment of quality of life in laryngeal cancer patients 显示文摘 | List MA Ritter-Sterr CA Baker TM | 1996 | Head Neck1996，18，1： | 1 |
| 10 | Patients with diabetes and depression may need additional support for exercise显示文摘 | Vickers KS Nies MA Patten CA | | 0，，04： | 1 |
| 11 | Regulation of delayed prostaglandin production in activated P388D1 macrophages by group IV cytosolic and group V secretory phospholipase A2s 显示文摘 | Shinohara H Balboa MA Johnson CA | 1999 | J Biol Chem1999，274，12： | 1 |
| 12 | Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy显示文摘 | de Veciana M Major CA Morgan MA | 1995 | N EngL J Med1995，9，19： | 1 |
| 13 | Application of recursive partitioning analysis and evaluation of the use of whole brain radiation among patients treated with stereotactic radiosurgery for newly diagnosed brain metastases显示文摘 | Chidel MA Suh JH Reddy CA Chao ST Lundbeck MF Barnett GH | 2010 | Int J Radiat Oncol Biol Phys2010，47，4： | 1 |
| 14 | Neuropsychological effects of third ventricle tumor surgery显示文摘 | Friedman MA Meyers CA Sawaya R | 2008 | Neurosurgery2008，52，4： | 1 |
| 15 | Evaluation of Water Soluble fl-D-Glucan from Auricularia Aurieular-Judae as Potential Anti-Tumor Agent显示文摘 | Ma Z C Wang J G Zhang L N et cA | 2010 | Carbohydrate Polymers2010，80，4： | 1 |
| 16 | A nowd LEMD3 mutatinn common to pa- tients with osteopoikiliosis with and without melorheostosis 显示文摘 | Couto AR Bruges-Armas J Peach CA Chapman K Brown MA Wordsworth BP | 2007 | Calcif Tissue Int2007，81，2： | 1 |
| 17 | Tissue engineered cartilage显示文摘 | Ashiku SK Randolph MA Vacanti CA | 1997 | Materials Science Forum1997，250，： | 1 |
| 18 | Pre-mRNA splicing aberrations and cancer显示文摘 | Pettigrew CA Brown MA | 2008 | Front Biosci2008，13，： | 1 |
| 19 | Cell-mediated immune response is better preserved by laparoscopic than laparotomy 显示文摘 | Gitzelmann CA Mendoza-Sagaon M Talamini MA | 2000 | Surgery2000，127，1： | 1 |
| 20 | Health promotion for women with physical disabilities: a pilot study 显示文摘 | Hughes RB Nosek MA Howland CA | 2003 | Rehabil Psychol2003，48，3： | 1 |
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