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| 1 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 1: Definitions and diagnosis显示文摘 | Axel Dignass Rami Eliakim Fernando Magro Christian Maaser Yehuda Chowers Karel Geboes Gerassimos Mantzaris Walter Reinisch Jean-Frederic Colombel Severine Vermeire Simon Travis James O. Lindsay Gert Van Assche | 2012 | Journal of Crohn’s and Colitis2012，，10： | 12 |
| 2 | How to perform gastrointestinal ultrasound: anatomy and normal findings显示文摘Gastrointestinal ultrasound is a practical, safe, cheap and reproducible diagnostic tool in inflammatorybowel disease gaining global prominence amongst clinicians. Understanding the embryological processes of the intestinal tract assists in the interpretation of abnormal sonographic findings. In general terms, the examination principally comprises interrogation of the colon, mesentery and small intestine using both lowfrequency and high-frequency probes. Interpretation of findings on GIUS includes assessment of bowel wall thickness, symmetry of this thickness, evidence of transmural changes, assessment of vascularity using Doppler imaging and assessment of other specific features including lymph nodes, mesentery and luminal motility. In addition to B-mode imaging, transperineal ultrasonography, elastography and contrast-enhanced ultrasonography are useful adjuncts. This supplement expands upon these features in more depth. | Nathan S S Atkinson Robert V Bryant Yi Dong Christian Maaser Torsten Kucharzik Giovanni Maconi Anil K Asthana Michael Blaivas Adrian Goudie Odd Helge Gilja Dieter Nuernberg Dagmar Schreiber-Dietrich Christoph F Dietrich | 2017 | World Journal of Gastroenterology2017，23，38： | 5 |
| 3 | Contrast-enhanced harmonic endoscopic ultrasound is able to discriminate benign submucosal lesions from gastrointestinal stromal tumors显示文摘 | Klaus Kannengiesser Reiner Mahlke Frauke Petersen Anja Peters Matthias Ross Torsten Kucharzik Christian Maaser | 2012 | Scandinavian Journal of Gastroenterology2012，，12： | 3 |
| 4 | Recent understanding of IBD pathogenesis: implications for future therapies 显示文摘 | Kucharzik T Maaser C Lugering A | 2006 | Inflamm Bowel Dis2006，12，11： | 1 |
| 5 | Extracellular nucleotides inhibit growth of human oesophageal cancer cells via P2Y2-receptors显示文摘 | Maaser K Hopfner M Kap H | 2002 | Br J Cancer2002，86，4： | 1 |
| 6 | Alpha-Melanocyte stimu- lating hormone and related tripeptides: biochemistry, antiinflam- matory and protective effects in vitro and in vivo, and future per- spectives for the treatment of immune-mediated inflammatory dis- eases显示文摘 | Brzoska T Luger TA Maaser C | 2008 | Endocr Rev2008，29，5： | 1 |
| 7 | Growth inhibition and apoptosis induced by P2Y2 receptors in human colorectal carcinoma cells:involvement of intracellular calcium and cyclic adenosine monophosphate显示文摘 | Hopfner M Maaser K Barthel B | 2001 | Int J Colorectal Dis2001，16，3： | 1 |
| 8 | Extracellular nucleotides inhibit growth of human oesophageal cancer cells via P2Y2 receptors显示文摘 | Maaser K Hopfner M Kap H Sutter AP Barthel B von Lampe B | 2002 | Br J Cancer2002，86，4： | 1 |
| 9 | Instant evaluation of contrast enhanced endoscopic ultrasound helps to differentiate various solid pancreatic lesions in daily routine显示文摘BACKGROUND Contrast enhanced harmonic endoscopic ultrasound(CEH-EUS) is a spreading technique; some studies have shown its value in the diagnosis of pancreatic adenocarcinoma using quantitative analysis.AIM To examine the value of CEH-EUS for differentiating various pancreatic lesions in everyday routine with qualitative and quantitative analysis.METHODS Data of 55 patients with pancreatic lesions who underwent CEH-EUS were analysed retrospectively. Perfusion characteristics were classified by the investigator qualitatively immediately upon investigation, quantitative analysis was performed later on. Samples from fine needle aspiration(EUS-FNA) or surgical specimen served as gold standard.RESULTS CEH-EUS showed 39 hypoenhanced lesions, 3 non-enhanced and 13 hyperenhanced lesions. Concordance of the investigators qualitative classification of peak contrast enhancement with quantitative analysis later on was 100%, while other parameters such as arrival time, time to peak or area under the curve did not show additional value. 34 of 39 hypoenhanced lesions were pancreatic adenocarcinoma; of the hyperenhanced lesions 4 were inflammatory, 3 neuroendocrine carcinomas, 1 lymphoma, 1 insulinoma and 4 metastases(2 of renal cell carcinoma, 2 of lung cancer). Non-enhanced lesions showed up as necroses. Sensitivity for the detection of pancreatic adenocarcinoma was 100%,specificity 87.2% for hypoenhancement alone; in otherwise healthy pancreatic tissue all hypoenhanced lesions were pancreatic adenocarcinoma(sensitivity and specificity 100%, PPV and NPV for adenocarcinoma 100%).CONCLUSION This study again shows the excellent value of CEH-EUS in everyday routine for diagnostics of various focal pancreatic lesions suggesting that qualitatively assessed hypoenhancement is highly predictive for adenocarcinoma. Additional quantitative analysis of perfusion parameters does not add diagnostic yield. In case of the various hyperenhanced pancreatic lesions in our data set, histologic sampling is essential for further treatment. | Klaus Kannengiesser Reiner Mahlke Frauke Petersen Anja Peters Torsten Kucharzik Christian Maaser | 2019 | World Journal of Clinical Cases2019，7，1： | 1 |
| 10 | Extracellular nucleotides inhibit growth of hu man oesophageal cancer cells via P2Y ( 2 )-receptors 显示文摘 | Maaser K Hopfner M Kap H Sutter A P Barthel B yon Lampe B | 2002 | Br J Cancer2002，86，： | 1 |
| 11 | A1- pha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of im- mune-mediated inflammatory diseases显示文摘 | BRZOSKA T LUGER TA MAASER C | 2008 | Endocr Rev2008，29，5： | 1 |
| 12 | Overexpression of the peripheral benzodiazepine receptor is a relevant prognostic factor in stage Ⅲ colorectal cancer显示文摘 | Maaser K Grabowski P Surter A P | | 0，，： | 1 |
| 13 | Recent understanding of IBD pathogenesis: implications for future therapies显示文摘 | Kucharzik T Maaser C Lugering A | 2006 | Inflamm Bowel Dis2006，12，11： | 1 |
| 14 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 1: Definitions and diagnosis显示文摘 | Axel Dignass Rami Eliakim Fernando Magro Christian Maaser Yehuda Chowers Karel Geboes Gerassimos Mantzaris Walter Reinisch Jean-Frederic Colombel Severine Vermeire Simon Travis James O. Lindsay Gert Van Assche | 2012 | Journal of Crohn’s and Colitis2012，，10： | 1 |
| 15 | Recent understanding of IBD pathogenesis:implications for future therapies 显示文摘 | Kuchrzik T Maaser C Ltigering A | 2006 | Inflamm Bowel Dis2006，12，11： | 1 |
| 16 | Mechanisms of mltochondrlal apoptosls induced hy peripheral benzodiazepine reeeptor ligands in human eoloreetal cancer cells 显示文摘 | Maaser K Sutter A P | 2005 | Biochemical and Biophysical Research Communicalions2005，332，3： | 1 |
| 17 | Alpha - melanocyte - stimu- lating hormone and related tripeptides: biochemistry, antiinflammato- ry and protective effects in vitro and in vivo, and future perspectives for the treatment of immune - mediated inflammatory diseases 显示文摘 | Brzoska T Luger TA Maaser C | 2008 | Endocr Rev2008，29，： | 1 |
| 18 | The lymphotoxin-βreceptor is critical for control of murine Citrobacter rodentium-induced colitis显示文摘 | Spahn T W Maaser C Eckmann L | 2004 | Gastroenterology2004，127，5： | 1 |
| 19 | Contrast-enhanced harmonic endoscopic ultrasound is able to discriminate benign submucosal lesions from gastrointestinal stromal tumors显示文摘 | Klaus Kannengiesser Reiner Mahlke Frauke Petersen Anja Peters Matthias Ross Torsten Kucharzik Christian Maaser | 2012 | Scandinavian Journal of Gastroenterology2012，，12： | 1 |
| 20 | Colonic epithelial cells induce endothelial cell expression of ICAM-1 and VCAM-1 by a NF-kappaB dependent mechanism显示文摘 | Maaser C Schoeppner S Kucharzik T | 2001 | Clin Exp Immunol2001，124，2： | 1 |
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